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List of works by Ricardo C. Calhelha

1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: synthesis, biological evaluation, and molecular modelling studies.

scientific article published on 7 July 2013

A comparison of the bioactivity and phytochemical profile of three different cultivars of globe amaranth: red, white, and pink

scientific article published on 17 December 2015

A detailed comparative study between chemical and bioactive properties of Ganoderma lucidum from different origins.

scientific article published on 11 September 2013

A new antitumoral Heteroarylaminothieno[3,2-b]pyridine derivative: its incorporation into liposomes and interaction with proteins monitored by fluorescence.

scientific article published on 16 October 2014

Aesculus hippocastanum L.: A Simple Ornamental Plant or a Source of Compelling Molecules for Industry?

scientific article published in 2023

Amantagula Fruit (Carissa macrocarpa (Eckl.) A.DC.): Nutritional and Phytochemical Characterization

scientific article published on 01 March 2019

Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells.

scientific article

Aminosquaraines as potential photodynamic agents: Synthesis and evaluation of in vitro cytotoxicity

scientific article published on 03 August 2017

Anthocyanin Profile of Elderberry Juice: A Natural-Based Bioactive Colouring Ingredient with Potential Food Application

scientific article published on 26 June 2019

Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate derivatives: in vitro evaluation, cell cycle analysis and QSAR studies.

scientific article published on 6 October 2011

Antimicrobial activity and bioactive compounds of Portuguese wild edible mushrooms methanolic extracts

article

Antimicrobial activity, growth inhibition of human tumour cell lines, and phytochemical characterization of the hydromethanolic extract obtained from Sapindus saponaria L. aerial parts.

scientific article published on 26 December 2013

Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives.

scientific article published on 15 September 2015

Antimicrobial and cytotoxic activities of Alnus rugosa L. aerial parts and identification of the bioactive components

scholarly article in Industrial Crops and Products, vol. 59, August 2014

Antimicrobial/Antibiofilm Activity and Cytotoxic Studies of β-Thujaplicin Derivatives.

scientific article published on 12 July 2016

Antioxidant Extracts of Three Russula Genus Species Express Diverse Biological Activity

scientific article published on 22 September 2020

Antioxidant activity of aminodiarylamines in the thieno[3,2-b]pyridine series: radical scavenging activity, lipid peroxidation inhibition and redox profile ⬇️

scientific article published on March 12, 2013

Antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of artichoke, milk thistle and borututu

article by Carla Pereira et al published August 2013 in Industrial Crops and Products

Antiproliferative Activity of Neem Leaf Extracts Obtained by a Sequential Pressurized Liquid Extraction

scientific article published on 30 July 2018

Antiproliferative Activity of Neem Leaf Extracts Obtained by a Sequential Pressurized Liquid Extraction

Basil as functional and preserving ingredient in "Serra da Estrela" cheese

scientific article

Benzothienoquinolines: New one-pot synthesis and fluorescence studies of their interaction with DNA and polynucleotides

Bioactive Properties of Tabebuia impetiginosa-Based Phytopreparations and Phytoformulations: A Comparison between Extracts and Dietary Supplements.

scientific article published on 21 December 2015

Bioactive formulations prepared from fruiting bodies and submerged culture mycelia of the Brazilian edible mushroom Pleurotus ostreatoroseus Singer

scientific article published in July 2015

Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile.

scientific article

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

article

Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil

Bioactive properties of medicinal plants from the Algerian flora: Selecting the species with the highest potential in view of application purposes

article

Bioactivity and chemical characterization in hydrophilic and lipophilic compounds of Chenopodium ambrosioides L

article by Lillian Barros et al published October 2013 in Journal of Functional Foods

Bioactivity and chemical characterization of Opuntia macrorhiza Engelm. seed oil: potential food and pharmaceutical applications

scientific article published on 26 July 2017

Bioactivity and phytochemical characterization of Arenaria montana L.

scientific article

Bioactivity of different enriched phenolic extracts of wild fruits from Northeastern Portugal: a comparative study

scientific article published on March 2014

Bioactivity, proximate, mineral and volatile profiles along the flowering stages of Opuntia microdasys (Lehm.): defining potential applications.

scientific article published on 15 February 2016

Biological Activity of Pumpkin Byproducts: Antimicrobial and Antioxidant Properties

scientific article published in 2022

By-Products of Camu-Camu [Myrciaria dubia (Kunth) McVaugh] as Promising Sources of Bioactive High Added-Value Food Ingredients: Functionalization of Yogurts

scientific article published on 24 December 2019

Calluna vulgaris (L.) Hull: chemical characterization, evaluation of its bioactive properties and effect on the vaginal microbiota

scientific article published on 01 January 2019

Camphor and Eucalyptol-Anticandidal Spectrum, Antivirulence Effect, Efflux Pumps Interference and Cytotoxicity

scientific article published on 06 January 2021

Castanea sativa male flower extracts as an alternative additive in the Portuguese pastry delicacy "pastel de nata"

scientific article published on 01 March 2020

Challenges of traditional herbal teas: plant infusions and their mixtures with bioactive properties

scientific article published on 30 August 2019

Characterization and Application of Pomegranate Epicarp Extracts as Functional Ingredients in a Typical Brazilian Pastry Product

scientific article published on 25 March 2020

Characterization of a Squaraine/Chitosan System for Photodynamic Therapy of Cancer

scientific article published on February 2016

Chemical Composition and Bioactive Characterisation of Impatiens walleriana

scientific article published on 04 March 2021

Chemical Composition and Plant Growth of Centaurea raphanina subsp. mixta Plants Cultivated under Saline Conditions

scientific article published on 08 May 2020

Chemical and bioactive characterization of the aromatic plant Levisticum officinale W.D.J. Koch: a comprehensive study

scientific article published on 01 February 2020

Chemical characterisation and bioactive properties of Prunus avium L.: The widely studied fruits and the unexplored stems ⬇️

article

Chemical characterization and bioactive properties of Geranium molle L.: from the plant to the most active extract and its phytochemicals.

scientific article published on 20 April 2016

Chemical characterization and bioactive properties of aqueous and organic extracts of Geranium robertianum L.

scientific article published on 6 September 2016

Chemical characterization and bioactive properties of two aromatic plants: Calendula officinalis L. (flowers) and Mentha cervina L. (leaves)

article

Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal "mushroom".

scientific article

Chemical characterization of the medicinal mushroom Phellinus linteus (Berkeley & Curtis) Teng and contribution of different fractions to its bioactivity

Chemical characterization, antioxidant, anti-inflammatory and cytotoxic properties of bee venom collected in Northeast Portugal

scientific article published on 8 June 2016

Chemical composition and bioactive properties of Cichorium spinosum L. in relation to nitrate/ammonium nitrogen ratio

scientific article published on 29 August 2019

Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils

article

Chemical, Cytotoxic, and Anti-Inflammatory Assessment of Honey Bee Venom from Apis mellifera intermissa

scientific article published on 10 December 2021

Comparative investigation on edible mushrooms Macrolepiota mastoidea, M. rhacodes and M. procera: functional foods with diverse biological activities

scientific article published on 01 December 2019

Contribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop

scientific article published on 6 February 2017

Crataegus monogyna buds and fruits phenolic extracts: Growth inhibitory activity on human tumor cell lines and chemical characterization by HPLC–DAD–ESI/MS

Cytotoxicity of Coprinopsis atramentaria extract, organic acids and their synthesized methylated and glucuronate derivatives

article

Cytotoxicity of Portuguese propolis: the proximity of the in vitro doses for tumor and normal cell lines.

scientific article

Detailed phytochemical characterization and bioactive properties of Myrtus nivelii Batt & Trab.

scientific article

Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties.

scientific article published on 14 October 2016

Development of dairy beverages functionalized with pure ergosterol and mycosterol extracts: an alternative to phytosterol-based beverages

scientific article published on 5 January 2017

Development of nutraceutical formulations based on the mycelium of Pleurotus ostreatus and Agaricus bisporus.

scientific article

Differentiating between Monofloral Portuguese Bee Pollens Using Phenolic and Volatile Profiles and Their Impact on Bioactive Properties

scientific article published in 2023

Echinacea purpurea (L.) Moench: Chemical Characterization and Bioactivity of Its Extracts and Fractions

scientific article published on 20 June 2020

Edible flowers as sources of phenolic compounds with bioactive potential

scientific article published on 20 November 2017

Effects of Growing Substrate and Nitrogen Fertilization on the Chemical Composition and Bioactive Properties of Centaurea raphanina ssp. mixta (DC.) Runemark

scientific article published in 2021

Effects of gamma irradiation on cytotoxicity and phenolic compounds of Thymus vulgaris L. and Mentha x piperita L

