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List of works by Francis J Castellino

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Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

scientific article
Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo

scientific article
Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

scientific article
Structure and function of the plasminogen/plasmin system

scientific article published on 01 April 2005
Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma.

scientific article
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

scientific article published on 19 October 2009
The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury

scientific article published on 20 February 2005
The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

scientific article
ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo

scientific article published on 10 March 2009
Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis

scientific article
Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination

scientific article published on October 14, 2012
Plasminogen receptors: the sine qua non of cell surface plasminogen activation

scientific article
Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

scientific article
The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications

scientific article
FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse

scientific article published on 01 April 2002
Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

scientific article published on 13 January 2009
Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy.

scientific article published in April 2013
Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier

scientific article
Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities

scientific article
Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse

scientific article
Oligomeric beta-structure of the membrane-bound HIV-1 fusion peptide formed from soluble monomers

scientific article
Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency

scientific article
A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse

scientific article published on 04 November 2004
Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse

scientific article published on March 2002
Plasma levels of bradykinin are suppressed in factor XII-deficient mice

scientific article published in June 2006
A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model

scientific article
Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats.

scientific article
A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells

scientific article published on 19 June 2006
Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture

scientific article
Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge

scientific article published on 01 September 2002
A trimeric HIV-1 fusion peptide construct which does not self-associate in aqueous solution and which has 15-fold higher membrane fusion rate

scientific article published in November 2004
Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice

scientific article published on 18 November 2003
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model

scientific article published in February 2003
Coagulation factor Xa modulates airway remodeling in a murine model of asthma

scientific article published on 2 November 2006
Rapid selection of Drosophila S2 cells with the puromycin resistance gene

scientific article published on September 1, 2003
Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation

scientific article published on 22 November 2011
Plasminogen inhibits TNFalpha-induced apoptosis in monocytes

scientific article published on 14 February 2006
Characterization of Streptokinases from Group A Streptococci Reveals a Strong Functional Relationship That Supports the Coinheritance of Plasminogen-binding M Protein and Cluster 2b Streptokinase

scientific article published on October 18, 2012
AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage.

scientific article published on December 2011
A Natural Inactivating Mutation in the CovS Component of the CovRS Regulatory Operon in a Pattern D Streptococcal pyogenes Strain Influences Virulence-associated Genes*

scientific article published on January 13, 2013
Critical role for conversion of glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces

scientific article
A single plasmid transfection that offers a significant advantage associated with puromycin selection in Drosophila Schneider S2 cells expressing heterologous proteins

scientific article published on 8 February 2008
Mutations in the Control of Virulence Sensor Gene from Streptococcus pyogenes after Infection in Mice Lead to Clonal Bacterial Variants with Altered Gene Regulatory Activity and Virulence

scientific article published on June 26, 2014
The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif

scientific article
The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin

scientific article published on 10 May 2002
Plasminogen enhances neuritogenesis on laminin-1.

scientific article published on October 2009
A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice

scientific article published on 24 January 2006
Conservation of critical functional domains in murine plasminogen activator inhibitor-1.

scientific article published on 12 February 2004
Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden.

scientific article
Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides

scientific article published on 10 May 2007

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