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List of works by Kazuhiro Ito

1335. Safety and Pharmacokinetic Profile of PC786, a Novel Inhibitor of Respiratory Syncytial Virus L-protein Polymerase, in a Single and Multiple-Ascending Dose Study in Healthy Volunteer and Mild Asthmatics

5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene

scientific article

A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.

scientific article

A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition.

scientific article

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9.

scientific article published on 17 April 2009

Accelerated ageing of the lung in COPD: new concepts.

scientific article

Activation of NF-kappaB transcription factor in asthma death

scientific article published in March 2009

Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers.

scientific article

Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease.

scientific article published in December 2005

Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus

scientific article published on 01 October 2019

Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.

scientific article

Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD.

scientific article

Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection

scientific article published on 01 July 2019

Association of air pollution exposure with exercise-induced oxygen desaturation in COPD

scientific article published on 31 March 2022

Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma.

scientific article published on 14 January 2015

COPD as a disease of accelerated lung aging

scientific article published on January 2009

Can we delay the accelerated lung aging in COPD? Anti-aging molecules and interventions

scientific article published on February 2013

Cigarette smoke activates human monocytes by an oxidant-AP-1 signaling pathway: implications for steroid resistance

scientific article

Comparison of Symbicort® versus Pulmicort® on steroid pharmacodynamic markers in asthma patients

scientific article

Correction: Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

scientific article published on 07 September 2018

Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase.

scientific article published on February 2004

Current approaches to the discovery of novel inhaled medicines

scientific article published on 20 May 2018

Decreased Serum Sirtuin-1 in COPD.

scientific article

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

scientific article

Decreased histone deacetylase activity in chronic obstructive pulmonary disease.

scientific article

Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD.

scientific article

Defect of adaptation to hypoxia in patients with COPD due to reduction of histone deacetylase 7

scientific article published on 15 December 2011

Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients

scientific article

Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma.

scientific article published on 25 November 2015

Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma

scientific article (publication date: 2011)

Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

scientific article

Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity

scientific article published on 01 May 2007

Differential patterns of histone acetylation in inflammatory bowel diseases

scientific article

Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.

scientific article published on 22 January 2016

Discovery of novel benzothienoazepine derivatives as potent inhibitors of respiratory syncytial virus

scientific article published on 23 March 2017

Effect of an inducible nitric oxide synthase inhibitor on differential flow-exhaled nitric oxide in asthmatic patients and healthy volunteers

scientific article

Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients

scientific article published on 21 August 2008

Effects of glucocorticoids on gene transcription

scientific article

Effects of intranasally dosed posaconazole on fungal load and biomarkers in Aspergillus fumigatus infected immunocompromised mice.

scientific article published on 11 July 2017

Epigenetic regulation of airway inflammation.

scientific article published on 27 August 2007

Epigenetics and airways disease

scientific article

Expression and activity of histone deacetylases in human asthmatic airways

scientific article published in August 2002

Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease ⬇️

scientific article published on September 21, 2012

Glucocorticoid pathways in chronic obstructive pulmonary disease therapy.

scientific article

Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy.

scientific article

Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma

scientific article published on 15 April 2004

Histone acetylation and histone deacetylation

scientific article

Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression

scientific article

Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils.

scientific article

Histone deacetylation: an important mechanism in inflammatory lung diseases

scientific article published on December 2005

Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.

scientific article published on 12 May 2008

Hypoxia-inducible factor 1alpha induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 transcription.

scientific article published on 30 October 2009

IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter

scientific article published on November 2006

Impact of protein acetylation in inflammatory lung diseases

scientific article published on 24 July 2007

Impaired Dual-Specificity Protein Phosphatase DUSP4 Reduces Corticosteroid Sensitivity.

scientific article published on 10 March 2017

In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection

scientific article

In Vitro and In Vivo Efficacy of a Novel and Long Acting Fungicidal Azole, PC1244 on Aspergillus fumigatus Infection.

scientific article published on 12 February 2018

In Vivo Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus fumigatus Infection in Immunocompromised Mice

scientific article published on 19 June 2017

In vitro antifungal activity of a novel topical triazole PC945 against emerging yeast Candida auris

scientific article published on 01 October 2019

Increased corticosteroid sensitivity by a long acting β2 agonist formoterol via β2 adrenoceptor independent protein phosphatase 2A activation

scientific article

Increased p21CIP1/WAF1and B Cell Lymphoma Leukemia-xLExpression and Reduced Apoptosis in Alveolar Macrophages from Smokers

scientific article published on 01 September 2002

Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice

scientific article published on 22 January 2009

Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding

scientific article published on 19 February 2004

Interactions between long-acting β2-agonists and glucocorticoids

scholarly article by Gaetano Caramori et al published September 2006 in Drug Discovery Today: Therapeutic Strategies

Interleukin-10 modulates pulmonary neutrophilic inflammation induced by cigarette smoke exposure

scientific article

Kinase inhibitors and airway inflammation.