Effects of gamma radiation on chemical and antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of borututu

Effects of gamma radiation on the bioactivity of medicinal and aromatic plants: Mentha × piperita L., Thymus vulgaris L. and Aloysia citrodora Paláu as case studies

Effects of in vitro gastrointestinal digestion and colonic fermentation on a rosemary (Rosmarinus officinalis L) extract rich in rosmarinic acid

scientific article published on 19 July 2018

Efficient synthesis of 6-(hetero)arylthieno[3,2-b]pyridines by Suzuki-Miyaura coupling. Evaluation of growth inhibition on human tumor cell lines, SARs and effects on the cell cycle

scientific article published on 17 September 2010

Evaluation of Antioxidant and Anticancer Activity of Mono- and Polyfloral Moroccan Bee Pollen by Characterizing Phenolic and Volatile Compounds

scientific article published in 2023

Exploiting the bioactive properties of γ-oryzanol from bran of different exotic rice varieties

scientific article published on 01 May 2019

Exploring the chemical and bioactive properties of Hibiscus sabdariffa L. calyces from Guinea-Bissau (West Africa)

scientific article published on 08 April 2019

Exploring the phytochemical profile of Cytinus hypocistis (L.) L. as a source of health-promoting biomolecules behind its in vitro bioactive and enzyme inhibitory properties

scientific article published on 21 December 2019

Extensional flow-based microfluidic device: deformability assessment of red blood cells in contact with tumor cells

article by Vera Faustino et al published March 2014 in Biochip journal

Flavones, Flavonols, and Glycosylated Derivatives-Impact on <i>Candida albicans</i> Growth and Virulence, Expression of <i>CDR1</i> and <i>ERG11</i>, Cytotoxicity

scientific article published on 30 December 2020

Flavonoid Composition and Antitumor Activity of Bee Bread Collected in Northeast Portugal.

scientific article published on 7 February 2017

Flow of Red Blood Cells Suspensions Through Hyperbolic Microcontractions

scholarly article published 17 November 2013

Fluorescence studies on new potential antitumoral benzothienopyran-1-ones in solution and in liposomes

scientific article published on 2 March 2010

Fluorescence studies on potential antitumor 6-(hetero)arylthieno[3,2-b]pyridine derivatives in solution and in nanoliposomes

Fractionation of the more active extracts of Geranium molle L.: a relationship between their phenolic profile and biological activity

scientific article published on 15 March 2018

HPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts of Zizyphus lotus (L.) Desf

scientific article published on 29 August 2019

Hibiscus sabdariffa L. as a source of nutrients, bioactive compounds and colouring agents.

scientific article

How extraction method affects yield, fatty acids composition and bioactive properties of cardoon seed oil?

article

In Vitro Interactions of Moroccan Propolis Phytochemical's on Human Tumor Cell Lines and Anti-Inflammatory Properties

scientific article published on 29 July 2019

Infusion and decoction of wild German chamomile: bioactivity and characterization of organic acids and phenolic compounds.

scientific article

Infusions and decoctions of Castanea sativa flowers as effective antitumor and antimicrobial matrices

scholarly article in Industrial Crops and Products, vol. 62, December 2014

Infusions of Herbal Blends as Promising Sources of Phenolic Compounds and Bioactive Properties

scientific article published on 04 May 2020

Infusions of gamma irradiated Aloysia citrodora L. and Mentha x piperita L.: Effects on phenolic composition, cytotoxicity, antibacterial and virucidal activities

article

Insights in the antioxidant activity of diarylamines from the 2,3-dimethylbenzo[b]thiophene through the redox profile

Insights on the Extraction Performance of Alkanediols and Glycerol: Using Juglans regia L. Leaves as a Source of Bioactive Compounds

scientific article published on 27 May 2020

Is honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects?

article

Leaves and decoction of Juglans regia L.: Different performances regarding bioactive compounds and in vitro antioxidant and antitumor effects

scholarly article in Industrial Crops and Products, vol. 51, November 2013

Lovage (Levisticum officinale W.D.J. Koch) Roots: A Source of Bioactive Compounds towards a Circular Economy

scientific article published in 2020

Magnetoliposomes Containing Calcium Ferrite Nanoparticles for Applications in Breast Cancer Therapy

scientific article published on 14 September 2019

Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats

scientific article

Melissa officinalis L. decoctions as functional beverages: a bioactive approach and chemical characterization.

scientific article published on July 2015

Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds

scientific article published on 17 October 2017

Mushroom-based cosmeceutical ingredients: Microencapsulation and in vitro release profile

scientific article published in November 2018

New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death.

scientific article published on 21 September 2013

New insights into the effects of formulation type and compositional mixtures on the antioxidant and cytotoxic activities of dietary supplements based-on hepatoprotective plants

scientific article

New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives: interaction with DNA and nanosized liposomes.

scientific article published on 12 May 2011

Non-edible parts of Solanum stramoniifolium Jacq. - a new potent source of bioactive extracts rich in phenolic compounds for functional foods

scientific article published on 10 May 2017

Novel 6-[(hetero)arylamino]thieno[3,2-b]pyridines: synthesis and antitumoral activities.

scientific article published on 17 September 2010

Nutrients, phytochemicals and bioactivity of wild Roman chamomile: a comparison between the herb and its preparations ⬇️

scientific article

Nutritional value, physicochemical characterization and bioactive properties of the Brazilian quinoa BRS Piabiru

scientific article published on 31 March 2020

Nutritive and Bioactive Properties of Mesquite (Prosopis pallida) Flour and Its Technological Performance in Breadmaking

scientific article published on 07 May 2020

Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry

scientific article published on 01 June 2019

Optimization of the Extraction Process to Obtain a Colorant Ingredient from Leaves of var.

scientific article published on 14 February 2019

Palladium-Catalysed Amination of Electron-Deficient or Relatively Electron-Rich Benzo[b]thienyl Bromides− Preliminary Studies of Antimicrobial Activity and SARs

Phenolic Composition and Bioactivity of (Mill.) Cav. Samples from Different Geographical Origin

scientific article published on 28 April 2018

Phenolic Profile and Bioactive Properties of Carissa macrocarpa (Eckl.) A.DC.: An In Vitro Comparative Study between Leaves, Stems, and Flowers

scientific article published on 30 April 2019

Phenolic compounds profile, nutritional compounds and bioactive properties of Lycium barbarum L.: A comparative study with stems and fruits

scientific article published in October 2018

Phenolic profile and in vitro bioactive potential of Saharan Juniperus phoenicea L. and Cotula cinerea (Del) growing in Algeria

scholarly article by Dalila Ghouti et al published 2018 in Food & Function

Phenolics and antimicrobial activity of traditional stoned table olives 'alcaparra'.

scientific article

Phytochemical Characterization and Bioactive Properties of Cinnamon Basil (Ocimum basilicum cv. 'Cinnamon') and Lemon Basil (Ocimum × citriodorum)

scientific article published on 29 April 2020

Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis 'Icterina' and Salvia mexicana Aqueous Extracts

scientific article published on 27 November 2019

Phytochemical characterization and bioactive properties of Osyris quadripartita Salzm. ex Decne. leaves from Algeria

scholarly article by Wahiba Rached et al published 2016 in RSC Advances

Phytochemicals and bioactive properties of Ilex paraguariensis: An in-vitro comparative study between the whole plant, leaves and stems

scientific article published on 28 September 2015

Porphyrin dye into biopolymeric chitosan films for localized photodynamic therapy of cancer

scientific article published on 19 May 2016

Promising Preserving Agents from Sage and Basil: A Case Study with Yogurts

Recovery of Anthocyanins from Passion Fruit Epicarp for Food Colorants: Extraction Process Optimization and Evaluation of Bioactive Properties

scientific article published on 14 July 2020

Revalorization of wild Asparagus stipularis Forssk. as a traditional vegetable with nutritional and functional properties.

