List of works - Cindy L Will

A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity

scientific article published on 5 July 2016

A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing

scientific article

ATPγS stalls splicing after B complex formation but prior to spliceosome activation

scientific article

An Ancient Mechanism for Splicing Control: U11 snRNP as an Activator of Alternative Splicing

scientific article (publication date: March 2010)

Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing

scientific article published on March 2006

Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein

scientific article

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis

scientific article

Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes

scientific article

Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes

scientific article

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation

scientific article published on 25 July 2017

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

scientific article published on 11 January 2017

Dynamic protein-protein interaction wiring of the human spliceosome

scientific article

Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes

scientific article published in April 2010

Functional spliceosomal A complexes can be assembled in vitro in the absence of a penta-snRNP.

scientific article published on 31 July 2006

HSPC117 is the essential subunit of a human tRNA splicing ligase complex

scientific article

Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation

scientific article published on 31 January 2010

Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions

scientific article published on May 2002

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.

scientific article

Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila

scientific article

Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8

scientific article

Isolation of an active step I spliceosome and composition of its RNP core

scientific article published on 5 March 2008

Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy

scientific article (publication date: March 2005)

Minor spliceosome components are predominantly localized in the nucleus

scientific article

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations

scientific article

Molecular Architecture of the Multiprotein Splicing Factor SF3b ⬇️

scientific article (publication date: 9 May 2003)

Molecular architecture of the human Prp19/CDC5L complex

scientific article

Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome

scientific article published on 01 December 2018

Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome

scientific article published on 16 December 2015

Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans

scientific article published on 05 March 2014

Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion

scientific article

Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions

scientific article published on July 2006

Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment

scientific article published on 9 November 2006

Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method

scientific article

Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing

scientific article

SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing

scientific article published on 30 March 2017

Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method

scientific article

Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome

scientific article

Splicing of a rare class of introns by the U12-dependent spliceosome

scientific article

Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site

scientific article published on 18 September 2015

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds

scientific article published on 24 March 2018

The Prp19 complex directly functions in mitotic spindle assembly

scientific article (publication date: 2013)

The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.

scientific article published on November 2012

The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex

scientific article published on 12 January 2018

The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes

scientific article

The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation

scientific article published on 5 February 2018

The U11-48K protein contacts the 5' splice site of U12-type introns and the U11-59K protein

scientific article

The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein

scientific article

The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome

scientific article

The spliceosome: design principles of a dynamic RNP machine

scientific article (publication date: 20 February 2009)

U2 snRNA-protein contacts in purified human 17S U2 snRNPs and in spliceosomal A and B complexes

scientific article published on April 2006

Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing

scientific article

List of works by Cindy L Will

A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity

A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing

ATPγS stalls splicing after B complex formation but prior to spliceosome activation

An Ancient Mechanism for Splicing Control: U11 snRNP as an Activator of Alternative Splicing

Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing

Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis

Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes

Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

Dynamic protein-protein interaction wiring of the human spliceosome

Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes

Functional spliceosomal A complexes can be assembled in vitro in the absence of a penta-snRNP.

HSPC117 is the essential subunit of a human tRNA splicing ligase complex

Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation

Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.

Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila

Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8

Isolation of an active step I spliceosome and composition of its RNP core

Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy

Minor spliceosome components are predominantly localized in the nucleus

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations

Molecular Architecture of the Multiprotein Splicing Factor SF3b ⬇️

Molecular architecture of the human Prp19/CDC5L complex

Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome

Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome

Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans

Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion

Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions

Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment

Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method

Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing

SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing

Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method

Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome

Splicing of a rare class of introns by the U12-dependent spliceosome

Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds

The Prp19 complex directly functions in mitotic spindle assembly

The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.

The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex

The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes

The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation

The U11-48K protein contacts the 5' splice site of U12-type introns and the U11-59K protein

The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein

The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome

The spliceosome: design principles of a dynamic RNP machine

U2 snRNA-protein contacts in purified human 17S U2 snRNPs and in spliceosomal A and B complexes

Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing