Search filters

List of works by Christophe Benoist

A broad analysis of IL1 polymorphism and rheumatoid arthritis.

scientific article

A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis

scientific article published on 31 August 2009

A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice

scientific article

A combination of cyclophosphamide and interleukin-2 allows CD4+ T cells converted to Tregs to control scurfy syndrome

scientific article published on 01 April 2021

A common polymorphism near PER1 and the timing of human behavioral rhythms

scientific article

A decade of AIRE.

scientific article published on 20 July 2007

A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice

scientific article

A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus

scientific article

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

scientific article published on 09 September 2012

A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity

scientific article

A plaidoyer for 'systems immunology'.

scientific article

A shared gene-expression signature in innate-like lymphocytes

scientific article

A special population of regulatory T cells potentiates muscle repair

scientific article

AIRE and APECED: molecular insights into an autoimmune disease

scientific article

Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function

scientific article

Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog

scientific article

Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells

scientific article published on June 2007

Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells

scientific article published on 2 November 2018

Aire

scientific article published on January 2009

Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing γδ T Cells to Promote Immunologic Tolerance.

scientific article published on November 2016

Aire controls gene expression in the thymic epithelium with ordered stochasticity

scientific article

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.

scholarly article

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

scientific article published on 27 December 2011

Aire's partners in the molecular control of immunological tolerance

scientific article

Aire’s plant homeodomain(PHD)-2 is critical for induction of immunological tolerance ⬇️

scientific article published on January 14, 2013

Altered natural killer cells in type 1 diabetic patients.

scientific article

An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint

scientific article published on 01 May 2020

An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.

scientific article published on 23 February 2017

An N-Terminal Mutation of the Foxp3 Transcription Factor Alleviates Arthritis but Exacerbates Diabetes ⬇️

scientific article published on May 10, 2012

An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription

scientific article published on 16 January 2014

Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor–specified peripheral niche constraints ⬇️

scientific article published on August 2, 2010

Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response

scientific article

Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice

scientific article published on April 2015

Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPARγ effects

scientific article

Arthritis critically dependent on innate immune system players

scientific article published in February 2002

Arthritogenic monoclonal antibodies from K/BxN mice

scientific article

B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients.

scholarly article

Back to central tolerance

scientific article published on May 2004

Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells

scientific article

CD4+ teff cell heterogeneity: the perspective from single-cell transcriptomics

scientific article published on 04 April 2020

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion

scientific article

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice

scientific article

Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model

scientific article published on September 2007

Commercially available outbred mice for genome-wide association studies.

scientific article

Common genetic variants modulate pathogen-sensing responses in human dendritic cells

scientific article

Conservation and divergence in the transcriptional programs of the human and mouse immune systems

scientific article published on 4 February 2013

Consortium biology in immunology: the perspective from the Immunological Genome Project ⬇️

scientific article published on September 7, 2012

Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4 + T cells ⬇️

scientific article published on December 31, 2012

Correction: A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus.

scientific article published on 25 May 2011

Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity

scientific article published in November 2011

Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis

scientific article

Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells

scientific article

Danger-free autoimmune disease in Aire-deficient mice

scholarly article

Deep learning of immune cell differentiation

scientific article published on 25 September 2020

Defective central tolerance induction in NOD mice: genomics and genetics

scientific article published on 01 March 2005

Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model

scientific article

Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature

scientific article

Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells

scientific article published on 01 January 2020

Different molecular complexes that mediate transcriptional induction and repression by FoxP3.

scientific article published on 11 September 2017

Differential response of regulatory and conventional CD4⁺ lymphocytes to CD3 engagement: clues to a possible mechanism of anti-CD3 action?

scientific article published on 28 August 2013

Differential splicing across immune system lineages

scientific article published on 09 August 2013

Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

scientific article published on 10 August 2020

Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors

scientific article published on 01 May 2019

Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging

scientific article published on 26 February 2012

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated

scholarly article

Endocrine self and gut non-self intersect in the pancreatic lymph nodes

scientific article

Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut

scientific article

Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes

scholarly article

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

scientific article

Erratum: Consortium biology in immunology: the perspective from the Immunological Genome Project

scholarly article by Christophe Benoist et al published 4 July 2014 in Nature Reviews Immunology

