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List of works by Samuel H Speck

A Persistent Interest in Viruses

scientific article published on 14 January 2016

A gammaherpesvirus 68 gene 50 null mutant establishes long-term latency in the lung but fails to vaccinate against a wild-type virus challenge.

scientific article

A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology

scientific article published on 10 March 2008

A simple reverse transcriptase PCR assay to distinguish EBNA1 gene transcripts associated with type I and II latency from those arising during induction of the viral lytic cycle

scientific article published in November 1996

A surface groove essential for viral Bcl-2 function during chronic infection in vivo

scientific article

A tissue culture model of murine gammaherpesvirus replication reveals roles for the viral cyclin in both virus replication and egress from infected cells

scientific article

Alternative splicing dictates translational start in Epstein-Barr virus transcripts

scientific article

Alternatively initiated gene 50/RTA transcripts expressed during murine and human gammaherpesvirus reactivation from latency

scientific article published on 29 October 2008

Amplification of JNK signaling is necessary to complete the murine gammaherpesvirus 68 lytic replication cycle

scientific article

An Epstein-Barr virus transcript from a latently infected, growth-transformed B-cell line encodes a highly repetitive polypeptide

scientific article

An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection

scientific article

An optimized CD8+ T-cell response controls productive and latent gammaherpesvirus infection

scientific article published on February 2005

Analysis of the transcript encoding the latent Epstein-Barr virus nuclear antigen I: a potentially polycistronic message generated by long-range splicing of several exons

scientific article published on December 1985

Antibody to a lytic cycle viral protein decreases gammaherpesvirus latency in B-cell-deficient mice

scientific article published on November 2002

Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses

scientific article

Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1.

scientific article published on March 1990

B cells regulate murine gammaherpesvirus 68 latency

scientific article published on June 1999

B-cell lines immortalized with an Epstein-Barr virus mutant lacking the Cp EBNA2 enhancer are biased toward utilization of the oriP-proximal EBNA gene promoter Wp1 ⬇️

scientific article published on December 1, 1997

Bidirectional transcription of the Epstein-Barr virus major internal repeat ⬇️

scientific article published on May 1, 1990

Binding of the ubiquitous cellular transcription factors Sp1 and Sp3 to the ZI domains in the Epstein-Barr virus lytic switch BZLF1 gene promoter

scientific article published on February 1997

Blimp-1-dependent plasma cell differentiation is required for efficient maintenance of murine gammaherpesvirus latency and antiviral antibody responses

scientific article

CD4 and CD8 T cells directly recognize murine gammaherpesvirus 68-immortalized cells and prevent tumor outgrowth

scientific article published on 20 March 2013

CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice

scientific article published on 28 August 2015

Characterization of Omental Immune Aggregates during Establishment of a Latent Gammaherpesvirus Infection ⬇️

scientific article published on August 29, 2012

Characterization of a cDNA clone corresponding to a transcript from the Epstein-Barr virus BamHI M fragment: evidence for overlapping mRNAs

scientific article published on September 1987

Characterization of a spontaneous 9.5-kilobase-deletion mutant of murine gammaherpesvirus 68 reveals tissue-specific genetic requirements for latency

scientific article

Characterization of gammaherpesvirus 68 gene 50 transcription

scientific article

Characterization of murine gammaherpesvirus 68 v-cyclin interactions with cellular cdks.

scientific article published on 15 August 2005

Characterization of the Epstein-Barr virus BZLF1 protein transactivation domain ⬇️

scientific article published on February 1, 1992

Characterization of the ZI domains in the Epstein-Barr virus BZLF1 gene promoter: role in phorbol ester induction

scientific article published in June 1996

Characterization of the deletion and rearrangement in the BamHI C region of the X50-7 Epstein-Barr virus genome, a mutant viral strain which exhibits constitutive BamHI W promoter activity ⬇️

scientific article published on September 1, 1992

Characterization of the interaction of cytochrome c and mitochondrial ubiquinol-cytochrome c reductase.

