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List of works by Morton J Cowan

A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking Native Americans

scientific article

A non-leaky Artemis-deficient mouse that accurately models the human severe combined immune deficiency phenotype, including resistance to hematopoietic stem cell transplantation

scientific article published on January 2009

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70

scientific article

A novel missense RAG-1 mutation results in T-B-NK+ SCID in Athabascan-speaking Dine Indians from the Canadian Northwest Territories

scientific article

A trial of alemtuzumab adjunctive therapy in allogeneic hematopoietic cell transplantation with minimal conditioning for severe combined immunodeficiency

scientific article

A trial of plerixafor adjunctive therapy in allogeneic hematopoietic cell transplantation with minimal conditioning for severe combined immunodeficiency

scientific article

Adenosine Deaminase (ADA)-Deficient Severe Combined Immune Deficiency (SCID) in the US Immunodeficiency Network (USIDNet) Registry

scientific article published on 02 September 2020

Adoptive Immunotherapy With CMV-specific Cytotoxic T Lymphocytes for Stem Cell Transplant Patients With Refractory CMV Infections ⬇️

scientific article published on April 1, 2012

Advancement of pediatric blood and marrow transplantation research in North America: priorities of the Pediatric Blood and Marrow Transplant Consortium

scientific article

Advances and highlights in primary immunodeficiencies in 2017

scientific article published on 29 August 2018

Airway management in children with mucopolysaccharidoses

scientific article published on January 2009

Allogeneic hematopoietic cell transplantation for primary immune deficiency diseases: current status and critical needs

scientific article

Allogeneic hematopoietic cell transplantation for refractory myasthenia gravis.

scientific article published in May 2009

Allograft and patient survival after sequential HSCT and kidney transplantation from the same donor-A multicenter analysis.

scientific article published on 13 July 2018

Application of a radiosensitivity flow assay in a patient with DNA ligase 4 deficiency

scientific article published on 01 August 2018

Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression

scientific article published in May 2005

Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis.

scientific article published on 13 October 2016

B cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation.

scientific article

B7.2-/- mature dendritic cells generate T-helper 2 and regulatory T donor cells in fetal mice after in utero allogeneic bone marrow transplantation

scientific article published in September 2005

Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency

scientific article

Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.

scientific article published in November 2016

Busulfan, Fludarabine, and Alemtuzumab As a Reduced Toxicity Regimen for Children with Malignant and Nonmalignant Diseases Improves Engraftment and Graft-versus-Host Disease without Delaying Immune Reconstitution ⬇️

scientific article published on May 15, 2012

Characterization of the Human Artemis Promoter by Heterologous Gene Expression In Vitro and In Vivo ⬇️

scientific article published on June 10, 2011

Chimerism-based pre-emptive immunotherapy with fast withdrawal of immunosuppression and donor lymphocyte infusions after allogeneic stem cell transplantation for pediatric hematologic malignancies

scientific article published on 31 January 2015

Chronic Granulomatous Disease-Associated IBD Resolves and Does Not Adversely Impact Survival Following Allogeneic HCT

scientific article published on 02 August 2019

Chronic granulomatous disease: lessons from a rare disorder

scientific article

Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation

scientific article

Combined umbilical cord blood and bone marrow from HLA-identical sibling donors for hematopoietic stem cell transplantation in children with hemoglobinopathies

scientific article published on 7 May 2014

Comparison of outcomes of hematopoietic stem cell transplantation without chemotherapy conditioning by using matched sibling and unrelated donors for treatment of severe combined immunodeficiency.

scientific article

Correction to: Infections in Infants with SCID: Isolation, Infection Screening and Prophylaxis in PIDTC Centers

scientific article published on 03 December 2020

Correction: Chronic Granulomatous Disease-Associated IBD Resolves and Does Not Adversely Impact Survival Following Allogeneic HCT

scientific article published on 29 August 2020

Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Conten

scientific article published on 10 October 2017

Cytotoxicity associated with artemis overexpression after lentiviral vector-mediated gene transfer

scientific article

Development of herpes simplex virus stomatitis during receipt of cidofovir therapy

scientific article published in October 2009

Devouring the Hematopoietic Stem Cell: Setting the Table for Marrow Cell Transplantation

scientific article published on November 2016

Donor lymphocyte infusion and methotrexate for immune recovery after T-cell depleted haploidentical transplantation.

scientific article

Effect of weight and maturation on busulfan clearance in infants and small children undergoing hematopoietic cell transplantation

scientific article published on 09 September 2013

Establishing diagnostic criteria for severe combined immunodeficiency disease (SCID), leaky SCID, and Omenn syndrome: the Primary Immune Deficiency Treatment Consortium experience

scientific article

Evaluation of Pre-Hematopoietic Cell Transplantation (HCT) Brain MRI and Neurologic Complications of Pediatric Patients Undergoing HCT for Hematologic Malignancies

scientific article

Excellent Outcomes Following Hematopoietic Cell Transplantation for Wiskott-Aldrich Syndrome: A PIDTC Report

scientific article published on 08 April 2020

Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency

scientific article

Extended Follow-up After Hematopoietic Cell Transplantation for IκBα Deficiency with Disseminated Mycobacterium avium Infection

scientific article published on 13 December 2019

Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID

scientific article

HLA-matched sibling bone marrow transplantation for β-thalassemia major

scientific article

Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey

scientific article published on 21 February 2020

Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant Research Report

scientific article

Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency.

scientific article

Hematopoietic cell transplant and use of massage for improved symptom management: results from a pilot randomized control trial

scientific article published on 9 February 2012

Hematopoietic stem cell transplantation for CD3δ deficiency

scientific article published on 16 July 2011

Hematopoietic stem cell transplantation for CD40 ligand deficiency: results from an EBMT/ESID-IEWP-SCETIDE-PIDTC Study

scientific article published on 17 January 2019

Hematopoietic stem cell transplantation for severe combined immunodeficiency diseases

scientific article published on January 2008

Hepatic venoocclusive disease in blood and bone marrow transplantation in children and young adults: incidence, risk factors, and outcome in a cohort of 241 patients

scientific article

IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo

scientific article published on 28 October 2011

Immune reconstitution and survival of 100 SCID patients post-hematopoietic cell transplant: a PIDTC natural history study.

scientific article published on 11 October 2017

Immunization of hematopoietic stem cell transplant recipients against vaccine-preventable diseases ⬇️

scientific article published on March 1, 2011

Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management

scientific article

Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers

scientific article published on 02 October 2020

Infusion of cytomegalovirus specific cytotoxic T lymphocytes from a sero-negative donor can facilitate resolution of infection and immune reconstitution.

scientific article

Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1

scientific article published on 01 April 2019

Lentivirus Mediated Correction of Artemis-Deficient Severe Combined Immunodeficiency

scientific article published on 9 September 2016

Long term outcomes of severe combined immunodeficiency: therapy implications.

scientific article published on 18 September 2017

Long-term outcome and lineage-specific chimerism in 194 patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980-2009: an international collaborative study

scientific article

Long-term survival and late deaths after hematopoietic cell transplantation for primary immunodeficiency diseases and inborn errors of metabolism.

scientific article

Low Exposure Busulfan Conditioning to Achieve Sufficient Multilineage Chimerism in Patients with Severe Combined Immunodeficiency

scientific article published on 12 March 2019

Malignancies after Hematopoietic Cell Transplantation for Primary Immune Deficiencies: A Report from the Center for International Blood and Marrow Transplant Research ⬇️

scientific article published on May 20, 2011

Massage for Children Undergoing Hematopoietic Cell Transplantation: A Qualitative Report ⬇️

scientific article published on February 23, 2012

Maternal T-cell engraftment associated with severe hemophagocytosis of the bone marrow in untreated X-linked severe combined immunodeficiency

scientific article published in May 2008

Megadose CD34(+) cell grafts improve recovery of T cell engraftment but not B cell immunity in patients with severe combined immunodeficiency disease undergoing haplocompatible nonmyeloablative transplantation

scientific article

Multilineage engraftment with minimal graft-versus-host disease following in utero transplantation of S-59 psoralen/ultraviolet a light-treated, sensitized T cells and adult T cell-depleted bone marrow in fetal mice

scientific article published in December 2002

Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B

scientific journal article

Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content

scientific article

Neurocognition across the spectrum of mucopolysaccharidosis type I: Age, severity, and treatment

scientific article

Neurologic event-free survival demonstrates a benefit for SCID patients diagnosed by newborn screening

scientific article published on 05 September 2017

New Insights Into Multicenter PICU Mortality Among Pediatric Hematopoietic Stem Cell Transplant Patients.

scientific article published on 29 May 2015

Newborn Screening for Severe Combined Immunodeficiency and T-cell Lymphopenia in California, 2010-2017

scientific article published on 01 February 2019

Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California: results of the first 2 years

scientific article published on July 2013

Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States

scientific article published in August 2014

Opening Marrow Niches in Patients Undergoing Autologous Hematopoietic Stem Cell Gene Therapy

scientific article published on 28 July 2017

Outcome of domino hematopoietic stem cell transplantation in human subjects: An international case series

scientific article published on 05 July 2018

Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders.

scientific article published on 6 April 2017

Pharmacokinetics and Model-Based Dosing to Optimize Fludarabine Therapy in Pediatric Hematopoietic Cell Transplant Recipients

scientific article

Population pharmacokinetics of busulfan in pediatric and young adult patients undergoing hematopoietic cell transplant: a model-based dosing algorithm for personalized therapy and implementation into routine clinical use.

scientific article

Prenatal diagnosis and carrier detection for Athabascan severe combined immunodeficiency disease

scientific article

Primary Immune Deficiency Treatment Consortium (PIDTC) report

scientific article published on 15 October 2013

Primary Immune Deficiency Treatment Consortium (PIDTC) update

scientific article published on 22 April 2016

Primary graft failure after umbilical cord blood transplant rescued by parental haplocompatible stem cell transplantation

scientific article published in April 2009

Processing of 3'-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease

scientific article

Psychosocial services for primary immunodeficiency disorder families during hematopoietic cell transplantation: A descriptive study

scientific article published on 01 August 2019

Quality of Life of Patients with Wiskott Aldrich Syndrome and X-Linked Thrombocytopenia: a Study of the Primary Immune Deficiency Consortium (PIDTC), Immune Deficiency Foundation, and the Wiskott-Aldrich Foundation

scientific article published on 16 October 2019

Radiation-sensitive severe combined immunodeficiency: The arguments for and against conditioning before hematopoietic cell transplantation--what to do?

scientific article

Radiosensitive severe combined immunodeficiency disease

scientific article

Recommendations for Screening and Management of Late Effects in Patients with Severe Combined Immunodeficiency after Allogenic Hematopoietic Cell Transplantation: A Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium

scientific article published on 4 May 2017

Reduced Toxicity Conditioning for Non-Malignant Hematopoietic Cell Transplants

scientific article published on 10 June 2020

Reduced-intensity conditioning regimens for allogeneic transplantation in children with acute lymphoblastic leukemia

scientific article

Reticular dysgenesis: international survey on clinical presentation, transplantation, and outcome

scientific article

Role of transgene regulation in ex vivo lentiviral correction of artemis deficiency

scientific article published on 13 April 2015

SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery

scientific article published on 28 August 2018

SCID patients with ARTEMIS vs RAG deficiencies following HCT: increased risk of late toxicity in ARTEMIS-deficient SCID.

scientific article published on 21 October 2013

Severe, persistent, and fatal T-cell immunodeficiency following therapy for infantile leukemia

scientific article published on 29 June 2016

Simian immunodeficiency virus infection of hematopoietic stem cells and bone marrow stromal cells

scientific article published in May 2004

Stem cell transplantation for primary immunodeficiency diseases: the North American experience

scientific article

Successful SCID Gene Therapy in Infant with Disseminated BCG

scientific article published on 16 September 2020

Successful newborn screening for SCID in the Navajo Nation

scientific article published on 8 March 2015

Supporting caregivers during hematopoietic cell transplantation for children with primary immunodeficiency disorders

scientific article published on 25 October 2018

Survey on retransplantation criteria for patients with severe combined immunodeficiency.

scientific article published on 10 December 2013

T Cell and B Cell Immunity can be Reconstituted with Mismatched Hematopoietic Stem Cell Transplantation Without Alkylator Therapy in Artemis-Deficient Mice Using Anti-Natural Killer Cell Antibody and Photochemically Treated Sensitized Donor T Cells ⬇️

scientific article published on October 19, 2011

Targeted disruption of the Artemis murine counterpart results in SCID and defective V(D)J recombination that is partially corrected with bone marrow transplantation.

scientific article published on February 2005

The Primary Immune Deficiency Treatment Consortium: how can it improve definitive therapy for PID?

scientific article

The Second Pediatric Blood and Marrow Transplant Consortium International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: Defining the Unique Late Effects of Children Undergoing Hematopoietic Cell [...]

scientific article

The genetic landscape of severe combined immunodeficiency in the United States and Canada in the current era (2010-2018)

scientific article published on 05 September 2018

The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation

scientific article published on 04 December 2008

The missing vital sign ⬇️

scientific article published on July 5, 2013

The natural history of children with severe combined immunodeficiency: baseline features of the first fifty patients of the primary immune deficiency treatment consortium prospective study 6901.

scientific article published on 02 July 2013

Transplacental maternal engraftment and posttransplantation graft-versus-host disease in children with severe combined immunodeficiency

scientific article published on 16 June 2016

Transplantation outcomes for severe combined immunodeficiency, 2000-2009.

scientific article

Treatment of infants identified as having severe combined immunodeficiency by means of newborn screening

scientific article

Two-tiered universal newborn screening strategy for severe combined immunodeficiency

scientific article published on 2 November 2005

Unknown Cytomegalovirus Serostatus in Primary Immunodeficiency Disorders: A New Category of Transplant Recipients

scientific article published on 10 November 2020

Unrelated Hematopoietic Cell Transplantation in a Patient with Combined Immunodeficiency with Granulomatous Disease and Autoimmunity Secondary to RAG Deficiency.

scientific article published on 18 August 2016

Unresolved issues in hematopoietic stem cell transplantation for severe combined immunodeficiency: need for safer conditioning and reduced late effects

scientific article published on May 2013

Wiskott-Aldrich syndrome: diagnosis, clinical and laboratory manifestations, and treatment

scientific article

X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease

scientific article

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