List of works - Gerhard Eisenbrand

7,7'-Diazaindirubin--a small molecule inhibitor of casein kinase 2 in vitro and in cells

scientific article published on 25 November 2013

7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine, a potent inhibitor of cAMP-specific phosphodiesterase, enhancing nuclear protein binding to the CRE consensus sequence in human tumour cells

scientific article

Acrylamide and glycidamide: approach towards risk assessment based on biomarker guided dosimetry of genotoxic/mutagenic effects in human blood

scientific article published on January 2005

Acrylamide and glycidamide: genotoxic effects in V79-cells and human blood.

scientific article published on February 2005

An Efficient Synthesis of a Lycobetaine-Tortuosine Analogue: A Potent Topoisomerase Inhibitor

An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands

scientific article published in April 2006

Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis

scientific article

Antioxidant effectiveness of coffee extracts and selected constituents in cell-free systems and human colon cell lines

scientific article published in December 2010

Antioxidant effectiveness of phenolic apple juice extracts and their gut fermentation products in the human colon carcinoma cell line caco-2.

scientific article

Antioxidant-rich coffee reduces DNA damage, elevates glutathione status and contributes to weight control: results from an intervention study

scientific article published on 4 April 2011

Apple juice intervention modulates expression of ARE-dependent genes in rat colon and liver.

scientific article published on 22 July 2010

Assessing the potential impact on the thyroid axis of environmentally relevant food constituents/contaminants in humans

scientific article published on 11 May 2016

Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex

scientific article

Biological effects of acrylamide after daily ingestion of various foods in comparison to water: A study in rats ⬇️

scientific article published on October 11, 2010

Biomarker monitoring of controlled dietary acrylamide exposure indicates consistent human endogenous background

scientific article published on 22 May 2017

Coffee consumption rapidly reduces background DNA strand breaks in healthy humans: Results of a short-term repeated uptake intervention study.

scientific article published on 29 December 2015

Correction to: Mode of action-based risk assessment of genotoxic carcinogens

scientific article published on 22 July 2020

Correction to: Revisiting the evidence for genotoxicity of acrylamide (AA), key to risk assessment of dietary AA exposure

scientific article published on 16 September 2020

Dicofol degradation to p,p'-dichlorobenzophenone - a potential antiandrogen

scientific article published on February 2011

Differential phosphodiesterase expression and cytosolic Ca2+ in human CNS tumour cells and in non-malignant and malignant cells of rat origin

scientific article

Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells

scientific article

Effect of coffee combining green coffee bean constituents with typical roasting products on the Nrf2/ARE pathway in vitro and in vivo

scientific article published on 14 September 2012

Effects of hemodialysis, dialyser type and iron infusion on oxidative stress in uremic patients

scientific article published in October 2004

Enhancement of oral bioavailability of E804 by self-nanoemulsifying drug delivery system (SNEDDS) in rats

scientific article published on 11 August 2013

Exposure assessment of process-related contaminants in food by biomarker monitoring

scientific article published on 4 January 2018

Fate of 14C-acrylamide in roasted and ground coffee during storage

scientific article published in May 2008

Formation of hydrogen peroxide in cell culture media by apple polyphenols and its effect on antioxidant biomarkers in the colon cell line HT-29.

scientific article published on October 2009

From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors

scientific article published in March 2005

Genotoxicity of glycidamide in comparison to (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and alpha-acetoxy-N-nitroso-diethanolamine in human blood and in mammalian V79-cells

scientific article published on April 2006

Genotoxicity of glycidamide in comparison to 3-N-nitroso-oxazolidin-2-one

scientific article

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

scientific article

Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells.

scientific article

In vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systems

In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans

scientific article published on 3 February 2009

Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling

scientific article

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

scientific article

Indirubin derivatives modulate TGFβ/BMP signaling at different levels and trigger ubiquitin-mediated depletion of nonactivated R-Smads

scientific article published in November 2012

Indirubin-3-Aminooxy-Acetate Inhibits Glycogen Phosphorylase by Binding at the Inhibitor and the Allosteric Site. Broad Specificities of the Two Sites

Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype?

scientific article published in June 2012

Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia

scientific article published in January 2005

Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity

scientific article

Intracellular localization of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine in membrane structures impeding the inhibition of cytosolic cyclic AMP-specific phosphodiesterase

scientific article

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

scientific article published on 04 February 2016

Microbial food cultures--opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG).

scientific article

Mode of action-based risk assessment of genotoxic carcinogens

scientific article published on 15 June 2020

Modulation of 3',5'-cyclic AMP homeostasis in human platelets by coffee and individual coffee constituents

scientific article published on 23 September 2014

Modulation of oxidative cell damage by reconstituted mixtures of phenolic apple juice extracts in human colon cell lines

scientific article published on April 2006

Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine

scientific article published on 31 August 2004

N7-glycidamide-guanine DNA adduct formation by orally ingested acrylamide in rats: a dose-response study encompassing human diet-related exposure levels

scientific article published on 31 January 2012

Natural flavonoids are potent inhibitors of glycogen phosphorylase

scientific article published in January 2006

Nitrate and nitrite in the diet: how to assess their benefit and risk for human health

scientific article

Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats.

scientific article

Ochratoxin A: induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells.

scientific article

Our senior editors. Gerhard Eisenbrand: food chemistry and environmental toxicology

scientific article published in February 2006

Physicochemical characterization and in vitro permeation of an indirubin derivative

scientific article published on 28 August 2013

Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines

scientific article published in January 2006

Revisiting the evidence for genotoxicity of acrylamide (AA), key to risk assessment of dietary AA exposure

scientific article published on 03 June 2020

Richard Loeppky (1937-2012).

scientific article published on 25 May 2012

Sensitive in vitro test systems to determine androgenic/antiandrogenic activity

scientific article published in September 2004

Synthesis and cytotoxicity of novel indirubin-5-carboxamides

scientific article

Synthesis of N-acetyl-S-(3-coumarinyl)-cysteine methyl ester and HPLC analysis of urinary coumarin metabolites

scientific article published in August 2003

Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs

scientific article

The health risk of nitrosamines with Gerhard Eisenbrand

scientific article published in March 2005

Toxicokinetics of acrylamide in primary rat hepatocytes: coupling to glutathione is faster than conversion to glycidamide

scientific article

Toxicological evaluation of red mould rice

scientific article published in March 2006

Update of the toxicological assessment of furanocoumarins in foodstuffs (Update of the SKLM statement of 23/24 September 2004)--Opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG).

scientific article published on 24 March 2011

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food

scientific article published on 17 January 2018

Urinary Excretion of Niacin Metabolites in Humans After Coffee Consumption.

scientific article published on 21 February 2018

List of works by Gerhard Eisenbrand

7,7'-Diazaindirubin--a small molecule inhibitor of casein kinase 2 in vitro and in cells

7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine, a potent inhibitor of cAMP-specific phosphodiesterase, enhancing nuclear protein binding to the CRE consensus sequence in human tumour cells

Acrylamide and glycidamide: approach towards risk assessment based on biomarker guided dosimetry of genotoxic/mutagenic effects in human blood

Acrylamide and glycidamide: genotoxic effects in V79-cells and human blood.

An Efficient Synthesis of a Lycobetaine-Tortuosine Analogue: A Potent Topoisomerase Inhibitor

An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands

Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis

Antioxidant effectiveness of coffee extracts and selected constituents in cell-free systems and human colon cell lines

Antioxidant effectiveness of phenolic apple juice extracts and their gut fermentation products in the human colon carcinoma cell line caco-2.

Antioxidant-rich coffee reduces DNA damage, elevates glutathione status and contributes to weight control: results from an intervention study

Apple juice intervention modulates expression of ARE-dependent genes in rat colon and liver.