scientific article published on January 1984

Complete sequence and genomic analysis of murine gammaherpesvirus 68 ⬇️

scientific article published on August 1, 1997

Complex transcription of the Epstein-Barr virus BamHI fragment H rightward open reading frame 1 (BHRF1) in latently and lytically infected B lymphocytes

scientific article

Constitutive activation of Epstein-Barr virus (EBV) nuclear antigen 1 gene transcription by IRF1 and IRF2 during restricted EBV latency

scientific article published on February 1997

Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice

scientific article published on 15 March 2007

Copper electron-nuclear double resonance of cytochrome c oxidase

scientific article

Critical role for a high-affinity chemokine-binding protein in gamma-herpesvirus-induced lethal meningitis

scientific article

Critical role of complement and viral evasion of complement in acute, persistent, and latent gamma-herpesvirus infection

scientific article published on August 2002

Cyclosporin A and FK506 block induction of the Epstein-Barr virus lytic cycle by anti-immunoglobulin

scientific article published on May 1995

Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member

scientific article published on January 1997

DNA-binding-defective mutants of the Epstein-Barr virus lytic switch activator Zta transactivate with altered specificities

scientific article published on May 1994

Definition of cytochrome c binding domains by chemical modification. Interaction of horse cytochrome c with beef sulfite oxidase and analysis of steady state kinetics ⬇️

scientific article published on July 25, 1981

Definition of cytochrome c binding domains by chemical modification: Kinetics of reaction with beef mitochondrial reductase and functional organization of the respiratory chain ⬇️

scientific article published on January 1, 1979

Deletion of Epstein-Barr virus regulatory sequences upstream of the EBNA gene promoter Wp1 is unfavorable for B-Cell immortalization

scientific article published on November 2002

Determining the role of the Epstein-Barr virus Cp EBNA2-dependent enhancer during the establishment of latency by using mutant and wild-type viruses recovered from cottontop marmoset lymphoblastoid cell lines

scientific article

Differential methylation of Epstein-Barr virus latency promoters facilitates viral persistence in healthy seropositive individuals.

scientific article published on December 1999

Disruption of gammaherpesvirus 68 gene 50 demonstrates that Rta is essential for virus replication

scientific article

Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation

scientific article

Disruption of the gene encoding the gammaHV68 v-GPCR leads to decreased efficiency of reactivation from latency

scientific article published in March 2003

Disruption of the murine gammaherpesvirus 68 M1 open reading frame leads to enhanced reactivation from latency

scientific article

Does EBV alter the pathogenesis of malaria?

scientific article

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

scientific article

EBV framed in Burkitt lymphoma

scientific article published on 01 October 2002

Effective Vaccination against Long-Term Gammaherpesvirus Latency

article by Scott A. Tibbetts et al published 1 April 2003 in Journal of Virology

Effective vaccination against long-term gammaherpesvirus latency

scientific article

Efficient transcription of the Epstein-Barr virus immediate-early BZLF1 and BRLF1 genes requires protein synthesis

scientific article published on December 1991

Epstein-Barr Virus In B Lymphocytes: Viral Gene Expression and Function in Latency

scientific article published on January 1, 1992

Epstein-Barr virus BZLF1 trans activator induces the promoter of a cellular cognate gene, c-fos

scientific article published on September 1990

Epstein-Barr virus transformation

scientific article published on January 1987

Establishment and maintenance of gammaherpesvirus latency are independent of infective dose and route of infection

scientific article

Establishment and maintenance of long-term murine gammaherpesvirus 68 latency in B cells in the absence of CD40.

scientific article

Establishment of B-cell lines latently infected with reactivation-competent murine gammaherpesvirus 68 provides evidence for viral alteration of a DNA damage-signaling cascade

scientific article published on 21 May 2008

Evidence for CDK-dependent and CDK-independent functions of the murine gammaherpesvirus 68 v-cyclin

scientific article

Evidence for coiled-coil dimer formation by an Epstein-Barr virus transactivator that lacks a heptad repeat of leucine residues

scientific article

Ex vivo stimulation of B cells latently infected with gammaherpesvirus 68 triggers reactivation from latency

scientific article

Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes ⬇️

scientific article published on August 1, 1991

Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance

scientific article published on 01 March 2008

Expansion of murine gammaherpesvirus latently infected B cells requires T follicular help

scientific article

Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity

scientific article

Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes

scientific article

Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter

scientific article

Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection

scientific article

Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis

scientific article

Host-cell-determined methylation of specific Epstein-Barr virus promoters regulates the choice between distinct viral latency programs

scientific article published on January 1997

IFN-gamma action in the media of the great elastic arteries, a novel immunoprivileged site

scientific article

Identification and initial characterization of the murine gammaherpesvirus 68 gene M3, encoding an abundantly secreted protein

scientific article published on May 1999

Identification and mapping of polypeptides encoded by the P3HR-1 strain of Epstein-Barr virus ⬇️

scientific article published on July 1, 1984

Identification of Novel Kaposi's Sarcoma-Associated Herpesvirus Orf50 Transcripts: Discovery of New RTA Isoforms with Variable Transactivation Potential.

