Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

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author: Per Hoffmann, Francesco Panza, Petroula Proitsi, L. Adrienne Cupples, Alexa Beiser, Gyungah Jun, Kathryn L. Lunetta, Jose Bras, Ammar Al-Chalabi, Lindsay A. Farrer, James Turton, Chiara Cupidi, Wayne W Poon, Claudia L Satizabal, Denise Harold, Kevin Morgan, Josée Dupuis, Daniela Galimberti, Benedetta Nacmias, Michael C O'Donovan, Philippe Amouyel, Patrizia Mecocci, Jerome I Rotter, Robert C. Green, Tatiana Foroud, Daniel Geschwind, Florence Pasquier, Clive Holmes, John Q. Trojanowski, Harald Hampel, Steven E. Arnold, Johannes Kornhuber, Valentina Escott-Price, Richard Mayeux, Christiane Reitz, Ekaterina Rogaeva, Peter Henry St George-Hyslop, Sandro Sorbi, Carol Brayne, Eliezer Masliah, Caroline Graff, Albert Hofman, Vilmundur Gudnason, John Anthony Hardy, Rita Guerreiro, David A Bennett, Lenore J Launer, Nilüfer Ertekin-Taner, Deborah Blacker, Carlo Caltagirone, Bruno Vellas, Ronald C. Petersen, Bruce L. Miller, Bradley Hyman, Eric M. Reiman, Magda N. Tsolaki, Chiara Fenoglio, Martin Dichgans, Walter A. Kukull, Randall L Woltjer, Michelle K Lupton, Bernadette McGuinness, Jonathan L Haines, Thomas G Beach, Richard B. Lipton, Ina Giegling, Dan Rujescu, Susanne Moebus, Didier Hannequin, Steffi G. Riedel-Heller, Martin Scherer, Bruce M. Psaty, William Seeley, Adam L Boxer, Harry V Vinters, Rudolph E. Tanzi, Martin Ingelsson, Thomas H Mosley, Myriam Fornage, Joshua C Bis, Julie A. Schneider, Dominique Campion, Deborah Mash, Bradley F Boeve, Nigel J Cairns, Paul K. Crane, Philip L. De Jager, Hakon Hakonarson, Bernardino F. Ghetti, Matthew Frosch, Liana G. Apostolova, Constantine G. Lyketsos, Eliecer Coto, Jennifer A. Brody, Christopher J O'Donnell, Jacques Epelbaum, Jayandra J. Himali, Rik Vandenberghe, Shubhabrata Mukherjee, Johanna Jakobsdottir, Neill R Graff-Radford, Howard J Rosen, Minerva M Carrasquillo, Russell H Swerdlow, Nick C. Fox, Oscar L Lopez, Kelley M Faber, Brian W Kunkle, Ronald L Hamilton, James J Lah, Clinton Baldwin, M. Ilyas Kamboh, James T Becker, James R Burke, Jeffrey Kaye, Joseph Quinn, Erik D. Roberson, Tricia A. Thornton-Wells, Clinton B Wright, Hieab H.H. Adams, Craig S Atwood, Jeffrey P Burns, David W Fardo, Joshua A. Sonnen, Robert A. Stern, Thomas S Wingo, Debby W Tsuang, Christopher Shaw, Joseph E Parisi, Anna M Karydas, Eileen H Bigio, Vernon Pankratz, Maria Serpente, Alberto Lleó, Sara Ortega-Cubero, James Uphill, John Collinge, Simon Mead, Vivianna M Van Deerlin, Sabrina Pichler, Maura Gallo, Sandra Weintraub, Marsel Mesulam, Ranjan Duara, Badri N Vardarajan, Douglas R. Galasko, Todd E Golde, Mariet Allen, Carlos Cruchaga, Elio Scarpini, Marla Gearing, Jean Paul G Vonsattel, Lawrence S Honig, Sonia Moreno-Grau, Juan C Troncoso, Pascual Sánchez-Juan, Jordi Clarimón, Martin R. Farlow, Joel H Kramer, Adam C Naj, Maria C Norton, JoAnn T Tschanz, Beth A Dombroski, Laura B Cantwell, Regina M Carney, Roger L Albin, Duane Beekly, Chuanhai Cao, Helena Chui, Elizabeth A Crocco, Kenneth B Fallon, John Growdon, Kara L Hamilton-Nelson, Lindy E Harrell, Christine M Hulette, Lee-Way Jin, Kim Oates, Neil Kowall, Frank M LaFerla, Allan Levey, Andrew P Lieberman, Daniel Marson, Wayne C McCormick, Susan M McCurry, Carol A Miller, John Olichney, Elaine Peskind, Aimee L Pierce, Huntington Potter, Murray Raskind, John M Ringman, Lon S Schneider, Linda J Van Eldik, Kathleen A Welsh-Bohmer, Matthew J Huentelman, Amanda J Myers, Henry Paulson, Otto Valladares, Rachel Raybould, Benjamin Grenier-Boley, Amanda B Kuzma, Robert Olaso, Markus M Nöthen, Seung-Hoan Choi, Delphine Bacq, Taniesha Morgan, Florentino Sanchez-Garcia, Nicola Denning, John Malamon, Maria Candida Deniz Naranjo, David Wallon, Patrice Whitehead, Christopher Medway, Xueqiu Jian, Kristelle Brown, Vincenzo Solfrizzi, Paolo Caffarra, Virginia Boccardi, Perrie M Adams, Markus Leber, Carlo Masullo, Rachelle Doody, Thomas Fairchild, Ryan M Huebinger, Mindy J. Katz, Alun Meggy, Amy Gerrish, Makrina Daniilidou, Yogen Patel, Annette M Hartmann, Roberta Cecchetti, Maria Donata Orfei, Antonio Ciaramella, Raffaele Maletta, Janet M Johnston, Brian Lawlor, Aoibhinn Lynch, Sandra Barral, Cynthia M Carlsson, Erin L Abner, Sid O'Bryant, Mark A Sager, Fabienne Garzia, Håkan Thonberg, Lena Kilander, RoseMarie Brundin, Letizia Concari, Seppo Helisalmi, Anne Maria Koivisto, Nathalie Fievet, Olivier Hanon, Carole Dufouil, Karen Ritchie, Christopher Keene, Annette L Fitzpatrick, Ron Munger, María Victoria Alvarez-Sánchez, Joan S Reisch, Donald R Royall, Olive Melissa Minor Peters, Reinhard Heun, Rebecca Sussams, Simon Lovestone, Peter Passmore, Anita L DeStefano, Mercè Boada, Peter Holmans, Gerard D Schellenberg, Peter Paul De Deyn, Onofre Combarros, Paolo Bosco, Michelangelo Mancuso, Davide Seripa, Lesley Jones, Andreas J Forstner, Elisa Majounie, David S Carrell, Anne Braae, Imelda S Barber, Melanie L Dunstan, Paola Bossù, Ana Frank García, Stefan Herms, Jean-François Deleuze, Nathan D Price, Melissa N Garcia, Paramita Chakrabarty, Ashley R Winslow, Christophe Tzourio, Thomas J Montine, Frank Jessen, Jill R Murrell, Roger N. Rosenberg, Steven G. Younkin, Lars Lannfelt, Jean-François Dartigues, Lena Lilius, Timothy K Behrens, ARUK Consortium, Alessio Squassina, Oscar Sotolongo-Grau, Maria Jesus Bullido Gomez-Heras, Marina Arcaro, Kirk Wilhelmsen, Ann McKee, Mary Sano, James D. Bowen, Amalia Cecilia Bruni, Marilyn S. Albert, Matthias Riemenschneider, Charles C White, Gary W Beecham, Eden R Martin, Daniel Levy, Lisa L. Barnes, Denis Evans, William T. Longstreth, Helena Schmidt, John Powell, Li-San Wang, Eric B Larson, Robert R Graham, Robert C Barber, Chris S Carlson, David G Clark, David H Cribbs, Malcolm Dick, John R Gilbert, Frank Martiniuk, William Perry, Ashok Raj, Amanda G Smith, Salvatore Spina, Jennifer Williamson, Thomas D. Bird, Steven L Carroll, Andrew McDavid, Claudine Berr

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