List of works - Matthew Frosch

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

scientific article

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

scientific article

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

scientific article published on 20 November 2011

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

scientific article published on May 2012

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

scientific article

Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease

scientific article published on 5 October 2006

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

scientific article published on October 17, 2010

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

scientific article published on February 2003

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

scientific article

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

scientific article published on 07 September 2015

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

scientific article

A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI.

scientific article published on 29 April 2015

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

scientific article published on 2 November 2016

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative

scientific article published in September 2002

Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup

scientific article

Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report

scientific article published on March 2007

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.

scientific article published on March 2017

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

scientific article published on May 2002

The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

scientific article

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain

scientific article

The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo

scientific article published on December 2008

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β

scientific article

Microemboli may link spreading depression, migraine aura, and patent foramen ovale

scientific article

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease

scientific article

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

scientific article

Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias

scientific article

Effects of gender on nigral gene expression and parkinson disease

scientific article published on 3 March 2007

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease

scientific article published in October 2004

Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems

scientific article (publication date: 3 December 2015)

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

scientific article published on 26 September 2004

Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape

scientific article

Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide

scientific article

Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

scientific article

Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy

scientific article published on October 1, 2010

Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain

scientific journal article

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

scientific article published on July 2, 2013

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain

scientific article

Beneficial effect of human anti-amyloid-β active immunization on neurite morphology and tau pathology

scientific article published on March 31, 2010

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

scientific article

The cerebral beta-amyloid angiopathies: hereditary and sporadic

scientific article

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

scientific article published in April 2018

Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease

scientific article published on December 2008

Expression of APP pathway mRNAs and proteins in Alzheimer's disease

scientific article

Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.

scientific article published on December 1, 2011

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

scientific article

Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies

scientific article published on 20 December 2016

Microbleeds versus macrobleeds: evidence for distinct entities

scientific article published on 14 May 2009

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

scientific article

Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy

scientific article published on 16 July 2007

List of works by Matthew Frosch

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI.

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative

Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup

Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain

The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β

Microemboli may link spreading depression, migraine aura, and patent foramen ovale

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias

Effects of gender on nigral gene expression and parkinson disease

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease

Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape

Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide

Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy

Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain

Beneficial effect of human anti-amyloid-β active immunization on neurite morphology and tau pathology

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

The cerebral beta-amyloid angiopathies: hereditary and sporadic

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease

Expression of APP pathway mRNAs and proteins in Alzheimer's disease

Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies

Microbleeds versus macrobleeds: evidence for distinct entities

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy