List of works - Faustino Mollinedo

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia

scientific article published on 19 June 2019

Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy

scientific article

Alteration of plasma membrane organization by an anticancer lysophosphatidylcholine analogue induces intracellular acidification and internalization of plasma membrane transporters in yeast

scientific article published on 23 January 2013

Antitumor activity of Lepidium latifolium and identification of the epithionitrile 1-cyano-2,3-epithiopropane as its major active component.

scientific article published on 26 October 2017

Antitumor activity of new enantiopure pybox-ruthenium complexes.

scientific article

Antitumor activity of new hydridotris(pyrazolyl)borate ruthenium(II) complexes containing the phosphanes PTA and 1-CH3-PTA.

scientific article published on 30 September 2010

Antitumor alkyl ether lipid edelfosine: tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing immunosuppressed mice.

scientific article

Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo

scientific article

Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.

scientific article published on 16 November 2004

Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cells

scientific article

C-Geranylated flavonoids from Paulownia tomentosa fruits with antimicrobial potential and synergistic activity with antibiotics.

scientific article

ChemInform Abstract: Cytotoxic Oxasqualenoids from the Red Alga Laurencia viridis.

scientific article published on 29 September 2011

Cloning and genomic characterization of sytdep, a new synaptotagmin XIV-related gene

scientific article

Combinatorial SNARE complexes modulate the secretion of cytoplasmic granules in human neutrophils.

scientific article published in September 2006

Complete inhibition of extranodal dissemination of lymphoma by edelfosine-loaded lipid nanoparticles

scientific article published on 01 May 2012

Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy

scientific article

Cytotoxic oxasqualenoids from the red alga Laurencia viridis

scientific article published on 29 April 2011

Cytotoxicity of an Anti-cancer Lysophospholipid through Selective Modification of Lipid Raft Composition

scientific article published in Journal of Biological Chemistry

DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin.

scientific article published on November 2005

Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes

scientific article

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

scientific article

Differential Targets and Subcellular Localization of Antitumor Alkyl-lysophospholipid in LeukemicVersusSolid Tumor Cells

scientific article published in Journal of Biological Chemistry

Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis.

scientific article published on 26 August 2002

Differential gene expression patterns coupled to commitment and acquisition of phenotypic hallmarks during neutrophil differentiation of human leukaemia HL-60 cells

scientific article

Doxorubicin and edelfosine lipid nanoparticles are effective acting synergistically against drug-resistant osteosarcoma cancer cells.

scientific article published on 17 December 2016

Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeast

scientific article published on 18 January 2013

ERK1/2 acts as a switch between necrotic and apoptotic cell death in ether phospholipid edelfosine-treated glioblastoma cells

scientific article

Edelfosine and miltefosine effects on lipid raft properties: membrane biophysics in cell death by antitumor lipids

scientific article

Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition

scientific article published on 16 November 2012

Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.

scientific article published on 26 September 2006

Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk.

scientific article published on 21 July 2008

Edelfosine is incorporated into rafts and alters their organization

scientific article published on 20 August 2008

Edelfosine lipid nanosystems overcome drug resistance in leukemic cell lines

scientific article published on 23 January 2013

Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranes.

scientific article published on 17 March 2006

Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.

scientific article published in November 2007

Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosine

scientific article

Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins.

scientific article published on 20 March 2013

Expression and subcellular localization of syntaxin 11 in human neutrophils

scientific article published on 4 March 2009

Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy.

scientific article

Fluorescent Phenylpolyene Analogues of the Ether Phospholipid Edelfosine for the Selective Labeling of Cancer Cells

scientific article published on 01 October 2004

Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.

scientific article published on January 2005

Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells

scientific article published on 03 September 2019

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiae.

scientific article published on 2 January 2009

Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis

scientific article published on 10 October 2017

In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts

scientific article published on 16 March 2010

In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosine

scientific article

In vitro and in vivo efficacy of edelfosine-loaded lipid nanoparticles against glioma.

scientific article

In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites

scientific article

Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells.

scientific article published on 2 March 2018

Inhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and Praziquantel

scientific article (publication date: 2015)

Intracellular location of syntaxin 7 in human neutrophils

scientific article

Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis

scientific article published on August 2004

Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells.

scientific article published on July 2011

Involvement of mitochondrial and survival signaling in berberine-induced apoptosis in melanoma cells.

scientific article published on 24 September 2010

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells

scientific article

Ipilimumab and vemurafenib: two different routes for targeting melanoma.

scientific article published on October 2013

Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds

scientific article published on 9 July 2009

Isolation of Lipid Rafts Through Discontinuous Sucrose Gradient Centrifugation and Fas/CD95 Death Receptor Localization in Raft Fractions.

scientific article published in January 2017

Lignopurines: a new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation.

scientific article

Lipid Raft Isolation by Sucrose Gradient Centrifugation and Visualization of Raft-Located Proteins by Fluorescence Microscopy: The Use of Combined Techniques to Assess Fas/CD95 Location in Rafts During Apoptosis Triggering

scientific article published on 01 January 2021

Lipid nanomedicines for anticancer drug therapy

scientific article published on August 2009

Lipid nanoparticles for alkyl lysophospholipid edelfosine encapsulation: development and in vitro characterization

scientific article published on 30 June 2007

Lipid raft connection between extrinsic and intrinsic apoptotic pathways.

scientific article

Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications

scientific article

Lipid rafts and Fas/CD95 signaling in cancer chemotherapy.

scientific article published on September 2011

Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy.

scientific article published on May 2010

Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling.

scientific article

Lipid rafts as major platforms for signaling regulation in cancer

scientific article

Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

scientific article published on 27 January 2020

Lipid rafts, death receptors and CASMERs: new insights for cancer therapy.

scientific article published in April 2010

Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine.

scientific article published on May 2014

Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents

scientific article published on 14 October 2020

Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.

scientific article published on 22 August 2017

Mitochondrial-derived ROS in edelfosine-induced apoptosis in yeasts and tumor cells

scientific article published on June 2007

Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells

scientific article published on 22 October 2014

Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.

scientific article

Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response

scientific article published on 01 July 2019

Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring

scientific article published on 13 March 2020

Quantitative determination of the antitumor alkyl ether phospholipid edelfosine by reversed-phase liquid chromatography–electrospray mass spectrometry: application to cell uptake studies and characterization of drug delivery systems

scientific article published on 01 October 2004

Rab27a regulates exocytosis of tertiary and specific granules in human neutrophils.

scientific article published on September 2008

Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism.

scientific article published on April 2003

Rapid human melanoma cell death induced by sanguinarine through oxidative stress

scientific article published on 13 March 2013

Selective Fusion of Azurophilic Granules with Leishmania-containing Phagosomes in Human Neutrophils ⬇️

scientific article published on August 26, 2010

Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells

scientific article published on 31 August 2018

Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activities.

scientific article published in February 2010

Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxin.

scientific article published on February 2004

Synthesis and cytotoxic activity of a new potential DNA bisintercalator: 1,4-Bis{3-[N-(4-chlorobenzo[g]phthalazin-1-yl)aminopropyl]}piperazine

scientific article published on 24 May 2010

Synthesis and evaluation as antitumor agents of 1,4-naphthohydroquinone derivatives conjugated with amino acids and purines.

scientific article published on 14 October 2013

The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine.

scientific article published in December 2013

The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death.

scientific article published on 6 July 2016

Triggers and signaling cross-talk controlling cell death commitment

scientific article published in January 2015

List of works by Faustino Mollinedo

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia

Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy

Alteration of plasma membrane organization by an anticancer lysophosphatidylcholine analogue induces intracellular acidification and internalization of plasma membrane transporters in yeast

Antitumor activity of Lepidium latifolium and identification of the epithionitrile 1-cyano-2,3-epithiopropane as its major active component.

Antitumor activity of new enantiopure pybox-ruthenium complexes.

Antitumor activity of new hydridotris(pyrazolyl)borate ruthenium(II) complexes containing the phosphanes PTA and 1-CH3-PTA.

Antitumor alkyl ether lipid edelfosine: tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing immunosuppressed mice.

Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo

Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.

Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cells

C-Geranylated flavonoids from Paulownia tomentosa fruits with antimicrobial potential and synergistic activity with antibiotics.

ChemInform Abstract: Cytotoxic Oxasqualenoids from the Red Alga Laurencia viridis.

Cloning and genomic characterization of sytdep, a new synaptotagmin XIV-related gene

Combinatorial SNARE complexes modulate the secretion of cytoplasmic granules in human neutrophils.

Complete inhibition of extranodal dissemination of lymphoma by edelfosine-loaded lipid nanoparticles

Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy

Cytotoxic oxasqualenoids from the red alga Laurencia viridis

Cytotoxicity of an Anti-cancer Lysophospholipid through Selective Modification of Lipid Raft Composition

DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin.

Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

Differential Targets and Subcellular Localization of Antitumor Alkyl-lysophospholipid in LeukemicVersusSolid Tumor Cells

Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis.

Differential gene expression patterns coupled to commitment and acquisition of phenotypic hallmarks during neutrophil differentiation of human leukaemia HL-60 cells

Doxorubicin and edelfosine lipid nanoparticles are effective acting synergistically against drug-resistant osteosarcoma cancer cells.

Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeast

ERK1/2 acts as a switch between necrotic and apoptotic cell death in ether phospholipid edelfosine-treated glioblastoma cells

Edelfosine and miltefosine effects on lipid raft properties: membrane biophysics in cell death by antitumor lipids

Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition

Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.

Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk.

Edelfosine is incorporated into rafts and alters their organization

Edelfosine lipid nanosystems overcome drug resistance in leukemic cell lines

Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranes.

Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.

Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosine

Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins.

Expression and subcellular localization of syntaxin 11 in human neutrophils

Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy.

Fluorescent Phenylpolyene Analogues of the Ether Phospholipid Edelfosine for the Selective Labeling of Cancer Cells

Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.

Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiae.

Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis

In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts

In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosine

In vitro and in vivo efficacy of edelfosine-loaded lipid nanoparticles against glioma.

In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites

Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells.

Inhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and Praziquantel

Intracellular location of syntaxin 7 in human neutrophils

Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis

Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells.

Involvement of mitochondrial and survival signaling in berberine-induced apoptosis in melanoma cells.

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells

Ipilimumab and vemurafenib: two different routes for targeting melanoma.

Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds

Isolation of Lipid Rafts Through Discontinuous Sucrose Gradient Centrifugation and Fas/CD95 Death Receptor Localization in Raft Fractions.

Lignopurines: a new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation.

Lipid Raft Isolation by Sucrose Gradient Centrifugation and Visualization of Raft-Located Proteins by Fluorescence Microscopy: The Use of Combined Techniques to Assess Fas/CD95 Location in Rafts During Apoptosis Triggering

Lipid nanomedicines for anticancer drug therapy

Lipid nanoparticles for alkyl lysophospholipid edelfosine encapsulation: development and in vitro characterization

Lipid raft connection between extrinsic and intrinsic apoptotic pathways.

Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications

Lipid rafts and Fas/CD95 signaling in cancer chemotherapy.

Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy.

Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling.

Lipid rafts as major platforms for signaling regulation in cancer

Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

Lipid rafts, death receptors and CASMERs: new insights for cancer therapy.

Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine.

Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents

Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.

Mitochondrial-derived ROS in edelfosine-induced apoptosis in yeasts and tumor cells

Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells

Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.

Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response