scientific article published on 16 February 2018

Rubus ulmifolius Schott as a Novel Source of Food Colorant: Extraction Optimization of Coloring Pigments and Incorporation in a Bakery Product

scientific article published on 10 June 2019

Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure-activity evaluation study

scientific article published in December 2004

Stability and biological activity of Merlot ( Vitis vinifera ) grape pomace phytochemicals after simulated in vitro gastrointestinal digestion and colonic fermentation

Stability of a cyanidin-3-O-glucoside extract obtained from Arbutus unedo L. and incorporation into wafers for colouring purposes

scientific article published on 17 September 2018

Study on the Potential Application of Impatiens balsamina L. Flowers Extract as a Natural Colouring Ingredient in a Pastry Product

scientific article published on 27 August 2021

Suillus luteus methanolic extract inhibits cell growth and proliferation of a colon cancer cell line

Suitability of lemon balm (Melissa officinalis L.) extract rich in rosmarinic acid as a potential enhancer of functional properties in cupcakes.

scientific article published on 4 January 2018

Synergisms in antioxidant and anti-hepatocellular carcinoma activities of artichoke, milk thistle and borututu syrups

article by Carla Pereira et al published January 2014 in Industrial Crops and Products

Synthesis and antimicrobial activity studies of ortho-chlorodiarylamines and heteroaromatic tetracyclic systems in the benzo[b]thiophene series.

scientific article

Synthesis and antioxidant activity evaluation of new 7-aryl or 7-heteroarylamino-2,3-dimethylbenzo[b]thiophenes obtained by Buchwald–Hartwig C–N cross-coupling

scientific article published in 2007

Synthesis and cytotoxic evaluation of new terpenylpurines

scholarly article in RSC Advances, vol. 6 no. 107, 2016

Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis.

scientific article published on 8 December 2010

Synthesis of novel 3-(aryl)benzothieno[2,3-c]pyran-1-ones from Sonogashira products and intramolecular cyclization: Antitumoral activity evaluation.

scientific article

Synthesis of pure stereoisomers of benzo[b]thienyl dehydrophenylalanines by Suzuki cross-coupling. Preliminary studies of antimicrobial activity

Synthesis of β-Benzo[b]thienyldehydrophenylalanine Derivatives by One-Pot Palladium-Catalyzed Borylation and Suzuki Coupling (BSC) and Metal-Assisted Intramolecular Cyclization - Studies of Fluorescence and Antimicrobial Activity

Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors.

scientific article

Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines

scientific article published in 2019

Tarragon phenolic extract as a functional ingredient for pizza dough: Comparative performance with ascorbic acid (E300)

The Effect of Nitrogen Fertigation and Harvesting Time on Plant Growth and Chemical Composition of Centaurea raphanina subsp. mixta (DC.) Runemark

scientific article published on 11 July 2020

The Effects of Biostimulants, Biofertilizers and Water-Stress on Nutritional Value and Chemical Composition of Two Spinach Genotypes (Spinacia oleracea L.).

scientific article published on 08 December 2019

The Health-Benefits and Phytochemical Profile of Salvia apiana and Salvia farinacea var. Victoria Blue Decoctions

scientific article published on 25 July 2019

The contribution of phenolic acids to the anti-inflammatory activity of mushrooms: Screening in phenolic extracts, individual parent molecules and synthesized glucuronated and methylated derivatives

scientific article published on 03 August 2015

The influence of electron beam radiation in the nutritional value, chemical composition and bioactivities of edible flowers of Bauhinia variegata L. var. candida alba Buch.-Ham from Brazil

scientific article published on 31 August 2017

The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties

scientific article published on 27 August 2013

The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits

scientific article published on 28 July 2017

The powerful in vitro bioactivity of Euterpe oleracea Mart. seeds and related phenolic compounds

scholarly article in Industrial Crops and Products, vol. 76, December 2015

Toxicity effects of fungicide residues on the wine-producing process

scientific article published on 30 September 2005

Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins.

scientific article published on 16 April 2014

Valorisation of the green waste parts from turnip, radish and wild cardoon: Nutritional value, phenolic profile and bioactivity evaluation

scientific article published on 03 September 2019

Wild Roman chamomile extracts and phenolic compounds: enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase.

scientific article published on 8 October 2015

Wild mushrooms and their mycelia as sources of bioactive compounds: Antioxidant, anti-inflammatory and cytotoxic properties

scientific article

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