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List of works by Lawrence F Bielak

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

scientific article

A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease

scientific article published on 01 April 2019

A Statistical Approach for Testing Cross-Phenotype Effects of Rare Variants

scientific article published on March 2016

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

scientific article published on 13 May 2012

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

scientific article

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

scientific article

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

scientific article published on 10 April 2019

A noncoding variant near PPP1R3B promotes liver glycogen storage and MetS, but protects against myocardial infarction

scientific article published on 24 November 2020

A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection

scientific article published on December 2008

A statistical approach for rare-variant association testing in affected sibships

scientific article

Age-dependent associations between blood pressure and coronary artery calcification in asymptomatic adults

scientific article published on April 2004

Ambulatory blood pressure and coronary artery calcification in middle-aged and younger adults

scientific article published in June 2002

An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group

scientific article published on 27 May 2016

Aortic pulse wave velocity is associated with the presence and quantity of coronary artery calcium: a community-based study

scientific article published on 27 December 2005

Aortic valve calcification: determinants and progression in the population

scientific article published on 21 December 2006

Application of machine learning algorithms to predict coronary artery calcification with a sibship-based design

scientific article

Arsenic exposure is associated with diminished insulin sensitivity in non-diabetic Amish adults

scientific article

Association between metabolic syndrome and subclinical coronary atherosclerosis in asymptomatic adults

scientific article published on 01 December 2004

Association of a 62 Variants Type 2 Diabetes Genetic Risk Score With Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study.

scientific article

Association of fibrinogen with quantity of coronary artery calcification measured by electron beam computed tomography

scientific article published on 01 September 2000

Association of plasma homocysteine with coronary artery calcification in different categories of coronary heart disease risk

scientific article published in February 2006

Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease

scientific article

Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification

scientific article

Associations between inflammation and cognitive function in African Americans and European Americans

scientific article

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Associations of serum uric acid with markers of inflammation, metabolic syndrome, and subclinical coronary atherosclerosis

scientific article published on 01 January 2007

Autosomal genome-wide scan for coronary artery calcification loci in sibships at high risk for hypertension

scientific article published in March 2002

Brachial artery diameter and vasodilator response to nitroglycerine, but not flow-mediated dilatation, are associated with the presence and quantity of coronary artery calcium in asymptomatic adults

scientific article published in February 2007

Breast arterial calcification is associated with reproductive factors in asymptomatic postmenopausal women

scientific article

Burden of higher lead exposure in African-Americans starts in utero and persists into childhood

scientific article published on 5 September 2017

C-reactive protein is related to arterial wave reflection and stiffness in asymptomatic subjects from the community

scientific article published in August 2005

Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent

scientific article published on 16 July 2013

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

scientific article

Circulating CD34+ Cell Count is Associated with Extent of Subclinical Atherosclerosis in Asymptomatic Amish Men, Independent of 10-Year Framingham Risk.

scientific article

Comparison of subclinical coronary atherosclerosis and risk factors in unselected populations in Germany and US-America

scientific article published on 29 May 2007

Coronary artery calcification measured at electron-beam CT: agreement in dual scan runs and change over time

scientific article published on 01 January 2001

Coronary artery calcification progression is heritable

scientific article published on 11 June 2007

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 23 August 2017

Determinants of coronary artery and aortic calcification in the Old Order Amish

scientific article

Development and Validation of a Predictive Screening Tool for Uninterpretable Coronary CT Angiography Results ⬇️

scientific article published on July 20, 2011

Differences in prevalence and severity of coronary artery calcification between two non-Hispanic white populations with diverse lifestyles

scientific article published on 26 March 2007

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

scientific article published on 23 November 2020

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

scientific article published on 24 August 2020

Early Subclinical Coronary Artery Calcification in Young Adults Who Were Pediatric Kidney Transplant Recipients

article

Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies

scientific article published on 10 January 2019

Electron-beam computed tomography in the diagnosis of coronary artery disease: a meta-analysis

scientific article

Electron-beam computed tomography screening for asymptomatic coronary artery disease ⬇️

scientific article published on January 1, 2003

Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans

scientific article published on 26 October 2020

Epigenomic Indicators of Age in African Americans

scientific article

Epistatic effects between two genes in the renin-angiotensin system and systolic blood pressure and coronary artery calcification.

