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List of works by Christine M. Lovly

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ROS1 rearrangements define a unique molecular class of lung cancers

scientific article
Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 Blockade

scientific article published on 26 September 2016
Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.

scientific article
Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer

scientific article
Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer

scientific article
Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.

scientific article
Extended Survival and Prognostic Factors for Patients With ALK-Rearranged Non-Small-Cell Lung Cancer and Brain Metastasis.

scientific article published on 05 October 2015
Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions

scientific article
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.

scientific article published on 24 August 2015
Therapeutic targeting of anaplastic lymphoma kinase in lung cancer: a paradigm for precision cancer medicine.

scientific article published on May 2015
Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors

scientific article
ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.

scientific article
Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials

scientific article (publication date: 2012)
Molecular pathways: resistance to kinase inhibitors and implications for therapeutic strategies

scientific article published on May 2014
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids

scientific article
Heterogeneous mechanisms of primary and acquired resistance to third-generation EGFR inhibitors

scientific article published on June 2016
An Acquired HER2T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer

scientific article
Impact of NRAS mutations for patients with advanced melanoma treated with immune therapies

scientific article
Characteristics of lung cancers harboring NRAS mutations

scientific article (publication date: May 2013)
Escaping ALK inhibition: mechanisms of and strategies to overcome resistance

scientific article published in February 2012
Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade

scientific article
The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas

scholarly article
Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation

scientific article
Enabling a genetically informed approach to cancer medicine: a retrospective evaluation of the impact of comprehensive tumor profiling using a targeted next-generation sequencing panel

scientific article
Therapeutic strategies utilized in the setting of acquired resistance to EGFR tyrosine kinase inhibitors

scientific article
Impact of EML4-ALK Variant on Resistance Mechanisms and Clinical Outcomes in ALK-Positive Lung Cancer.

scientific article published on 26 January 2018
Translating genomic information into clinical medicine: lung cancer as a paradigm

scientific article
MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking

scientific article
EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib

scientific article
Survivorship in Immune Therapy: Assessing Chronic Immune Toxicities, Health Outcomes, and Functional Status among Long-term Ipilimumab Survivors at a Single Referral Center.

scientific article published on 3 February 2015
Beyond histology: translating tumor genotypes into clinically effective targeted therapies

scientific article
EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer

scientific article published on 7 January 2016
Lung cancer in 2010: One size does not fit all.

scientific article published on February 2011
EGFR Fusions as Novel Therapeutic Targets in Lung Cancer

scientific article published on 21 April 2016
Accurate mass-driven analysis for the characterization of protein phosphorylation. Study of the human Chk2 protein kinase

scientific article published in April 2006
SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer

scientific article published on 17 April 2017
Mechanisms of receptor tyrosine kinase activation in cancer

scientific article
Prognostic impact of KRAS mutation subtypes in 677 patients with metastatic lung adenocarcinomas

scientific article published on March 2015
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379

scientific article
Ensartinib (X-396) in ALK-Positive Non-Small Cell Lung Cancer: Results from a First-in-Human Phase I/II, Multicenter Study.

scientific article published on 21 March 2018
Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse

scientific article
Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors

scientific article
Emergence of FGFR3-TACC3 fusions as a potential by-pass resistance mechanism to EGFR tyrosine kinase inhibitors in EGFR mutated NSCLC patients

scientific article published on 11 July 2017
Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer

scientific article
The Path(way) Less Traveled: A Pathway-Oriented Approach to Providing Information about Precision Cancer Medicine on My Cancer Genome

scientific article published on April 2016
Correlation between KRAS mutation status and response to chemotherapy in patients with advanced non-small cell lung cancer☆.

scientific article published on 10 November 2015
YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics

scientific article published on 6 June 2018
Guiding Oncology Patients Through the Maze of Precision Medicine

scientific article
Anaplastic Lymphoma Kinase as a Therapeutic Target in Non-Small Cell Lung Cancer

scientific article published on September 2015
Quantifying Drug Combination Synergy along Potency and Efficacy Axes

scientific article published on 20 February 2019

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