List of works - Sebastian Kügler

A MicroRNA124 Target Sequence Restores Astrocyte Specificity of gfaABC1D-Driven Transgene Expression in AAV-Mediated Gene Transfer.

scientific article published on 6 April 2017

A dual‐AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice

scientific article published on 01 January 2019

A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.

scientific article published on 24 June 2011

AAV-mediated expression of BAG1 and ROCK2-shRNA promote neuronal survival and axonal sprouting in a rat model of rubrospinal tract injury

scientific article published on 13 April 2015

AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice

scientific article

Adeno-associated Virus-mediated, Mifepristone-regulated Transgene Expression in the Brain

scientific article published on 16 July 2013

Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury.

scientific article published in April 2007

Adenovirus-mediated Bcl-X(L) expression using a neuron-specific synapsin-1 promoter protects against disseminated neuronal injury and brain infarction following focal cerebral ischemia in mice.

scientific article

Adenovirus-mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo

scientific article published on 01 June 2000

Adenovirus-mediated glial cell line-derived neurotrophic factor (GDNF) expression protects against subsequent cortical cold injury in rats.

scientific article

Adhesion molecule L1 binds to amyloid beta and reduces Alzheimer's disease pathology in mice.

scientific article published on 29 April 2013

Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex

scientific article

Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons

scientific article published on 14 December 2011

Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease.

scientific article published on 10 September 2014

Alzheimer's disease: old problem, new views from transgenic and viral models

scientific article published on 21 March 2010

BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity.

scientific article published on 29 August 2008

CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis

scientific article published on 20 May 2010

CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies

scientific article published on 06 February 2019

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease

scientific article published in August 2012

Chicken vigilin gene: a distinctive pattern of hypersensitive sites is characteristic for its transcriptional activity.

scientific article published on September 1997

Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand.

scientific article

Chronic imaging of cortical sensory map dynamics using a genetically encoded calcium indicator

scientific article published on 14 November 2011

Comparison of AAV2 and AAV5 in gene transfer in the injured spinal cord of mice

scientific article published in August 2011

Comparison of test systems for RNAinterference

scientific article published on 9 January 2006

Correction to: Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.

scientific article published on 25 May 2018

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

scientific article published on 5 April 2017

Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration

scientific article

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

scientific article

Differential transgene expression in brain cells in vivo and in vitro from AAV-2 vectors with small transcriptional control units.

scientific article

Dimerization propensities of Synucleins are not predictive for Synuclein aggregation.

scientific article published on 8 May 2015

Dopamine promotes the neurodegenerative potential of β-synuclein

scientific article published on 30 July 2020

Dose-dependent rescue of axotomized rat retinal ganglion cells by adenovirus-mediated expression of glial cell-line derived neurotrophic factor in vivo.

scientific article published on February 2002

Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo.

scientific article published on 19 January 2005

Efficient gene therapy for Parkinson's disease using astrocytes as hosts for localized neurotrophic factor delivery

scientific article

Ehlers-Danlos syndrome type VI: lysyl hydroxylase deficiency due to a novel point mutation (W612C)

scientific article published on 01 April 1998

Epac-mediated cAMP-signalling in the mouse model of Rett Syndrome ⬇️

scientific article published on January 11, 2011

Evaluation of long-term upregulation of Calbindin D28K as a preventive approach for ischaemic stroke

scientific article published in August 2010

Evidence for a novel cytoplasmic tRNA-protein complex containing the KH-multidomain protein vigilin.

scientific article published on November 1996

Evidence for posttranscriptional regulation of the multi K homology domain protein vigilin by a small peptide encoded in the 5' leader sequence.

scientific article published on August 2003

Excess Bcl-XL increases the intrinsic growth potential of adult CNS neurons in vitro.

scientific article published in May 2004

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

scientific article

Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis.

scientific article published on 25 November 2013

Functional applications of novel Semliki Forest virus vectors are limited by vector toxicity in cultures of primary neurons in vitro and in the substantia nigra in vivo

scientific article published on 20 October 2004

Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons

scientific article

HDAC1 regulates fear extinction in mice.

scientific article published in April 2012

Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors

scientific article published on 27 November 2019

Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area.

scientific article published in February 2003

Imaging cytoplasmic cAMP in mouse brainstem neurons

scientific article

Imaging of respiratory network topology in living brainstem slices.

scientific article published on 30 October 2007

Improved high-capacity adenoviral vectors for high-level neuron-restricted gene transfer to the CNS.

scientific article published on 2 May 2006

Increased GABAergic Efficacy of Central Amygdala Projections to Neuropeptide S Neurons in the Brainstem During Fear Memory Retrieval.

scientific article published on 4 May 2015

Increased protein expression from adenoviral shuttle plasmids and vectors by insertion of a small chimeric intron sequence

scientific article published in December 2004

Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload

scientific article published on 25 November 2015

Lentiviral Delivery of miR-133b Improves Functional Recovery After Spinal Cord Injury in Mice

scientific article published on 13 July 2016

Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.

scientific article published in November 1999

Long-Term Assessment of AAV-Mediated Zinc Finger Nuclease Expression in the Mouse Brain.

scientific article

Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion.

scientific article

Long-term in vivo and in vitro AAV-2-mediated RNA interference in rat retinal ganglion cells and cultured primary neurons.

scientific article published in January 2005

Long-term rescue of a lethal inherited disease by adeno-associated virus-mediated gene transfer in a mouse model of molybdenum-cofactor deficiency

scientific journal article

MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain

scientific article published on 01 January 2019

Metabolic differences in hippocampal 'Rett' neurons revealed by ATP imaging

scientific article published on 03 January 2014

Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer's disease

scientific article published on 24 August 2010

Moderate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats

scientific article

Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells

scientific article

Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is Accompanied by Intensified Mitochondrial O Consumption and ROS Release

scientific article published on 30 April 2019

Neuronal Trans-differentiation by Transcription Factors Ascl1 and Nurr1: Induction of a Dopaminergic Neurotransmitter Phenotype in Cortical GABAergic Neurons

scientific article published on 17 July 2019

Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathways

scientific article published on 25 February 2015

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease

scientific article published on 27 July 2015

Neuropeptide Y stimulates autophagy in hypothalamic neurons

scientific article

Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein

scientific article published on 01 January 2019

Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice

scientific article

Optogenetic stimulation of the auditory pathway.

scientific article

Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats

scientific article (publication date: 2014)

Pathophysiological Consequences of Neuronal α-Synuclein Overexpression: Impacts on Ion Homeostasis, Stress Signaling, Mitochondrial Integrity, and Electrical Activity.

scientific article

Patterning inconsistencies restrict the true potential of dopaminergic neurons derived from human induced pluripotent stem cells

scientific article published on 01 April 2021

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

scientific article

Pharmacologically controlled, discontinuous GDNF gene therapy restores motor function in a rat model of Parkinson's disease.

scientific article published on 15 January 2014

Potential synergistic protection of retinal ganglion cells from axotomy-induced apoptosis by adenoviral administration of glial cell line-derived neurotrophic factor and X-chromosome-linked inhibitor of apoptosis

scientific article published on October 2002

Potentiation of in vivo neuroprotection by BclX(L) and GDNF co-expression depends on post-lesion time in deafferentiated CNS neurons.

scientific article published on 13 July 2006

Pre-existing immunity to adeno-associated virus (AAV)2 limits transgene expression following intracerebral AAV2-based gene delivery in a 6-hydroxydopamine model of Parkinson's disease.

scientific article published on September 2014

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

scientific article

Probing the function of glycinergic neurons in the mouse respiratory network using optogenetics

scientific article published on 03 November 2018

Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis

scientific article

Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and Orexin-A and differentiate to functional neurons.

scientific article

Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

scientific article

Publisher Correction: β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration

scientific article published on 01 March 2019

Remodelling of the respiratory network in a mouse model of Rett syndrome depends on brain-derived neurotrophic factor regulated slow calcium buffering.

scientific article published on 9 April 2009

Reorganization of cortical population activity imaged throughout long-term sensory deprivation

scientific article

Reply: To PMID 23536356.

scientific article published in August 2013

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

scientific article published on 23 March 2016

Restoration of visual response in aged dystrophic RCS rats using AAV-mediated channelopsin-2 gene transfer.

scientific article published in August 2007

Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model

scientific article published on 8 September 2016

Silencing and un-silencing of tetracycline-controlled genes in neurons

scientific article

Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor

scientific article published in September 2008

Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease

scientific article published on 18 October 2019

Sumoylation inhibits alpha-synuclein aggregation and toxicity.

scientific article

Thalamocortical Connections Drive Intracortical Activation of Functional Columns in the Mislaminated Reeler Somatosensory Cortex

scientific article published on 11 November 2015

The X-linked inhibitor of apoptosis (XIAP) prevents cell death in axotomized CNS neurons in vivo.

scientific article published in September 2000

The extracellular matrix glycoprotein tenascin-C is beneficial for spinal cord regeneration

scientific article

The human vigilin gene: identification, chromosomal localization and expression pattern

scientific article

The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

scientific article

Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free “GeneSwitch” vector

article

Tissue-Specific Promoters in the CNS.

scientific article published on January 2016

Transduction of axotomized retinal ganglion cells by adenoviral vector administration at the optic nerve stump: an in vivo model system for the inhibition of neuronal apoptotic cell death.

scientific article published in October 1999

Transfection of "naked" siRNA results in endosomal uptake and metabolic impairment in cultured neurons

scientific article published in March 2004

Vigilin contains a functional nuclear localisation sequence and is present in both the cytoplasm and the nucleus

scientific article

Vti1b promotes TRPV1 sensitization during inflammatory pain

scientific article published on 01 February 2019

β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration

scientific article published on 20 February 2019

List of works by Sebastian Kügler

A MicroRNA124 Target Sequence Restores Astrocyte Specificity of gfaABC1D-Driven Transgene Expression in AAV-Mediated Gene Transfer.

A dual‐AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice

A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.

AAV-mediated expression of BAG1 and ROCK2-shRNA promote neuronal survival and axonal sprouting in a rat model of rubrospinal tract injury

AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice

Adeno-associated Virus-mediated, Mifepristone-regulated Transgene Expression in the Brain

Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury.

Adenovirus-mediated Bcl-X(L) expression using a neuron-specific synapsin-1 promoter protects against disseminated neuronal injury and brain infarction following focal cerebral ischemia in mice.

Adenovirus-mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo

Adenovirus-mediated glial cell line-derived neurotrophic factor (GDNF) expression protects against subsequent cortical cold injury in rats.

Adhesion molecule L1 binds to amyloid beta and reduces Alzheimer's disease pathology in mice.

Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex

Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons

Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease.

Alzheimer's disease: old problem, new views from transgenic and viral models

BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity.

CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis

CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease

Chicken vigilin gene: a distinctive pattern of hypersensitive sites is characteristic for its transcriptional activity.

Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand.

Chronic imaging of cortical sensory map dynamics using a genetically encoded calcium indicator

Comparison of AAV2 and AAV5 in gene transfer in the injured spinal cord of mice

Comparison of test systems for RNAinterference

Correction to: Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Differential transgene expression in brain cells in vivo and in vitro from AAV-2 vectors with small transcriptional control units.

Dimerization propensities of Synucleins are not predictive for Synuclein aggregation.

Dopamine promotes the neurodegenerative potential of β-synuclein

Dose-dependent rescue of axotomized rat retinal ganglion cells by adenovirus-mediated expression of glial cell-line derived neurotrophic factor in vivo.

Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo.

Efficient gene therapy for Parkinson's disease using astrocytes as hosts for localized neurotrophic factor delivery

Ehlers-Danlos syndrome type VI: lysyl hydroxylase deficiency due to a novel point mutation (W612C)

Epac-mediated cAMP-signalling in the mouse model of Rett Syndrome ⬇️

Evaluation of long-term upregulation of Calbindin D28K as a preventive approach for ischaemic stroke

Evidence for a novel cytoplasmic tRNA-protein complex containing the KH-multidomain protein vigilin.

Evidence for posttranscriptional regulation of the multi K homology domain protein vigilin by a small peptide encoded in the 5' leader sequence.

Excess Bcl-XL increases the intrinsic growth potential of adult CNS neurons in vitro.

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis.

Functional applications of novel Semliki Forest virus vectors are limited by vector toxicity in cultures of primary neurons in vitro and in the substantia nigra in vivo

Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons

HDAC1 regulates fear extinction in mice.

Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors

Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area.

Imaging cytoplasmic cAMP in mouse brainstem neurons

Imaging of respiratory network topology in living brainstem slices.

Improved high-capacity adenoviral vectors for high-level neuron-restricted gene transfer to the CNS.

Increased GABAergic Efficacy of Central Amygdala Projections to Neuropeptide S Neurons in the Brainstem During Fear Memory Retrieval.

Increased protein expression from adenoviral shuttle plasmids and vectors by insertion of a small chimeric intron sequence

Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload

Lentiviral Delivery of miR-133b Improves Functional Recovery After Spinal Cord Injury in Mice

Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.

Long-Term Assessment of AAV-Mediated Zinc Finger Nuclease Expression in the Mouse Brain.

Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion.

Long-term in vivo and in vitro AAV-2-mediated RNA interference in rat retinal ganglion cells and cultured primary neurons.

Long-term rescue of a lethal inherited disease by adeno-associated virus-mediated gene transfer in a mouse model of molybdenum-cofactor deficiency

MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain

Metabolic differences in hippocampal 'Rett' neurons revealed by ATP imaging

Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer's disease

Moderate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats

Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells

Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is Accompanied by Intensified Mitochondrial O Consumption and ROS Release

Neuronal Trans-differentiation by Transcription Factors Ascl1 and Nurr1: Induction of a Dopaminergic Neurotransmitter Phenotype in Cortical GABAergic Neurons

Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathways

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease

Neuropeptide Y stimulates autophagy in hypothalamic neurons

Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein

Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice

Optogenetic stimulation of the auditory pathway.

Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats

Pathophysiological Consequences of Neuronal α-Synuclein Overexpression: Impacts on Ion Homeostasis, Stress Signaling, Mitochondrial Integrity, and Electrical Activity.

Patterning inconsistencies restrict the true potential of dopaminergic neurons derived from human induced pluripotent stem cells

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

Pharmacologically controlled, discontinuous GDNF gene therapy restores motor function in a rat model of Parkinson's disease.

Potential synergistic protection of retinal ganglion cells from axotomy-induced apoptosis by adenoviral administration of glial cell line-derived neurotrophic factor and X-chromosome-linked inhibitor of apoptosis

Potentiation of in vivo neuroprotection by BclX(L) and GDNF co-expression depends on post-lesion time in deafferentiated CNS neurons.