List of works - Jan Potempa

Pharmacokinetics of sulbactam and ampicillin intravenously applied in combination to healthy volunteers and patients. Determination of the ratio of the two drugs in serum and in various tissues

scientific article published on 01 November 1988

An elastase inhibitor from equine leukocyte cytosol belongs to the serpin superfamily. Further characterization and amino acid sequence of the reactive center

scientific article published on May 25, 1988

Functional characteristics of antibodies induced by Arg-gingipain (HRgpA) and Lys-gingipain (Kgp) from Porphyromonas gingivalis

scientific article published in August 2001

The primary elastase inhibitor (elastasin) and trypsin inhibitor (contrapsin) in the goat are serpins related to human alpha 1-anti-chymotrypsin

scientific article published on February 1995

Effects of elastase and cathepsin G on the levels of membrane and soluble TNFalpha

scientific article

Gingipain enzymes from Porphyromonas gingivalis preferentially bind immobilized extracellular proteins: a mechanism favouring colonization?

scientific article

Cleavage of the human C5A receptor by proteinases derived from Porphyromonas gingivalis: cleavage of leukocyte C5a receptor

scientific article

Activation of protein C by arginine-specific cysteine proteinases (gingipains-R) from Porphyromonas gingivalis

scientific article published on 01 January 1999

Manipulation of Neutrophils by Porphyromonas gingivalis in the Development of Periodontitis

scientific article

Genes Contributing to Porphyromonas gingivalis Fitness in Abscess and Epithelial Cell Colonization Environments

scientific article published on 28 August 2017

The use of alpha 2-antiplasmin as a model for the demonstration of complex reversibility in serpins

scientific article published on 01 August 1989

Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes.

scientific article

A pathogenic trace of Tannerella forsythia - shedding of soluble fully active tumor necrosis factor α from the macrophage surface by karilysin

scientific article

Bacterial peptidases

scientific article published in January 2005

Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency

scientific article published in July 2002

A novel mechanism of latency in matrix metalloproteinases

scientific article published on 2 January 2015

Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B.

scientific article published in April 2007

Comparative cleavage sites within the reactive-site loop of native and oxidized alpha1-proteinase inhibitor by selected bacterial proteinases

scientific article published on 01 October 1999

Activation of blood coagulation factor IX by gingipains R, arginine-specific cysteine proteinases from Porphyromonas gingivalis

scientific article

Isolation and properties of extracellular proteinases of Penicillium marneffei

scientific article published on July 2006

FACIN, a Double-Edged Sword of the Emerging Periodontal Pathogen Filifactor alocis: A Metabolic Enzyme Moonlighting as a Complement Inhibitor.

scientific article published on 16 September 2016

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

scientific article published in November 2017

Differential regulation by Toll-like receptor agonists reveals that MCPIP1 is the potent regulator of innate immunity in bacterial and viral infections

scientific article published on 06 July 2012

Pyocyanina contributory factor in haem acquisition and virulence enhancement of Porphyromonas gingivalis in the lung [corrected]

scientific article

Carbamylated LL-37 as a modulator of the immune response

scientific article published on 15 February 2016

Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.

scientific article

Serpins: structure and mechanism of action

scientific article published on May 1990

Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids

scientific article

The activity of bacterial peptidylarginine deiminase is important during formation of dual-species biofilm by periodontal pathogen Porphyromonas gingivalis and opportunistic fungus Candida albicans.

scientific article

Cartilage proteoglycan degradation by a mouse transformed macrophage cell line is mediated by macrophage metalloelastase

scientific article published in May 1999

Effect of calcium binding on conformational changes of staphylococcal metalloproteinase measured by means of intrinsic protein fluorescence

scientific article published on 01 June 1986

Mirolysin, a LysargiNase from Tannerella forsythia, proteolytically inactivates the human cathelicidin, LL-37.

scientific article published on 20 December 2016

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.

scientific article published on 23 February 2018

Glutaminyl cyclases as novel targets for the treatment of septic arthritis

scientific article published on 29 November 2012

Structure of the catalytic domain of theTannerella forsythiamatrix metallopeptidase karilysin in complex with a tetrapeptidic inhibitor

scientific article

PPAD remains a credible candidate for inducing autoimmunity in rheumatoid arthritis: comment on the article by Konig et al.

scientific article

MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production.

scientific article

In vitro testing the potential of a novel chimeric IgG variant for inhibiting collagen fibrils formation in recurrent hereditary gingival fibromatosis: chimeric antibody in a gingival model

scientific article published on 01 August 2014

Association of Distinct Fine Specificities of Anti-Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis

scientific article published on 30 October 2017

Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase

scientific article

Interaction of a novel form of Pseudomonas aeruginosa alkaline protease (aeruginolysin) with interleukin-6 and interleukin-8

scientific article published on 01 July 2006

Use of sensitive, broad-spectrum molecular assays and human airway epithelium cultures for detection of respiratory pathogens

scientific article

The Staphylococcus aureus leucine aminopeptidase is localized to the bacterial cytosol and demonstrates a broad substrate range that extends beyond leucine

scientific article published on June 2013

Isolation of Nine Human Plasma Proteinase Inhibitors by Sequential Affinity Chromatography

scientific article published on January 1, 1990

Characterisation of a highly specific, endogenous inhibitor of cysteine protease from Staphylococcus epidermidis, a new member of the staphostatin family

scientific article published in June 2004

Spontaneous inactivation of human lung tryptase as probed by size-exclusion chromatography and chemical cross-linking: dissociation of active tetrameric enzyme into inactive monomers is the primary event of the entire process

scientific article published on June 11, 1998

The functional role of acute phase plasma proteinase inhibitors

scientific article published on December 1988

Periodontal Pathogens and Associated Intrathecal Antibodies in Early Stages of Alzheimer's Disease

scientific article published on 01 January 2018

Human SCCA Serpins Inhibit Staphylococcal Cysteine Proteases by Forming Classic “Serpin-Like” Covalent Complexes

scientific article published on January 1, 2011

Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis

scientific article

List of works by Jan Potempa

Pharmacokinetics of sulbactam and ampicillin intravenously applied in combination to healthy volunteers and patients. Determination of the ratio of the two drugs in serum and in various tissues

An elastase inhibitor from equine leukocyte cytosol belongs to the serpin superfamily. Further characterization and amino acid sequence of the reactive center

Functional characteristics of antibodies induced by Arg-gingipain (HRgpA) and Lys-gingipain (Kgp) from Porphyromonas gingivalis

The primary elastase inhibitor (elastasin) and trypsin inhibitor (contrapsin) in the goat are serpins related to human alpha 1-anti-chymotrypsin

Effects of elastase and cathepsin G on the levels of membrane and soluble TNFalpha

Gingipain enzymes from Porphyromonas gingivalis preferentially bind immobilized extracellular proteins: a mechanism favouring colonization?

Cleavage of the human C5A receptor by proteinases derived from Porphyromonas gingivalis: cleavage of leukocyte C5a receptor

Activation of protein C by arginine-specific cysteine proteinases (gingipains-R) from Porphyromonas gingivalis

Manipulation of Neutrophils by Porphyromonas gingivalis in the Development of Periodontitis

Genes Contributing to Porphyromonas gingivalis Fitness in Abscess and Epithelial Cell Colonization Environments

The use of alpha 2-antiplasmin as a model for the demonstration of complex reversibility in serpins

Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes.

A pathogenic trace of Tannerella forsythia - shedding of soluble fully active tumor necrosis factor α from the macrophage surface by karilysin

Bacterial peptidases

Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency

A novel mechanism of latency in matrix metalloproteinases

Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B.

Comparative cleavage sites within the reactive-site loop of native and oxidized alpha1-proteinase inhibitor by selected bacterial proteinases

Activation of blood coagulation factor IX by gingipains R, arginine-specific cysteine proteinases from Porphyromonas gingivalis

Isolation and properties of extracellular proteinases of Penicillium marneffei

FACIN, a Double-Edged Sword of the Emerging Periodontal Pathogen Filifactor alocis: A Metabolic Enzyme Moonlighting as a Complement Inhibitor.

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

Differential regulation by Toll-like receptor agonists reveals that MCPIP1 is the potent regulator of innate immunity in bacterial and viral infections

Pyocyanina contributory factor in haem acquisition and virulence enhancement of Porphyromonas gingivalis in the lung [corrected]

Carbamylated LL-37 as a modulator of the immune response

Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.

Serpins: structure and mechanism of action

Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids

The activity of bacterial peptidylarginine deiminase is important during formation of dual-species biofilm by periodontal pathogen Porphyromonas gingivalis and opportunistic fungus Candida albicans.

Cartilage proteoglycan degradation by a mouse transformed macrophage cell line is mediated by macrophage metalloelastase

Effect of calcium binding on conformational changes of staphylococcal metalloproteinase measured by means of intrinsic protein fluorescence

Mirolysin, a LysargiNase from Tannerella forsythia, proteolytically inactivates the human cathelicidin, LL-37.

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.

Glutaminyl cyclases as novel targets for the treatment of septic arthritis

Structure of the catalytic domain of theTannerella forsythiamatrix metallopeptidase karilysin in complex with a tetrapeptidic inhibitor

PPAD remains a credible candidate for inducing autoimmunity in rheumatoid arthritis: comment on the article by Konig et al.

MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production.

In vitro testing the potential of a novel chimeric IgG variant for inhibiting collagen fibrils formation in recurrent hereditary gingival fibromatosis: chimeric antibody in a gingival model

Association of Distinct Fine Specificities of Anti-Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis

Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase

Interaction of a novel form of Pseudomonas aeruginosa alkaline protease (aeruginolysin) with interleukin-6 and interleukin-8

Use of sensitive, broad-spectrum molecular assays and human airway epithelium cultures for detection of respiratory pathogens

The Staphylococcus aureus leucine aminopeptidase is localized to the bacterial cytosol and demonstrates a broad substrate range that extends beyond leucine

Isolation of Nine Human Plasma Proteinase Inhibitors by Sequential Affinity Chromatography

Characterisation of a highly specific, endogenous inhibitor of cysteine protease from Staphylococcus epidermidis, a new member of the staphostatin family

Spontaneous inactivation of human lung tryptase as probed by size-exclusion chromatography and chemical cross-linking: dissociation of active tetrameric enzyme into inactive monomers is the primary event of the entire process

The functional role of acute phase plasma proteinase inhibitors

Periodontal Pathogens and Associated Intrathecal Antibodies in Early Stages of Alzheimer's Disease

Human SCCA Serpins Inhibit Staphylococcal Cysteine Proteases by Forming Classic “Serpin-Like” Covalent Complexes

Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis