List of works - Chao-Qiang Lai

A Database of Gene-Environment Interactions Pertaining to Blood Lipid Traits, Cardiovascular Disease and Type 2 Diabetes.

scientific article published on January 2011

A Genome-Wide Association Study Identifies Blood Disorder-Related Variants Influencing Hemoglobin A1c With Implications for Glycemic Status in U.S. Hispanics/Latinos

scientific article published on 18 June 2019

A critical role for the Drosophila dopamine D1-like receptor Dop1R2 at the onset of metamorphosis

scientific article

A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network

scientific article published on March 2012

A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS.

scientific article

A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI.

scientific article published on 2 November 2011

ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study

scientific article published on 18 December 2008

APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations

scientific article

Anti-senescence effect and molecular mechanism of the major royal jelly proteins on human embryonic lung fibroblast (HFL-I) cell line

scientific article published on 01 December 2018

Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin

scientific article

Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study

scientific article

Association between BDNF rs6265 and obesity in the Boston Puerto Rican Health Study

scientific article published on 27 December 2012

Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states

scientific article published on 03 December 2008

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

scientific article published on 04 September 2019

Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study

scientific article

Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study

scientific article

Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization

scientific article published on 14 September 2016

CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis

scientific article

CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids

scientific article published on 21 October 2009

CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American

scientific article

CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits

scientific article

Circulating 25-hydroxyvitamin D, IRS1 variant rs2943641, and insulin resistance: replication of a gene-nutrient interaction in 4 populations of different ancestries

scientific article

Clustering by plasma lipoprotein profile reveals two distinct subgroups with positive lipid response to fenofibrate therapy

scientific article (publication date: 2012)

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

scientific article

Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians

scientific article

Curcumin supplementation increases survival and lifespan in Drosophila under heat stress conditions

scientific article published on 29 November 2018

Detection of gene-environment interactions in a family-based population using SCAD.

scientific article published on 13 July 2017

Development of a Genetic Score to Predict an Increase in HDL Cholesterol Concentration After a Dietary Intervention in Adults with Metabolic Syndrome

scientific article published on 01 July 2019

Dietary epicatechin improves survival and delays skeletal muscle degeneration in aged mice.

scientific article published on 10 August 2018

Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study

scientific article (publication date: 2 May 2006)

Dietary modulators of statin efficacy in cardiovascular disease and cognition.

scientific article published on 09 May 2014

Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults

scientific article

Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites

scientific article

Environmental and epigenetic regulation of postprandial lipemia.

scientific article

Epigenome-wide association study of triglyceride postprandial responses to a high-fat dietary challenge.

scientific article published on 24 October 2016

Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity

scientific article published on 01 July 2018

Functional Genomics Analysis of Big Data Identifies Novel Peroxisome Proliferator-Activated Receptor γ Target Single Nucleotide Polymorphisms Showing Association With Cardiometabolic Outcomes

scientific article

Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site

scientific article

Genetic admixture and body composition in Puerto Rican adults from the Boston Puerto Rican Osteoporosis Study

scientific article

Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance

scientific article

Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and women

scientific article published on 25 March 2009

Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population).

scientific article

Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study

scientific article

Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits

scientific article published on 28 October 2013

Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits

scientific article

Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study

scientific article published on January 2013

Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries

scientific article published on 20 July 2016

Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium

scientific article

Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population

scientific article

Long-term consumption of a Mediterranean diet improves postprandial lipemia in patients with type 2 diabetes: the Cordioprev randomized trial

scientific article published on 01 November 2018

Low-density lipoprotein receptor-related protein 1 variant interacts with saturated fatty acids in Puerto Ricans

scientific article published on March 2013

MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate

scientific article

Mechanism of action of recombinant acc-royalisin from royal jelly of Asian honeybee against gram-positive bacteria

scientific article

Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity

scientific article published on 13 April 2020

Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated fatty acids to modulate plasma homocysteine in puerto rican adults

scientific article

Modulation of gene expression by α-tocopherol and α-tocopheryl phosphate in THP-1 monocytes ⬇️

scientific article published on October 26, 2010

Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study

scientific article

Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study

scientific article

Polyunsaturated Fatty Acids Modulate the Association between PIK3CA-KCNMB3 Genetic Variants and Insulin Resistance

scientific article

Quantifying diet for nutrigenomic studies

scientific article

Replication of a Gene-Diet Interaction at CD36, NOS3 and PPARG in Response to Omega-3 Fatty Acid Supplements on Blood Lipids: A Double-Blind Randomized Controlled Trial.

scientific article published on 17 April 2018

Saturated fat intake modulates the association between an obesity genetic risk score and body mass index in two US populations

scientific article

Significance of Increasing n-3 PUFA Content in Pork on Human Health

scientific article published on 03 August 2015

Supplementation with Major Royal-Jelly Proteins Increases Lifespan, Feeding, and Fecundity in Drosophila.

scientific article published on 7 July 2016

The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site

scientific article published in 2011

The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate

scientific article published on March 2012

The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs

scientific article published on 16 April 2008

The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter

scientific article published on 31 October 2015

The rubber tree genome reveals new insights into rubber production and species adaptation.

scientific article published on 23 May 2016

Trans-ethnic Evaluation Identifies Novel Low Frequency Loci Associated with 25-Hydroxyvitamin D Concentrations.

scientific article published on 9 January 2018

Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults

scientific article

Variants of the CD36 gene and metabolic syndrome in Boston Puerto Rican adults

scientific article

WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake

scientific article

Weight gain prevention buffers the impact of CETP rs3764261 on high density lipoprotein cholesterol in young adulthood: The Study of Novel Approaches to Weight Gain Prevention (SNAP).

scientific article published on 6 March 2018

List of works by Chao-Qiang Lai

A Database of Gene-Environment Interactions Pertaining to Blood Lipid Traits, Cardiovascular Disease and Type 2 Diabetes.

A Genome-Wide Association Study Identifies Blood Disorder-Related Variants Influencing Hemoglobin A1c With Implications for Glycemic Status in U.S. Hispanics/Latinos

A critical role for the Drosophila dopamine D1-like receptor Dop1R2 at the onset of metamorphosis

A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network

A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS.

A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI.

ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study

APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations

Anti-senescence effect and molecular mechanism of the major royal jelly proteins on human embryonic lung fibroblast (HFL-I) cell line

Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin

Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study

Association between BDNF rs6265 and obesity in the Boston Puerto Rican Health Study

Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study

Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study

Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization

CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis

CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids

CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American

CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits

Circulating 25-hydroxyvitamin D, IRS1 variant rs2943641, and insulin resistance: replication of a gene-nutrient interaction in 4 populations of different ancestries

Clustering by plasma lipoprotein profile reveals two distinct subgroups with positive lipid response to fenofibrate therapy

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians

Curcumin supplementation increases survival and lifespan in Drosophila under heat stress conditions

Detection of gene-environment interactions in a family-based population using SCAD.

Development of a Genetic Score to Predict an Increase in HDL Cholesterol Concentration After a Dietary Intervention in Adults with Metabolic Syndrome

Dietary epicatechin improves survival and delays skeletal muscle degeneration in aged mice.

Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study

Dietary modulators of statin efficacy in cardiovascular disease and cognition.

Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults

Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites

Environmental and epigenetic regulation of postprandial lipemia.

Epigenome-wide association study of triglyceride postprandial responses to a high-fat dietary challenge.

Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity

Functional Genomics Analysis of Big Data Identifies Novel Peroxisome Proliferator-Activated Receptor γ Target Single Nucleotide Polymorphisms Showing Association With Cardiometabolic Outcomes

Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site

Genetic admixture and body composition in Puerto Rican adults from the Boston Puerto Rican Osteoporosis Study

Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance

Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and women

Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population).

Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study

Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits

Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits

Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study

Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries

Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium

Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population

Long-term consumption of a Mediterranean diet improves postprandial lipemia in patients with type 2 diabetes: the Cordioprev randomized trial

Low-density lipoprotein receptor-related protein 1 variant interacts with saturated fatty acids in Puerto Ricans

MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate

Mechanism of action of recombinant acc-royalisin from royal jelly of Asian honeybee against gram-positive bacteria

Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity

Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated fatty acids to modulate plasma homocysteine in puerto rican adults

Modulation of gene expression by α-tocopherol and α-tocopheryl phosphate in THP-1 monocytes ⬇️

Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study

Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study

Polyunsaturated Fatty Acids Modulate the Association between PIK3CA-KCNMB3 Genetic Variants and Insulin Resistance

Quantifying diet for nutrigenomic studies

Replication of a Gene-Diet Interaction at CD36, NOS3 and PPARG in Response to Omega-3 Fatty Acid Supplements on Blood Lipids: A Double-Blind Randomized Controlled Trial.

Saturated fat intake modulates the association between an obesity genetic risk score and body mass index in two US populations

Significance of Increasing n-3 PUFA Content in Pork on Human Health

Supplementation with Major Royal-Jelly Proteins Increases Lifespan, Feeding, and Fecundity in Drosophila.

The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site

The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate

The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs

The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter

The rubber tree genome reveals new insights into rubber production and species adaptation.

Trans-ethnic Evaluation Identifies Novel Low Frequency Loci Associated with 25-Hydroxyvitamin D Concentrations.

Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults

Variants of the CD36 gene and metabolic syndrome in Boston Puerto Rican adults

WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake

Weight gain prevention buffers the impact of CETP rs3764261 on high density lipoprotein cholesterol in young adulthood: The Study of Novel Approaches to Weight Gain Prevention (SNAP).