Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Author/s

author: Anubha Mahajan, Mark Caulfield, Paul W. Franks, Niels Grarup, Torben Hansen, Nancy L Heard-Costa, Jaakko Kaprio, Lambertus Kiemeney, Helena Kuivaniemi, Ruifang Li-Gao, Lili Milani, Oluf Borbye Pedersen, Tinca Polderman, Matthias B Schulze, Albert V. Smith, Rudolf Uher, Giovanni Veronesi, Henrik Vestergaard, Daniel R. Witte, Wei Zhao, Krina Zondervan, Fernando Rivadeneira, Panos Deloukas, Tim Frayling, Gerard Pasterkamp, Ilaria Gandin, Angela L Mazul, Massimiliano Cocca, Tune H Pers, Betina H Thuesen, Marit E. Jørgensen, Martina Müller-Nurasyid, Honghuang Lin, Mika Kähönen, Grant W. Montgomery, Oscar H Franco, Ian Deary, Dale R Nyholt, Tuğçe Karaderi, Uwe Völker, Valgerdur Steinthorsdottir, Francis Collins, Unnur Þorsteinsdóttir, Karen L Mohlke, Jerome I Rotter, Rebecca S. Fine, Jennifer Wessel, Ellen W Demerath, Tõnu Esko, Markus Perola, Veikko Salomaa, Jaakko Tuomilehto, Carol A Wang, Christopher P Nelson, Trevor A Mori, Marianne Benn, Claudia Langenberg, Paul Elliott, Andrew J Lotery, Terho Lehtimäki, Roberta McKean-Cowdin, Penny Gordon-Larsen, Eirini Marouli, Ching-Ti Liu, Alex W. Hewitt, John D. Rioux, Allan Linneberg, Andrew Tym Hattersley, Lynne E. Wagenknecht, Matthias Blüher, Tamara B. Harris, Lars Wallentin, Stavroula Kanoni, Stefan Johansson, Mark McCarthy, Heiner Boeing, Nilesh Samani, Douglas F. Easton, Igor Rudan, Artitaya Lophatananon, Michael Stumvoll, Anke Tönjes, Torben Jørgensen, Pål R Njølstad, Nicholas J. Wareham, Gonçalo Abecasis, Evangelos Evangelou, Michael Boehnke, Anne U Jackson, Ruth J. Loos, Erwin Böttinger, Erik Ingelsson, Gudmar Thorleifsson, Sandosh Padmanabhan, Danish Saleheen, Satu Männistö, Eric Boerwinkle, Vilmundur Gudnason, Naveed Sattar, Stella Trompet, Markku Laakso, Sekar Kathiresan, Anette P. Gjesing, Sven Bergmann, Børge G. Nordestgaard, Antonietta Robino, Heather M Stringham, Lars Lind, Stefan Gustafsson, Frida Renström, Dragana Vuckovic, Yongmei Liu, Alison Dunning, Charles Kooperberg, Kári Stefánsson, Hanieh Yaghootkar, Konstantin Strauch, Annette Peters, Cecilia Lindgren, Fredrik Karpe, Anu Loukola, Leo-Pekka Lyytikäinen, Johanna Kuusisto, Andrew C. Heath, Zoltán Kutalik, René S. Kahn, Cora E Lewis, Ivan Brandslund, Sharon L R Kardia, Myriam Fornage, Ingrid B Borecki, Lisa Bastarache, Paul Ridker, Kari E North, Olli Raitakari, Mary Feitosa, Daniel I Chasman, Mariaelisa Graff, David J Carey, Kjell Nikus, Patricia B Munroe, Yen-Chu Chen, Eleuterio Ferrannini, Digna R. Velez Edwards, Todd L. Edwards, Heather M. Highland, Mauno Vanhala, Jaspal Kooner, Kent D Taylor, Hakon Hakonarson, Donald W Bowden, Nicholette D Palmer, Lawrence F Bielak, Patricia A Peyser, Dawn Waterworth, Dennis O Mook-Kanamori, Alexander Teumer, J Wouter Jukema, James G. Wilson, Gerome Breen, John Danesh, Laura M Yerges-Armstrong, Alisa Manning, Tim Spector, Steven A Lubitz, Patrick T Ellinor, Joel Hirschhorn, Peter Kovacs, Maria Karaleftheri, Jean-Claude Tardif, Andre Franke, Robert A Scott, Andrew R Wood, David-Alexandre Trégouët, Folkert Asselbergs, Adam S. Butterworth, Jessica D. Faul, Oddgeir L Holmen, M. Arfan Ikram, Timo A. Lakka, Colin Palmer, Gina M Peloso, Katherine S Ruth, Kerrin S. Small, Elizabeth K Speliotes, John M Starr, Jonathan P Tyrer, Sita H Vermeulen, Helen R Warren, Cristen J. Willer, Jennifer E Huffman, G Kees Hovingh, Christian T Have, Struan F.A. Grant, Ozren Polašek, Inês Barroso, Sameer E Alharthi, Joshua C. Denny, Jean Ferrières, Sarah E. Medland, Craig E. Pennell, Ailith Pirie, Andrew J. Slater, Valerie Turcot, Nicholas G D Masca, Poorva Mudgal, Xiuqing Guo, Katja K H Aben, Dewan S Alam, Paul L Auer, Lia E. Bang, Carsten A. Böger, Jette Bork-Jensen, Michiel Bots, Murray H. Brilliant, Linda Broer, Amber Burt, Rajiv Chowdhury, Cramer Christensen, Audrey Chu, Janie Corley, Jordi Corominas Galbany, Paul I W de Bakker, Joe Dennis, Emanuele Di Angelantonio, Fotios Drenos, Aliki-Eleni Farmaki, Ruth Frikke-Schmidt, Ayush Giri, Iris M Heid, Jussi A Hernesniemi, Joanna Howson, Jan-Håkan Jansson, Gail P. Jarvik, Yucheng Jia, Bratati Kahali, Pia R. Kamstrup, Frank Kee, Hidetoshi Kitajima, Jaana Lindström, Gaelle Marenne, Karina Meidtner, Mike A Nalls, Matt J Neville, Sune G. Nielsen, Jeffrey R. O'Connel, Loes M Olde Loohuis, Roel Ophoff, Aniruddh Pradip Patel, Alison Pattie, Peggy Peissig, Asif Rasheed, Olov Rolandsson, Marcelo P Segura-Lepe, Svati H Shah, Xueling Sim, Suthesh Sivapalaratnam, Lorraine Southam, Praveen Surendran, Deborah Thompson, Emmanouil Tsafantakis, Anette Varbo, Feijie Wang, Dajiang J Liu, Guillaume Lettre, Nele Friedrich, Myriam Rheinberger, Jonathan P Bradfield, MAGIC investigators, ReproGen Consortium, Hannu Puolijoki, EPIC InterAct Consortium, Caroline Hayward, Wayne Huey-Herng Sheu, Audrey E Hendricks, Adelheid Lempradl, Tamuno Alfred, Sailaja Vedantam, Matthew A. Allison, Beverley Balkau, Marco Brumat, Stefania Cappellani, Eulalia Catamo, David R Crosslin, Angela D'Eustacchio, Renée de Mutsert, Martin den Heijer, Sascha Fauser, Hans Jörgen Grabe, Jeff Haessler, Anke R Hammerschlag, Tellervo Korhonen, Kari Kuulasmaa, Nanette R Lee, Keng-Hung Lin, Vanisha Mistry, Marie Moitry, Carmel Moore, Michelle L O'Donoghue, Rainer Rauramaa, Yadav Sapkota, Hayato Tada, Gerard Tromp, Erin Ware, John Andrew Pospisilik, CHD Exome+ Consortium, ExomeBP Consortium, INTERVAL Study, T2D-Genes Consortium, Understanding Society, Gorm Boje Jensen, James A Perry, Leslie A. Lange, Kathleen Stirrups, George Dedoussis, Vilmantas Giedraitis, Sadaf Farooqi, Andrew P Morris, Ian Ford, Harvey White, Pamela J Schreiner, John R. B. Perry

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