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List of works by Makoto Shibutani

A 13-week subchronic toxicity study of madder color in F344 rats

scientific article published on 14 August 2007

A 90-day subchronic toxicity study of nivalenol, a trichothecene mycotoxin, in F344 rats

scientific article published on 18 July 2007

A case of rapid recurrence of apocrine ductal carcinoma originating from the oral scent gland of a Richardson's ground squirrel (Urocitellus richardsonii)

scientific article published on 29 March 2018

A case report of a cerebellar neuroblastoma in a p53 null mutation mouse

scientific article published in March 2009

A case report of a renal mixed epithelial and stromal tumor in a heterozygous S1P2 receptor deficient mouse.

scientific article published in May 2008

A case report of a spontaneous gastrointestinal stromal tumor (GIST) occurring in a F344 rat.

scientific article

A case report of an uncommon sex-cord stromal tumor consisted of luteal and sertoli cells in a spayed bitch

scientific article published on 25 November 2009

A mixed apocrine gland tumor with metastases to the bone and bone marrow in a miniature poodle.

scientific article published on 30 June 2010

A neuroendocrine carcinoma of undetermined origin in a dog.

scientific article

A repeated 28-day oral dose toxicity study of nonylphenol in rats, based on the 'Enhanced OECD Test Guideline 407' for screening of endocrine-disrupting chemicals.

scientific article

Aberrant Epigenetic Gene Regulation in GABAergic Interneuron Subpopulations in the Hippocampal Dentate Gyrus of Mouse Offspring Following Developmental Exposure to Hexachlorophene

scientific article published on 2 January 2018

Aberrant activation of M phase proteins by cell proliferation-evoking carcinogens after 28-day administration in rats.

scientific article published on 25 March 2013

Aberrant activation of ubiquitin D at G2 phase and apoptosis by carcinogens that evoke cell proliferation after 28-day administration in rats.

scientific article

Aberrant cell cycle regulation in rat liver cells induced by post-initiation treatment with hepatocarcinogens/hepatocarcinogenic tumor promoters

scientific article published on 8 July 2016

Aberrant epigenetic gene regulation in hippocampal neurogenesis of mouse offspring following maternal exposure to 3,3'-iminodipropionitrile

scientific article published on 01 January 2019

Aberration in epigenetic gene regulation in hippocampal neurogenesis by developmental exposure to manganese chloride in mice.

scientific article published on 23 August 2013

Acute renal failure in an adult cat following oral administration of fosfomycin

scientific article published on 30 July 2018

Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats.

scientific article published in January 2012

Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals ⬇️

scientific article published on November 4, 2003

Ameliorating effect of postweaning exposure to antioxidant on disruption of hippocampal neurogenesis induced by developmental hypothyroidism in rats

scientific article published on 01 January 2019

Anti-inflammatory effects of the selective phosphodiesterase 3 inhibitor, cilostazol, and antioxidants, enzymatically-modified isoquercitrin and α-lipoic acid, reduce dextran sulphate sodium-induced colorectal mucosal injury in mice

scientific article published on 12 January 2017

Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats.

scientific article published on January 2011

Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats.

scientific article published on 22 December 2009

Antioxidant enzymatically modified isoquercitrin suppresses the development of liver preneoplastic lesions in rats induced by beta-naphthoflavone.

scientific article published on 5 January 2010

Apocynin and enzymatically modified isoquercitrin suppress the expression of a NADPH oxidase subunit p22phox in steatosis-related preneoplastic liver foci of rats

scientific article published on 24 October 2016

Assessment of developmental effects of hypothyroidism in rats from in utero and lactation exposure to anti-thyroid agents.

scientific article published on 4 May 2009

Canine mammary minute oncocytomas with neuroendocrine differentiation associated with multifocal acinar cell oncocytic metaplasia

scientific article published on 3 October 2016

Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay

scientific article

Cellular distribution of cell cycle-related molecules in the renal tubules of rats treated with renal carcinogens for 28 days: relationship between cell cycle aberration and carcinogenesis.

scientific article published on 13 March 2012

Cellular distributions of molecules with altered expression specific to the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model

scientific article published on 26 June 2008

Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model

scientific journal article

Chemoprevention of acrylamide toxicity by antioxidative agents in rats--effective suppression of testicular toxicity by phenylethyl isothiocyanate

scientific article published on 28 April 2005

Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats

scientific article published in January 2002

Choroid plexus carcinoma with neuronal and glial differentiation in a 7-week-old male Sprague-Dawley rat.

