List of works - Jan Potempa

Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease

scientific article

Verification of a topology model of PorT as an integral outer-membrane protein in Porphyromonas gingivalis

scientific article published in February 2009

Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase

scientific article published on July 2015

Stimulatory effect of inflammatory cytokines on alpha 1-antichymotrypsin expression in human lung-derived epithelial cells

scientific article published on June 1995

Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity

scientific article

The inactivation of human plasma alpha 1-proteinase inhibitor by proteinases from Staphylococcus aureus.

scientific article published on 01 October 1986

Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis.

scientific article

Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases

scientific article published in April 2004

Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production

scientific article published on June 2002

The Staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease

scientific article

Alpha-2-antiplasmin: a serpin with two separate but overlapping reactive sites

scientific article published on 01 August 1988

Purification and characterization of a novel cysteine proteinase (periodontain) from Porphyromonas gingivalis. Evidence for a role in the inactivation of human alpha1-proteinase inhibitor

scientific article published on 01 April 1999

Citrullination in the periodontium--a possible link between periodontitis and rheumatoid arthritis.

scientific article published on 13 August 2015

pH-regulated secretion of a glyceraldehyde-3-phosphate dehydrogenase from Streptococcus gordonii FSS2: purification, characterization, and cloning of the gene encoding this enzyme

scientific article

Neuropeptide release from dental pulp cells by RgpB via proteinase-activated receptor-2 signaling

scientific article

Two allelic forms of the aureolysin gene (aur) within Staphylococcus aureus

scientific article

Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis.

scientific article

Proteolysis of interleukin-6 receptor (IL-6R) by Porphyromonas gingivalis cysteine proteinases (gingipains) inhibits interleukin-6-mediated cell activation

scientific article

Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage

scientific article published on 22 October 2012

Neutrophils in chronic and aggressive periodontitis in interaction with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

scientific article

Protease-dependent mechanisms of complement evasion by bacterial pathogens

scientific article published on September 1, 2012

Emerging family of proline-specific peptidases of Porphyromonas gingivalis: purification and characterization of serine dipeptidyl peptidase, a structural and functional homologue of mammalian prolyl dipeptidyl peptidase IV

scientific article

Effect of free and vesicle-bound cysteine proteinases of Porphyromonas gingivalis on plasma clot formation: implications for bleeding tendency at periodontitis sites

scientific article published on December 1, 1995

Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues

scientific article

Heparin-dependent Modification of the Reactive Center Arginine of Antithrombin and Consequent Increase in Heparin Binding Affinity

scientific article published on August 8, 1997

Activation of human prothrombin by arginine-specific cysteine proteinases (Gingipains R) from porphyromonas gingivalis

scientific article

A New Autocatalytic Activation Mechanism for Cysteine Proteases Revealed by Prevotella intermedia Interpain A

scientific article

Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhaemoglobin

scientific article published on 04 June 2007

Proteolytic inactivation of LL-37 by karilysin, a novel virulence mechanism of Tannerella forsythia

scientific article

Proteolytic inactivation of the leukocyte C5a receptor by proteinases derived from Porphyromonas gingivalis

scientific article

The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin

scientific article published on February 2008

Arginine-specific gingipains from Porphyromonas gingivalis stimulate production of hepatocyte growth factor (scatter factor) through protease-activated receptors in human gingival fibroblasts in culture

scientific article published in November 2005

Cleavage of human immunoglobulins by serine proteinase from Staphylococcus aureus

scientific article published on February 15, 1992

Kallikreins - The melting pot of activity and function

scientific article published on 23 September 2015

Filifactor alocis infection and inflammatory responses in the mouse subcutaneous chamber model

scientific article published on 30 December 2013

High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism

scientific article

Porphyromonas gingivalis DPP-7 represents a novel type of dipeptidylpeptidase

scientific article

A Peptide Domain on Gingipain R Which Confers Immunity against Porphyromonas gingivalis Infection in Mice

scientific article published on September 1, 1998

KLIKK proteases of Tannerella forsythia: putative virulence factors with a unique domain structure

scientific article published on 21 April 2015

Citrullination alters immunomodulatory function of LL-37 essential for prevention of endotoxin-induced sepsis.

scientific article

Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis

scientific article

Evidence of mutualism between two periodontal pathogens: co-operative haem acquisition by the HmuY haemophore of Porphyromonas gingivalis and the cysteine protease interpain A (InpA) of Prevotella intermedia

scientific article

Proteolysis of ICAM-1 on Human Oral Epithelial Cells by Gingipains

scientific article published on October 1, 2003

Porphyromonas gingivalis gingipains selectively reduce CD14 expression, leading to macrophage hyporesponsiveness to bacterial infection

scientific article

Identification of an intracellular M17 family leucine aminopeptidase that is required for virulence in Staphylococcus aureus.

