Search filters

List of works by Francis J Castellino

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.

scientific article published on 8 December 2015

A Natural Inactivating Mutation in the CovS Component of the CovRS Regulatory Operon in a Pattern D Streptococcal pyogenes Strain Influences Virulence-associated Genes* ⬇️

scientific article published on January 13, 2013

A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse

scientific article published on 04 November 2004

A deficiency of the GluN2C subunit of the N-methyl-D-aspartate receptor is neuroprotective in a mouse model of ischemic stroke

scientific article published on 31 October 2017

A deficiency of uPAR alters endothelial angiogenic function and cell morphology ⬇️

scientific article

A fast-acting, modular-structured staphylokinase fusion with Kringle-1 from human plasminogen as the fibrin-targeting domain offers improved clot lysis efficacy

scientific article published on 19 March 2003

A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice

scientific article published on 24 January 2006

A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection

scientific article

A local α-helix drives structural evolution of streptococcal M-protein affinity for host human plasminogen

scientific article published on 09 April 2020

A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis

scientific article published on 11 June 2008

A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues.

scientific article published in February 2004

A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells

scientific article published on 19 June 2006

A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model

scientific article

A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice

scientific article published on 13 March 2009

A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide

scientific article published in October 2004

A single plasmid transfection that offers a significant advantage associated with puromycin selection in Drosophila Schneider S2 cells expressing heterologous proteins

scientific article published on 8 February 2008

A trimeric HIV-1 fusion peptide construct which does not self-associate in aqueous solution and which has 15-fold higher membrane fusion rate

scientific article published in November 2004

A unique combination of glycoside hydrolases in Streptococcus suis specifically and sequentially acts on host-derived αGal-epitope glycans

scientific article published on 09 June 2020

AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage.

scientific article published on December 2011

ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo

scientific article published on 10 March 2009

Abnormal whole blood thrombi in humans with inherited platelet receptor defects

scientific article

Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia ⬇️

scientific article published on 23 March 2015

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

scientific article

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

scientific article

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

scientific article published on 19 October 2009

Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis

scientific article published on 18 January 2016

Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency

scientific article

An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia

scientific article

Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signaling

scientific article published in 2013

Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination ⬇️

scientific article published on October 14, 2012

Binding and orientation of conantokins in PL vesicles and aligned PL multilayers.

scientific article published in November 2003

Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography ⬇️

scientific article published on September 1, 2011

Ca 2+-induced self-assembly in designed peptides with optimally spaced gamma-carboxyglutamic acid residues.

scientific article published on 8 October 2010

Cathepsin E is a specific marker of dysplasia in APC mouse intestine.

scientific article

Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia.

scientific article

Characterization of Streptokinases from Group A Streptococci Reveals a Strong Functional Relationship That Supports the Coinheritance of Plasminogen-binding M Protein and Cluster 2b Streptokinase ⬇️

scientific article published on October 18, 2012

Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation

scientific article published on 12 December 2013

Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection

scientific article published on 19 April 2019

Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation

scientific article published on 11 May 2017

Coagulation factor Xa modulates airway remodeling in a murine model of asthma

scientific article published on 2 November 2006

Comparative pathogenomic characterization of a non-invasive serotype M71 strain Streptococcus pyogenes NS53 reveals incongruent phenotypic implications from distinct genotypic markers

scientific article

Complement-mediated Opsonization of Invasive Group A Streptococcus pyogenes Strain AP53 Is Regulated by the Bacterial Two-component Cluster of Virulence Responder/Sensor (CovRS) System ⬇️

scientific article published on 08 August 2013

Conantokin-G attenuates detrimental effects of NMDAR hyperactivity in an ischemic rat model of stroke

scientific article published on 30 March 2015

Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice

scientific article

Conantokins inhibit NMDAR-dependent calcium influx in developing rat hippocampal neurons in primary culture with resulting effects on CREB phosphorylation

scientific article

Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen.

scientific article published on 19 July 2017

Conservation of critical functional domains in murine plasminogen activator inhibitor-1.

scientific article published on 12 February 2004

Contributions of different modules of the plasminogen-binding Streptococcus pyogenes M-protein that mediate its functional dimerization

scientific article published on 30 July 2018

CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants

scientific article

Critical role for conversion of glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces

scientific article

Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis

scientific article

Dimerization is not a determining factor for functional high affinity human plasminogen binding by the group A streptococcal virulence factor PAM and is mediated by specific residues within the PAM a1a2 domain.

scientific article

Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein

scientific article published on 12 June 2015

Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors.

scientific article

Draft Genome Sequences of Six Skin Isolates of Streptococcus pyogenes.

scientific article

Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury.

scientific article published on 17 May 2016

Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans

scientific article

Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma.

scientific article

Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29.

scientific article

Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM).

scientific article

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

scientific article published on 13 January 2009

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier

scientific article

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

scientific article

Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice.

scientific article published on 18 November 2003

Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo

scientific article

FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse

scientific article published on 01 April 2002

Factor VII deficiency impairs cutaneous wound healing in mice

scientific article published on 11 February 2010

Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII.

scientific article

Fas ligand expression and its correlation with apoptosis and proliferation in Lobund-Wistar prostate carcinomas

scientific article published in January 2005

Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden.

scientific article

Fibrinogen facilitates the anti-tumor effect of nonnative endostatin

scientific article published on 22 January 2009

Fibrinogen has chaperone-like activity

scientific article published on 04 December 2008

Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse

scientific article published on March 2002

Fibrinolysis in Trauma: "Myth," "Reality," or "Something in Between".

scientific article published on 20 February 2017

Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene

scientific article published on 01 December 2006

Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β‐domains ⬇️

scientific article published on 07 March 2013

Functional dissection of Streptococcus pyogenes M5 protein: the hypervariable region is essential for virulence

scientific article

Gene targeting of components of the fibrinolytic system

scientific article published on 01 January 2002

Generation of genetically-altered mice producing very low levels of coagulation factorVII

scientific article published on 01 September 2005

Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity

scientific article published on 04 April 2016

Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives.

scientific article

Heteromerization of ligand binding domains of N-methyl-D-aspartate receptor requires both coagonists, L-glutamate and glycine

scientific article published on 8 January 2015

Host Pathways of Hemostasis that Regulate Group A Streptococcus pyogenes Pathogenicity

scientific article published on 01 January 2020

Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors

scientific article published on 5 June 2015

In situ metabolite and lipid analysis of GluN2D-/- and wild-type mice after ischemic stroke using MALDI MSI

scientific article published on 28 February 2020

Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation

scientific article published on 27 July 2006

Maternal fibrinogen is necessary for embryonic development

scientific article

Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg (2+)-con-T[K7gamma] complex.

scientific article

Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities

scientific article

Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge

scientific article published on 01 September 2002

Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen ⬇️

scientific article published on June 16, 2011

Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence

scientific article

N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein

scientific article

NMR backbone dynamics of VEK-30 bound to the human plasminogen kringle 2 domain

scientific article

NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins

scientific article published on October 2008

Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection

scientific article published on 03 July 2018

Non-invasive imaging and analysis of cerebral ischemia in living rats using positron emission tomography with 18F-FDG.

scientific article published on 28 December 2014

Non-strict strand orientation of the Ca2+-induced dimerization of a conantokin peptide variant with sequence-shifted gamma-carboxyglutamate residues

scientific article published on 24 January 2009

Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potential for evolutionary persistence

scientific article published on 21 June 2016

Oligomeric beta-structure of the membrane-bound HIV-1 fusion peptide formed from soluble monomers

scientific article

Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors ⬇️

scientific article published on January 27, 2012

Past and Present Behçet's Disease Animal Models

scientific article published on 18 July 2020

Pharmacology of triheteromeric N-Methyl-D-Aspartate Receptors

scientific article published on 22 February 2016

Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps

scientific article published on 8 November 2016

Plasma levels of bradykinin are suppressed in factor XII-deficient mice

scientific article published in June 2006

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation.

scientific article published on 23 March 2017

Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture

scientific article

Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4.

scientific article published on 14 June 2016

Plasminogen enhances neuritogenesis on laminin-1.

scientific article published on October 2009

Plasminogen inhibits TNFalpha-induced apoptosis in monocytes

scientific article published on 14 February 2006

Plasminogen receptors: the sine qua non of cell surface plasminogen activation

scientific article

Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy.