Assessing the potential impact on the thyroid axis of environmentally relevant food constituents/contaminants in humans

Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex

Biological effects of acrylamide after daily ingestion of various foods in comparison to water: A study in rats ⬇️

Biomarker monitoring of controlled dietary acrylamide exposure indicates consistent human endogenous background

Coffee consumption rapidly reduces background DNA strand breaks in healthy humans: Results of a short-term repeated uptake intervention study.

Correction to: Mode of action-based risk assessment of genotoxic carcinogens

Correction to: Revisiting the evidence for genotoxicity of acrylamide (AA), key to risk assessment of dietary AA exposure

Dicofol degradation to p,p'-dichlorobenzophenone - a potential antiandrogen

Differential phosphodiesterase expression and cytosolic Ca2+ in human CNS tumour cells and in non-malignant and malignant cells of rat origin

Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells

Effect of coffee combining green coffee bean constituents with typical roasting products on the Nrf2/ARE pathway in vitro and in vivo

Effects of hemodialysis, dialyser type and iron infusion on oxidative stress in uremic patients

Enhancement of oral bioavailability of E804 by self-nanoemulsifying drug delivery system (SNEDDS) in rats

Exposure assessment of process-related contaminants in food by biomarker monitoring

Fate of 14C-acrylamide in roasted and ground coffee during storage

Formation of hydrogen peroxide in cell culture media by apple polyphenols and its effect on antioxidant biomarkers in the colon cell line HT-29.

From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors

Genotoxicity of glycidamide in comparison to (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and alpha-acetoxy-N-nitroso-diethanolamine in human blood and in mammalian V79-cells

Genotoxicity of glycidamide in comparison to 3-N-nitroso-oxazolidin-2-one

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells.

In vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systems

In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans

Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

Indirubin derivatives modulate TGFβ/BMP signaling at different levels and trigger ubiquitin-mediated depletion of nonactivated R-Smads

Indirubin-3-Aminooxy-Acetate Inhibits Glycogen Phosphorylase by Binding at the Inhibitor and the Allosteric Site. Broad Specificities of the Two Sites

Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype?

Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia

Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity

Intracellular localization of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine in membrane structures impeding the inhibition of cytosolic cyclic AMP-specific phosphodiesterase

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

Microbial food cultures--opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG).

Mode of action-based risk assessment of genotoxic carcinogens

Modulation of 3',5'-cyclic AMP homeostasis in human platelets by coffee and individual coffee constituents

Modulation of oxidative cell damage by reconstituted mixtures of phenolic apple juice extracts in human colon cell lines

Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine

N7-glycidamide-guanine DNA adduct formation by orally ingested acrylamide in rats: a dose-response study encompassing human diet-related exposure levels

Natural flavonoids are potent inhibitors of glycogen phosphorylase

Nitrate and nitrite in the diet: how to assess their benefit and risk for human health

Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats.

Ochratoxin A: induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells.

Our senior editors. Gerhard Eisenbrand: food chemistry and environmental toxicology

Physicochemical characterization and in vitro permeation of an indirubin derivative

Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines

Revisiting the evidence for genotoxicity of acrylamide (AA), key to risk assessment of dietary AA exposure

Richard Loeppky (1937-2012).

Sensitive in vitro test systems to determine androgenic/antiandrogenic activity

Synthesis and cytotoxicity of novel indirubin-5-carboxamides

Synthesis of N-acetyl-S-(3-coumarinyl)-cysteine methyl ester and HPLC analysis of urinary coumarin metabolites

Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs

The health risk of nitrosamines with Gerhard Eisenbrand

Toxicokinetics of acrylamide in primary rat hepatocytes: coupling to glutathione is faster than conversion to glycidamide

Toxicological evaluation of red mould rice

Update of the toxicological assessment of furanocoumarins in foodstuffs (Update of the SKLM statement of 23/24 September 2004)--Opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG).

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food

Urinary Excretion of Niacin Metabolites in Humans After Coffee Consumption.