List of works - Jan Potempa

Functional and structural characterization of Spl proteases from Staphylococcus aureus

scientific article published on 13 February 2006

Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms.

scientific article

The potential role of alpha 2-macroglobulin in the control of cysteine proteinases (gingipains) from Porphyromonas gingivalis

scientific article published on 01 January 1997

Periodontal pathogens affect the level of protease inhibitors in gingival crevicular fluid.

scientific article published on 7 December 2011

Cytoplasmic control of premature activation of a secreted protease zymogen: deletion of staphostatin B (SspC) in Staphylococcus aureus 8325-4 yields a profound pleiotropic phenotype

scientific article

Papain-like proteases of Staphylococcus aureus

scientific article published on January 2011

Molecular diversity of a putative virulence factor: purification and characterization of isoforms of an extracellular serine glutamyl endopeptidase of Enterococcus faecalis with different enzymatic activities

scientific article

The lysine-specific gingipain of Porphyromonas gingivalis : importance to pathogenicity and potential strategies for inhibition

scientific article published on January 2011

Unaltered expression of the major protease genes in a non-virulent recA-defective mutant of Porphyromonas gingivalis W83.

scientific article published in February 2000

Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells

scientific article

Cleavage of human complement component C5 by cysteine proteinases from Porphyromonas (Bacteroides) gingivalis. Prior oxidation of C5 augments proteinase digestion of C5

scientific article published on 01 April 1996

Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis

scientific article published on 19 July 2013

Fighting an enemy within: cytoplasmic inhibitors of bacterial cysteine proteases.

scientific article published in August 2005

Proteinase-mediated release of epithelial cell-associated CD44. Extracellular CD44 complexes with components of cellular matrices

scientific article published on 10 September 2002

Inter-alpha-trypsin inhibitor. Inhibition spectrum of native and derived forms

scientific article published on 01 September 1989

Secretory leukocyte proteinase inhibitor-competent DNA deposits are potent stimulators of plasmacytoid dendritic cells: implication for psoriasis

scientific article published on 11 July 2012

Porphyromonas gingivalis proteinases in periodontitis, a review

scientific article

The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities

scientific article published in December 2004

Prokaryote-derived protein inhibitors of peptidases: A sketchy occurrence and mostly unknown function

scientific article

Porphyromonas gingivalis fimbriae dampen P2X7-dependent interleukin-1β secretion.

scientific article

Role of the cysteine protease interpain A of Prevotella intermedia in breakdown and release of haem from haemoglobin

scientific article

Cigarette smoke-exposed neutrophils die unconventionally but are rapidly phagocytosed by macrophages

scientific article published on March 17, 2011

A Dual Role for P2X7 Receptor during Porphyromonas gingivalis Infection

scientific article

Porphyromonas gingivalis Virulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine Peptidases

scientific article

The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain

scientific article published on 23 March 2016

Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis

scientific article

Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus

scientific article

Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis

scientific article

Purification and Characterization of an Arginine-specific Peptidase from Ragweed (Ambrosia artemisiifolia) Pollen

scientific article published on March 1, 1998

The HA2 haemagglutinin domain of the lysine-specific gingipain (Kgp) of Porphyromonas gingivalis promotes micro-oxo bishaem formation from monomeric iron(III) protoporphyrin IX

scientific article published on 01 June 2006

Staphostatins resemble lipocalins, not cystatins in fold

scientific article

Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases

scientific article

Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases

scientific article published on 18 August 2014

Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia

scientific article

A relationship between proteinase activity and clinical parameters in the treatment of periodontal disease

scientific article published on July 1, 1998

Novel polymeric inhibitors of HCoV-NL63.

scientific article published on 29 November 2012

Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis

scientific article published on September 2008

Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop

scientific article

Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study

scientific article published on 4 November 2015

Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin

scientific article

Citrullination and proteolytic processing of chemokines by Porphyromonas gingivalis.

scientific article

Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C.

scientific article

Carbamylation of immunoglobulin abrogates activation of the classical complement pathway

scientific article

Effect of metalloproteinase from Staphylococcus aureus on in vitro stimulation of human lymphocytes

scientific article published in March 1991

Gingipains: Critical Factors in the Development of Aspiration Pneumonia Caused by Porphyromonas gingivalis

scientific article published on 28 November 2015

Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients

scientific article

Release of a new vascular permeability enhancing peptide from kininogens by human neutrophil elastase

scientific article published in June 2002

Growth phase-dependent production of a cell wall-associated elastinolytic cysteine proteinase by Staphylococcus epidermidis

scientific article published on June 2004

Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.

scientific article

Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases

scientific article published on 10 April 2013

List of works by Jan Potempa

Functional and structural characterization of Spl proteases from Staphylococcus aureus

Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms.

The potential role of alpha 2-macroglobulin in the control of cysteine proteinases (gingipains) from Porphyromonas gingivalis

Periodontal pathogens affect the level of protease inhibitors in gingival crevicular fluid.

Cytoplasmic control of premature activation of a secreted protease zymogen: deletion of staphostatin B (SspC) in Staphylococcus aureus 8325-4 yields a profound pleiotropic phenotype

Papain-like proteases of Staphylococcus aureus

Molecular diversity of a putative virulence factor: purification and characterization of isoforms of an extracellular serine glutamyl endopeptidase of Enterococcus faecalis with different enzymatic activities

The lysine-specific gingipain of Porphyromonas gingivalis : importance to pathogenicity and potential strategies for inhibition

Unaltered expression of the major protease genes in a non-virulent recA-defective mutant of Porphyromonas gingivalis W83.

Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells

Cleavage of human complement component C5 by cysteine proteinases from Porphyromonas (Bacteroides) gingivalis. Prior oxidation of C5 augments proteinase digestion of C5

Sequence-independent processing site of the C-terminal domain (CTD) influences maturation of the RgpB protease from Porphyromonas gingivalis

Fighting an enemy within: cytoplasmic inhibitors of bacterial cysteine proteases.

Proteinase-mediated release of epithelial cell-associated CD44. Extracellular CD44 complexes with components of cellular matrices

Inter-alpha-trypsin inhibitor. Inhibition spectrum of native and derived forms

Secretory leukocyte proteinase inhibitor-competent DNA deposits are potent stimulators of plasmacytoid dendritic cells: implication for psoriasis

Porphyromonas gingivalis proteinases in periodontitis, a review

The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities

Prokaryote-derived protein inhibitors of peptidases: A sketchy occurrence and mostly unknown function

Porphyromonas gingivalis fimbriae dampen P2X7-dependent interleukin-1β secretion.

Role of the cysteine protease interpain A of Prevotella intermedia in breakdown and release of haem from haemoglobin

Cigarette smoke-exposed neutrophils die unconventionally but are rapidly phagocytosed by macrophages

A Dual Role for P2X7 Receptor during Porphyromonas gingivalis Infection

Porphyromonas gingivalis Virulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine Peptidases

The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain

Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis

Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus

Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis

Purification and Characterization of an Arginine-specific Peptidase from Ragweed (Ambrosia artemisiifolia) Pollen

The HA2 haemagglutinin domain of the lysine-specific gingipain (Kgp) of Porphyromonas gingivalis promotes micro-oxo bishaem formation from monomeric iron(III) protoporphyrin IX

Staphostatins resemble lipocalins, not cystatins in fold

Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases

Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases

Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia

A relationship between proteinase activity and clinical parameters in the treatment of periodontal disease

Novel polymeric inhibitors of HCoV-NL63.

Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis

Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop

Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study

Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin

Citrullination and proteolytic processing of chemokines by Porphyromonas gingivalis.

Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C.

Carbamylation of immunoglobulin abrogates activation of the classical complement pathway

Effect of metalloproteinase from Staphylococcus aureus on in vitro stimulation of human lymphocytes

Gingipains: Critical Factors in the Development of Aspiration Pneumonia Caused by Porphyromonas gingivalis

Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients

Release of a new vascular permeability enhancing peptide from kininogens by human neutrophil elastase

Growth phase-dependent production of a cell wall-associated elastinolytic cysteine proteinase by Staphylococcus epidermidis

Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.

Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases