List of works - Susanne Vrtala

4th Pediatric Allergy and Asthma Meeting (PAAM)

scientific article (publication date: November 2016)

A human monoclonal IgE antibody defines a highly allergenic fragment of the major timothy grass pollen allergen, Phl p 5: molecular, immunological, and structural characterization of the epitope-containing domain.

scientific article

A hypoallergenic hybrid molecule with increased immunogenicity consisting of derivatives of the major grass pollen allergens, Phl p 2 and Phl p 6

scientific article published on 01 July 2008

A hypoallergenic peptide mix containing T cell epitopes of the clinically relevant house dust mite allergens

scientific article published on 03 October 2019

A molecular sensitization map of European children reveals exposome‐ and climate‐dependent sensitization profiles

scientific article published in 2023

Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip.

scientific article published on 22 October 2013

Allergen cleavage by effector cell-derived proteases regulates allergic inflammation.

scientific article published on 3 April 2006

Allergen-induced interleukin-9 production in vitro: correlation with atopy in human adults and comparison with interleukin-5 and interleukin-13.

scientific article published in February 2006

Altered IgE epitope presentation: A model for hypoallergenic activity revealed for Bet v 1 trimer.

scientific article published on 18 November 2010

Analysis of the antibody responses induced by subcutaneous injection immunotherapy with birch and Fagales pollen extracts adsorbed onto aluminum hydroxide

scientific article published on 06 August 2009

Association in molecular profiles of IgE sensitization to mugwort pollen allergens in Chinese parents and their offspring

scientific article published in 2023

Betamethasone prevents human rhinovirus- and cigarette smoke- induced loss of respiratory epithelial barrier function.

scientific article published on 26 June 2018

Biochemical, biophysical and IgE-epitope characterization of the wheat food allergen, Tri a 37

scientific article

Calcium-dependent immunoglobulin E recognition of the apo- and calcium-bound form of a cross-reactive two EF-hand timothy grass pollen allergen, Phl p 7.

scientific article

Carbohydrate-based particles: a new adjuvant for allergen-specific immunotherapy

scientific article published on 01 December 2002

Carrier-bound nonallergenic Der p 2 peptides induce IgG antibodies blocking allergen-induced basophil activation in allergic patients.

scientific article

Characterization of Der p 21, a new important allergen derived from the gut of house dust mites.

scientific article

Cigarette smoke facilitates allergen penetration across respiratory epithelium.

scientific article

Clinical and immunological differences between asymptomatic HDM-sensitized and HDM-allergic rhinitis patients.

scientific article published on 27 February 2019

Clinical evaluation of genetically engineered hypoallergenic rBet v 1 derivatives

scientific article published on 01 February 1999

Clinical improvement and immunological changes in atopic dermatitis patients undergoing subcutaneous immunotherapy with a house dust mite allergoid: a pilot study.

scientific article published on September 2007

Clinical validation of a house dust mite environmental challenge chamber model

scientific article published on 24 February 2017

Comparison of genetically engineered hypoallergenic rBet v 1 derivatives with rBet v 1 wild-type by skin prick and intradermal testing: results obtained in a French population

scientific article published on 01 August 2000

Comparison of inflammatory responses to genetically engineered hypoallergenic derivatives of the major birch pollen allergen Bet v 1 and to recombinant Bet v 1 wild type in skin chamber fluids collected from birch pollen–allergic patients

article

Comparison of purified Dermatophagoides pteronyssinus allergens and extract by two-dimensional immunoblotting and quantitative immunoglobulin E inhibitions

scientific article published on 01 October 2005

Complementary DNA cloning of the major allergen Phl p I from timothy grass (Phleum pratense); recombinant Phl p I inhibits IgE binding to group I allergens from eight different grass species.

scholarly article

Conversion of Der p 23, a new major house dust mite allergen, into a hypoallergenic vaccine.

scientific article

Conversion of the major birch pollen allergen, Bet v 1, into two nonanaphylactic T cell epitope-containing fragments: candidates for a novel form of specific immunotherapy

scientific article published on April 1997

Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis.

scientific article

Development of an in vitro system for the study of allergens and allergen-specific immunoglobulin E and immunoglobulin G: Fcepsilon receptor I supercross-linking is a possible new mechanism of immunoglobulin G-dependent enhancement of type I allergi

scientific article published in June 2005

Diagnosis of grass pollen allergy with recombinant timothy grass (Phleum pratense) pollen allergens

scientific article

Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children

scientific article

Dissociation of allergen-specific IgE and IgA responses in sera and tears of pollen-allergic patients: a study performed with purified recombinant pollen allergens

scientific article published on 01 April 2000

Division of the major birch pollen allergen, Bet v 1, into two non-anaphylactic fragments.

scientific article

Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases.

scientific article published in February 2018

Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life

scientific article published on 19 October 2016

Expression in Escherichia coli and Purification of Folded rDer p 20, the Arginine Kinase From Dermatophagoides pteronyssinus: A Possible Biomarker for Allergic Asthma

scientific article published on 01 January 2021

Expulsion of allergen-containing materials from hydrated rye grass (Lolium perenne) pollen revealed by using immunogold field emission scanning and transmission electron microscopy

scientific article published on 01 June 2000

From allergen genes to new forms of allergy diagnosis and treatment.

scientific article published on March 2008

Genetic engineering of recombinant hypoallergenic oligomers of the major birch pollen allergen, Bet v 1: candidates for specific immunotherapy

scientific article published on 01 February 1999

Genetic engineering of trimers of hypoallergenic fragments of the major birch pollen allergen, Bet v 1, for allergy vaccination

scientific article

Glutathione-S-transferase: a minor allergen in birch pollen due to limited release from hydrated pollen

scientific article

High-level expression in Escherichia coli and purification of recombinant plant profilins: comparison of IgE-binding capacity and allergenic activity

scientific article published on 01 September 1996

House dust mites as potential carriers for IgE sensitization to bacterial antigens.

scientific article published on 25 July 2017

Humoral immune responses to recombinant tree pollen allergens (Bet v I and Bet v II) in mice: construction of a live oral allergy vaccine.

scientific article

Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly.

scientific article

Identification by serological proteome analysis of paramyosin as prominent allergen in dust mite allergy.

scientific article

Identification of Der p 23, a peritrophin-like protein, as a new major Dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets.

scientific article

Immunization with a low-dose replicon DNA vaccine encoding Phl p 5 effectively prevents allergic sensitization.

scientific article published on 6 June 2006

Immunologic characterization of purified recombinant timothy grass pollen (Phleum pratense) allergens (Phl p 1, Phl p2, Phl p 5)

scientific article published on 01 March 1996

Induction of IgE antibodies in mice and rhesus monkeys with recombinant birch pollen allergens: Different allergenicity of Bet v 1 and Bet v 2

scientific article published on 01 November 1996

Innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated pH

scientific article

Intranasal treatment with a recombinant hypoallergenic derivative of the major birch pollen allergen Bet v 1 prevents allergic sensitization and airway inflammation in mice.

scientific article

Isolation of a high-affinity Bet v 1-specific IgG-derived ScFv from a subject vaccinated with hypoallergenic Bet v 1 fragments.

scientific article published on 20 February 2018

Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2.

scientific article

Mites and other indoor allergens - from exposure to sensitization and treatment.

scientific article published on 9 May 2015

Molecular Aspects of Allergens and Allergy.

scientific article

Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer

scientific article published on 19 January 2018

Molecular and immunological characterization of Tri a 36, a low molecular weight glutenin, as a novel major wheat food allergen.

scientific article

Molecular characterization of Der p 10: a diagnostic marker for broad sensitization in house dust mite allergy

scientific article

Molecular characterization of Phl p II, a major timothy grass (Phleum pratense) pollen allergen.

scientific article published on December 1993

Molecular characterization of human IgG monoclonal antibodies specific for the major birch pollen allergen Bet v 1. Anti-allergen IgG can enhance the anaphylactic reaction.

scientific article published in January 2000

Molecular, Structural and Immunological Characterization of Der p 18, a Chitinase-Like House Dust Mite Allergen

scientific article

Molecular, immunological, and structural characterization of Phl p 6, a major allergen and P-particle-associated protein from Timothy grass (Phleum pratense) pollen

scientific article

Monitoring of two allergens, Bet v I and profilin, in dry and rehydrated birch pollen by immunogold electron microscopy and immunoblotting

scientific article published on 01 May 1993

Mucosal tolerance induction with hypoallergenic molecules in a murine model of allergic asthma

scientific article published on 01 January 2001

Nasal application of rBet v 1 or non-IgE-reactive T-cell epitope-containing rBet v 1 fragments has different effects on systemic allergen-specific antibody responses

scientific article published on 31 July 2010

Nasal challenges with recombinant derivatives of the major birch pollen allergen Bet v 1 induce fewer symptoms and lower mediator release than rBet v 1 wild-type in patients with allergic rhinitis.

scientific article published on October 2002

Non–IgE-mediated chronic allergic skin inflammation revealed with rBet v 1 fragments

scientific article published on 01 February 2008

Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta1 and IL-10-producing properties

scientific article published on 26 June 2010

Prevention of allergen-specific IgE production and suppression of an established Th2-type response by immunization with DNA encoding hypoallergenic allergen derivatives of Bet v 1, the major birch-pollen allergen

scientific article published on 01 June 2003

Prevention of allergic asthma through Der p 2 peptide vaccination.

scientific article

Properties of tree and grass pollen allergens: reinvestigation of the linkage between solubility and allergenicity

scientific article published on 01 January 1993

Prophylactic and therapeutic vaccination with carrier-bound Bet v 1 peptides lacking allergen-specific T cell epitopes reduces Bet v 1-specific T cell responses via blocking antibodies in a murine model for birch pollen allergy.

scientific article

Real-Life Study for the Diagnosis of House Dust Mite Allergy - The Value of Recombinant Allergen-Based IgE Serology.

scientific article published on 10 August 2016

Recombinant allergen and peptide-based approaches for allergy prevention by oral tolerance.

scientific article published on 19 September 2017

Recombinant allergens for immunoblot diagnosis of tree-pollen allergy ⬇️

scientific article published on December 1, 1991

Recombinant allergens promote expression of aminopeptidase-n (CD13) on basophils in allergic patients.

scientific article published in January 2008

Recombinant house dust mite allergens.

scientific article

Reduction of the in vivo allergenicity of Der p 2, the major house-dust mite allergen, by genetic engineering.

scientific article published on 4 March 2008

Release of allergen-bearing cytoplasm from hydrated pollen: a mechanism common to a variety of grass (Poaceae) species revealed by electron microscopy

scientific article published on 01 July 2001

Reliable mite-specific IgE testing in nasal secretions by means of allergen microarray

scientific article published on 18 February 2017

Selection of house dust mite-allergic patients by molecular diagnosis may enhance success of specific immunotherapy

scientific article published on 14 November 2018

Similar localization of conformational IgE epitopes on the house dust mite allergens Der p 5 and Der p 21 despite limited IgE-cross-reactivity.

scientific article published on 10 January 2018

Skin test evaluation of genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1: results obtained with a mix of two recombinant Bet v 1 fragments and recombinant Bet v 1 trimer in a Swedish population before the

scientific article published on 01 November 1999

Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study

scientific article published on 22 June 2016

Specific IgE reactivity to Tri a 36 in children with wheat food allergy.

scientific article

T cell epitope-containing hypoallergenic recombinant fragments of the major birch pollen allergen, Bet v 1, induce blocking antibodies

scientific article published on 01 December 2000

The Importance of Recombinant Allergens for Diagnosis and Therapy of IgE–Mediated Allergies

scientific article published on 01 February 1999

The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils

scientific article published on 7 January 2008

The high molecular weight glutenin subunit Bx7 allergen from wheat contains repetitive IgE epitopes.

scientific article

The immunoglobulin E-allergen interaction: a target for therapy of type I allergic diseases.

scientific article published in July 1998

The majority of allergen-specific IgE in the blood of allergic patients does not originate from blood-derived B cells or plasma cells.

scientific article published in September 2012

The quantity and quality of α-gal-specific antibodies differ in individuals with and without delayed red meat allergy

scientific article published on 04 June 2016

The role of Foxp3+ T cells in long-term efficacy of prophylactic and therapeutic mucosal tolerance induction in mice.

scientific article published on February 2006

Tropomyosins in mosquito and house dust mite cross-react at the humoral and cellular level

scientific article published on 14 August 2018

Underestimation of house dust mite-specific IgE with extract-based ImmunoCAPs compared with molecular ImmunoCAPs

scientific article published on 27 July 2018

Vaccination with genetically engineered allergens prevents progression of allergic disease.

scholarly article

Vaccines for birch pollen allergy based on genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1.

scientific article published in January 2004

Wheat allergy in children evaluated with challenge and IgE antibodies to wheat components

scientific article published on 01 March 2015

cDNA cloning of a major allergen from timothy grass (Phleum pratense) pollen; characterization of the recombinant Phl pV allergen ⬇️

scientific article published on November 1, 1993

pET-prof, a plasmid for high-level expression of recombinant peptides fused to a birch profilin-derived hexadecapeptide tag: a system for the detection and presentation of recombinant antigens

scientific article published on 01 September 1999

α-Purothionin, a new wheat allergen associated with severe allergy

scientific article published on 28 June 2013

List of works by Susanne Vrtala

4th Pediatric Allergy and Asthma Meeting (PAAM)

A human monoclonal IgE antibody defines a highly allergenic fragment of the major timothy grass pollen allergen, Phl p 5: molecular, immunological, and structural characterization of the epitope-containing domain.

A hypoallergenic hybrid molecule with increased immunogenicity consisting of derivatives of the major grass pollen allergens, Phl p 2 and Phl p 6

A hypoallergenic peptide mix containing T cell epitopes of the clinically relevant house dust mite allergens

A molecular sensitization map of European children reveals exposome‐ and climate‐dependent sensitization profiles

Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip.

Allergen cleavage by effector cell-derived proteases regulates allergic inflammation.

Allergen-induced interleukin-9 production in vitro: correlation with atopy in human adults and comparison with interleukin-5 and interleukin-13.

Altered IgE epitope presentation: A model for hypoallergenic activity revealed for Bet v 1 trimer.

Analysis of the antibody responses induced by subcutaneous injection immunotherapy with birch and Fagales pollen extracts adsorbed onto aluminum hydroxide

Association in molecular profiles of IgE sensitization to mugwort pollen allergens in Chinese parents and their offspring

Betamethasone prevents human rhinovirus- and cigarette smoke- induced loss of respiratory epithelial barrier function.

Biochemical, biophysical and IgE-epitope characterization of the wheat food allergen, Tri a 37

Calcium-dependent immunoglobulin E recognition of the apo- and calcium-bound form of a cross-reactive two EF-hand timothy grass pollen allergen, Phl p 7.

Carbohydrate-based particles: a new adjuvant for allergen-specific immunotherapy

Carrier-bound nonallergenic Der p 2 peptides induce IgG antibodies blocking allergen-induced basophil activation in allergic patients.

Characterization of Der p 21, a new important allergen derived from the gut of house dust mites.

Cigarette smoke facilitates allergen penetration across respiratory epithelium.

Clinical and immunological differences between asymptomatic HDM-sensitized and HDM-allergic rhinitis patients.

Clinical evaluation of genetically engineered hypoallergenic rBet v 1 derivatives

Clinical improvement and immunological changes in atopic dermatitis patients undergoing subcutaneous immunotherapy with a house dust mite allergoid: a pilot study.

Clinical validation of a house dust mite environmental challenge chamber model

Comparison of genetically engineered hypoallergenic rBet v 1 derivatives with rBet v 1 wild-type by skin prick and intradermal testing: results obtained in a French population

Comparison of inflammatory responses to genetically engineered hypoallergenic derivatives of the major birch pollen allergen Bet v 1 and to recombinant Bet v 1 wild type in skin chamber fluids collected from birch pollen–allergic patients

Comparison of purified Dermatophagoides pteronyssinus allergens and extract by two-dimensional immunoblotting and quantitative immunoglobulin E inhibitions

Complementary DNA cloning of the major allergen Phl p I from timothy grass (Phleum pratense); recombinant Phl p I inhibits IgE binding to group I allergens from eight different grass species.

Conversion of Der p 23, a new major house dust mite allergen, into a hypoallergenic vaccine.

Conversion of the major birch pollen allergen, Bet v 1, into two nonanaphylactic T cell epitope-containing fragments: candidates for a novel form of specific immunotherapy

Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis.

Development of an in vitro system for the study of allergens and allergen-specific immunoglobulin E and immunoglobulin G: Fcepsilon receptor I supercross-linking is a possible new mechanism of immunoglobulin G-dependent enhancement of type I allergi

Diagnosis of grass pollen allergy with recombinant timothy grass (Phleum pratense) pollen allergens

Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children

Dissociation of allergen-specific IgE and IgA responses in sera and tears of pollen-allergic patients: a study performed with purified recombinant pollen allergens

Division of the major birch pollen allergen, Bet v 1, into two non-anaphylactic fragments.

Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases.

Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life

Expression in Escherichia coli and Purification of Folded rDer p 20, the Arginine Kinase From Dermatophagoides pteronyssinus: A Possible Biomarker for Allergic Asthma

Expulsion of allergen-containing materials from hydrated rye grass (Lolium perenne) pollen revealed by using immunogold field emission scanning and transmission electron microscopy

From allergen genes to new forms of allergy diagnosis and treatment.

Genetic engineering of recombinant hypoallergenic oligomers of the major birch pollen allergen, Bet v 1: candidates for specific immunotherapy

Genetic engineering of trimers of hypoallergenic fragments of the major birch pollen allergen, Bet v 1, for allergy vaccination

Glutathione-S-transferase: a minor allergen in birch pollen due to limited release from hydrated pollen

High-level expression in Escherichia coli and purification of recombinant plant profilins: comparison of IgE-binding capacity and allergenic activity

House dust mites as potential carriers for IgE sensitization to bacterial antigens.

Humoral immune responses to recombinant tree pollen allergens (Bet v I and Bet v II) in mice: construction of a live oral allergy vaccine.

Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly.

Identification by serological proteome analysis of paramyosin as prominent allergen in dust mite allergy.

Identification of Der p 23, a peritrophin-like protein, as a new major Dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets.

Immunization with a low-dose replicon DNA vaccine encoding Phl p 5 effectively prevents allergic sensitization.

Immunologic characterization of purified recombinant timothy grass pollen (Phleum pratense) allergens (Phl p 1, Phl p2, Phl p 5)

Induction of IgE antibodies in mice and rhesus monkeys with recombinant birch pollen allergens: Different allergenicity of Bet v 1 and Bet v 2

Innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated pH

Intranasal treatment with a recombinant hypoallergenic derivative of the major birch pollen allergen Bet v 1 prevents allergic sensitization and airway inflammation in mice.

Isolation of a high-affinity Bet v 1-specific IgG-derived ScFv from a subject vaccinated with hypoallergenic Bet v 1 fragments.

Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2.

Mites and other indoor allergens - from exposure to sensitization and treatment.

Molecular Aspects of Allergens and Allergy.

Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer

Molecular and immunological characterization of Tri a 36, a low molecular weight glutenin, as a novel major wheat food allergen.

Molecular characterization of Der p 10: a diagnostic marker for broad sensitization in house dust mite allergy

Molecular characterization of Phl p II, a major timothy grass (Phleum pratense) pollen allergen.

Molecular characterization of human IgG monoclonal antibodies specific for the major birch pollen allergen Bet v 1. Anti-allergen IgG can enhance the anaphylactic reaction.

Molecular, Structural and Immunological Characterization of Der p 18, a Chitinase-Like House Dust Mite Allergen

Molecular, immunological, and structural characterization of Phl p 6, a major allergen and P-particle-associated protein from Timothy grass (Phleum pratense) pollen

Monitoring of two allergens, Bet v I and profilin, in dry and rehydrated birch pollen by immunogold electron microscopy and immunoblotting

Mucosal tolerance induction with hypoallergenic molecules in a murine model of allergic asthma

Nasal application of rBet v 1 or non-IgE-reactive T-cell epitope-containing rBet v 1 fragments has different effects on systemic allergen-specific antibody responses

Nasal challenges with recombinant derivatives of the major birch pollen allergen Bet v 1 induce fewer symptoms and lower mediator release than rBet v 1 wild-type in patients with allergic rhinitis.

Non–IgE-mediated chronic allergic skin inflammation revealed with rBet v 1 fragments

Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta1 and IL-10-producing properties

Prevention of allergen-specific IgE production and suppression of an established Th2-type response by immunization with DNA encoding hypoallergenic allergen derivatives of Bet v 1, the major birch-pollen allergen

Prevention of allergic asthma through Der p 2 peptide vaccination.

Properties of tree and grass pollen allergens: reinvestigation of the linkage between solubility and allergenicity

Prophylactic and therapeutic vaccination with carrier-bound Bet v 1 peptides lacking allergen-specific T cell epitopes reduces Bet v 1-specific T cell responses via blocking antibodies in a murine model for birch pollen allergy.

Real-Life Study for the Diagnosis of House Dust Mite Allergy - The Value of Recombinant Allergen-Based IgE Serology.

Recombinant allergen and peptide-based approaches for allergy prevention by oral tolerance.

Recombinant allergens for immunoblot diagnosis of tree-pollen allergy ⬇️

Recombinant allergens promote expression of aminopeptidase-n (CD13) on basophils in allergic patients.

Recombinant house dust mite allergens.