scientific article published on 28 March 2006

Evaluation and clinical implications of aortic valve calcification measured by electron-beam computed tomography

scientific article published on 12 July 2004

Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish

scientific article published on November 2010

Fetal and early postnatal lead exposure measured in teeth associates with infant gut microbiota

scientific article published on 29 August 2020

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

scientific article published on 08 October 2018

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

scientific article published on 21 June 2013

Gender- and age-dependent relationships between the E-selectin S128R polymorphism and coronary artery calcification

scientific article published in July 2001

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

scientific article published on 05 May 2020

Genetic Research and Women's Heart Disease: a Primer

scientific article

Genetic influences on blood pressure response to the cold pressor test: results from the Heredity and Phenotype Intervention Heart Study

scientific article published in April 2008

Genetics of Subclinical Coronary Atherosclerosis

scientific article published on 13 July 2018

Genetics of coronary artery calcification among African Americans, a meta-analysis

scientific article

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

scientific article

Genome-wide association of body fat distribution in African ancestry populations suggests new loci

scientific article

Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction

scientific article

Genome-wide association study of gene by smoking interactions in coronary artery calcification

scientific article

Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology

scientific article published on 05 February 2021

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

scientific article published on 13 October 2017

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

scientific article

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 27 April 2017

Genomic loci with pleiotropic effects on coronary artery calcification

scientific article published on 27 July 2005

Heritability of coronary artery calcium quantity measured by electron beam computed tomography in asymptomatic adults

scientific article

Hypertension during pregnancy is associated with coronary artery calcium independent of renal function.

scientific article

In utero metal exposures measured in deciduous teeth and birth outcomes in a racially-diverse urban cohort

journal article published in 2019

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

scientific article published on 14 October 2020

Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without Diabetes

scientific article published on 18 April 2019

Lack of association between lipoprotein(a) and coronary artery calcification in the Genetic Epidemiology Network of Arteriopathy (GENOA) study

scientific article published in October 2004

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiography

scientific article published on July 2001

Low-density lipoprotein particle size and coronary atherosclerosis in subjects belonging to hypertensive sibships

scientific article published in September 2004

Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity

scientific article

Matrix Gla Protein Gene Polymorphism Is Associated With Increased Coronary Artery Calcification Progression ⬇️

scientific article published on January 10, 2013

Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease

scientific article published on 10 May 2019

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes

scientific article

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

article

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

scientific article published in Nature Communications

Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.

scientific article published on 21 November 2016

Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation

scientific article published on 05 December 2016

Neighborhood-Level Poverty at Menarche and Prepregnancy Obesity in African-American Women.

scientific article published on 22 June 2016

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

scientific article published on 18 June 2018

Oral calcium supplements do not affect the progression of aortic valve calcification or coronary artery calcification

scientific article published in November 2009

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

Potential of quantity of coronary artery calcification to identify new risk factors for asymptomatic atherosclerosis

scientific article

Probabilistic model for prediction of angiographically defined obstructive coronary artery disease using electron beam computed tomography calcium score strata

scientific article published on 01 July 2000

Progression of coronary artery calcification: a pilot study

scientific article published on 01 April 1999

Progression of subclinical coronary atherosclerosis: does obesity make a difference?

scientific article

Prospective associations between beverage intake during the midlife and subclinical carotid atherosclerosis: The Study of Women's Health Across the Nation

scientific article published on 10 July 2019

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Quantity of coronary artery calcium detected by electron beam computed tomography in asymptomatic subjects and angiographically studied patients

scientific article published on 01 March 1995

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

article

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

scientific article published on 9 April 2018

Relation of C-reactive protein and fibrinogen to coronary artery calcium in subjects with systemic hypertension

scientific article published on 01 July 2003

Relationship between Vascular Calcification and Bone Mineral Density in the Old-Order Amish

scientific article published on 13 April 2007

Relationship of blood pressure measures with coronary artery calcification

scientific article published on 01 December 2002

Relationships of Clinical and Computed Tomography-Imaged Adiposity with Cognition in Middle-Aged and Older African Americans

scientific article

Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

scientific article published on 08 June 2020

SNP Set Association Analysis for Familial Data ⬇️

scientific article published on September 11, 2012

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

scientific article published on 6 March 2019

Serum 25-hydroxyvitamin d levels are not associated with subclinical vascular disease or C-reactive protein in the old order amish

scientific article

Sex-specific associations of lipoprotein(a) with presence and quantity of coronary artery calcification in an asymptomatic population

scientific article

Shared genetic architecture in the relationship between adult stature and subclinical coronary artery atherosclerosis.

scientific article published on 30 August 2011

Small lesions in the heart identified at electron beam CT: calcification or noise?

scientific article published on 01 September 1994

Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose

scientific article published on 07 May 2020

Testing cross-phenotype effects of rare variants in longitudinal studies of complex traits

scientific article published on 30 March 2018

The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults

scientific article published on 19 September 2008

The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study

scientific article published on 5 March 2008

The power of genetic diversity in genome-wide association studies of lipids

The relationship between diastolic blood pressure and coronary artery calcification is dependent on single nucleotide polymorphisms on chromosome 9p21.3.

scientific article

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin

scientific article

Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis

scientific article published in December 2023

Western Dietary Pattern Derived by Multiple Statistical Methods Is Prospectively Associated with Subclinical Carotid Atherosclerosis in Midlife Women

scientific article published on 01 March 2020

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