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List of works by Daniel Pens Gelain

A longitudinal study of neurotrophic, oxidative, and inflammatory markers in first-onset depression in midlife women.

scientific article

A statistical method to calculate blood contamination in the measurement of salivary hormones in healthy women

scientific article published on 16 December 2016

A systematic review of human antioxidant genes.

scientific article published on January 2009

Activated peripheral blood mononuclear cell mediators trigger astrocyte reactivity

scientific article published on 05 June 2019

Acute Administration of Branched-Chain Amino Acids Increases the Pro-BDNF/Total-BDNF Ratio in the Rat Brain

scientific article published on 14 February 2015

Acute brain inflammation and oxidative damage are related to long-term cognitive deficits and markers of neurodegeneration in sepsis-survivor rats

scientific article

Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures.

scientific article published on 24 March 2018

Anti-NMDA Receptor Autoantibody Is an Independent Predictor of Hospital Mortality but Not Brain Dysfunction in Septic Patients

Anti-RAGE antibody selectively blocks acute systemic inflammatory responses to LPS in serum, liver, CSF and striatum.

scientific article

Anti-inflammatory and antixidant properties of blend formulated with compounds of Malpighia emarginata D.C (acerola) and Camellia sinensis L. (green tea) in lipopolysaccharide-stimulated RAW 264.7 macrophages

scientific article published on 29 May 2020

Anticancer activity of flavonoids isolated from Achyrocline satureioides in gliomas cell lines.

scientific article

Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models

scientific article published on 14 January 2013

Antinociceptive Activity of Atranorin in Mice Orofacial Nociception Tests ⬇️

scientific article published on September 1, 2010

Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass

scientific article published on 11 April 2011

Antinociceptive effects of citronellal in formalin-, capsaicin-, and glutamate-induced orofacial nociception in rodents and its action on nerve excitability

scientific article published on January 1, 2010

Antioxidant Therapies for Neurodegenerative Diseases: Mechanisms, Current Trends, and Perspectives ⬇️

scientific article published on December 5, 2012

Antioxidant activity and mechanisms of action of natural compounds isolated from lichens: a systematic review.

scientific article published on 12 September 2014

Antioxidant and Anti-Inflammatory Properties of Anacardium occidentale Leaf Extract.

scientific article

Antioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic Extract of Combretum duarteanum in Rodents

scientific article published on 11 June 2011

Apoptotic signaling pathways induced by acute administration of branched-chain amino acids in an animal model of maple syrup urine disease

scientific article

Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas.

scientific article published on 24 December 2014

BRCA-1 depletion impairs pro-inflammatory polarization and activation of RAW 264.7 macrophages in a NF-κB-dependent mechanism

scientific article published on 24 August 2019

Bioactive compounds and protective effect of red and black rice brans extracts in human neuron-like cells (SH-SY5Y)

scientific article published on 30 June 2018

Bioassay-guided evaluation of antioxidant and antinociceptive activities of carvacrol.

scientific article published on December 2010

Brain markers of neurodegeneration in sepsis survivor rats.

scientific article

Cadmium stimulates MAPKs and Hsp27 phosphorylation in bovine adrenal chromaffin cells

scientific article published on 04 February 2007

Can electrons travel through actin microfilaments and generate oxidative stress in retinol treated Sertoli cell?

scientific article published on 03 January 2007

Carvacrol suppresses LPS-induced pro-inflammatory activation in RAW 264.7 macrophages through ERK1/2 and NF-kB pathway

scientific article published on 26 July 2019

Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress

scientific article

Changes in ectonucleotidase activities in rat Sertoli cells during sexual maturation

scientific article published on May 2003

Characterization and modulation of microglial phenotypes in an animal model of severe sepsis

scientific article published on 26 October 2019

Characterization of blood oxidative stress in type 2 diabetes mellitus patients: increase in lipid peroxidation and SOD activity.

