List of works - Lawrence J. Marnett

Identification and functional characterization of brainstem cannabinoid CB2 receptors

scientific article

Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides

scientific article published on 19 September 2002

Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways

scientific article published on September 19, 2011

Systems Analysis of Protein Modification and Cellular Responses Induced by Electrophile Stress

scientific article published on May 18, 2010

Aberrant cannabinoid signaling impairs oviductal transport of embryos

scientific article published on 19 September 2004

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385

scientific article

Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen

scientific article

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

scientific article

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

scientific article published on November 1, 2011

Identifying mechanism-of-action targets for drugs and probes.

scientific article

Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala.

scientific article

The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase

scientific article in 2003

Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid

scientific article

Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents

scientific article

Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

scientific article

Fatty acid amide hydrolase deficiency limits early pregnancy events

scientific article

The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells

scholarly article

Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde

scientific article published on November 5, 2003

Cannabinoids, endocannabinoids, and cancer

scientific article

Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation

scientific article

Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation

scientific article

Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2.

scientific article

Chemical stability of 2-arachidonylglycerol under biological conditions

scientific article published in October 2002

Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349

scientific article in 2002

Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

scientific article

Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis

scientific article

Fluorinated COX-2 Inhibitors as Agents in PET Imaging of Inflammation and Cancer

scientific article published on September 7, 2011

Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation

scientific article published on 28 November 2006

Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides

scientific article

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

scientific article published on 3 September 2016

Measurement of the malondialdehyde-2'-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

scientific article

Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase

scientific article (publication date: April 2002)

In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG.

scholarly article

Identification of the protein targets of the reactive metabolite of teucrin A in vivo in the rat.

scientific article

Structure of an oligodeoxynucleotide containing a 1,N(2)-propanodeoxyguanosine adduct positioned in a palindrome derived from the Salmonella typhimurium hisD3052 gene: Hoogsteen pairing at pH 5.2

scientific article

Genetic loss of Faah compromises male fertility in mice

scientific article

Design, Synthesis, and Structure–Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase-2 as Targeted Optical Imaging Agents

scientific article published on March 28, 2013

Structure and Stereochemical Determination of Hypogeamicins from a Cave-Derived Actinomycete.

scientific article

Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry

scientific article

Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors

scientific article published on 19 September 2005

Conjugation of cisplatin analogues and cyclooxygenase inhibitors to overcome cisplatin resistance.

scientific article

Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes

scientific article

Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network

scientific article

Structural and Functional Analysis of Sulfolobus solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde−Deoxyguanosine Adduct ,

scientific article

Insertion of dNTPs Opposite the 1, N 2 -Propanodeoxyguanosine Adduct by Sulfolobus solfataricus P2 DNA Polymerase IV † ‡

scientific article

Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors

scientific article published in February 2002

NMDA-induced seizure intensity is enhanced in COX-2 deficient mice

scientific article

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure

scientific article

123I-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation

scientific article published on November 12, 2010

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics

scientific article published on 5 April 2017

List of works by Lawrence J. Marnett

Identification and functional characterization of brainstem cannabinoid CB2 receptors

Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides

Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways

Systems Analysis of Protein Modification and Cellular Responses Induced by Electrophile Stress

Aberrant cannabinoid signaling impairs oviductal transport of embryos

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385

Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

Identifying mechanism-of-action targets for drugs and probes.

Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala.

The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase

Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid

Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents

Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

Fatty acid amide hydrolase deficiency limits early pregnancy events

The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells

Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde

Cannabinoids, endocannabinoids, and cancer

Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation

Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation

Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2.

Chemical stability of 2-arachidonylglycerol under biological conditions

Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349

Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis

Fluorinated COX-2 Inhibitors as Agents in PET Imaging of Inflammation and Cancer

Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation

Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

Measurement of the malondialdehyde-2'-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase

In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG.

Identification of the protein targets of the reactive metabolite of teucrin A in vivo in the rat.

Structure of an oligodeoxynucleotide containing a 1,N(2)-propanodeoxyguanosine adduct positioned in a palindrome derived from the Salmonella typhimurium hisD3052 gene: Hoogsteen pairing at pH 5.2

Genetic loss of Faah compromises male fertility in mice

Design, Synthesis, and Structure–Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase-2 as Targeted Optical Imaging Agents

Structure and Stereochemical Determination of Hypogeamicins from a Cave-Derived Actinomycete.

Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry

Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors

Conjugation of cisplatin analogues and cyclooxygenase inhibitors to overcome cisplatin resistance.

Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes

Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network

Structural and Functional Analysis of Sulfolobus solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde−Deoxyguanosine Adduct ,

Insertion of dNTPs Opposite the 1, N 2 -Propanodeoxyguanosine Adduct by Sulfolobus solfataricus P2 DNA Polymerase IV † ‡

Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors

NMDA-induced seizure intensity is enhanced in COX-2 deficient mice

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure

123I-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics