List of works - Kazuhiro Ito

Differential patterns of histone acetylation in inflammatory bowel diseases

scientific article

Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine

scientific article published on 2 February 2009

Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.

scientific article published on 12 May 2008

Impact of protein acetylation in inflammatory lung diseases

scientific article published on 24 July 2007

Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy

scientific article published on June 2007

Toll-like receptor 3 stimulation causes corticosteroid-refractory airway neutrophilia and hyperresponsiveness in mice.

scientific article published in July 2013

Glucocorticoid pathways in chronic obstructive pulmonary disease therapy.

scientific article

Hypoxia-inducible factor 1alpha induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 transcription.

scientific article published on 30 October 2009

New drugs targeting Th2 lymphocytes in asthma

scientific article

Increased corticosteroid sensitivity by a long acting β2 agonist formoterol via β2 adrenoceptor independent protein phosphatase 2A activation

scientific article

Histone acetylation and histone deacetylation

scientific article

Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages

scientific article published on 18 July 2003

Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin

scientific article published on October 2015

Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils.

scientific article

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD.

scientific article

Oxidative stress modulates theophylline effects on steroid responsiveness

scientific article published on 23 October 2008

Effect of an inducible nitric oxide synthase inhibitor on differential flow-exhaled nitric oxide in asthmatic patients and healthy volunteers

scientific article

Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients

scientific article published on 21 August 2008

Mode of glucocorticoid actions in airway disease

scientific article

Defect of adaptation to hypoxia in patients with COPD due to reduction of histone deacetylase 7

scientific article published on 15 December 2011

New insights into the molecular mechanisms of corticosteroids actions.

scientific article published on June 2006

Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor

scientific article

Molecular mechanisms of respiratory virus-induced asthma and COPD exacerbations and pneumonia.

scientific article published on January 2006

Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity

scientific article published on 01 May 2007

Sputum plasminogen activator inhibitor-1 elevation by oxidative stress-dependent nuclear factor-κB activation in COPD.

scientific article published in August 2013

Can we delay the accelerated lung aging in COPD? Anti-aging molecules and interventions

scientific article published on February 2013

Activation of NF-kappaB transcription factor in asthma death

scientific article published in March 2009

Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD.

scientific article

Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor

scientific article published on 26 June 2017

Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis.

scientific article

Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure.

scientific article

STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects.

scientific article

Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma.

scientific article published on 14 January 2015

Decreased Serum Sirtuin-1 in COPD.

scientific article

In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection

scientific article

Therapeutic targets for new therapy for corticosteroid refractory asthma

scientific article published on September 2009

Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.

scientific article published on 22 January 2016

Triamcinolone acetonide and dexamethasome suppress TNF-alpha-induced histone H4 acetylation on lysine residues 8 and 12 in mononuclear cells

scientific article

Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers.

scientific article

Comparison of Symbicort® versus Pulmicort® on steroid pharmacodynamic markers in asthma patients

scientific article

Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD.

scientific article

The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure.

scientific article published on 6 March 2018

5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene

scientific article

Current approaches to the discovery of novel inhaled medicines

scientific article published on 20 May 2018

Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma.

scientific article published on 25 November 2015

Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease

scientific article published on 11 December 2017

Osteoprotegerin in sputum is a potential biomarker in COPD

scientific article published on 02 December 2010

Targeting Th2 cells in asthmatic airways

scientific article published in September 2004

Interleukin-10 modulates pulmonary neutrophilic inflammation induced by cigarette smoke exposure

scientific article

RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and -γ selectivity, suppresses COPD inflammation.

scientific article

List of works by Kazuhiro Ito

Differential patterns of histone acetylation in inflammatory bowel diseases

Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine

Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.

Impact of protein acetylation in inflammatory lung diseases

Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy

Toll-like receptor 3 stimulation causes corticosteroid-refractory airway neutrophilia and hyperresponsiveness in mice.

Glucocorticoid pathways in chronic obstructive pulmonary disease therapy.

Hypoxia-inducible factor 1alpha induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 transcription.

New drugs targeting Th2 lymphocytes in asthma

Increased corticosteroid sensitivity by a long acting β2 agonist formoterol via β2 adrenoceptor independent protein phosphatase 2A activation

Histone acetylation and histone deacetylation

Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages

Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin

Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils.

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD.

Oxidative stress modulates theophylline effects on steroid responsiveness

Effect of an inducible nitric oxide synthase inhibitor on differential flow-exhaled nitric oxide in asthmatic patients and healthy volunteers

Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients

Mode of glucocorticoid actions in airway disease

Defect of adaptation to hypoxia in patients with COPD due to reduction of histone deacetylase 7

New insights into the molecular mechanisms of corticosteroids actions.

Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor

Molecular mechanisms of respiratory virus-induced asthma and COPD exacerbations and pneumonia.

Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity

Sputum plasminogen activator inhibitor-1 elevation by oxidative stress-dependent nuclear factor-κB activation in COPD.

Can we delay the accelerated lung aging in COPD? Anti-aging molecules and interventions

Activation of NF-kappaB transcription factor in asthma death

Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD.

Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor

Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis.

Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure.

STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects.

Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma.

Decreased Serum Sirtuin-1 in COPD.

In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection

Therapeutic targets for new therapy for corticosteroid refractory asthma

Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.

Triamcinolone acetonide and dexamethasome suppress TNF-alpha-induced histone H4 acetylation on lysine residues 8 and 12 in mononuclear cells

Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers.

Comparison of Symbicort® versus Pulmicort® on steroid pharmacodynamic markers in asthma patients

Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD.

The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure.

5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene

Current approaches to the discovery of novel inhaled medicines

Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma.

Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease

Osteoprotegerin in sputum is a potential biomarker in COPD

Targeting Th2 cells in asthmatic airways

Interleukin-10 modulates pulmonary neutrophilic inflammation induced by cigarette smoke exposure

RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and -γ selectivity, suppresses COPD inflammation.