List of works - Kazuhiro Ito

Decreased histone deacetylase activity in chronic obstructive pulmonary disease

scientific article

Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression

scientific article

COPD as a disease of accelerated lung aging

scientific article published on January 2009

Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.

scientific article

A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.

scientific article

Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase.

scientific article published on February 2004

Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.

scientific article

Expression and activity of histone deacetylases in human asthmatic airways

scientific article published in August 2002

Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease

scientific article

Update on glucocorticoid action and resistance

scientific article published on 01 March 2006

Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.

scientific article

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9.

scientific article published on 17 April 2009

Epigenetic regulation of airway inflammation.

scientific article published on 27 August 2007

Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy.

scientific article

Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice

scientific article published on 22 January 2009

Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma

scientific article published on 15 April 2004

Effects of glucocorticoids on gene transcription

scientific article

Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients

scientific article

NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription

scientific article published on January 2006

Accelerated ageing of the lung in COPD: new concepts.

scientific article

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

scientific article

Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3.

scientific article published on February 2007

Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease.

scientific article

Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2.

scientific article published on 3 May 2009

Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

scientific article

Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma

scientific article published on 12 May 2008

Epigenetics and airways disease

scientific article

Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease

scientific article published on 28 September 2005

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer

scientific article

A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition.

scientific article

Kinase inhibitors and airway inflammation.

scientific article

Histone deacetylation: an important mechanism in inflammatory lung diseases

scientific article published on December 2005

Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease.

scientific article published in December 2005

Cigarette smoke activates human monocytes by an oxidant-AP-1 signaling pathway: implications for steroid resistance

scientific article

Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma

scientific article (publication date: 2012)

Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease

scientific article

MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients.

scientific article published in September 2009

Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma

scientific article (publication date: 2011)

IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter

scientific article published on November 2006

Increased p21CIP1/WAF1and B Cell Lymphoma Leukemia-xLExpression and Reduced Apoptosis in Alveolar Macrophages from Smokers

scientific article published on 01 September 2002

Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ

scientific article

Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding

scientific article published on 19 February 2004

Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells

scientific article published on 2 September 2011

Passive smoking impairs histone deacetylase-2 in children with severe asthma.

scientific article published on February 2014

Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease

scientific article published on 24 September 2009

Steroid resistance in asthma: a major problem requiring novel solutions or a non-issue?

scientific article published on June 2004

Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor κB and c-Jun N-terminal kinase activation.

scientific article published on 18 July 2013

p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma

scientific article published on 14 September 2011

Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease

scientific article published on September 21, 2012

Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response.

scientific article

List of works by Kazuhiro Ito

Decreased histone deacetylase activity in chronic obstructive pulmonary disease

Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression

COPD as a disease of accelerated lung aging

Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.

A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.

Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase.

Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.

Expression and activity of histone deacetylases in human asthmatic airways

Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease

Update on glucocorticoid action and resistance

Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9.

Epigenetic regulation of airway inflammation.

Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy.

Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice

Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma

Effects of glucocorticoids on gene transcription

Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients

NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription

Accelerated ageing of the lung in COPD: new concepts.

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3.

Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease.

Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2.

Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma

Epigenetics and airways disease

Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer

A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition.

Kinase inhibitors and airway inflammation.

Histone deacetylation: an important mechanism in inflammatory lung diseases

Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease.

Cigarette smoke activates human monocytes by an oxidant-AP-1 signaling pathway: implications for steroid resistance

Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma

Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease

MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients.

Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma

IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter

Increased p21CIP1/WAF1and B Cell Lymphoma Leukemia-xLExpression and Reduced Apoptosis in Alveolar Macrophages from Smokers

Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ

Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding

Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells

Passive smoking impairs histone deacetylase-2 in children with severe asthma.

Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease

Steroid resistance in asthma: a major problem requiring novel solutions or a non-issue?

Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor κB and c-Jun N-terminal kinase activation.

p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma

Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease

Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response.