List of works by Xueling Sim

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

scientific article published on 27 April 2018

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

scientific article

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

scientific article published on 24 March 2017

A catalog of genetic loci associated with kidney function from analyses of a million individuals

scientific article published on 31 May 2019

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

scientific article published on 10 April 2019

An atlas of genetic scores to predict multi-omic traits

scientific article published on 29 March 2023

Analyses of biomarker traits in diverse UK biobank participants identify associations missed by European-centric analysis strategies

scientific article published in 2021

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

scientific article published on 04 September 2019

Association of G6PD variants with hemoglobin A1c and impact on diabetes diagnosis in East Asian individuals

scientific article published on 01 March 2020

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer's and Parkinson's diseases

scientific article published on 01 January 2020

Biological, clinical and population relevance of 95 loci for blood lipids

scientific article

Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease

scientific article

Coffee, Black Tea, and Green Tea Consumption in Relation to Plasma Metabolites in an Asian Population

scientific article published on 29 October 2020

Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract

scientific article published on 11 December 2020

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

scientific article published on 30 October 2017

Correction: Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo.

scientific article

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

scientific article published on 23 November 2020

Distribution and medical impact of loss-of-function variants in the Finnish founder population

scientific article

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

Estimation of kinship coefficient in structured and admixed populations using sparse sequencing data.

scientific article published on 29 September 2017

Ethnic differences in the time trend of female breast cancer incidence: Singapore, 1968-2002.

scientific article

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

scientific article published on 31 July 2020

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

scientific article

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

article by Jason Flannick et al published 22 May 2019 in Nature

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

Exploring Factors Underlying Ethnic Difference in Age-related Macular Degeneration Prevalence

scientific article published on 08 June 2020

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

scientific article published on 08 October 2018

Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo

scientific article published in October 2010

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers

scientific article published on 27 March 2013

Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia

scientific article

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

scientific article published on 05 May 2020

Genetic loci for retinal arteriolar microcirculation

scientific article

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians.

scientific article published on April 2017

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention ⬇️

scientific article published on 7 September 2022

Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function

scientific article published on 21 January 2020

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

Haploinsufficiency for CYP8B1 associates with increased insulin sensitivity in humans

scientific article published in 2022

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

scientific article

Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.

scientific article published on 21 February 2018

Identification of type 2 diabetes loci in 433,540 East Asian individuals

scientific article published on 06 May 2020

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

scientific article published on 12 September 2017

Incidence, mortality and survival patterns of prostate cancer among residents in Singapore from 1968 to 2002

scientific article

Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis

scientific article

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

scientific article published in Nature Communications

Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium

scientific article

Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence

scientific article published on 04 June 2019

Learning in glaucoma genetic risk assessment

scientific article published in January 2010

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

scientific article published on 07 May 2020

Meta-analysis identifies common variants associated with body mass index in east Asians

scientific article published on 19 February 2012

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

scientific article published on 15 July 2012

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

scientific article

Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error

scientific article

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

scientific article

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

article

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

scientific article published in Nature Communications

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

scientific article published in October 2017

Novel Genetic Loci Associated With Retinal Microvascular Diameter

scientific article published on 13 November 2015

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

scientific article published on 18 June 2018

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen consortium

scientific article published on 6 March 2013

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes

scientific article published on 17 March 2022

Plasma Sphingolipids and Subclinical Atherosclerosis – Novel Associations Uncovered by a Large-scale Lipidomic Analysis (P18-129-19)

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

Serum acylcarnitines and amino acids and risk of type 2 diabetes in a multiethnic Asian population

scientific article published on 01 October 2020

Seven new loci associated with age-related macular degeneration

scientific article

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The power of genetic diversity in genome-wide association studies of lipids

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

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