scientific article published on 16 February 2018

Cilostazol and enzymatically modified isoquercitrin attenuate experimental colitis and colon cancer in mice by inhibiting cell proliferation and inflammation

scientific article

Clinical and pathological characteristics of acute myelogenous leukemia in a female koala with diabetes mellitus

scientific article published on 02 July 2019

Clinical and pathological features and outcome of bilateral incidental adrenocortical carcinomas in a dog.

scientific article published on 4 August 2017

Complex apocrine carcinoma with dominant myoepithelial proliferation in a dog.

scientific article

Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by β-naphthoflavone involving TNFα-signaling due to oxidative cellular stress in rats.

scientific article published on 2 February 2011

Concurrent administration of ascorbic acid enhances liver tumor-promoting activity of kojic acid in rats.

scientific article published in May 2008

Continuous Exposure to Alpha-Glycosyl Isoquercitrin from Gestation Ameliorates Disrupted Hippocampal Neurogenesis in Rats Induced by Gestational Injection of Valproic Acid

scientific article published in 2022

Continuous exposure to α-glycosyl isoquercitrin from developmental stages to adulthood is necessary for facilitating fear extinction learning in rats

scientific article published on 13 August 2020

Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model

scientific article published on 20 March 2009

Cuprizone decreases intermediate and late-stage progenitor cells in hippocampal neurogenesis of rats in a framework of 28-day oral dose toxicity study

scientific article published on 6 June 2015

Current Topics in Biological Safety Tests on Foods, Food Additives and Contaminants ⬇️

scientific article published on 01 January 2010

Cytokeratin 8/18 is a useful immunohistochemical marker for hepatocellular proliferative lesions in mice

scientific article published on 25 December 2009

Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma

scientific article published on February 2009

Developmental Exposure of Mice to T-2 Toxin Increases Astrocytes and Hippocampal Neural Stem Cells Expressing Metallothionein

scientific article published on 29 November 2018

Developmental Exposure to Aluminum Chloride Irreversibly Affects Postnatal Hippocampal Neurogenesis Involving Multiple Functions in Mice

scientific article published on 4 April 2018

Developmental Exposure to Manganese Chloride Induces Sustained Aberration of Neurogenesis in the Hippocampal Dentate Gyrus of Mice ⬇️

scientific article published on March 9, 2012

Developmental cuprizone exposure impairs oligodendrocyte lineages differentially in cortical and white matter tissues and suppresses glutamatergic neurogenesis signals and synaptic plasticity in the hippocampal dentate gyrus of rats

scientific article published on 11 November 2015

Developmental exposure of aflatoxin B1 reversibly affects hippocampal neurogenesis targeting late-stage neural progenitor cells through suppression of cholinergic signaling in rats

scientific article published on 7 August 2015

Developmental exposure of citreoviridin transiently affects hippocampal neurogenesis targeting multiple regulatory functions in mice

scientific article published on 30 July 2018

Developmental exposure to T-2 toxin reversibly affects postnatal hippocampal neurogenesis and reduces neural stem cells and progenitor cells in mice

scientific article published on 28 August 2015

Developmental exposure to cuprizone reduces intermediate-stage progenitor cells and cholinergic signals in the hippocampal neurogenesis in rat offspring

scientific article published on 19 February 2015

Developmental exposure to diacetoxyscirpenol reversibly disrupts hippocampal neurogenesis by inducing oxidative cellular injury and suppressed differentiation of granule cell lineages in mice

scientific article published on 10 December 2019

Developmental hypothyroidism abolishes bilateral differences in sonic hedgehog gene control in the rat hippocampal dentate gyrus

scientific article published on 23 December 2014

Developmental toxicity of brominated flame retardants, tetrabromobisphenol A and 1,2,5,6,9,10-hexabromocyclododecane, in rat offspring after maternal exposure from mid-gestation through lactation.

scientific article

Dietary influence on the impact of ethinylestradiol-induced alterations in the endocrine/reproductive system with perinatal maternal exposure

scientific article published in January 2004

Differential effects between developmental and postpubertal exposure to N-methyl-N-nitrosourea on progenitor cell proliferation of rat hippocampal neurogenesis in relation to COX2 expression in granule cells

scientific article published on 5 July 2017

Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats

scientific article published on 01 January 2018

Differential responses on energy metabolic pathway reprogramming between genotoxic and non-genotoxic hepatocarcinogens in rat liver cells

scientific article published on 28 July 2019

Direct progression of capsular invasive carcinomas from subcapsular focal hyperplasias induced by hypothyroidism-mediated tumor promotion in a rat two-stage thyroid carcinogenesis model ⬇️

scientific article published on November 1, 2012

Disruption of Smad-dependent signaling for growth of GST-P-positive lesions from the early stage in a rat two-stage hepatocarcinogenesis model.

scientific article published on 25 April 2010

Disruption of spindle checkpoint function ahead of facilitation of cell proliferation by repeated administration of hepatocarcinogens in rats

scientific article published on January 2015

Disruption of spindle checkpoint function in rats following 28 days of repeated administration of renal carcinogens

scientific article published in February 2016

Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a (p16(Ink4a)) in early-stage liver tumor-promotion facilitating liver cell regeneration in rats.

scientific article published on 30 May 2012

Disruptive neuronal development by acrylamide in the hippocampal dentate hilus after developmental exposure in rats

scientific article published on December 2010

Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation

scientific article published in October 2004

Down-regulation of GAT-1 mRNA expression in the microdissected hypothalamic medial preoptic area of rat offspring exposed maternally to ethinylestradiol

scientific journal article

Downregulation of TMEM70 in Rat Liver Cells After Hepatocarcinogen Treatment Related to the Warburg Effect in Hepatocarcinogenesis Producing GST-P-Expressing Proliferative Lesions

scientific article published in September 2017

Downregulation of UBE2E2 in rat liver cells after hepatocarcinogen treatment facilitates cell proliferation and slowing down of DNA damage response in GST-P-expressing preneoplastic lesions

scientific article published on 9 September 2017

Downregulation of low-density lipoprotein receptor class A domain-containing protein 4 (Ldlrad4) in the liver of rats treated with nongenotoxic hepatocarcinogen to induce transforming growth factor β signaling promoting cell proliferation and suppre

scientific article published on 28 June 2020

Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model.

scientific article published on 27 August 2009

Effect of enzymatically modified isoquercitrin on preneoplastic liver cell lesions induced by thioacetamide promotion in a two-stage hepatocarcinogenesis model using rats ⬇️

scientific article published on January 11, 2013

Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model

scientific article published on 27 January 2020

Elevation of cell proliferation via generation of reactive oxygen species by piperonyl butoxide contributes to its liver tumor-promoting effects in mice.

scientific article published on 26 January 2010

Endometrial adenocarcinoma with choriocarcinomatous differentiation in the uterus of a goat

scientific article

Enhanced liver tumor promotion activity in rats subjected to combined administration of phenobarbital and orphenadrine ⬇️

scientific article published on January 1, 2013

Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and β-naphthoflavone.

scientific article published in January 2012

Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture

scientific article published on 10 June 2020

Establishment of a novel experimental model for muscle-invasive bladder cancer using a dog bladder cancer organoid culture

scientific article published on 23 July 2019

Evaluation of in vivo genotoxic potential of fenofibrate in rats subjected to two-week repeated oral administration.

scientific article published on 3 December 2010

Evaluation of in vivo liver genotoxic potential of Wy-14,643 and piperonyl butoxide in rats subjected to two-week repeated oral administration

scientific journal article

Exposure to MnCl2 · 4H2O during development induces activation of microglial and perivascular macrophage populations in the hippocampal dentate gyrus of rats

scientific article

Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens

article

Expression alterations of genes on both neuronal and glial development in rats after developmental exposure to 6-propyl-2-thiouracil

scientific journal article

Expression of A-kinase anchor protein 13 and Rho-associated coiled-coil containing protein kinase in restituted and regenerated mucosal epithelial cells following mucosal injury and colorectal cancer cells in mouse models

scientific article published on 20 April 2017

Expression patterns of cell cycle proteins in the livers of rats treated with hepatocarcinogens for 28 days.

scientific article published on 15 February 2013

Extraskeletal chondrosarcoma in the abdominal cavity of a cow

scientific article published on 23 October 2019

Fluctuations in cell proliferation, apoptosis, and cell cycle regulation at the early stage of tumor promotion in rat two-stage carcinogenesis models

scientific article published in January 2012

Fluorescence contrast-enhanced proliferative lesion imaging by enema administration of indocyanine green in a rat model of colon carcinogenesis

scientific article

Fluorescence tumor imaging by i.v. administered indocyanine green in a mouse model of colitis-associated colon cancer.

