List of works - Stephen C Hyde

A Phase I/IIa Safety and Efficacy Study of Nebulized Liposome-mediated Gene Therapy for Cystic Fibrosis Supports a Multidose Trial

scientific article published on December 2015

A novel mixing device for the reproducible generation of nonviral gene therapy formulations.

scientific article published in September 2010

A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis.

scientific article

A randomised, double-blind, placebo-controlled phase IIB clinical trial of repeated application of gene therapy in patients with cystic fibrosis

scientific article

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

scientific article

A second dose of a CFTR cDNA-liposome complex is as effective as the first dose in restoring cAMP-dependent chloride secretion to null CF mice trachea

scientific article

Aerosol delivery of DNA/liposomes to the lung for cystic fibrosis gene therapy.

scientific article published on 27 May 2014

An immunocytochemical assay to detect human CFTR expression following gene transfer

scientific article

Assessment of CFTR function after gene transfer in vitro and in vivo.

scientific article

Assessment of F/HN-pseudotyped lentivirus as a clinically relevant vector for lung gene therapy

scientific article

Assessment of selected media supplements to improve F/HN lentiviral vector production yields.

scientific article

Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation

scientific article

Clinical improvement in cystic fibrosis following anti-tumourous chemotherapy.

scientific article published in December 2004

Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

scientific article (publication date: 18 March 1993)

CpG-free plasmid expression cassettes for cystic fibrosis gene therapy

scientific article

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.

scientific article published on 27 April 2008

Delivery of genes into the CF airway.

scientific article published on 11 July 2014

Detection of plasmid DNA vectors following gene transfer to the murine airways.

scientific article

Effects of a novel archaeal tetraether-based colipid on the in vivo gene transfer activity of two cationic amphiphiles.

scientific article published on 30 July 2014

Efficient in vivo transfection and safety profile of a CpG-free and codon optimized luciferase plasmid using a cationic lipophosphoramidate in a multiple intravenous administration procedure.

scientific article published on 15 May 2015

Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA.

scientific article published on 3 August 2005

Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung.

scientific article published in May 2007

Electroporation-mediated interleukin-10 overexpression in skeletal muscle reduces acute rejection in rat cardiac allografts

scientific article published on 01 February 2006

Enhanced Lung Gene Expression After Aerosol Delivery of Concentrated pDNA/PEI Complexes

article

Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways

scientific article published on 23 February 2006

Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import

scientific article published on 28 July 2009

Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids

scientific article published on 23 October 2020

Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA.

scientific article published on 26 August 2015

Identification of transfected cell types following non-viral gene transfer to the murine lung.

scientific article published on March 2007

Ignoring the nonsense: a phase II trial in cystic fibrosis

scientific article

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.

scientific article

Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.

scientific article

Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury.

scientific article published on 28 January 2005

Lack of repeat transduction by recombinant adeno-associated virus type 5/5 vectors in the mouse airway

scientific article

Limitations of the murine nose in the development of nonviral airway gene transfer.

scientific article published on 31 July 2009

Lung-targeting lentiviral vector for passive immunisation against influenza

scientific article published on 03 September 2020

Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature

scientific article published on 10 January 2018

Optimisation of real-time quantitative RT-PCR for the evaluation of non-viral mediated gene transfer to the airways.

scientific article published in October 2002

Optimizing aerosol gene delivery and expression in the ovine lung

scientific article published on February 2007

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.

scientific article published on 21 April 2011

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis.

scientific article

Progress and prospects: the design and production of plasmid vectors.

scientific article published on 08 January 2009

Prolonged amelioration of acute lung allograft rejection by overexpression of human interleukin-10 under control of a long acting ubiquitin C promoter in rats

scientific article published on 01 December 2006

RNA-seq analysis of the human surfactant air-liquid interface culture reveals alveolar type II cell-like transcriptome

scientific article published on 24 November 2021

Rapid identification of novel functional promoters for gene therapy.

scientific article

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial.

scientific article

Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer.

scientific article published on 15 January 2011

Self-reactive CFTR T cells in humans: implications for gene therapy.

scientific article published on 19 July 2013

Sendai virus-mediated CFTR gene transfer to the airway epithelium.

scientific article

Strategies for long-term expression of transgenes in the respiratory epithelium.

scientific article published on August 2010

Synergistic effect of low dose cyclosporine A and human interleukin 10 overexpression on acute rejection in rat lung allotransplantation

scientific article published on 09 April 2005

Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.

scientific article published on October 1994

Temporal regulation of CFTR expression during ovine lung development: implications for CF gene therapy

scientific article

The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins

scientific article published on 18 July 2018

The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep.

scientific article published on 3 October 2013

The significance of plasmid DNA preparations contaminated with bacterial genomic DNA on inflammatory responses following delivery of lipoplexes to the murine lung

scientific article published on 23 September 2011

The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes.

scientific article

The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways

scientific article

Towards gene therapy for cystic fibrosis: a clinical progress report.

scientific article

Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung

scientific article published on 7 November 2013

Transfection efficiency and toxicity following delivery of naked plasmid DNA and cationic lipid–DNA complexes to ovine lung segments ⬇️

scientific article published on October 1, 2003

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

scientific article (publication date: 27 February 1992)

List of works by Stephen C Hyde

A Phase I/IIa Safety and Efficacy Study of Nebulized Liposome-mediated Gene Therapy for Cystic Fibrosis Supports a Multidose Trial

A novel mixing device for the reproducible generation of nonviral gene therapy formulations.

A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis.

A randomised, double-blind, placebo-controlled phase IIB clinical trial of repeated application of gene therapy in patients with cystic fibrosis

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

A second dose of a CFTR cDNA-liposome complex is as effective as the first dose in restoring cAMP-dependent chloride secretion to null CF mice trachea

Aerosol delivery of DNA/liposomes to the lung for cystic fibrosis gene therapy.

An immunocytochemical assay to detect human CFTR expression following gene transfer

Assessment of CFTR function after gene transfer in vitro and in vivo.

Assessment of F/HN-pseudotyped lentivirus as a clinically relevant vector for lung gene therapy

Assessment of selected media supplements to improve F/HN lentiviral vector production yields.

Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation

Clinical improvement in cystic fibrosis following anti-tumourous chemotherapy.

Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

CpG-free plasmid expression cassettes for cystic fibrosis gene therapy

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.

Delivery of genes into the CF airway.

Detection of plasmid DNA vectors following gene transfer to the murine airways.

Effects of a novel archaeal tetraether-based colipid on the in vivo gene transfer activity of two cationic amphiphiles.

Efficient in vivo transfection and safety profile of a CpG-free and codon optimized luciferase plasmid using a cationic lipophosphoramidate in a multiple intravenous administration procedure.

Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA.

Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung.

Electroporation-mediated interleukin-10 overexpression in skeletal muscle reduces acute rejection in rat cardiac allografts

Enhanced Lung Gene Expression After Aerosol Delivery of Concentrated pDNA/PEI Complexes

Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways

Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import

Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids

Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA.

Identification of transfected cell types following non-viral gene transfer to the murine lung.

Ignoring the nonsense: a phase II trial in cystic fibrosis

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.

Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.

Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury.

Lack of repeat transduction by recombinant adeno-associated virus type 5/5 vectors in the mouse airway

Limitations of the murine nose in the development of nonviral airway gene transfer.

Lung-targeting lentiviral vector for passive immunisation against influenza

Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature

Optimisation of real-time quantitative RT-PCR for the evaluation of non-viral mediated gene transfer to the airways.

Optimizing aerosol gene delivery and expression in the ovine lung

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis.

Progress and prospects: the design and production of plasmid vectors.

Prolonged amelioration of acute lung allograft rejection by overexpression of human interleukin-10 under control of a long acting ubiquitin C promoter in rats

RNA-seq analysis of the human surfactant air-liquid interface culture reveals alveolar type II cell-like transcriptome

Rapid identification of novel functional promoters for gene therapy.

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial.

Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer.

Self-reactive CFTR T cells in humans: implications for gene therapy.

Sendai virus-mediated CFTR gene transfer to the airway epithelium.

Strategies for long-term expression of transgenes in the respiratory epithelium.

Synergistic effect of low dose cyclosporine A and human interleukin 10 overexpression on acute rejection in rat lung allotransplantation

Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.

Temporal regulation of CFTR expression during ovine lung development: implications for CF gene therapy

The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins

The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep.

The significance of plasmid DNA preparations contaminated with bacterial genomic DNA on inflammatory responses following delivery of lipoplexes to the murine lung

The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes.

The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways

Towards gene therapy for cystic fibrosis: a clinical progress report.

Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung

Transfection efficiency and toxicity following delivery of naked plasmid DNA and cationic lipid–DNA complexes to ovine lung segments ⬇️

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein