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List of works by Nigel Gooderham

2'-O-(2-methoxyethyl) nucleosides are not phosphorylated or incorporated into the genome of Human Lymphoblastoid TK6 Cells

scientific article published on 9 January 2018

A triple-helix forming oligonucleotide targeting genomic DNA fails to induce mutation ⬇️

scientific article published on August 21, 2012

Bariatric Surgery Modulates Urinary Levels of MicroRNAs Involved in the Regulation of Renal Function.

scientific article published on 21 May 2019

Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles

scientific article published on 22 March 2019

Distribution and Elimination of [2-14C]Amino-3, 8-Dimethylimidazo [4, 5-f] quinoxaline in Mice. Analysis by Whole Animal Autoradiography ⬇️

scientific article published on September 1, 1991

Dose-dependent synergistic and antagonistic mutation responses of binary mixtures of the environmental carcinogen benzo[a]pyrene with food-derived carcinogens

scientific article published on 26 September 2018

Effects of treatment with androgen receptor ligands on microRNA expression of prostate cancer cells

scientific article

Elevated serum microRNA 483-5p levels may predict patients at risk of post-operative atrial fibrillation

scientific article published on 15 July 2016

Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents.

scientific article published on 13 September 2011

Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer ⬇️

scientific article published on April 1, 2003

Extra-nuclear location of histones in activated human peripheral blood lymphocytes and cultured T-cells ⬇️

scientific article published on July 31, 1995

FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients

scientific article published on 18 November 2019

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients

scientific article published on 24 November 2018

FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients

scientific article published on 08 October 2019

FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results

scientific article

Identification of human urinary biomarkers of cruciferous vegetable consumption by metabonomic profiling

scientific article published on 31 August 2011

Impact of structural and metabolic variations on the toxicity and carcinogenicity of hydroxy- and alkoxy-substituted allyl- and propenylbenzenes.

scientific article published on 11 June 2014

Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid

scientific article published on 09 November 2016

Improved physiology and metabolic flux after Roux-en-Y gastric bypass is associated with temporal changes in the circulating microRNAome: a longitudinal study in humans.

scientific article published on 31 May 2018

Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis

scientific article

Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3.

scientific article

Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells

scientific article published on 12 September 2019

Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef ⬇️

scientific article published on November 15, 1992

Mechanistic evidence that benzo[a]pyrene promotes an inflammatory microenvironment that drives the metastatic potential of human mammary cells

article

Metabolic surgery and cancer: protective effects of bariatric procedures

scientific article

Mutagenesis by an Antisense Oligonucleotide and Its Degradation Product ⬇️

scientific article published on August 7, 2012

N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver

scientific article published on December 1, 1992

Post-operative atrial fibrillation is associated with a pre-existing structural and electrical substrate in human right atrial myocardium.

scientific article published on 28 June 2016

Pre-operative serum VCAM-1 as a biomarker of atrial fibrillation after coronary artery bypass grafting

scientific article published on 18 August 2017

Safety evaluation of substituted thiophenes used as flavoring ingredients

scientific article

Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs

scientific article published on 8 July 2017

Synergistic and Antagonistic Mutation Responses of Human MCL-5 Cells to Mixtures of Benzo[a]pyrene and 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]pyridine: Dose-Related Variation in the Joint Effects of Common Dietary Carcinogens

scientific article

The Lack of Mutagenic Potential of a Guanine-Rich Triplex Forming Oligonucleotide in Physiological Conditions.

scientific article

The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells.

scientific article

The in vitro metabolism of N,N-dimethylaniline by guinea pig and rabbit tissue preparations ⬇️

scientific article published on January 1, 1981

The safety evaluation of food flavouring substances: the role of metabolic studies

scientific article published on 28 March 2018

The selective cytotoxicity of the alkenyl glucosinolate hydrolysis products and their presence in Brassica vegetables

scientific article published on 9 June 2015

Transdifferentiated rat pancreatic progenitor cells (AR42J-B13/H) respond to phenobarbital in a rat hepatocyte-specific manner

scientific article published on 14 July 2016

Using 3D MCF-7 mammary spheroids to assess the genotoxicity of mixtures of the food-derived carcinogens benzo[a]pyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

scientific article published on 18 November 2015

Using microRNA profiles to predict and evaluate hepatic carcinogenic potential.

scientific article published on 30 April 2014

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