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List of works by Michael A Schwarzschild

(E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B.

scientific article

A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitization

scientific article published in May 2005

A prospective analysis of airborne metal exposures and risk of Parkinson disease in the nurses' health study cohort

scientific article

A prospective study of bowel movement frequency and risk of Parkinson's disease

scientific article

A prospective study of night shift work, sleep duration, and risk of Parkinson's disease

scientific article published on 22 February 2006

Adenosine A2A receptor gene disruption protects in an α‐synuclein model of Parkinson's disease ⬇️

scientific article published on February 1, 2012

Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia

scientific article published on 10 August 2005

Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation: implications for the treatment of dyskinesias in Parkinson's disease

scientific article published on December 2003

Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes.

scientific article published in February 2012

Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine

scientific article

Air Pollution and Risk of Parkinson's Disease in a Large Prospective Study of Men.

scientific article published on 18 August 2017

Alcohol and risk of Parkinson's disease in a large, prospective cohort of men and women

scientific article published on 19 June 2012

Alcohol consumption and the incidence of Parkinson's disease

scientific article published on August 2003

Allopurinol reduces levels of urate and dopamine but not dopaminergic neurons in a dual pesticide model of Parkinson's disease

scientific article published on 26 March 2014

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

scientific article published on May 2009

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease

scientific article

Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study ⬇️

scientific article published on September 23, 2011

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice

scientific article published on 31 January 2018

Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials

scientific article published on 24 February 2017

Caffeinated clues and the promise of adenosine A(2A) antagonists in PD.

scientific article

Caffeine and risk of Parkinson's disease in a large cohort of men and women

scientific article published on 27 August 2012

Caffeine consumption and risk of dyskinesia in CALM-PD.

scientific article published on 21 January 2013

Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration

scientific article

Caffeine's neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity shows no tolerance to chronic caffeine administration in mice

scientific article published in March 2002

Calcium channel blocker use and risk of Parkinson's disease

scientific article

Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses

scientific article published in March 2004

Conditional neural knockout of the adenosine A(2A) receptor and pharmacological A(2A) antagonism reduce pilocarpine-induced tremulous jaw movements: studies with a mouse model of parkinsonian tremor

scientific article published on September 2012

Consumption of dairy products and risk of Parkinson's disease

scientific article

Could MAO-B Inhibitor Withdrawal Rather than Nilotinib Benefit Explain the Dopamine Metabolite Increase in Parkinsonian Study Subjects?

scientific article published on 23 December 2016

Cross-sensitization between caffeine- and L-dopa-induced behaviors in hemiparkinsonian mice

scientific article published on 17 October 2005

DARPP chocolate: a caffeinated morsel of striatal signaling

scientific article

Declining quality of life in Parkinson disease before and after diagnosis

scientific article published on January 2012

Deletion of adenosine A1 or A2A receptors reduces l-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease ⬇️

scientific article published on September 7, 2010

Diet, urate, and Parkinson's disease risk in men.

scientific article published on 7 March 2008

Dietary antioxidants and Parkinson's disease

scientific article published on 4 October 2017

Differences in Parkinson's Disease Risk with Caffeine Intake and Postmenopausal Hormone Use.

scientific article

Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration ⬇️

scientific article published on December 17, 2012

Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease

scholarly article by Xiqun Chen et al published November 2018 in EBioMedicine

Dopamine D1-dependent trafficking of striatal N-methyl-D-aspartate glutamate receptors requires Fyn protein tyrosine kinase but not DARPP-32.

scientific article published on January 2004

Dopamine transporter imaging is associated with long-term outcomes in Parkinson's disease

scientific article

Dual-target-directed drugs that block monoamine oxidase B and adenosine A(2A) receptors for Parkinson's disease

scientific article published on January 2009

Efficient determination of purine metabolites in brain tissue and serum by high‐performance liquid chromatography with electrochemical and UV detection ⬇️

scientific article published on June 5, 2012

Erectile function and risk of Parkinson's disease

scientific article published on 17 September 2007

Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

scientific article published in January 2006

Folate intake and risk of Parkinson's disease

scientific article

Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice.

scientific article

Genetic and pharmacological inactivation of adenosine A2A receptor reveals an Egr-2-mediated transcriptional regulatory network in the mouse striatum

scientific article

Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage

scientific article

Genetic determinants of hair color and Parkinson's disease risk

scientific article published on January 2009

Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease

scientific article published on 29 August 2007

If LRRK2 Set the Fire, Can Nonsteroidal Anti-inflammatory Drugs Wet the Flames?

scientific article published on 01 October 2020

Inactivation of adenosine A2A receptors selectively attenuates amphetamine-induced behavioral sensitization

scientific article published on 9 April 2003

Inactivation of neuronal forebrain A receptors protects dopaminergic neurons in a mouse model of Parkinson's disease

scientific article

Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial

scientific article

Intake of antioxidant vitamins and risk of Parkinson's disease

scientific article published on 27 October 2016

Intake of dairy foods and risk of Parkinson disease

scientific article published on 08 June 2017

Integration of risk factors for Parkinson disease in 2 large longitudinal cohorts

scientific article published on 11 April 2018

Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risk

scientific article published on 10 January 2018

Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice

scientific journal article

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

scientific article

Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway.

scientific article

Meeting report: consensus statement-Parkinson's disease and the environment: collaborative on health and the environment and Parkinson's Action Network (CHE PAN) conference 26-28 June 2007

scientific article

Mendelian randomization of serum urate and parkinson disease progression

scientific article

Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine

scientific article

Molecular markers of early Parkinson's disease based on gene expression in blood

scientific article

Monoamine oxidase B inhibition and neuroprotection: studies on selective adenosine A2A receptor antagonists

scientific article

Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice

scientific article

Neuroprotection by caffeine and more specific A2A receptor antagonists in animal models of Parkinson's disease

scientific article published on December 2003

Neuroprotective effects of urate are mediated by augmenting astrocytic glutathione synthesis and release

scientific article

Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease

scientific article (publication date: August 2003)

Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease

scientific article (publication date: December 2005)

Novel pharmacological targets for the treatment of Parkinson's disease

scientific article published on October 2006

Obesity and restless legs syndrome in men and women

scientific article published on April 2009

Obesity and the risk of Parkinson's disease

scientific article published in March 2004

Obesity, diabetes, and risk of Parkinson's disease

scientific article published on 7 July 2011

Oral Inosine Persistently Elevates Plasma antioxidant capacity in Parkinson's disease

scientific article published on 25 January 2016

Particulate matter and risk of Parkinson disease in a large prospective study of women

scientific article

Pathophysiological roles for purines: adenosine, caffeine and urate

scientific article

Perceived imbalance and risk of Parkinson's disease

scientific article published on March 2008

Peripheral inflammatory biomarkers and risk of Parkinson's disease

scientific article published on 22 September 2007

Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors.

scientific article published in February 2002

Pesticide exposure and risk for Parkinson's disease

scientific article

Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis

Plasma urate and Parkinson's disease in women

scientific article

Plasma urate and progression of mild cognitive impairment

scientific article

Postmortem brain levels of urate and precursors in Parkinson's disease and related disorders

scientific article published on 28 February 2013

Prenatal and early life factors and risk of Parkinson's disease

scientific article

Prospective Study of Statin Use and Risk of Parkinson Disease ⬇️

scientific article published on March 1, 2012

Prospective study of dietary pattern and risk of Parkinson disease

scientific article

Prospective study of phobic anxiety and risk of Parkinson's disease

scientific article published on June 2003

Prospective study of plasma urate and risk of Parkinson disease in men and women

scientific article published on 13 January 2016

Protection of dopaminergic cells by urate requires its accumulation in astrocytes ⬇️

scientific article published on August 22, 2012

Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease ⬇️

scientific article published on September 18, 2010

Recreational physical activity and risk of Parkinson's disease

scientific article published on January 2008

Red hair, MC1R variants, and risk for Parkinson's disease - a meta-analysis

scientific article published on 24 February 2017

Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells

scientific article published in September 2003

Reproductive factors, exogenous estrogen use, and risk of Parkinson's disease

scientific article published on July 2009

Restless legs syndrome and Parkinson's disease in men ⬇️

scientific article published on November 15, 2010

Restless legs syndrome and erectile dysfunction.

scientific article

Restless legs syndrome: an early clinical feature of Parkinson disease in men.

scientific article published on February 2014

Role of adenosine A2A receptors in parkinsonian motor impairment and l-DOPA-induced motor complications

scientific article (publication date: December 2007)

Serum cholesterol and the progression of Parkinson's disease: results from DATATOP.

scientific article

Serum urate and probability of dopaminergic deficit in early "Parkinson's disease".

scientific article

Serum urate as a predictor of clinical and radiographic progression in Parkinson disease

scientific article

Serum urate at trial entry and ALS progression in EMPOWER.

scientific article published on 28 September 2016

Sex differences by design and outcome in the Safety of Urate Elevation in PD (SURE-PD) trial

scientific article published on 04 September 2019

Sleep regulation in adenosine A2A receptor-deficient mice

scientific article

Smoking and Parkinson's disease: using parental smoking as a proxy to explore causality

scientific article

Survival of Parkinson's disease patients in a large prospective cohort of male health professionals

scientific article published in July 2006

Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin

scientific article published on June 2002

Targeting adenosine A2A receptors in Parkinson's disease

scientific article

Targeting urate to reduce oxidative stress in Parkinson disease

scientific article

Telomere length and risk of Parkinson's disease

scientific article published on January 2008

The epidemiology of Parkinson's disease: risk factors and prevention

scientific article

The melanoma-linked "redhead" MC1R influences dopaminergic neuron survival

scientific article published on 26 December 2016

The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia

scientific article

Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease

scientific article

Treatment of Parkinson's disease: what's in the non-dopaminergic pipeline?

scientific article published on January 2014

Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study

scientific article published on 25 September 2013

Urate and Its Transgenic Depletion Modulate Neuronal Vulnerability in a Cellular Model of Parkinson's Disease ⬇️

scientific article published on May 14, 2012

Urate as a predictor of the rate of clinical decline in Parkinson disease

scientific article

Urate in Parkinson's disease: more than a biomarker?

scientific article published on August 2012

Urate: A Novel Biomarker of Parkinson‘s Disease Risk, Diagnosis and Prognosis ⬇️

scientific article published on October 1, 2010

Use of ibuprofen and risk of Parkinson disease

scientific article

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