scientific article

Chemical composition, antinociceptive, anti-inflammatory and redox properties in vitro of the essential oil from Remirea maritima Aubl. (Cyperaceae)

scientific article published on 23 December 2014

Choline and Cystine Deficient Diets in Animal Models with Hepatocellular Injury: Evaluation of Oxidative Stress and Expression of RAGE, TNF-α, and IL-1β.

scientific article published on 2 June 2015

Chronic administration of branched-chain amino acids impairs spatial memory and increases brain-derived neurotrophic factor in a rat model

scientific article published on 30 October 2012

Chronic ozone exposure alters the secondary metabolite profile, antioxidant potential, anti-inflammatory property, and quality of red pepper fruit from Capsicum baccatum

scientific article published on 10 March 2016

Chronic retinyl palmitate supplementation to middle-aged Wistar rats disrupts the brain redox homeostasis and induces changes in emotional behavior.

scientific article published on 23 March 2015

Coadministration of branched-chain amino acids and lipopolysaccharide causes matrix metalloproteinase activation and blood-brain barrier breakdown

scientific article published on 5 January 2014

Coal and tire burning mixtures containing ultrafine and nanoparticulate materials induce oxidative stress and inflammatory activation in macrophages ⬇️

scientific article published on July 13, 2013

Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies

scientific article published on 7 April 2010

Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats.

scientific article

Delayed neurochemical effects of prenatal exposure to MeHg in the cerebellum of developing rats

scientific article published on 16 December 2017

Developmental neurotoxicity of the hippocampus following in utero exposure to methylmercury: impairment in cell signaling

scientific article published on 18 August 2017

Effect of N-salicyloyltryptamine (STP), a novel tryptamine analogue, on parameters of cell viability, oxidative stress, and immunomodulation in RAW 264.7 macrophages.

scientific article published on 21 April 2013

Effect of Paullinia cupana Mart. Commercial Extract During the Aging of Middle Age Wistar Rats: Differential Effects on the Hippocampus and Striatum

scientific article published on 27 March 2017

Effects of Achyrocline satureioides Inflorescence Extracts against Pathogenic Intestinal Bacteria: Chemical Characterization, In Vitro Tests, and In Vivo Evaluation.

scientific article published on 7 September 2017

Effects of Freeze-Thaw and Storage on Enzymatic Activities, Protein Oxidative Damage, and Immunocontent of the Blood, Liver, and Brain of Rats.

scientific article published on 23 September 2016

Effects of chronic elevated ozone concentration on the redox state and fruit yield of red pepper plant Capsicum baccatum

scientific article published on 13 November 2013

Effects of different products of peach (Prunus persica L. Batsch) from a variety developed in southern Brazil on oxidative stress and inflammatory parameters in vitro and ex vivo.

scientific article

Effects of follicle-stimulating hormone and vitamin A upon purinergic secretion by rat Sertoli cells

scientific article published in October 2005

Effects of methylmercury and retinol palmitate co-administration in rats during pregnancy and breastfeeding: Metabolic and redox parameters in dams and their offspring

scientific article published on 01 October 2018

Eurobehavioral and oxidative stress alterations following methylmercury and retinyl palmitate co-administration in pregnant and lactating rats and their offspring

scientific article published on 11 October 2018

Evidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study.

scientific article published on 16 September 2014

Evidence of increased reactive species formation by retinol, but not retinoic acid, in PC12 cells

scientific article

Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells.

scientific article published on 22 August 2017

Extracellular inosine is modulated by H2O2 and protects sertoli cells against lipoperoxidation and cellular injury

scientific article published in January 2004

Extracellular inosine modulates ERK 1/2 and p38 phosphorylation in cultured Sertoli cells: possible participation in TNF-alpha modulation of ERK 1/2.

scientific article published on 23 June 2005

Extracellular inosine participates in tumor necrosis factor-alpha induced nitric oxide production in cultured Sertoli cells

scientific article published in January 2006

Extracellular purines from cells of seminiferous tubules

scientific article published in March 2003

Focussed microarray analysis of apoptosis in periodontitis and its potential pharmacological targeting by carvacrol

scientific article published on 28 January 2014

Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: involvement of toll-like receptor 4 signaling.

scientific article

Gastrin-releasing peptide receptor antagonist effects on an animal model of sepsis

scientific article

Gene Expression Profile of NF-κB, Nrf2, Glycolytic, and p53 Pathways During the SH-SY5Y Neuronal Differentiation Mediated by Retinoic Acid

scientific article

Glycine Administration Alters MAPK Signaling Pathways and Causes Neuronal Damage in Rat Brain: Putative Mechanisms Involved in the Neurological Dysfunction in Nonketotic Hyperglycinemia.

scientific article published on 3 January 2017

Guarana (Paullinia cupana Mart.) alters gut microbiota and modulates redox status, partially via caffeine in Wistar rats

scientific article published on 02 October 2018

Guarana (Paullinia cupana Mart.) prevents β-amyloid aggregation, generation of advanced glycation-end products (AGEs), and acrolein-induced cytotoxicity on human neuronal-like cells.

scientific article published on 19 May 2014

Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation

scientific article published on 13 March 2019

Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line.

scientific article published on January 2014

High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress

scientific article published on 20 October 2020

Host–guest inclusion complexation of β-cyclodextrin and hecogenin acetate to enhance anti-hyperalgesic effect in an animal model of musculoskeletal pain

scientific article published in 2017

Hydroethanolic extracts from different genotypes of açaí (Euterpe oleracea) presented antioxidant potential and protected human neuron-like cells (SH-SY5Y).

scientific article published on 7 December 2016

Immune neutralization of the receptor for advanced glycation endproducts reduce liver oxidative damage induced by an acute systemic injection of lipopolysaccharide

scientific article published on 22 January 2018

Improvement of p-cymene antinociceptive and anti-inflammatory effects by inclusion in β-cyclodextrin

scientific article published on 26 January 2013

In Vitro Neuroprotective Effect of Shikimic Acid Against Hydrogen Peroxide-Induced Oxidative Stress

scientific article

In vitro optimization of retinoic acid-induced neuritogenesis and TH endogenous expression in human SH-SY5Y neuroblastoma cells by the antioxidant Trolox

scientific article published on 7 July 2011

Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis.

scientific article published on 8 July 2014

Inflammatory landscape of human brain tumors reveals an NFκB dependent cytokine pathway associated with mesenchymal glioblastoma

scientific article published on 19 December 2016

Inhibition of MDR1 expression by retinol treatment increases sensitivity to etoposide (VP16) in human neoplasic cell line

scientific article published on 15 January 2008

Is there a role for high mobility group box 1 and the receptor for advanced glycation end products in the genesis of long-term cognitive impairment in sepsis survivors?

scientific article published on 20 December 2012

L-NAME co-treatment prevent oxidative damage in the lung of adult Wistar rats treated with vitamin A supplementation

scientific article published on 01 April 2012

LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis

scientific article published on 01 January 2020

Major Components of Energy Drinks (Caffeine, Taurine, and Guarana) Exert Cytotoxic Effects on Human Neuronal SH-SY5Y Cells by Decreasing Reactive Oxygen Species Production ⬇️

scientific article published on May 22, 2013

Matrix metalloproteinase-2 and metalloproteinase-9 activities are associated with blood-brain barrier dysfunction in an animal model of severe sepsis.

scientific article published on 12 March 2013

Metabolism of amino acids by cultured rat Sertoli cells

scientific article published in April 2005

Mitochondrial bioenergetics deregulation caused by long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies in rat brain: a possible role of mPTP opening as a pathomechanism in these disorders?

scientific article published on 16 June 2014

Mitochondrial superoxide production is related to the control of cytokine release from peritoneal macrophage after antioxidant treatment in septic rats

scientific article published on 09 May 2007

Modulation in reproductive tissue redox profile in sexually receptive female rats after short-term exposure to male chemical cues

scientific article published on 2 February 2009

Morinda citrifolia Linn leaf extract possesses antioxidant activities and reduces nociceptive behavior and leukocyte migration

scientific article published on 6 May 2011

Morphological and oxidative alterations on Sertoli cells cytoskeleton due to retinol-induced reactive oxygen species

scientific article published in March 2005

N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis.

scientific article published on February 2017

NFκB inhibitors induce cell death in glioblastomas.

scientific article published on 30 October 2010

NRF2 Mediates Neuroblastoma Proliferation and Resistance to Retinoic Acid Cytotoxicity in a Model of In Vitro Neuronal Differentiation.

scientific article published on 5 November 2015

Nuclear RXRα and RXRβ receptors exert distinct and opposite effects on RA-mediated neuroblastoma differentiation

scientific article published on 07 December 2018

Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats

scientific article published on 01 September 2018

Obesity associated with coal ash inhalation triggers systemic inflammation and oxidative damage in the hippocampus of rats

scientific article published on 17 August 2019

Oral administration of carvacrol/β-cyclodextrin complex protects against 6-hydroxydopamine-induced dopaminergic denervation

scientific article published on 05 March 2019

Oral administration of curcumin relieves behavioral alterations and oxidative stress in the frontal cortex, hippocampus, and striatum of ovariectomized Wistar rats.

scientific article published in April 2016

PACAP stimulates the sustained phosphorylation of tyrosine hydroxylase at serine 40

scientific article published on 03 January 2007

Participation of 47C>T SNP (Ala-9Val polymorphism) of the SOD2 gene in the intracellular environment of human peripheral blood mononuclear cells with and without lipopolysaccharides ⬇️

scientific article published on September 15, 2012

Passiflora manicata (Juss.) aqueous leaf extract protects against reactive oxygen species and protein glycation in vitro and ex vivo models.

scientific article published on 20 July 2013

Plasma oxidative parameters and mortality in patients with severe burn injury

scientific article published on 27 May 2003

Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage

scientific article published on 16 September 2014

Putative model for heat shock protein 70 complexation with receptor of advanced glycation end products through fluorescence proximity assays and normal mode analyses

scientific article published on 17 November 2016

Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment.

scientific article published on 10 November 2017

Redox characterization of usnic acid and its cytotoxic effect on human neuron-like cells (SH-SY5Y) ⬇️

scientific article published on December 13, 2011

Redox properties and cytoprotective actions of atranorin, a lichen secondary metabolite

scientific article published on 25 November 2010

Redox-Active Profile Characterization of Remirea maritima Extracts and Its Cytotoxic Effect in Mouse Fibroblasts (L929) and Melanoma (B16F10) Cells.

scientific article

Retinoic acid downregulates thiol antioxidant defences and homologous recombination while promotes A549 cells sensitization to cisplatin

scientific article published on 06 July 2019

Retinoic acid induces apoptosis by a non-classical mechanism of ERK1/2 activation.

scientific article

Retinol (Vitamin A) Increases α-Synuclein, β-Amyloid Peptide, Tau Phosphorylation and RAGE Content in Human SH-SY5Y Neuronal Cell Line.

scientific article

Retinol activates tyrosine hydroxylase acutely by increasing the phosphorylation of serine40 and then serine31 in bovine adrenal chromaffin cells

scientific article published in October 2007

Retinol and retinoic acid modulate catalase activity in Sertoli cells by distinct and gene expression-independent mechanisms.

scientific article published on 25 March 2008

Retinol increases catalase activity and protein content by a reactive species-dependent mechanism in Sertoli cells.

scientific article published on 2 May 2008

Retinol induces morphological alterations and proliferative focus formation through free radical-mediated activation of multiple signaling pathways

scientific article published on 19 March 2012

Retinol induces the ERK1/2-dependent phosphorylation of CREB through a pathway involving the generation of reactive oxygen species in cultured Sertoli cells.