scientific article published in April 2013

Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons

scientific article published on 15 January 2014

Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen.

scientific article published on 13 March 2008

Rapid selection of Drosophila S2 cells with the puromycin resistance gene ⬇️

scientific article published on September 1, 2003

Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48.

scientific article published on 20 February 2018

Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis

scientific article published on 01 January 2019

Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties

scientific article

Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes

scientific article published on 10 July 2019

Solution structure and functional characterization of human plasminogen kringle 5

scientific article

Solution structure of the complex of VEK-30 and plasminogen kringle 2

scientific article

Stable genetic integration of a red fluorescent protein in a virulent Group A Streptococcus strain

scientific article published on 25 September 2019

Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence

scientific article published on 18 November 2020

Streptococcus pyogenes Employs Strain-dependent Mechanisms of C3b Inactivation to Inhibit Phagocytosis and Killing of Bacteria

scientific article published on 4 March 2016

Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding

scientific article published on 08 July 2019

Structure and function of the plasminogen/plasmin system

scientific article published on 01 April 2005

Structure-function analysis of the streptokinase amino terminus (residues 1-59).

scientific article

Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides

scientific article published on 10 May 2007

Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice

scientific article

Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy

scientific article published on 21 February 2020

Synthetic conantokin peptides potently inhibit N-methyl-D-aspartate receptor-mediated currents of retinal ganglion cells

scientific article published on 10 July 2014

Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury

scientific article published on 21 May 2014

Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy

scientific article published on 10 March 2016

The M-protein of Streptococcus pyogenes strain AP53 retains cell surface functional plasminogen binding after inactivation of the sortase A gene

scientific article published on 02 March 2020

The Streptococcal protease SpeB antagonizes the biofilms of the human pathogen Staphylococcus aureus USA300 through cleavage of the Staphylococcal SdrC protein

scientific article published on 23 March 2020

The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin

scientific article published on 10 May 2002

The anti-ischemia agent ranolazine promotes the development of intestinal tumors in APC(Min/+) mice

scientific article

The crystal structure of the calcium-bound con-G[Q6A] peptide reveals a novel metal-dependent helical trimer

scientific article published on 10 November 2010

The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif

scientific article

The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

scientific article

The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine

scientific article published on 10 July 2012

The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury

scientific article published on 20 February 2005

The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection

scientific article published on August 2003

The hemostasis system in murine atherosclerosis

scientific article published on March 2008

The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.

scientific article published on 26 November 2007

The molecular basis of conantokin antagonism of NMDA receptor function

scientific article published on May 2007

The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications ⬇️

scientific article

The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.

scientific article

The β-domain of cluster 2b streptokinase is a major determinant for the regulation of its plasminogen activation activity by cellular plasminogen receptors

scientific article published on 31 January 2014

Thromboelastography in Orthopaedic Trauma Acute Pelvic Fracture Resuscitation: A Descriptive Pilot Study.

scientific article published on 21 January 2016

Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model

scientific article published in February 2003

Tissue distribution of fetal liver cells following in utero transplantation in mice

scientific article published on 01 December 2005

Tranexamic Acid for Trauma Resuscitation in the United States of America

scientific article published on December 2016

Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse

scientific article

Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats.

scientific article

Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation

scientific article published on 22 November 2011

Unique genomic arrangements in an invasive serotype M23 strain of Streptococcus pyogenes identify genes that induce hypervirulence

scientific article

Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review

scientific article published on 20 May 2019

Use of phospholipid bilayers and monolayers in binding studies of vitamin K-dependent blood coagulation proteins

scientific article

Variable region in streptococcal M-proteins provides stable binding with host fibrinogen for plasminogen-mediated bacterial invasion

scientific article published on 9 March 2017

Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen

scientific article published on 14 March 2019

X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM.

scientific article

alpha Domain deletion converts streptokinase into a fibrin-dependent plasminogen activator through mechanisms akin to staphylokinase and tissue plasminogen activator

scientific article

gamma-Glutamate and beta-hydroxyaspartate in proteins

scientific article

gamma-glutamate and beta-hydroxyaspartate in proteins

scientific article published on 01 January 2002

Paulina is supported by:

About Paulina

Help