scientific article

LABAs and p38MAPK Inhibitors Reverse the Corticosteroid-Insensitivity of IL-8 in Airway Smooth Muscle Cells of COPD

scientific article published on 22 November 2019

Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium.

scientific article

Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells

scientific article published on 2 September 2011

MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients.

scientific article published in September 2009

MicroRNA-570 is a novel regulator of cellular senescence and inflammaging

scientific article published on 29 August 2018

Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages

scientific article published on 18 July 2003

Mode of glucocorticoid actions in airway disease.

scientific article

Molecular mechanisms of respiratory virus-induced asthma and COPD exacerbations and pneumonia.

scientific article published on January 2006

NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription

scientific article published on January 2006

Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis.

scientific article

Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor

scientific article

New drugs targeting Th2 lymphocytes in asthma

scientific article

New insights into the molecular mechanisms of corticosteroids actions.

scientific article published on June 2006

Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2.

scientific article published on 3 May 2009

Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease

scientific article published on 24 September 2009

Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease

scientific article published on 28 September 2005

Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ

scientific article

Osteoprotegerin in sputum is a potential biomarker in COPD

scientific article published on 02 December 2010

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD.

scientific article

Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy

scientific article published on June 2007

Oxidative stress modulates theophylline effects on steroid responsiveness

scientific article published on 23 October 2008

PC945, a Novel Inhaled Antifungal Agent, for the Treatment of Respiratory Fungal Infections

scientific article published on 17 December 2020

Passive smoking impairs histone deacetylase-2 in children with severe asthma.

scientific article published on February 2014

Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine

scientific article published on 2 February 2009

Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor

scientific article published on 26 June 2017

Protein tyrosine phosphatase PTP-RR regulates corticosteroid sensitivity.

scientific article published on 24 March 2016

Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease

scientific article published on 11 December 2017

RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and -γ selectivity, suppresses COPD inflammation.

scientific article

Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response.

scientific article

Reduced HDAC2 in skeletal muscle of COPD patients

scientific article

Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure.

scientific article

Reduced denitration activity in peripheral lung of chronic obstructive pulmonary disease.

scientific article

Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3.

scientific article published on February 2007

Repeated lipopolysaccharide exposure causes corticosteroid insensitive airway inflammation via activation of phosphoinositide-3-kinase δ pathway

scientific article published on 28 July 2016

Reply to Rojas, "The Imperative Authentication of Cell Lines".

scientific article published on 24 October 2017

Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin

scientific article published on October 2015

Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma

scientific article (publication date: 2012)

Retraction notice to Kinase inhibitors and airway inflammation [Eur. J. Pharmacol 533/1-3 (2006) 118 – 132 of Kinase inhibitors and airway inflammation] ⬇️

scientific article published on May 15, 2012

Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor κB and c-Jun N-terminal kinase activation.

scientific article published on 18 July 2013

Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease

scientific article

STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects.

scientific article

Safety and Anti-viral Effects of Nebulized PC786 in a Respiratory Syncytial Virus Challenge Study

scientific article published on 20 November 2020

Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent

scientific article published on 01 February 2021

Sirtuin 1: Endocan and Sestrin 2 in Different Biological Samples in Patients with Asthma. Does Severity Make the Difference?

scientific article published on 09 February 2020

Sputum plasminogen activator inhibitor-1 elevation by oxidative stress-dependent nuclear factor-κB activation in COPD.

scientific article published in August 2013

Steroid resistance in asthma: a major problem requiring novel solutions or a non-issue?

scientific article published on June 2004

Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma

scientific article published on 12 May 2008

Superior anti-inflammatory effects of narrow-spectrum kinase inhibitors in airway smooth muscle cells from subjects with chronic obstructive pulmonary disease.

scientific article

Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease

scientific article

Targeting Th2 cells in asthmatic airways

scientific article published in September 2004

Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.

scientific article

The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure.

scientific article published on 6 March 2018

The role of antifungals in the management of patients with severe asthma

scientific article published on 06 November 2020

Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.

scientific article

Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease.

scientific article

Therapeutic targets for new therapy for corticosteroid refractory asthma

scientific article published on September 2009

Toll-like receptor 3 stimulation causes corticosteroid-refractory airway neutrophilia and hyperresponsiveness in mice.

scientific article published in July 2013

Transcription factors in asthma and COPD.

scientific article published in August 2004

Triamcinolone acetonide and dexamethasome suppress TNF-alpha-induced histone H4 acetylation on lysine residues 8 and 12 in mononuclear cells

scientific article

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer.

scientific article

Update on glucocorticoid action and resistance

scientific article published on 01 March 2006

Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach

scientific article published on 13 August 2020

[TNF-α Decreased Corticosteroid Responsiveness in Mice Models of Airway Inflammation Induced by Double Strand RNA and/or Tobacco Smoke Exposure]

scientific article published on 02 April 2019

[The Involvement of Src in Airway Inflammation Induced by Repeated Exposure to Lipopolysaccharide in Mice]

scientific article published on 13 June 2019

p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma

scientific article published on 14 September 2011

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