scientific article

Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage

scientific article published on December 2009

The structure of the catalytic domain of Tannerella forsythia karilysin reveals it is a bacterial xenologue of animal matrix metalloproteinases

scientific article

Protease-armed bacteria in the skin

scientific article

The role of proteolytic enzymes in the development of pulmonary emphysema and periodontal disease

scientific article published on 01 December 1994

Dual regulation of interleukin-8 production in human oral epithelial cells upon stimulation with gingipains from Porphyromonas gingivalis

scientific article

List of works by Jan Potempa

Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease

Verification of a topology model of PorT as an integral outer-membrane protein in Porphyromonas gingivalis

Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase

Stimulatory effect of inflammatory cytokines on alpha 1-antichymotrypsin expression in human lung-derived epithelial cells

Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity

The inactivation of human plasma alpha 1-proteinase inhibitor by proteinases from Staphylococcus aureus.

Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis.

Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases

Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production

The Staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease

Alpha-2-antiplasmin: a serpin with two separate but overlapping reactive sites

Purification and characterization of a novel cysteine proteinase (periodontain) from Porphyromonas gingivalis. Evidence for a role in the inactivation of human alpha1-proteinase inhibitor

Citrullination in the periodontium--a possible link between periodontitis and rheumatoid arthritis.

pH-regulated secretion of a glyceraldehyde-3-phosphate dehydrogenase from Streptococcus gordonii FSS2: purification, characterization, and cloning of the gene encoding this enzyme

Neuropeptide release from dental pulp cells by RgpB via proteinase-activated receptor-2 signaling

Two allelic forms of the aureolysin gene (aur) within Staphylococcus aureus

Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis.

Proteolysis of interleukin-6 receptor (IL-6R) by Porphyromonas gingivalis cysteine proteinases (gingipains) inhibits interleukin-6-mediated cell activation

Inactivation of epidermal growth factor by Porphyromonas gingivalis as a potential mechanism for periodontal tissue damage

Neutrophils in chronic and aggressive periodontitis in interaction with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

Protease-dependent mechanisms of complement evasion by bacterial pathogens

Emerging family of proline-specific peptidases of Porphyromonas gingivalis: purification and characterization of serine dipeptidyl peptidase, a structural and functional homologue of mammalian prolyl dipeptidyl peptidase IV

Effect of free and vesicle-bound cysteine proteinases of Porphyromonas gingivalis on plasma clot formation: implications for bleeding tendency at periodontitis sites

Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues

Heparin-dependent Modification of the Reactive Center Arginine of Antithrombin and Consequent Increase in Heparin Binding Affinity

Activation of human prothrombin by arginine-specific cysteine proteinases (Gingipains R) from porphyromonas gingivalis

A New Autocatalytic Activation Mechanism for Cysteine Proteases Revealed by Prevotella intermedia Interpain A

Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhaemoglobin

Proteolytic inactivation of LL-37 by karilysin, a novel virulence mechanism of Tannerella forsythia

Proteolytic inactivation of the leukocyte C5a receptor by proteinases derived from Porphyromonas gingivalis

The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin

Arginine-specific gingipains from Porphyromonas gingivalis stimulate production of hepatocyte growth factor (scatter factor) through protease-activated receptors in human gingival fibroblasts in culture

Cleavage of human immunoglobulins by serine proteinase from Staphylococcus aureus

Kallikreins - The melting pot of activity and function

Filifactor alocis infection and inflammatory responses in the mouse subcutaneous chamber model

High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism

Porphyromonas gingivalis DPP-7 represents a novel type of dipeptidylpeptidase

A Peptide Domain on Gingipain R Which Confers Immunity against Porphyromonas gingivalis Infection in Mice

KLIKK proteases of Tannerella forsythia: putative virulence factors with a unique domain structure

Citrullination alters immunomodulatory function of LL-37 essential for prevention of endotoxin-induced sepsis.

Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis

Evidence of mutualism between two periodontal pathogens: co-operative haem acquisition by the HmuY haemophore of Porphyromonas gingivalis and the cysteine protease interpain A (InpA) of Prevotella intermedia

Proteolysis of ICAM-1 on Human Oral Epithelial Cells by Gingipains

Porphyromonas gingivalis gingipains selectively reduce CD14 expression, leading to macrophage hyporesponsiveness to bacterial infection

Identification of an intracellular M17 family leucine aminopeptidase that is required for virulence in Staphylococcus aureus.

Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage

The structure of the catalytic domain of Tannerella forsythia karilysin reveals it is a bacterial xenologue of animal matrix metalloproteinases

Protease-armed bacteria in the skin

The role of proteolytic enzymes in the development of pulmonary emphysema and periodontal disease

Dual regulation of interleukin-8 production in human oral epithelial cells upon stimulation with gingipains from Porphyromonas gingivalis