scientific article published on 9 March 2018

Gene expression profile in the livers of rats orally administered ethinylestradiol for 28 days using a microarray technique

scientific article

Gene expression profile of brain regions reflecting aberrations in nervous system development targeting the process of neurite extension of rat offspring exposed developmentally to glycidol

scientific article published on 7 January 2014

Gene expression profiling and cellular distribution of molecules with altered expression in the hippocampal CA1 region after developmental exposure to anti-thyroid agents in rats

scientific article

Gene expression profiling of the hippocampal dentate gyrus in an adult toxicity study captures a variety of neurodevelopmental dysfunctions in rat models of hypothyroidism

scientific article published on 30 March 2015

Global DNA methylation screening of liver in piperonyl butoxide-treated mice in a two-stage hepatocarcinogenesis model.

scientific article published on 19 August 2013

Global gene expression profiles in brain regions reflecting abnormal neuronal and glial functions targeting myelin sheaths after 28-day exposure to cuprizone in rats

scientific article

Glycidol Induces Axonopathy by Adult-Stage Exposure and Aberration of Hippocampal Neurogenesis Affecting Late-Stage Differentiation by Developmental Exposure in Rats ⬇️

scientific article published on April 17, 2013

Glycidol induces axonopathy and aberrations of hippocampal neurogenesis affecting late-stage differentiation by exposure to rats in a framework of 28-day toxicity study

scientific article published in November 2013

Hepatocarcinogenic susceptibility of fenofibrate and its possible mechanism of carcinogenicity in a two-stage hepatocarcinogenesis model of rasH2 mice.

scientific article

Hepatocarcinogenic susceptibility of rasH2 mice to troglitazone in a two-stage hepatocarcinogenesis model.

scientific article published on 3 July 2008

High-grade myofibroblastic sarcoma of inguinal region in a dog.

scientific article published on 9 December 2011

Hypothalamus region-specific global gene expression profiling in early stages of central endocrine disruption in rat neonates injected with estradiol benzoate or flutamide

scientific article

Identification of epigenetically downregulated Tmem70 and Ube2e2 in rat liver after 28-day treatment with hepatocarcinogenic thioacetamide showing gene product downregulation in hepatocellular preneoplastic and neoplastic lesions produced by tumor p

scientific article published on 30 November 2016

Identification of gene targets of developmental neurotoxicity focusing on DNA hypermethylation involved in irreversible disruption of hippocampal neurogenesis in rats

scientific article published on 04 November 2020

Immunohistochemical analyses at the late stage of tumor promotion by oxfendazole in a rat hepatocarcinogenesis model

scientific article published on 26 May 2010

Immunohistochemical cellular distribution of proteins related to M phase regulation in early proliferative lesions induced by tumor promotion in rat two-stage carcinogenesis models

scientific article published on 23 July 2013

Immunohistochemical expression of autophagosome markers LC3 and p62 in preneoplastic liver foci in high fat diet-fed rats

scientific article published on 01 January 2019

Immunohistochemistry of aberrant neuronal development induced by 6-propyl-2-thiouracil in rats

scientific article published on 20 August 2016

Immunotoxicity of nivalenol after subchronic dietary exposure to rats.

scientific article

Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life ⬇️

scientific article published on November 5, 2003

Impact of maternal dietary exposure to endocrine-acting chemicals on progesterone receptor expression in microdissected hypothalamic medial preoptic areas of rat offspring.

scientific article published in October 2005

Impaired oligodendroglial development by decabromodiphenyl ether in rat offspring after maternal exposure from mid-gestation through lactation

scientific article published on 21 September 2010

In vivo imaging of tissue-remodeling activity involving infiltration of macrophages by a systemically administered protease-activatable probe in colon cancer tissues

scientific article published on December 2013

Increased cellular distribution of vimentin and Ret in the cingulum induced by developmental hypothyroidism in rat offspring maternally exposed to anti-thyroid agents ⬇️

scientific article published on April 6, 2012

Increased cellular distribution of vimentin and ret in the cingulum of rat offspring after developmental exposure to decabromodiphenyl ether or 1,2,5,6,9,10-hexabromocyclododecane

scientific article published on June 2013

Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine

scientific article

Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats.

scientific article published on 20 December 2009

Induction of duodenal mucosal tumors of intestinal epithelial cell origin showing frequent nuclear β-catenin accumulation similar to the concurrently induced colorectal tumors in rats after treatment with azoxymethane

scientific article published on 17 April 2015

Induction of kidney and liver cancers by the natural food additive madder color in a two-year rat carcinogenicity study

scientific article

Induction of liver preneoplastic foci in F344 rats subjected to 28-day oral administration of diheptyl phthalate and its in vivo genotoxic potential.

scientific article published on 28 July 2009

Induction of ovarian toxicity in a subchronic oral toxicity study of citrinin in female BALB/c mice.

scientific article published in January 2012

Inhibitory effect of α-lipoic acid on thioacetamide-induced tumor promotion through suppression of inflammatory cell responses in a two-stage hepatocarcinogenesis model in rats.

scientific article published on 2 July 2013

Intermediate-grade mammary gland adenocarcinoma in an 18-year-old female black leopard (Panthera pardus) with acute pancreatic necrosis and chronic interstitial nephropathy

scientific article published on 19 December 2017

Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development

scientific article published on 28 February 2016

Involvement of PTEN/Akt signaling and oxidative stress on indole-3-carbinol (I3C)-induced hepatocarcinogenesis in rats ⬇️

scientific article published on January 4, 2013

Involvement of PTEN/Akt signaling in capsular invasive carcinomas developed in a rat two-stage thyroid carcinogenesis model after promotion with sulfadimethoxine.

scientific article published on 26 June 2010

Involvement of glycogen synthase kinase-3beta signaling and aberrant nucleocytoplasmic localization of retinoblastoma protein in tumor promotion in a rat two-stage thyroid carcinogenesis model.

scientific article

Involvement of multiple cell cycle aberrations in early preneoplastic liver cell lesions by tumor promotion with thioacetamide in a two-stage rat hepatocarcinogenesis model ⬇️

scientific article published on March 7, 2013

Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of food-flavouring substances uniquely used in Japan that belong to the class of aliphatic primary alcohols, aldehydes, carboxylic acids, acetals and esters containing add

scientific article published on 25 May 2017

Lac color inhibits development of rat thyroid carcinomas through targeting activation of plasma hyaluronan-binding protein

scientific article published on June 19, 2012

Lack of chronic toxicity or carcinogenicity of dietary N-acetylglucosamine in F344 rats

scientific article

Lack of in vivo mutagenicity of acetamide in a 13-week comprehensive toxicity study using F344 gpt delta rats

scientific article published on 21 September 2020

Lack of maternal dietary exposure effects of bisphenol A and nonylphenol during the critical period for brain sexual differentiation on the reproductive/endocrine systems in later life ⬇️

scientific article published on October 1, 2003

Lack of modifying effects of genistein on disruption of the reproductive system by perinatal dietary exposure to ethinylestradiol in rats

scientific article

Lack of preventive effect of maternal exposure to α-glycosyl isoquercitrin and α-lipoic acid on developmental hypothyroidism-induced aberrations of hippocampal neurogenesis in rat offspring

scientific article published on 31 May 2019

Lack of preventive effects of dietary fibers or chlorophyllin against acrylamide toxicity in rats

scientific article

Lack of significant effects of genistein on the progression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats.

scientific article published in January 2003

Late Effect of Developmental Exposure to 3,3'-Iminodipropionitrile on Neurogenesis in the Hippocampal Dentate Gyrus of Mice.

scientific article published on 6 February 2017

Late effect of developmental exposure to glycidol on hippocampal neurogenesis in mice: Loss of parvalbumin-expressing interneurons

scientific article

Life stage-related differences in susceptibility to acrylamide-induced neural and testicular toxicity ⬇️

scientific article published on January 6, 2011

Limited lactational transfer of acrylamide to rat offspring on maternal oral administration during the gestation and lactation periods

scientific article published on 21 March 2009

Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model

scientific article

Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action.

scientific article published on January 2012

Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action ⬇️

scientific article published on January 1, 2012

Liver tumor promoting effect of orphenadrine in rats and its possible mechanism of action including CAR activation and oxidative stress.

scientific article published on January 2013

Maternal Exposure to Valproic Acid Primarily Targets Interneurons Followed by Late Effects on Neurogenesis in the Hippocampal Dentate Gyrus in Rat Offspring.

scientific article published on 26 August 2016

Maternal exposure to 3,3'-iminodipropionitrile targets late-stage differentiation of hippocampal granule cell lineages to affect brain-derived neurotrophic factor signaling and interneuron subpopulations in rat offspring

scientific article published on 25 November 2014

Maternal exposure to hexachlorophene targets intermediate-stage progenitor cells in the hippocampal neurogenesis involving myelin vacuolation of cholinergic and glutamatergic inputs in mice

scientific article

Maternal exposure to hexachlorophene targets intermediate-stage progenitor cells of the hippocampal neurogenesis in rat offspring via dysfunction of cholinergic inputs by myelin vacuolation

scientific article published on 11 December 2014

Maternal exposure to ochratoxin A targets intermediate progenitor cells of hippocampal neurogenesis in rat offspring via cholinergic signal downregulation and oxidative stress responses

scientific article published on 23 June 2016

Mechanistic study on hepatocarcinogenesis of piperonyl butoxide in mice.

scientific article published on 18 August 2009

Mechanistic study on liver tumor promoting effects of flutamide in rats.

scientific article published on 11 November 2011

Methacarn as a whole brain fixative for gene and protein expression analyses of specific brain regions in rats ⬇️

scientific article published on January 1, 2013

Methacarn fixation for genomic DNA analysis in microdissected, paraffin-embedded tissue specimens

scientific article published in September 2002

Methacarn fixation--effects of tissue processing and storage conditions on detection of mRNAs and proteins in paraffin-embedded tissues

scientific article published on 8 February 2006

Microdissected region-specific gene expression analysis with methacarn-fixed, paraffin-embedded tissues by real-time RT-PCR.

scientific article

Modification of dietary copper levels on the early stage of tumor-promotion with propylthiouracil in a rat two-stage thyroid carcinogenesis model

scientific journal article

Modifying effect of Siraitia grosvenori extract on piperonyl butoxide-promoted hepatocarcinogenesis in rats.

scientific article published in May 2008

Modifying effects of liver tumor promotion in rats subjected to co-administration of indole-3-carbinol and phenobarbital

scientific article published on February 2014

Molecular expression analysis of beta-naphthoflavone-induced hepatocellular tumors in rats.

scientific article published on 23 April 2009

Molecular profiling of genes up-regulated during promotion by phenobarbital treatment in a medium-term rat liver bioassay

scientific article published in June 2002

Neuroendocrine carcinoma of the apocrine glands of the anal sac in a dog

scientific article published on 08 June 2011

No Modifying Effect of Antioxidant N-Acetyl-L-Cysteine on Fenofibrate-induced Hepatocarcinogenesis in Rats

scientific article published on 21 December 2009

No effect of sustained systemic growth retardation on the distribution of Reelin-expressing interneurons in the neuron-producing hippocampal dentate gyrus in rats.

scientific article published on 27 October 2010

Ochratoxin A induces karyomegaly and cell cycle aberrations in renal tubular cells without relation to induction of oxidative stress responses in rats

scientific article published on 11 October 2013

One-year chronic toxicity of madder color in F344 rats--induction of preneoplastic/neoplastic lesions in the kidney and liver

scientific article

Onset of hepatocarcinogen-specific cell proliferation and cell cycle aberration during the early stage of repeated hepatocarcinogen administration in rats

scientific article published on 22 May 2015

Oral Exposure to Lead Acetate for 28 Days Reduces the Number of Neural Progenitor Cells but Increases the Number and Synaptic Plasticity of Newborn Granule Cells in Adult Hippocampal Neurogenesis of Young-Adult Rats

scientific article published in 2022

Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).

scientific article

Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods - a preliminary study

scientific article

Possible contribution of rubiadin, a metabolite of madder color, to renal carcinogenesis in rats

scientific article

Preferential tumor cellular uptake and retention of indocyanine green for in vivo tumor imaging

scientific article published on 23 March 2016

Preventive effects of calcitriol on the development of capsular invasive carcinomas in a rat two-stage thyroid carcinogenesis model.

scientific article

Promoter-region hypermethylation and expression downregulation of Yy1 (Yin yang 1) in preneoplastic liver lesions in a thioacetamide rat hepatocarcinogenesis model

scientific article published on 22 August 2014

Promoting effects of carminic acid-enriched cochineal extracts on capsular invasive thyroid carcinomas through targeting activation of angiogenesis in rats ⬇️

scientific article published on January 1, 2012

Promoting potential of a Jamaica quassia extract in a rat medium-term hepatocarcinogenesis bioassay

scientific article

Protective Effect of <i>Stachybotrys microspora</i> Triprenyl Phenol-7on the Deposition of IgA to the Glomerular Mesangium in Nivalenol-induced IgA Nephropathy Using BALB/c Mice ⬇️

scientific article published on June 1, 2012

Pulmonary neuroendocrine tumor in a female wolf (Canis lupus lupus).

scientific article published on 11 February 2017

Rapid deposition of glomerular IgA in BALB/c mice by nivalenol and its modifying effect on high IgA strain (HIGA) mice

scientific article published on 27 September 2009

Relationship between CYP1A induction by indole-3-carbinol or flutamide and liver tumor-promoting potential in rats.

scientific article published on 4 January 2011

Relationship between brain accumulation of manganese and aberration of hippocampal adult neurogenesis after oral exposure to manganese chloride in mice

scientific article published on 16 February 2015

Reversible aberration of neurogenesis affecting late-stage differentiation in the hippocampal dentate gyrus of rat offspring after maternal exposure to manganese chloride.

scientific article published on 4 May 2012

Reversible aberration of neurogenesis targeting late-stage progenitor cells in the hippocampal dentate gyrus of rat offspring after maternal exposure to acrylamide.

scientific article published on 18 January 2012

Reversible effect of developmental exposure to chlorpyrifos on late-stage neurogenesis in the hippocampal dentate gyrus in mouse offspring

scientific article published on 18 February 2013

Reversible effect of maternal exposure to chlorpyrifos on the intermediate granule cell progenitors in the hippocampal dentate gyrus of rat offspring.

scientific article

Role of Nrf2 and oxidative stress on fenofibrate-induced hepatocarcinogenesis in rats

scientific article

Similar distribution changes of GABAergic interneuron subpopulations in contrast to the different impact on neurogenesis between developmental and adult-stage hypothyroidism in the hippocampal dentate gyrus in rats.

scientific article published on 31 March 2012

Spironolactone in Combination with α-glycosyl Isoquercitrin Prevents Steatosis-related Early Hepatocarcinogenesis in Rats through the Observed NADPH Oxidase Modulation

scientific article published on 29 May 2018

Subchronic toxicity study of dietary N-acetylglucosamine in F344 rats

scientific article published in April 2004

Subchronic toxicity study of water pepper extract in F344 rats

scientific article published on 20 March 2006

Suppression of epithelial restitution using an inhibitor against Rho-associated coiled-coil containing protein kinase aggravates colitis through reduced epithelial expression of A-kinase anchor protein 13.

scientific article published on 20 May 2017

Suppressive effect of Siraitia grosvenorii extract on dicyclanil-promoted hepatocellular proliferative lesions in male mice

scientific article published in February 2009

Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats ⬇️

scientific article published on March 29, 2011

Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide

scientific article published on January 2013

Sustained production of Reelin-expressing interneurons in the hippocampal dentate hilus after developmental exposure to anti-thyroid agents in rats

scientific article published on 27 March 2010

The JFFMA assessment of flavoring substances structurally related to menthol and uniquely used in Japan

scientific article published on 02 December 2013

The Japan Flavour and Fragrance Materials Association's (JFFMA) safety assessment of acetal food flavouring substances uniquely used in Japan

scientific article published on 25 July 2015

The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice.

scientific article published in February 2010

Threshold dose of liver tumor promoting effect of β-naphthoflavone in rats ⬇️

scientific article published on January 1, 2012

Transient aberration of neuronal development in the hippocampal dentate gyrus after developmental exposure to brominated flame retardants in rats.

scientific article published on 14 March 2012

Transient suppression of late-stage neuronal progenitor cell differentiation in the hippocampal dentate gyrus of rat offspring after maternal exposure to nicotine.

scientific article published on 27 July 2013

Tumor promotion by copper-overloading and its enhancement by excess iron accumulation involving oxidative stress responses in the early stage of a rat two-stage hepatocarcinogenesis model.

scientific article published on 17 March 2010

Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model

scientific article published on 26 March 2014

Twenty-eight-day repeated oral doses of sodium valproic acid increases neural stem cells and suppresses differentiation of granule cell lineages in adult hippocampal neurogenesis of postpubertal rats

scientific article published on 11 May 2019

β-catenin Mutations Are Not Involved in Early-stage Hepatocarcinogenesis Induced by Protoporphyrinogen Oxidase Inhibitors in Mice

scientific article published in January 2017

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