FOXP3 controls regulatory T cell function through cooperation with NFAT

scientific article

Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet beta-cell-reactive T-cells

scientific article published on 01 November 2004

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas

scientific article (publication date: 2016)

Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.

scientific article published on 10 April 2017

Fluorescent exendin-4 derivatives for pancreatic β-cell analysis

scientific article

FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes.

scientific article published on 21 December 2017

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

scientific article published on 01 November 2007

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

scientific article published on July 2009

Gene expression microarrays: glimpses of the immunological genome.

scientific article

Genetic determinants of co-accessible chromatin regions in activated T cells across humans

scientific article published on 09 July 2018

Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy.

scientific article

Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice

scientific article

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

scientific article

Genomic responses to inflammation in mouse models mimic humans: we concur, apples to oranges comparisons won't do.

scientific article published on 24 December 2014

Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.

scientific article

Good riddance: Thymocyte clonal deletion prevents autoimmunity

scientific article published in April 2004

Green T(R) cells

scientific article published in March 2005

Gut immune maturation depends on colonization with a host-specific microbiota

scientific article

How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease

scientific article published on 18 March 2002

How defects in central tolerance impinge on a deficiency in regulatory T cells

scientific journal article

How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets

scientific article

IL-17-producing T cells can augment autoantibody-induced arthritis

scientific article

Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types

article published in the Proceedings of the National Academy of Sciences of the United States of America

Identification of transcriptional regulators in the mouse immune system

scientific article

Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice

scientific article

Imaging inflammation of the pancreatic islets in type 1 diabetes

scholarly article

Imaging the emergence and natural progression of spontaneous autoimmune diabetes.

scientific article published on 24 August 2017

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3.

scientific article

ImmVar project: Insights and design considerations for future studies of "healthy" immune variation

scientific article published on February 2015

Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance

scientific article

Immunology. Flow cytometry, amped up

scientific article published on 01 May 2011

Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).

scientific article published on 12 June 2008

Imputing gene expression from selectively reduced probe sets

scientific article

Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen

scholarly article

Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk.

scientific article

Interindividual variation in human T regulatory cells

scientific article published on 07 March 2014

Interleukin-4 can be a key positive regulator of inflammatory arthritis

scientific article published in June 2005

Intersection of population variation and autoimmunity genetics in human T cell activation

scientific article published on September 2014

Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution

scientific article

Lack of Foxp3 function and expression in the thymic epithelium

scientific article

Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis

scientific article

Levees of immunological tolerance

scientific article published on 17 December 2009

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity

scholarly article

Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders.

scientific article published in April 2003

Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected

scientific article published on 01 November 2007

MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells.

scientific article published on 13 August 2015

Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1

scholarly article

Mast cells in autoimmune disease

scientific article

Mast cells: a cellular link between autoantibodies and inflammatory arthritis

scientific article

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells

scholarly article

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

scientific article published on 25 December 2019

Microbiota and Autoimmune Disease: The Hosted Self ⬇️

scientific article published on October 20, 2011

Mining the Human Gut Microbiota for Immunomodulatory Organisms

scientific article

Modeling CTLA4-linked autoimmunity with RNA interference in mice

scholarly article

Modifier loci condition autoimmunity provoked by Aire deficiency

scientific article

Molecular diversification of regulatory T cells in nonlymphoid tissues

scientific article published on 01 September 2018

Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity

scientific article

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice.

scientific article

Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity

scientific article published on June 2009

Network pharmacology of JAK inhibitors

scientific article published on 11 August 2016

Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle

scientific article published on 26 February 2020

Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1

scientific article (publication date: March 2010)

Nobels: Toll pioneers deserve recognition

scientific article published on 9 November 2011

Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes

scientific article

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients

scientific article

Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients.

scientific article

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion

scientific article published on 15 February 2012

Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.

scientific article

Orientation bias of optically selected galaxy clusters and its impact on stacked weak-lensing analyses ⬇️

article

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells ⬇️

scientific article published on June 28, 2012

Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand

scientific article published on 01 December 2003

Parsing the Interferon Transcriptional Network and Its Disease Associations

scientific article published on January 2016

Particularities of the vasculature can promote the organ specificity of autoimmune attack.

scientific article published on 29 January 2006

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model ⬇️

scientific article published on November 17, 2003

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

scientific article published on May 2014

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

scientific article published on 9 February 2016

Population dynamics of islet-infiltrating cells in autoimmune diabetes.

scientific article

Profound Treg perturbations correlate with COVID-19 severity

scientific article published on 11 December 2020

Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview

scientific article

Projection of an immunological self shadow within the thymus by the aire protein

scientific article (publication date: 15 November 2002)

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

scientific article

Promiscuity Promotes Tolerance

scientific article published on 01 April 2016

Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny.

scientific article published on 22 August 2017

Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

scientific article published on 01 June 2018

Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice

scientific article published on June 2010

Rapid, high efficiency isolation of pancreatic ß-cells

scientific article

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2.

scientific article

Regulatory T cells in nonlymphoid tissues

scientific article

Regulatory T cells: recommendations to simplify the nomenclature.

scientific article published in April 2013

Regulatory T-cell differentiation: Committed to control: a precocious choice?

scientific article published on 20 February 2007

Response to Letter from Mucida et al

scholarly article by Jonathan A. Hill et al published April 2009 in Immunity

Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells

scientific article

Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis

scientific article

Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells

scientific article

Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes

scholarly article

Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4<sup>+</sup> T cell perturbations

scientific article published on 08 April 2021

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.

scientific article published on 12 February 2018

Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice

scientific article

Singular role for T-BET+CXCR3+ regulatory T cells in protection from autoimmune diabetes

scientific article

Stability of the regulatory T cell lineage in vivo.

scientific article

Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells

scientific article

Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity

scientific article published in September 2003

Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation.

scholarly article

T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33

scientific article published on 15 April 2019

T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle

scientific article published on 10 December 2019

T-cell compartments of prediabetic NOD mice

scientific article published on 01 February 2003

TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype

scientific article published on 07 June 2018

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets

scientific article

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

scientific article published on 18 February 2008

The Human Cell Atlas

scientific article

The Human Cell Atlas

The Human Cell Atlas White Paper ⬇️

journal article from 'arXiv:1810.05192 [q-bio]' published in 2018

The K/BxN arthritis model

scientific article published in May 2008

The K/BxN mouse model of inflammatory arthritis: theory and practice.

scientific article published in January 2007

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability

scientific article published on 30 October 2019

The XMM Cluster Survey: optical analysis methodology and the first data release

article

The cellular mechanism of Aire control of T cell tolerance.

scientific article

The cis-Regulatory Atlas of the Mouse Immune System

scientific article published on 24 January 2019

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

scholarly article

The immune system's involvement in obesity-driven type 2 diabetes

scientific article

The influence of the microbiota on type-1 diabetes: on the threshold of a leap forward in our understanding

scientific article published on January 2012

The molecular program induced in T cells undergoing homeostatic proliferation

scholarly article

The neuropeptide neuromedin U promotes autoantibody-mediated arthritis

scientific article

The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease

scientific article published on January 2004

The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice

scholarly article

The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms.

scientific article published on 15 September 2009

The transcriptional landscape of αβ T cell differentiation

scientific article

The transcriptional regulator Aire binds to and activates super-enhancers

scientific article published on 30 January 2017

The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription

scholarly article

Thymic negative selection is functional in NOD mice ⬇️

scientific article published on February 13, 2012

Tissue Tregs

scientific article published on May 2016

Tissular Tregs: A unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism ⬇️

scientific article published on 02 July 2011

Transcriptional impact of Aire varies with cell type

scholarly article

Transcriptomes of the B and T Lineages Compared by Multiplatform Microarray Profiling ⬇️

scientific article published on February 9, 2011

Treg Cells, Life History, and Diversity ⬇️

scientific article published on September 1, 2012

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses

scientific article

Treg cells limit IFN-γ production to control macrophage accrual and phenotype during skeletal muscle regeneration

scientific article published on 23 February 2018

Treg cells: guardians for life

scientific article published on 01 February 2007

Unstable FoxP3+ T regulatory cells in NZW mice

scientific article published on 14 January 2016

Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains

scientific article

Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice

scientific article

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

scientific journal article

Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis

article

Paulina is supported by:

About Paulina

Help