scientific article published on 28 February 2006

Retinol up-regulates the receptor for advanced glycation endproducts (RAGE) by increasing intracellular reactive species

scientific article published on 5 March 2008

Reverse engineering the neuroblastoma regulatory network uncovers MAX as one of the master regulators of tumor progression

scientific article

Role of vitamin A oral supplementation on oxidative stress and inflammatory response in the liver of trained rats.

scientific article published on 25 July 2017

Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice

scientific article

Serum heat shock protein 70 levels, oxidant status, and mortality in sepsis

scientific article published on 01 May 2011

Shikimic acid inhibits LPS-induced cellular pro-inflammatory cytokines and attenuates mechanical hyperalgesia in mice.

scientific article

Short and long TNF-alpha exposure recapitulates canonical astrogliosis events in human-induced pluripotent stem cells-derived astrocytes

scientific article published on 31 January 2020

Sperm quality and oxidative status as affected by homogenization of liquid-stored boar semen diluted in short- and long-term extenders

scientific article published on 12 February 2017

Structure–activity relationship of terpenes with anti-inflammatory profile – a systematic review

scientific article published on September 2014

Subcellular distribution of human tyrosine hydroxylase isoforms 1 and 4 in SH-SY5Y cells

scientific article published on 11 July 2019

Sulfite disrupts brain mitochondrial energy homeostasis and induces mitochondrial permeability transition pore opening via thiol group modification.

scientific article published on 2 May 2014

Supplementation with Achyrocline satureioides Inflorescence Extracts to Pregnant and Breastfeeding Rats Induces Tissue-Specific Changes in Enzymatic Activity and Lower Neonatal Survival.

scientific article published on 29 August 2017

Supplementation with vitamin A enhances oxidative stress in the lungs of rats submitted to aerobic exercise.

scientific article published on 17 August 2015

Systemic Inflammation Changes the Site of RAGE Expression from Endothelial Cells to Neurons in Different Brain Areas

scientific article published on 09 August 2018

Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA-induced dopaminergic denervation

scientific article published on 18 August 2017

The NF kappa B-mediated control of RS and JNK signaling in vitamin A-treated cells: duration of JNK-AP-1 pathway activation may determine cell death or proliferation

scientific article published on 31 December 2008

The effects of retinol oral supplementation in 6-hydroxydopamine dopaminergic denervation model in Wistar rats

scientific article published on 07 February 2019

The janus face of resveratrol in astroglial cells.

scientific article

The oxidation of HSP70 is associated with functional impairment and lack of stimulatory capacity

scientific article

Transcriptomic analysis reveals pH-responsive antioxidant gene networks

scientific article published on June 2012

Turnera subulata Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.

scientific article published on 7 September 2016

Ultra high frequency-electromagnetic field irradiation during pregnancy leads to an increase in erythrocytes micronuclei incidence in rat offspring

scientific article published on 23 August 2006

Vitamin A (retinol) downregulates the receptor for advanced glycation endproducts (RAGE) by oxidant-dependent activation of p38 MAPK and NF-kB in human lung cancer A549 cells

scientific article published on 16 January 2013

Vitamin A (retinol) up-regulates the receptor for advanced glycation endproducts (RAGE) through p38 and Akt oxidant-dependent activation

scientific journal article

Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats

scientific article

Vitamin A supplementation for different periods alters oxidative parameters in lungs of rats

scientific article published in December 2009

Vitamin A supplementation induces oxidative stress and decreases the immunocontent of catalase and superoxide dismutase in rat lungs

scientific article published in June 2009

Vitamin A supplementation to pregnant and breastfeeding female rats induces oxidative stress in the neonatal lung ⬇️

scientific article published on June 8, 2010

Vitamin A treatment induces apoptosis through an oxidant-dependent activation of the mitochondrial pathway

scientific article published on 7 September 2007

Xanthine oxidase activity in patients with sepsis

scientific article

β-Cyclodextrin-complexed (-)-linalool produces antinociceptive effect superior to that of (-)-linalool in experimental pain protocols.

scientific article

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