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List of works by Philip L. De Jager

24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex

scientific article

5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy.

scientific article published on 10 February 2014

A 17q12 allele is associated with altered NK cell subsets and function.

scientific article published on 15 February 2012

A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease

scientific article published on 5 March 2018

A High-Density Admixture Map for Disease Gene Discovery in African Americans

scientific article

A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology

scientific article published on March 2015

A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

scientific article published on 8 December 2016

A coding variant in CR1 interacts with APOE-ε4 to influence cognitive decline

scientific article published on 17 February 2012

A common polymorphism near PER1 and the timing of human behavioral rhythms

scientific article

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

scientific article published on 02 August 2019

A genome-wide association study of aging

scientific article

A genome-wide association study of depressive symptoms

scientific journal article

A genome-wide profiling of brain DNA hydroxymethylation in Alzheimer's disease.

scientific article published on 06 January 2017

A genome-wide scan for common variants affecting the rate of age-related cognitive decline

scientific article published on 4 November 2011

A high-density screen for linkage in multiple sclerosis

scientific article

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants.

scientific article published in December 2017

A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.

scientific article

A method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis

scientific article published on 15 December 2014

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

article

A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

scientific article published on 07 August 2018

A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity

scientific article

A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis

scientific article

A random change point model for cognitive decline in Alzheimer's disease and mild cognitive impairment

scientific article

A scalable online tool for quantitative social network assessment reveals potentially modifiable social environmental risks

scientific article published in Nature Communications

A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease

scientific article published on 01 August 2020

A second major histocompatibility complex susceptibility locus for multiple sclerosis

scientific article published on March 2007

A transcriptomic atlas of aged human microglia.

scientific article published on 7 February 2018

A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

scientific article published on 25 September 2005

APOE and cerebral amyloid angiopathy in community-dwelling older persons

scientific article

APOE ε2ε4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults

scientific article published on 11 May 2018

APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans

scientific article

APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease

scientific article published on 05 November 2019

Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels

scientific article published on 8 March 2007

Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women

scientific article published on 11 December 2013

Allelic variant in CTLA4 alters T cell phosphorylation patterns

scholarly article

Alterations of the human gut microbiome in multiple sclerosis.

scientific article published on 28 June 2016

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

Alzheimer disease susceptibility loci: evidence for a protein network under natural selection

scientific article published in April 2012

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

scientific article

Alzheimer's loci: epigenetic associations and interaction with genetic factors

scientific article published on 24 April 2015

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

scientific article published on 8 December 2016

An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity

scientific article

An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults.

scientific article published in January 2019

An inflection point in gene discovery efforts for neurodegenerative diseases: from syndromic diagnoses toward endophenotypes and the epigenome

scientific article published on June 2013

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

scientific article published on 4 September 2017

Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

scientific article published on 10 June 2019

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

scientific article published on 29 September 2013

Analysis of shared heritability in common disorders of the brain

scientific article published on 21 June 2018

Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells

scientific article

Applying a new generation of genetic maps to understand human inflammatory disease

scientific article

Assessment of Early Evidence of Multiple Sclerosis in a Prospective Study of Asymptomatic High-Risk Family Members

scientific article published on 17 January 2017

Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline

scientific article published on 30 October 2017

Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease

scientific article published on 22 June 2020

Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease

scientific article published in August 2005

Association between DNA methylation levels in brain tissue and late-life depression in community-based participants

scientific article published on 30 July 2020

Association of APOE with tau-tangle pathology with and without β-amyloid

scientific article

Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease

scientific article

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

scientific article

Association of Cortical β-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease

scientific article published on 01 July 2019

Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies

scientific article

Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals

scientific article

Association of Parkinson disease risk loci with mild parkinsonian signs in older persons

scientific article

Association of Social Network Structure and Physical Function in Patients With Multiple Sclerosis

scientific article published on 07 August 2020

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue

scientific article published on 02 December 2021

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Author Correction: Molecular estimation of neurodegeneration pseudotime in older brains

scientific article published on 03 December 2020

Author Correction: Nuclei multiplexing with barcoded antibodies for single-nucleus genomics

scientific article published on 02 November 2020

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

scientific article published on 01 May 2019

Automated high-dimensional flow cytometric data analysis

scientific article

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology

scientific article published on 29 July 2020

Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics

scientific article published on 10 September 2020

Bayesian integrative analysis of epigenomic and transcriptomic data identifies Alzheimer's disease candidate genes and networks

scientific article published on 07 April 2020

Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes

scientific article

Brain expression of the vascular endothelial growth factor gene family in cognitive aging and alzheimer's disease

scientific article published on 22 July 2019

Brain microRNAs are associated with variation in cognitive trajectory in advanced age

scientific article published on 01 February 2022

Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia

scientific article published on 06 February 2020

Brain proteome-wide association study implicates novel proteins in depression pathogenesis

scientific article published on 12 April 2021

Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease

scientific article

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

scientific article published on 23 May 2013

CD33 modulates TREM2: convergence of Alzheimer loci.

scientific article

CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility

scientific article published on 30 December 2013

CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis

scientific article

CR1 is associated with amyloid plaque burden and age-related cognitive decline

scientific article

Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis

article

Cerebral small vessel disease genomics and its implications across the lifespan

scientific article published on 08 December 2020

Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant.

scientific article published on 13 January 2016

Charting a dynamic DNA methylation landscape of the human genome

scientific article published on 07 August 2013

Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1.

scientific article published on 21 November 2016

Class II HLA interactions modulate genetic risk for multiple sclerosis

scientific article published on 07 September 2015

Classifying multiple sclerosis patients on the basis of SDMT performance using machine learning

scientific article published on 04 November 2020

Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus

scientific article published on 30 October 2013

Cognition may link cortical IGFBP5 levels with motor function in older adults

scientific article published on 12 August 2019

Common genetic variants modulate pathogen-sensing responses in human dendritic cells

scientific article

Common risk alleles for inflammatory diseases are targets of recent positive selection

scientific article published on 21 March 2013

Common variants at 12q14 and 12q24 are associated with hippocampal volume

scientific article

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

scientific article

Common variants in DRD2 are associated with sleep duration: the CARe consortium

scientific article

Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis

scientific article published on 16 July 2018

Complex Neurological Phenotype in Female Carriers of NHE6 Mutations

scientific article published on 06 March 2019

Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset

scientific article published on 26 July 2016

Considerations for integrative multi-omic approaches to explore Alzheimer's disease mechanisms

scientific article published on 12 July 2020

Correction: Genetic data and cognitively defined late-onset Alzheimer's disease subgroups

scientific article published on 15 January 2019

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 7 July 2017

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

scientific article published on November 2016

Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons

scientific article published on 01 July 2020

CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease

scientific article published on 29 May 2019

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia

scientific article published on 01 September 2020

Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells

scientific article published on 21 June 2008

De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot

scientific article published on 13 July 2009

Deconstructing and targeting the genomic architecture of human neurodegeneration

scientific article published on 26 September 2018

Deconvolving the contributions of cell-type heterogeneity on cortical gene expression

scientific article published on 17 August 2020

Defining the role of the MHC in autoimmunity: a review and pooled analysis

scientific article

Designing an epigenomic study

scientific article published on 01 April 2018

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.

scientific article

Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease

scientific article published on 03 April 2017

Early Elevation of Serum Tumor Necrosis Factor-α is Associated with Poor Outcome in Subarachnoid Hemorrhage ⬇️

scientific article published on October 1, 2012

Early complement genes are associated with visual system degeneration in multiple sclerosis

scientific article published on 01 September 2019

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

scientific article

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

article

Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping

article

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.

scientific article published on 17 December 2018

Epigenomics in translational research

scientific article

Epigenomics of Alzheimer's disease

scientific article

Erratum: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

article

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

scientific article

Erratum: Multicolored stain-free histopathology with coherent Raman imaging

scholarly article published in Laboratory Investigation

Evaluating more naturalistic outcome measures: A 1-year smartphone study in multiple sclerosis

scientific article

Evaluating the role of genetic variation in the epigenome in health and disease

scientific article published on 01 May 2018

Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis

scientific article published in March 2006

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study

Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease

scientific article published on 18 June 2016

Evaluation of an online platform for multiple sclerosis research: patient description, validation of severity scale, and exploration of BMI effects on disease course

scientific article

Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals

scientific article

Evidence for a common pathway linking neurodegenerative diseases

scientific article

Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study

scientific article published on 03 February 2020

Exploration of changes in disability after menopause in a longitudinal multiple sclerosis cohort

scientific article published on 7 October 2015

Exploring the role of the epigenome in multiple sclerosis: A window onto cell-specific transcriptional potential ⬇️

scientific article published on January 31, 2012

Fatal COVID-19 in an MS patient on natalizumab: A case report

scientific article published on 01 July 2020

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects

scientific article published in November 2013

Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach

scientific article published on 24 May 2008

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms

scientific article published on 25 September 2013

Functional screening of Alzheimer pathology genome-wide association signals in Drosophila

scientific article

Functional variations modulating PRKCA expression and alternative splicing predispose to multiple sclerosis

scientific article

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity

scientific article

GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium

scientific article

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

scientific article published on 21 June 2013

GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease

scientific article

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy

scientific article

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.

scientific article

Gene expression and DNA methylation are extensively coordinated with MRI-based brain microstructural characteristics

scientific article published on 01 August 2019

Gene expression elucidates functional impact of polygenic risk for schizophrenia

scientific article published on 26 September 2016

Gene expression profiling in MS: what is the clinical relevance?

scientific article published on 01 May 2004

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

scientific article

Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk

scientific article published on 19 November 2015

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

scholarly article published 28 August 2017

Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines

scientific article

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of transcripts under balancing selection

Genetic and epigenetic fine mapping of causal autoimmune disease variants

scientific article

Genetic and gene expression signatures in multiple sclerosis

scientific article published on 22 January 2020

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Genetic architecture of age-related cognitive decline in African Americans

scientific article published on 21 December 2016

Genetic architecture of subcortical brain structures in 38,851 individuals

scientific article published on 21 October 2019

Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.

scientific article published on 4 December 2018

Genetic data and cognitively-defined late-onset Alzheimer's disease subgroups

Genetic determinants of co-accessible chromatin regions in activated T cells across humans

scientific article published on 09 July 2018

Genetic diversity is a predictor of mortality in humans

scientific article

Genetic epistasis regulates amyloid deposition in resilient aging

scientific article

Genetic influence of plasma homocysteine on Alzheimer's disease.

scientific article published on 13 October 2017

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

scientific article

Genetic risk for Alzheimer's dementia predicts motor deficits through multi-omic systems in older adults

scientific article published on 03 October 2019

Genetic risk variants in African Americans with multiple sclerosis

scientific article published on 14 June 2013

Genetic susceptibility for Alzheimer disease neuritic plaque pathology

scientific article published on September 2013

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

scientific article published on 18 April 2016

Genetic variants in Alzheimer disease - molecular and brain network approaches

scientific article

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

scientific article

Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus.

scientific article

Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology

scientific article published on 08 June 2020

Genetics of rheumatoid arthritis contributes to biology and drug discovery

scientific article

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans.

scientific article published on 23 November 2016

Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults

scientific article

Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery

scientific article

Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias

scientific article

Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria

scientific article published on 04 June 2019

Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis

scientific article

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers

scientific article published on 28 February 2017

Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene

scientific article

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

scientific article

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

scientific article published in Nature Communications

Genome-wide association study of the rate of cognitive decline in Alzheimer's disease

scientific article

Genome-wide chromatin state transitions associated with developmental and environmental cues

scientific article

Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease

scientific article published on 29 April 2020

Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility

scientific article published on 23 April 2015

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

scientific article

Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk

scientific article

HLA-C levels impact natural killer cell subset distribution and function.

scientific article published on 10 August 2016

HLA-DRB1*1501 and spinal cord magnetic resonance imaging lesions in multiple sclerosis

scientific article published in December 2009

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control

scientific article published on 11 December 2012

Higher brain BDNF gene expression is associated with slower cognitive decline in older adults

scientific article published on 27 January 2016

How do we measure the epigenome(s)?

scientific article published on 01 April 2018

Human Herpesvirus 6 Detection in Alzheimer's Disease Cases and Controls across Multiple Cohorts

scientific article published on 23 January 2020

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway

scientific article

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

scientific article

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data

scientific article (publication date: April 2017)

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome

scientific article published on 08 January 2021

ImmVar project: Insights and design considerations for future studies of "healthy" immune variation

scientific article published on February 2015

Integrated analysis of the aging brain transcriptome and proteome in tauopathy

scientific article published on 29 September 2020

Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models

scientific article published on 29 March 2018

Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer's Disease

scientific article published on 01 July 2019

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis

scientific article published on 28 January 2021

Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score

scientific article

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene

scientific article

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility

scientific article published on 08 October 2018

Interindividual variation in human T regulatory cells

scientific article published on 07 March 2014

Intermediate phenotypes identify divergent pathways to Alzheimer's disease

scientific article (publication date: 21 June 2010)

Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex

scientific article

Is the goal of an epigenomic study to determine causality?

scientific article published on 01 June 2018

Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis

scientific article published on June 2010

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

scientific article published on 12 October 2020

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

scientific article

Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level

scientific article published on 03 February 2022

Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

scientific article published on 13 April 2020

Life extension factor klotho enhances cognition

scientific article

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types.

scientific article published on 20 February 2017

Loneliness 5 years ante-mortem is associated with disease-related differential gene expression in postmortem dorsolateral prefrontal cortex.

scientific article published on 10 January 2018

Low frequency and rare coding variation contributes to multiple sclerosis risk

MS AHI1 genetic risk promotes IFNγ+ CD4+ T cells

scientific article published on 8 December 2017

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

scientific article published on 21 October 2009

Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

scientific article published on 01 July 2020

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

scientific article

Methylation profiles in peripheral blood CD4+ lymphocytes versus brain: The relation to Alzheimer's disease pathology

scientific article published on 23 March 2016

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

scientific article

Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline

scientific article published on 26 July 2019

Modeling disease severity in multiple sclerosis using electronic health records

scientific article

Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

scientific article

Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA

scientific article

Molecular estimation of neurodegeneration pseudotime in older brains

scientific article published on 13 November 2020

Multi-omic Directed Networks Describe Features of Gene Regulation in Aged Brains and Expand the Set of Genes Driving Cognitive Decline

article

Multicolored stain-free histopathology with coherent Raman imaging.

scientific article

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

scientific article published on 7 February 2015

Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies

scientific article published on 04 August 2016

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.

scientific article

Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline

scientific article published on 15 June 2017

Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles

scientific article published on April 2009

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

scientific article published in Nature Communications

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

scientific article

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

scientific article published on February 2016

New therapeutic approaches for multiple sclerosis

scientific article published on January 2007

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis

scientific article

No sex-specific difference in disease trajectory in multiple sclerosis patients before and after age 50

scientific article

Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease

scientific article published on August 2013

Novel genetic loci associated with hippocampal volume

scientific article published on 18 January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association

scientific article (publication date: 3 October 2016)

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

scientific article

Nuclei multiplexing with barcoded antibodies for single-nucleus genomics

scientific article published on 02 July 2019

OR.102. The CD58 Pathway is Implicated in MS Susceptibility

Parkinson's Disease: Genetics and Pathogenesis ⬇️

scientific article published on January 1, 2011

Parsing the Interferon Transcriptional Network and Its Disease Associations

scientific article published on January 2016

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

Peripheral serum metabolomic profiles inform central cognitive impairment

scientific article published on 20 August 2020

Personality Polygenes, Positive Affect, and Life Satisfaction

scientific article published on 22 August 2016

Pervasive sharing of genetic effects in autoimmune disease

scientific article

PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis

scientific article

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

scientific article published on May 2014

Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

scientific article published on 24 July 2018

Polygenic risk of Alzheimer disease is associated with early- and late-life processes

scientific article published on 6 July 2016

Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments

scientific article published on 27 November 2010

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

scientific article

Re: GAMES issue study: Are international genetic consortia functional?