scientific article published on 19 October 2016

Identification of a Negative cis Element within the ZII Domain of the Epstein-Barr Virus Lytic Switch BZLF1 Gene Promoter ⬇️

scientific article published on October 1, 1998

Identification of a gammaherpesvirus selective chemokine binding protein that inhibits chemokine action

scientific article

Identification of alternative transcripts encoding the essential murine gammaherpesvirus lytic transactivator RTA

scientific article

Identification of an Rta responsive promoter involved in driving gammaHV68 v-cyclin expression during virus replication

scientific article published on 02 May 2007

Identification of candidate gammaherpesvirus 68 genes required for virus replication by signature-tagged transposon mutagenesis

scientific article published in October 2004

Identification of closely spaced but distinct transcription initiation sites for the murine gammaherpesvirus 68 latency-associated M2 gene

scientific article

Identification of critical cis elements involved in mediating Epstein-Barr virus nuclear antigen 2-dependent activity of an enhancer located upstream of the viral BamHI C promoter ⬇️

scientific article published on May 1, 1992

Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent protein

scientific article published on 22 April 2009

Identification of phorbol ester response elements in the promoter of Epstein-Barr virus putative lytic switch gene BZLF1

scientific article published on March 1990

Identification of spliced gammaherpesvirus 68 LANA and v-cyclin transcripts and analysis of their expression in vivo during latent infection

scientific article

Identification of the in vivo role of a viral bcl-2

scientific article

Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus

scientific article published on July 2002

Influence of Burkitt's lymphoma and primary B cells on latent gene expression by the nonimmortalizing P3J-HR-1 strain of Epstein-Barr virus

scientific article published on April 1989

Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency

scientific article

Inhibition of NF-kappaB signaling reduces virus load and gammaherpesvirus-induced pulmonary fibrosis

scientific article

Insights into chronic gamma-herpesvirus infections

scientific article published on 3 June 2013

Interaction of cytochrome c with the blue copper proteins, plastocyanin and azurin ⬇️

scientific article published on May 25, 1983

Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation

scientific article published on 31 July 2020

Interleukin 21 signaling in B cells is required for efficient establishment of murine gammaherpesvirus latency

scientific article

Isolation and characterization of cDNA clones corresponding to transcripts from the BamHI H and F regions of the Epstein-Barr virus genome

scientific article

Long-term latent murine Gammaherpesvirus 68 infection is preferentially found within the surface immunoglobulin D-negative subset of splenic B cells in vivo

scientific article

Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice

article

Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells

scientific article published on April 1999

Maintenance of gammaherpesvirus latency requires viral cyclin in the absence of B lymphocytes

scientific article

Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68.

scientific article

Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta

scientific article

Methylation of the EBV genome and establishment of restricted latency in low-passage EBV-infected 293 epithelial cells

scientific article published on July 2002

Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth

scientific article

Murine Gamma-herpesvirus Immortalization of Fetal Liver-Derived B Cells Requires both the Viral Cyclin D Homolog and Latency-Associated Nuclear Antigen ⬇️

scientific article published on September 8, 2011

Murine Gammaherpesvirus 68 Infection of Mice: A Small Animal Model for Characterizing Basic Aspects of Gammaherpesvirus Pathogenesis

Murine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease.

scientific article published in December 1997

Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genome

scientific article

Murine gammaherpesvirus 68 Rta-dependent activation of the gene 57 promoter.

scientific article published on March 2005

Murine gammaherpesvirus 68 encodes a functional regulator of complement activation

scientific article

Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice

scientific article

Murine gammaherpesvirus 68 reactivation from B cells requires IRF4 but not XBP-1.

scientific article

Murine gammaherpesvirus M2 antigen modulates splenic B cell activation and terminal differentiation in vivo

scientific article published on 2 August 2017

Murine gammaherpesvirus M2 protein induction of IRF4 via the NFAT pathway leads to IL-10 expression in B cells

scientific article

Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment

scientific article published on 30 April 2020

Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

scientific article published on 01 March 2000

Mutually exclusive use of viral promoters in Epstein-Barr virus latently infected lymphocytes

scientific article

NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency

scientific article published on 04 March 2009

ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and p53 in virus replication

scientific article published on 15 August 2007

Ongoing viral replication is required for gammaherpesvirus 68-induced vascular damage

scientific article

Pathogenesis and Host Control of Gammaherpesviruses: Lessons from the Mouse ⬇️

scientific article published on January 1, 2011

Preferred sites for electron transfer between cytochrome c and iron and cobalt complexes ⬇️

scientific article published on May 25, 1983

Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes

scientific article published on March 1990

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

scientific article

Rapamycin ameliorates the CTLA4-Ig-mediated defect in CD8(+) T cell immunity during gammaherpesvirus infection

scientific article

Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells

scientific article published in April 2006

Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene.

scientific article published on October 1997

Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell lines

scientific article

Regulation of EBNA gene transcription in lymphoblastoid cell lines: characterization of sequences downstream of BCR2 (Cp).

scientific article

Regulation of the BZLF1 promoter of Epstein-Barr virus by second messengers in anti-immunoglobulin-treated B cells

scientific article

Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3

scientific article published on 07 September 2018

Role for MyD88 signaling in murine gammaherpesvirus 68 latency

scientific article

Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection

scientific article published on May 1991

Role of B-cell proliferation in the establishment of gammaherpesvirus latency

scientific article

Role of phospholipid in the low affinity reactions between cytochrome c and cytochrome oxidase

scientific article published on 01 December 1983

Signaling through Toll-like receptors induces murine gammaherpesvirus 68 reactivation in vivo

scientific article published on 19 November 2008

Single catalytic site model for the oxidation of ferrocytochrome c by mitochondrial cytochrome c oxidase

scientific article

Site-specific anti-cytochrome c antibodies. Inhibition of the reactions between cytochrome c and its respiratory chain electron exchange partners ⬇️

scientific article published on December 25, 1979

Structural basis of chemokine sequestration by a herpesvirus decoy receptor

scientific article

Synergistic autoactivation of the Epstein-Barr virus immediate-early BRLF1 promoter by Rta and Zta.

scientific article published on June 2003

Systematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infection

scientific article

The Epstein-Barr virus BamHI F promoter is an early lytic promoter: lack of correlation with EBNA 1 gene transcription in group 1 Burkitt's lymphoma cell lines

scientific article

The Epstein-Barr virus-induced Ca2+/calmodulin-dependent kinase type IV/Gr promotes a Ca(2+)-dependent switch from latency to viral replication.

scientific article

The M4 gene of gammaHV68 encodes a secreted glycoprotein and is required for the efficient establishment of splenic latency

scientific article published on 26 September 2005

The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiation

scientific article

The Murine Gammaherpesvirus 68 M2 Gene Is Required for Efficient Reactivation from Latently Infected B Cells

The Murine Gammaherpesvirus 68 v-Cyclin Gene Is an Oncogene That Promotes Cell Cycle Progression in Primary Lymphocytes

The absence of M1 leads to increased establishment of murine gammaherpesvirus 68 latency in IgD-negative B cells

scientific article published on 9 January 2013

The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency

scientific article

The gammaherpesvirus 68 latency-associated nuclear antigen homolog is critical for the establishment of splenic latency

scientific article published on October 2003

The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells

scientific article

The murine gammaherpesvirus 68 v-cyclin gene is an oncogene that promotes cell cycle progression in primary lymphocytes

scientific article

The murine gammaherpesvirus 68 v-cyclin is a critical regulator of reactivation from latency.

scientific article published on August 2000

The murine gammaherpesvirus immediate-early Rta synergizes with IRF4, targeting expression of the viral M1 superantigen to plasma cells

scientific article

The presteady state reaction of chemically modified cytochromes c with cytochrome oxidase ⬇️

scientific article published on May 10, 1983

The reaction of primate cytochromes c with cytochrome c oxidase. Analysis of the polarographic assay ⬇️

scientific article published on May 10, 1983

Three distinct regions of the murine gammaherpesvirus 68 genome are transcriptionally active in latently infected mice

scientific article

Tracking Murine Gammaherpesvirus 68 Infection of Germinal Center B Cells In Vivo ⬇️

scientific article published on March 13, 2012

Transcription of the Epstein-Barr virus nuclear antigen 1 (EBNA1) gene occurs before induction of the BCR2 (Cp) EBNA gene promoter during the initial stages of infection in B cells

scientific article published in June 1996

Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells ⬇️

scientific article published on December 15, 1992

Tyrosine 129 of the murine gammaherpesvirus M2 protein is critical for M2 function in vivo

scientific article

Unbiased mutagenesis of MHV68 LANA reveals a DNA-binding domain required for LANA function in vitro and in vivo

scientific article

Unraveling immunity to gamma-herpesviruses: a new model for understanding the role of immunity in chronic virus infection

scientific article

Variable methylation of the Epstein-Barr virus Wp EBNA gene promoter in B-lymphoblastoid cell lines

scientific article published on December 2004

Viral latency and its regulation: lessons from the gamma-herpesviruses

scientific article

ZEBRA and a Fos-GCN4 chimeric protein differ in their DNA-binding specificities for sites in the Epstein-Barr virus BZLF1 promoter ⬇️

scientific article published on August 1, 1991

oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines.

scientific article published in September 1996

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