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List of works by Lawrence J. Marnett

(R)-N-(1-Methyl-2-hydroxyethyl)-13-(S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes

scientific article published on 21 September 2018

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2 ⬇️

scientific article published on November 1, 2011

123I-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation ⬇️

scientific article published on November 12, 2010

13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase

scientific article

2-Carbaborane-3-phenyl-1H-indoles--synthesis via McMurry reaction and cyclooxygenase (COX) inhibition activity.

scientific article published on 09 January 2013

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385

scientific article

Aberrant cannabinoid signaling impairs oviductal transport of embryos

scientific article published on 19 September 2004

Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer

scientific article published on 4 May 2015

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics

scientific article published on 5 April 2017

Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2.

scientific article published on 30 March 2015

Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors

scientific article published in February 2002

Analysis of endocannabinoids, their congeners and COX-2 metabolites

scientific article published on 21 May 2009

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

scientific article published on 3 September 2016

Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors

scientific article

Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication

scientific article (publication date: May 2003)

Assay of Endocannabinoid Oxidation by Cyclooxygenase-2.

scientific article published on January 2016

Cannabinoids, endocannabinoids, and cancer

scientific article

Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry

scientific article

Characterization of an AM404 analogue, N-(3-hydroxyphenyl)arachidonoylamide, as a substrate and inactivator of prostaglandin endoperoxide synthase

scientific article

Chemical stability of 2-arachidonylglycerol under biological conditions

scientific article published in October 2002

Conjugates of cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming cisplatin resistance.

scientific article

Conjugation of cisplatin analogues and cyclooxygenase inhibitors to overcome cisplatin resistance.

scientific article

Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics

scientific article

Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349

scientific article in 2002

Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis

scientific article

Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2′-Des-methyl-sulindac Sulfide Scaffold ⬇️

scientific article published on February 14, 2012

Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.

scientific article

Design, Synthesis, and Structure–Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase-2 as Targeted Optical Imaging Agents ⬇️

scientific article published on March 28, 2013

Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain

scientific article published on 09 May 2018

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

scientific article

Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

scientific article

Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation

scientific article published on 28 November 2006

Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid

scientific article

Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer

scientific article published on 24 May 2019

Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site

scientific article

Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers

scientific article published on 16 May 2013

Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition.

scientific article published on 15 December 2016

Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways ⬇️

scientific article published on September 19, 2011

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure

scientific article

Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib

scientific article

Fatty acid amide hydrolase deficiency limits early pregnancy events

scientific article

Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site

scientific article published on 18 April 2019

Fluorescent probes of the apoptolidins and their utility in cellular localization studies

scientific article

Fluorinated COX-2 Inhibitors as Agents in PET Imaging of Inflammation and Cancer ⬇️

scientific article published on September 7, 2011

Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization

scientific article

Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer

scientific article

Functional Implications of Biochemical and Molecular Characteristics of Donation After Circulatory Death Livers

scientific article published on 15 June 2015

Functional analysis of the molecular determinants of cyclooxygenase-2 acetylation by 2-acetoxyphenylhept-2-ynyl sulfide

scientific article

Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation

scientific article

Genetic loss of Faah compromises male fertility in mice

scientific article

Harmaline Analogs as Substrate-Selective Cyclooxygenase-2 Inhibitors

scientific article published on 14 February 2020

High-Throughput Quantification of Bioactive Lipids by MALDI Mass Spectrometry: Application to Prostaglandins ⬇️

scientific article published on September 1, 2011

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid

scientific article

IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain

scientific article published on 01 July 2019

Identification and functional characterization of brainstem cannabinoid CB2 receptors

scientific article

Identification of the protein targets of the reactive metabolite of teucrin A in vivo in the rat.

scientific article

Identifying mechanism-of-action targets for drugs and probes.

scientific article

In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG.

scholarly article

Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors

scientific article published on 19 September 2005

Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde ⬇️

scientific article published on November 5, 2003

Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice

scientific article published in August 2005

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

scientific article published on 23 August 2016

Insertion of dNTPs Opposite the 1, N 2 -Propanodeoxyguanosine Adduct by Sulfolobus solfataricus P2 DNA Polymerase IV † ‡

scientific article

Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry ⬇️

scientific article

Measurement of the malondialdehyde-2'-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

scientific article

Metabolism in vitro and in vivo of the DNA base adduct, M1G.

scientific article

Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides

scientific article published on 19 September 2002

Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen

scientific article

NMDA-induced seizure intensity is enhanced in COX-2 deficient mice

scientific article

Nuclear Oxidation of a Major Peroxidation DNA Adduct, M1dG, in the Genome

scientific article published on 15 October 2015

Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network

scientific article

Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond

scientific article

Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine

scientific article published on March 2008

PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.

scientific article

Podophyllotoxin analogues active versus Trypanosoma brucei

scientific article

Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A.

scientific article

Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6

scientific article

Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.

scientific article published on 14 June 2017

Protein modification by adenine propenal

scientific article

Quantitative Analysis and Discovery of Lysine and Arginine Modifications.

scientific article published on 16 December 2016

RNA-seq data analysis at the gene and CDS levels provides a comprehensive view of transcriptome responses induced by 4-hydroxynonenal

scientific article

Recent developments in cyclooxygenase inhibition

scientific article (publication date: August 2002)

Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase

scientific article (publication date: April 2002)

Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala.

scientific article

Seeing it through: translational validation of new medical imaging modalities

scientific article

Selection of Monoclonal Antibodies Against 6-oxo-M1dG and Their Use in an LC-MS/MS Assay for the Presence of 6-oxo-M1dG in Vivo ⬇️

scientific article published on January 24, 2012

Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2.

scientific article

Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents

scientific article

Structural and Chemical Biology of the Interaction of Cyclooxygenase with Substrates and Non-Steroidal Anti-Inflammatory Drugs

scientific article published on 01 July 2020

Structural and Functional Analysis of Sulfolobus solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde−Deoxyguanosine Adduct ,

scientific article

Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides

scientific article

Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2alpha glyceryl esters in RAW 264.7 cells and H1819 cells

scientific article published on 10 February 2010

Structure and Stereochemical Determination of Hypogeamicins from a Cave-Derived Actinomycete. ⬇️

scientific article

Structure of an oligodeoxynucleotide containing a 1,N(2)-propanodeoxyguanosine adduct positioned in a palindrome derived from the Salmonella typhimurium hisD3052 gene: Hoogsteen pairing at pH 5.2

scientific article

Structure of the 1,N(2)-propanodeoxyguanosine adduct in a three-base DNA hairpin loop derived from a palindrome in the Salmonella typhimurium hisD3052 gene

scientific article

Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites

scientific article

Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes

scientific article

Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation

scientific article

Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

scientific article

Systems analysis of protein modification and cellular responses induced by electrophile stress

scientific article

Targeted Detection of Cyclooxygenase-1 in Ovarian Cancer

scientific article published on 24 July 2019

Targeted imaging of cancer by fluorocoxib C, a near-infrared cyclooxygenase-2 probe

scientific article published on May 2015

The 2′-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor ⬇️

scientific article published on March 25, 2013

The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells

scholarly article

The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives

scientific article published on 23 April 2009

The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase

scientific article in 2003

Total Synthesis of (+)-7-Bromotrypargine and Unnatural Analogues: Biological Evaluation Uncovers Activity at CNS Targets of Therapeutic Relevance ⬇️

scientific article published on November 16, 2011

Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs

scientific article

Trifluoromethyl fluorocoxib a detects cyclooxygenase-2 expression in inflammatory tissues and human tumor xenografts

scientific article

nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2

scientific article published on 18 June 2015

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