scientific article published in August 2004

Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells

scientific article

Relation of genomic variants for Alzheimer disease dementia to common neuropathologies

scientific article published on July 2016

Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

scientific article published on 18 March 2009

Reply to Brynedal et al.: Accumulating genetic and functional evidence for a role of in multiple sclerosis

scientific article

Reply: To PMID 25545807.

scientific article published on 9 June 2015

Reproductive period and epigenetic modifications of the oxidative phosphorylation pathway in the human prefrontal cortex ⬇️

scientific article published on 27 July 2018

Review: Identifying patient subtypes in multiple sclerosis and tailoring immunotherapy: challenges for the future ⬇️

scientific article published on November 1, 2009

Rituximab for tumefactive inflammatory demyelination: A case report ⬇️

scientific article published on April 2, 2012

Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts

scientific article published on 04 September 2018

Selection of first-line therapy in multiple sclerosis using risk-benefit decision analysis

scientific article published on 13 January 2017

Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein

scientific article

Sex Difference in Daily Rhythms of Clock Gene Expression in the Aged Human Cerebral Cortex ⬇️

scientific article published on April 1, 2013

Sex differences in the genetic predictors of Alzheimer's pathology

scientific article published on 01 September 2019

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

scientific article published on 01 August 2018

Sex-specific genetic predictors of Alzheimer's disease biomarkers

scientific article published on 02 July 2018

Shared Causal Paths underlying Alzheimer's dementia and Type 2 Diabetes

scientific article published on 05 March 2020

Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis

scientific article published on 22 January 2013

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease

scientific article published on 30 November 2020

Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes.

scientific article published on February 2016

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

scientific article

Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer's dementia

scientific article published on 11 December 2019

Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses

scientific article published on February 2009

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

scientific article published on 29 May 2018

Switching from natalizumab to ocrelizumab in patients with multiple sclerosis

scientific article published on 19 June 2020

TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits

scientific article published on 20 June 2019

TOMM40 in Cerebral Amyloid Angiopathy Related Intracerebral Hemorrhage: Comparative Genetic Analysis with Alzheimer's Disease

scientific article

TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype

scientific article published on 20 January 2017

Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia

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Tau Activates Transposable Elements in Alzheimer's Disease

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Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease

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Tau-mediated Disruption of the Spliceosome Triggers Cryptic RNA-splicing and Neurodegeneration in Alzheimer's Disease

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Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

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The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation

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The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease

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The Impact of MRI T1 Hypointense Brain Lesions on Cerebral Deep Gray Matter Volume Measures in Multiple Sclerosis

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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

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The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia

scholarly article by Shinya Tasaki et al published 2018 in Frontiers in Neuroscience

The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility

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The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults

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The TMEM106B locus and TDP-43 pathology in older persons without FTLD

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The association of magnetic resonance imaging measures with cognitive function in a biracial population sample

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The complex genetics of gait speed: genome-wide meta-analysis approach

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The educational impact of childhood-onset multiple sclerosis: Why assessing academic achievement is imperative

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The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism

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The era of GWAS is over - No.

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The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages

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The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions

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The power of genetic diversity in genome-wide association studies of lipids

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The transcriptional landscape of age in human peripheral blood

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Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci

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Transethnic genome-wide scan identifies novel Alzheimer's disease loci

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Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans

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UNC5C variants are associated with cerebral amyloid angiopathy

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Ultra-rare mutations in SRCAP segregate in Caribbean Hispanic families with Alzheimer disease

scientific article published on 24 August 2017

Uncovering the Role of the Methylome in Dementia and Neurodegeneration

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Uncovering the genetic architecture of multiple sclerosis.

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Uncovering the genetic architecture of white matter disease

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Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.

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Using Transcriptomic Hidden Variables to Infer Context-Specific Genotype Effects in the Brain

scientific article published on 22 August 2019

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans

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Variation within DNA repair pathway genes and risk of multiple sclerosis

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What is the epigenome and is it involved in multiple sclerosis?

scientific article published in March 2018

cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis

scientific article published on 01 August 2019

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