List of works - Lawrence J. Marnett

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

scientific article published on 23 August 2016

nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2

scientific article published on 18 June 2015

The 2′-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor

scientific article published on March 25, 2013

Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2alpha glyceryl esters in RAW 264.7 cells and H1819 cells

scientific article published on 10 February 2010

Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2.

scientific article published on 30 March 2015

Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2′-Des-methyl-sulindac Sulfide Scaffold

scientific article published on February 14, 2012

Analysis of endocannabinoids, their congeners and COX-2 metabolites

scientific article published on 21 May 2009

Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer

scientific article published on 4 May 2015

Metabolism in vitro and in vivo of the DNA base adduct, M1G.

scientific article

13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase

scientific article

High-Throughput Quantification of Bioactive Lipids by MALDI Mass Spectrometry: Application to Prostaglandins

scientific article published on September 1, 2011

Conjugates of cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming cisplatin resistance.

scientific article

Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs

scientific article

Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.

scientific article published on 14 June 2017

Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A.

scientific article

Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers

scientific article published on 16 May 2013

Recent developments in cyclooxygenase inhibition

scientific article (publication date: August 2002)

Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine

scientific article published on March 2008

Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2.

scientific article

Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer

scientific article published on March 21, 2016

Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6

scientific article

IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain

scientific article published on 01 July 2019

RNA-seq data analysis at the gene and CDS levels provides a comprehensive view of transcriptome responses induced by 4-hydroxynonenal

scientific article

Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.

scientific article

Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain

scientific article published on 09 May 2018

Total Synthesis of (+)-7-Bromotrypargine and Unnatural Analogues: Biological Evaluation Uncovers Activity at CNS Targets of Therapeutic Relevance

scientific article published on November 16, 2011

Structure of the 1,N(2)-propanodeoxyguanosine adduct in a three-base DNA hairpin loop derived from a palindrome in the Salmonella typhimurium hisD3052 gene

scientific article

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid

scientific article

Fluorescent probes of the apoptolidins and their utility in cellular localization studies

scientific article

Seeing it through: translational validation of new medical imaging modalities

scientific article

2-Carbaborane-3-phenyl-1H-indoles--synthesis via McMurry reaction and cyclooxygenase (COX) inhibition activity.

scientific article published on 09 January 2013

Trifluoromethyl Fluorocoxib A Detects Cyclooxygenase-2 Expression in Inflammatory Tissues and Human Tumor Xenografts

scientific article published on January 23, 2014

Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond

scientific article

PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.

scientific article

Selection of Monoclonal Antibodies Against 6-oxo-M1dG and Their Use in an LC-MS/MS Assay for the Presence of 6-oxo-M1dG in Vivo

scientific article published on January 24, 2012

Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry

scientific article

Nuclear Oxidation of a Major Peroxidation DNA Adduct, M1dG, in the Genome

scientific article published on November 11, 2015

Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib

scientific article

Protein Modification by Adenine Propenal

scientific article published on September 24, 2014

Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site

scientific article

The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives

scientific article published on 23 April 2009

Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice

scientific article published in August 2005

Targeted imaging of cancer by fluorocoxib C, a near-infrared cyclooxygenase-2 probe

scientific article published on May 2015

Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication

scientific article (publication date: May 2003)

Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors

scientific article

(R)-N-(1-Methyl-2-hydroxyethyl)-13-(S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes

scientific article published on 21 September 2018

Assay of Endocannabinoid Oxidation by Cyclooxygenase-2.

scientific article published on January 2016

Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites

scientific article

Podophyllotoxin analogues active versus Trypanosoma brucei

scientific article

Quantitative Analysis and Discovery of Lysine and Arginine Modifications.

scientific article published on 16 December 2016

List of works by Lawrence J. Marnett

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2

The 2′-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor

Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2alpha glyceryl esters in RAW 264.7 cells and H1819 cells

Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2.

Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2′-Des-methyl-sulindac Sulfide Scaffold

Analysis of endocannabinoids, their congeners and COX-2 metabolites

Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer

Metabolism in vitro and in vivo of the DNA base adduct, M1G.

13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase

High-Throughput Quantification of Bioactive Lipids by MALDI Mass Spectrometry: Application to Prostaglandins

Conjugates of cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming cisplatin resistance.

Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs

Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.

Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A.

Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers

Recent developments in cyclooxygenase inhibition

Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine

Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2.

Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer

Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6

IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain

RNA-seq data analysis at the gene and CDS levels provides a comprehensive view of transcriptome responses induced by 4-hydroxynonenal

Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.

Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain

Total Synthesis of (+)-7-Bromotrypargine and Unnatural Analogues: Biological Evaluation Uncovers Activity at CNS Targets of Therapeutic Relevance

Structure of the 1,N(2)-propanodeoxyguanosine adduct in a three-base DNA hairpin loop derived from a palindrome in the Salmonella typhimurium hisD3052 gene

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid

Fluorescent probes of the apoptolidins and their utility in cellular localization studies

Seeing it through: translational validation of new medical imaging modalities

2-Carbaborane-3-phenyl-1H-indoles--synthesis via McMurry reaction and cyclooxygenase (COX) inhibition activity.

Trifluoromethyl Fluorocoxib A Detects Cyclooxygenase-2 Expression in Inflammatory Tissues and Human Tumor Xenografts

Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond

PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.

Selection of Monoclonal Antibodies Against 6-oxo-M1dG and Their Use in an LC-MS/MS Assay for the Presence of 6-oxo-M1dG in Vivo

Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry

Nuclear Oxidation of a Major Peroxidation DNA Adduct, M1dG, in the Genome

Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib

Protein Modification by Adenine Propenal

Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site

The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives

Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice

Targeted imaging of cancer by fluorocoxib C, a near-infrared cyclooxygenase-2 probe

Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication

Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors

(R)-N-(1-Methyl-2-hydroxyethyl)-13-(S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes

Assay of Endocannabinoid Oxidation by Cyclooxygenase-2.

Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites

Podophyllotoxin analogues active versus Trypanosoma brucei

Quantitative Analysis and Discovery of Lysine and Arginine Modifications.