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List of works by Christine M. Lovly

A 75-year-old man with progressive bronchioalveolar carcinoma

scientific article published in February 2013

A Review of Immunotherapy for Stage III and Metastatic Non‐Small Cell Lung Cancer and the Rationale for the ECOG‐ACRIN EA5181 Study

journal article

A patient with metastatic lung adenocarcinoma harboring concurrent EGFR L858R, EGFR germline T790M, and PIK3CA mutations: the challenge of interpreting results of comprehensive mutational testing in lung cancer

scientific article

ALK Fusion Partners Impact Response to ALK Inhibition: Differential Effects on Sensitivity, Cellular Phenotypes, and Biochemical Properties

scientific article published on 12 July 2018

ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.

scientific article

Accurate mass-driven analysis for the characterization of protein phosphorylation. Study of the human Chk2 protein kinase

scientific article published in April 2006

An Acquired HER2T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer.

scientific article

Anaplastic Lymphoma Kinase as a Therapeutic Target in Non-Small Cell Lung Cancer

scientific article published on September 2015

BRAF internal deletions and resistance to BRAF/MEK inhibitor therapy.

scientific article published on 24 November 2017

Beyond histology: translating tumor genotypes into clinically effective targeted therapies

scientific article

COVID-19 and immune checkpoint inhibitors: initial considerations

scientific article published on 01 May 2020

Characteristics of lung cancers harboring NRAS mutations

scientific article (publication date: May 2013)

Combating acquired resistance to tyrosine kinase inhibitors in lung cancer

scientific article

Correction: An Acquired HER2 T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer

scientific article published on 01 February 2019

Correlation between KRAS mutation status and response to chemotherapy in patients with advanced non-small cell lung cancer☆.

scientific article published on 10 November 2015

Cracking the Code of Resistance across Multiple Lines of ALK Inhibitor Therapy in Lung Cancer

scientific article published on October 2016

Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.

scientific article

EGFR Fusions as Novel Therapeutic Targets in Lung Cancer

scientific article published on 21 April 2016

EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib

scientific article

EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer

scientific article published on 7 January 2016

Emergence of FGFR3-TACC3 fusions as a potential by-pass resistance mechanism to EGFR tyrosine kinase inhibitors in EGFR mutated NSCLC patients.

scientific article published on 11 July 2017

Enabling a genetically informed approach to cancer medicine: a retrospective evaluation of the impact of comprehensive tumor profiling using a targeted next-generation sequencing panel

scientific article

Ensartinib (X-396) in ALK-Positive Non-Small Cell Lung Cancer: Results from a First-in-Human Phase I/II, Multicenter Study.

scientific article published on 21 March 2018

Escaping ALK inhibition: mechanisms of and strategies to overcome resistance.

scientific article published in February 2012

Established, emerging, and elusive molecular targets in the treatment of lung cancer.

scientific article published on 17 January 2018

Expanding Access to Lung Cancer Clinical Trials by Reducing the Use of Restrictive Exclusion Criteria: Perspectives of a Multistakeholder Working Group

scientific article published on 26 February 2020

Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors.

scientific article

Extended Survival and Prognostic Factors for Patients With ALK-Rearranged Non-Small-Cell Lung Cancer and Brain Metastasis.

scientific article published on 05 October 2015

Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids

scientific article

Genomic landscape of a metastatic malignant proliferating tricholemmal tumor and its response to PI3K inhibition

scientific article published on 15 February 2019

Guiding Oncology Patients Through the Maze of Precision Medicine

scientific article

Heterogeneous mechanisms of primary and acquired resistance to third-generation EGFR inhibitors

scientific article published on June 2016

Identification of protein phosphorylation sites within Ser/Thr-rich cluster domains using site-directed mutagenesis and hybrid linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry

scientific article published in January 2007

Identifying a Clinically Applicable Mutational Burden Threshold as a Potential Biomarker of Response to Immune Checkpoint Therapy in Solid Tumors

scientific article published on 07 December 2017

Impact of EML4-ALK Variant on Resistance Mechanisms and Clinical Outcomes in ALK-Positive Lung Cancer.

scientific article published on 26 January 2018

Impact of NRAS mutations for patients with advanced melanoma treated with immune therapies

scientific article

Improved Prognosis and Increased Tumor-Infiltrating Lymphocytes in Patients Who Have SCLC With Neurologic Paraneoplastic Syndromes

scientific article published on 12 June 2019

Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions

scientific article

Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors

scientific article

Liquid biopsies reveal the dynamic nature of resistance mechanisms in solid tumors

scientific article published on 01 July 2015

Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse

scientific article

Lung cancer in 2010: One size does not fit all.

scientific article published on February 2011

MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking

scientific article

MINI01.02: Response and Plasma Genotyping from Phase I/II Trial of Ensartinib (X-396) in Patients (pts) with ALK+ NSCLC: Topic: Medical Oncology

scientific article

Major milestones in translational oncology.

scientific article published on 28 July 2016

Managing Resistance to EFGR- and ALK-Targeted Therapies

scientific article published on January 2017

Mechanisms of receptor tyrosine kinase activation in cancer

scientific article

Melanoma driver mutations and immune therapy

scientific article published on 10 March 2016

Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.

scientific article

Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade

scientific article

Molecular pathways: resistance to kinase inhibitors and implications for therapeutic strategies

scientific article published on May 2014

Monitoring Therapeutic Response and Resistance: Analysis of Circulating Tumor DNA in Patients With ALK+ Lung Cancer

scientific article published on 22 August 2019

My Cancer Genome: Evaluating an Educational Model to Introduce Patients and Caregivers to Precision Medicine Information

scientific article published on 20 July 2016

N-[18F]-Fluoroacetylcrizotinib: A potentially potent and selective PET tracer for molecular imaging of non-small cell lung cancer

scientific article published on 02 June 2020

NCCN Working Group report: designing clinical trials in the era of multiple biomarkers and targeted therapies

scientific article

New Approaches to SCLC Therapy: From the Laboratory to the Clinic

scientific article published on 01 February 2020

On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation

scientific article published on 22 February 2019

Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer

scientific article

P1.44 (also presented as PD2.02): Phase I/II Trial of X-396, A Novel ALK Inhibitor, in Patients With ALK+ NSCLC: Track: Advanced NSCLC.

scientific article

PD2.02 (also presented as P1.44): Phase I/II Trial of X-396, a Novel ALK Inhibitor, in Patients With ALK+ NSCLC.

scientific article

Prognostic impact of KRAS mutation subtypes in 677 patients with metastatic lung adenocarcinomas

scientific article published on March 2015

Quantifying Drug Combination Synergy along Potency and Efficacy Axes

scientific article published on 20 February 2019

RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.

scientific article published on 24 August 2015

ROS1 rearrangements define a unique molecular class of lung cancers

scientific article

Rapidly fatal pneumonitis from immunotherapy and concurrent SARS-CoV-2 infection in a patient with newly diagnosed lung cancer

scientific article published on 02 May 2020

Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer

scientific article

Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379

scientific article

Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation

scientific article

Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials

scientific article (publication date: 2012)

SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer

scientific article published on 17 April 2017

Sequencing Therapy for Genetically Defined Subgroups of Non-Small Cell Lung Cancer

scientific article published on 01 May 2018

Shades of T790M: Intratumor Heterogeneity in EGFR-Mutant Lung Cancer

scientific article published in July 2015

Small Cell Lung Cancer Transformation as a Mechanism of Resistance to PD-1 Therapy in KRAS-Mutant Lung Adenocarcinoma: A Report of Two Cases

scientific article published on 10 December 2018

Somatic Genomic Testing in Patients With Metastatic or Advanced Cancer: ASCO Provisional Clinical Opinion

scientific article published on 17 February 2022

Stop fRETting the Target: Next-Generation RET Inhibitors Have Arrived

scientific article published on 01 July 2018

Strategies for overcoming EGFR resistance in the treatment of advanced-stage NSCLC

scientific article published on 01 December 2012

Survivorship in Immune Therapy: Assessing Chronic Immune Toxicities, Health Outcomes, and Functional Status among Long-term Ipilimumab Survivors at a Single Referral Center.

scientific article published on 3 February 2015

Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 Blockade

scientific article published on 26 September 2016

Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer

scientific article

The Pan-Cancer Landscape of Coamplification of the Tyrosine Kinases KIT, KDR, and PDGFRA

scientific article published on 11 October 2019

The Path(way) Less Traveled: A Pathway-Oriented Approach to Providing Information about Precision Cancer Medicine on My Cancer Genome

scientific article published on April 2016

The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas

scholarly article

Therapeutic strategies utilized in the setting of acquired resistance to EGFR tyrosine kinase inhibitors

scientific article

Therapeutic targeting of anaplastic lymphoma kinase in lung cancer: a paradigm for precision cancer medicine.

scientific article published on May 2015

Translating genomic information into clinical medicine: lung cancer as a paradigm

scientific article

Tumor Heterogeneity and Therapeutic Resistance

scientific article published on January 2016

Update on HER1-3 in advanced non-small-cell lung cancer

scientific article

Variable Response to ALK Inhibitors in NSCLC with a Novel MYT1L-ALK Fusion

scientific article published on 01 February 2019

Vitamin D3 Metabolites Demonstrate Prognostic Value in EGFR-Mutant Lung Adenocarcinoma and Can be Deployed to Oppose Acquired Therapeutic Resistance

scientific article published on 13 March 2020

Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition

scientific article published on 17 June 2020

YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.

scientific article published on 6 June 2018

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