List of works - Samuel H Speck

Complete sequence and genomic analysis of murine gammaherpesvirus 68

scientific article published on August 1, 1997

Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells

scientific article published on April 1999

Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68.

scientific article

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

scientific article

Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1.

scientific article published on March 1990

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

scientific article published on May 12, 2014

Murine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease.

scientific article published in December 1997

B cells regulate murine gammaherpesvirus 68 latency

scientific article published on June 1999

Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene.

scientific article published on October 1997

Pathogenesis and Host Control of Gammaherpesviruses: Lessons from the Mouse

scientific article published on January 1, 2011

Viral latency and its regulation: lessons from the gamma-herpesviruses

scientific article

Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes

scientific article published on March 1990

Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

scientific article published on 01 March 2000

Identification of a gammaherpesvirus selective chemokine binding protein that inhibits chemokine action

scientific article

Identification of phorbol ester response elements in the promoter of Epstein-Barr virus putative lytic switch gene BZLF1

scientific article published on March 1990

Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells

scientific article published in April 2006

Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis

scientific article

Three distinct regions of the murine gammaherpesvirus 68 genome are transcriptionally active in latently infected mice

scientific article

The murine gammaherpesvirus 68 v-cyclin is a critical regulator of reactivation from latency.

scientific article published on August 2000

Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection

scientific article published on May 1991

Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell lines

scientific article

Long-term latent murine Gammaherpesvirus 68 infection is preferentially found within the surface immunoglobulin D-negative subset of splenic B cells in vivo

scientific article

Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter

scientific article

Unraveling immunity to gamma-herpesviruses: a new model for understanding the role of immunity in chronic virus infection

scientific article

Disruption of the murine gammaherpesvirus 68 M1 open reading frame leads to enhanced reactivation from latency

scientific article

Identification of the in vivo role of a viral bcl-2

scientific article

Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member

scientific article published on January 1997

Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation

scientific article

Mutually exclusive use of viral promoters in Epstein-Barr virus latently infected lymphocytes

scientific article

The gammaherpesvirus 68 latency-associated nuclear antigen homolog is critical for the establishment of splenic latency

scientific article published on October 2003

Establishment and maintenance of gammaherpesvirus latency are independent of infective dose and route of infection

scientific article

Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus

scientific article published on July 2002

Characterization of gammaherpesvirus 68 gene 50 transcription

scientific article

Evidence for coiled-coil dimer formation by an Epstein-Barr virus transactivator that lacks a heptad repeat of leucine residues

scientific article

Influence of Burkitt's lymphoma and primary B cells on latent gene expression by the nonimmortalizing P3J-HR-1 strain of Epstein-Barr virus

scientific article published on April 1989

oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines.

scientific article published in September 1996

Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes

scientific article published on August 1, 1991

An Epstein-Barr virus transcript from a latently infected, growth-transformed B-cell line encodes a highly repetitive polypeptide

scientific article

Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice

article

Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice

scientific article

Identification of critical cis elements involved in mediating Epstein-Barr virus nuclear antigen 2-dependent activity of an enhancer located upstream of the viral BamHI C promoter

scientific article published on May 1, 1992

IFN-gamma action in the media of the great elastic arteries, a novel immunoprivileged site

scientific article

Critical role for a high-affinity chemokine-binding protein in gamma-herpesvirus-induced lethal meningitis

scientific article

Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth

scientific article

Structural basis of chemokine sequestration by a herpesvirus decoy receptor

scientific article

Analysis of the transcript encoding the latent Epstein-Barr virus nuclear antigen I: a potentially polycistronic message generated by long-range splicing of several exons

scientific article published on December 1985

Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice

scientific article published on 15 March 2007

Constitutive activation of Epstein-Barr virus (EBV) nuclear antigen 1 gene transcription by IRF1 and IRF2 during restricted EBV latency

scientific article published on February 1997

Characterization of the Epstein-Barr virus BZLF1 protein transactivation domain

scientific article published on February 1, 1992

Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency

scientific article published in January 2007

List of works by Samuel H Speck

Complete sequence and genomic analysis of murine gammaherpesvirus 68

Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells

Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68.

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1.

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

Murine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease.

B cells regulate murine gammaherpesvirus 68 latency

Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene.

Pathogenesis and Host Control of Gammaherpesviruses: Lessons from the Mouse

Viral latency and its regulation: lessons from the gamma-herpesviruses

Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes

Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

Identification of a gammaherpesvirus selective chemokine binding protein that inhibits chemokine action

Identification of phorbol ester response elements in the promoter of Epstein-Barr virus putative lytic switch gene BZLF1

Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells

Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis

Three distinct regions of the murine gammaherpesvirus 68 genome are transcriptionally active in latently infected mice

The murine gammaherpesvirus 68 v-cyclin is a critical regulator of reactivation from latency.

Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection

Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell lines

Long-term latent murine Gammaherpesvirus 68 infection is preferentially found within the surface immunoglobulin D-negative subset of splenic B cells in vivo

Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter

Unraveling immunity to gamma-herpesviruses: a new model for understanding the role of immunity in chronic virus infection

Disruption of the murine gammaherpesvirus 68 M1 open reading frame leads to enhanced reactivation from latency

Identification of the in vivo role of a viral bcl-2

Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member

Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation

Mutually exclusive use of viral promoters in Epstein-Barr virus latently infected lymphocytes

The gammaherpesvirus 68 latency-associated nuclear antigen homolog is critical for the establishment of splenic latency

Establishment and maintenance of gammaherpesvirus latency are independent of infective dose and route of infection

Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus

Characterization of gammaherpesvirus 68 gene 50 transcription

Evidence for coiled-coil dimer formation by an Epstein-Barr virus transactivator that lacks a heptad repeat of leucine residues

Influence of Burkitt's lymphoma and primary B cells on latent gene expression by the nonimmortalizing P3J-HR-1 strain of Epstein-Barr virus

oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines.

Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes

An Epstein-Barr virus transcript from a latently infected, growth-transformed B-cell line encodes a highly repetitive polypeptide

Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice

Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice

Identification of critical cis elements involved in mediating Epstein-Barr virus nuclear antigen 2-dependent activity of an enhancer located upstream of the viral BamHI C promoter

IFN-gamma action in the media of the great elastic arteries, a novel immunoprivileged site

Critical role for a high-affinity chemokine-binding protein in gamma-herpesvirus-induced lethal meningitis

Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth

Structural basis of chemokine sequestration by a herpesvirus decoy receptor

Analysis of the transcript encoding the latent Epstein-Barr virus nuclear antigen I: a potentially polycistronic message generated by long-range splicing of several exons

Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice

Constitutive activation of Epstein-Barr virus (EBV) nuclear antigen 1 gene transcription by IRF1 and IRF2 during restricted EBV latency

Characterization of the Epstein-Barr virus BZLF1 protein transactivation domain

Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency