List of works - Frédéric Becq

9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.

scientific article published on 25 February 2008

A Novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells

scientific journal article

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells.

scientific article published on 8 August 2015

A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.

scientific article published on 14 June 2014

ANO1 contributes to angiotensin-II-activated Ca2+-dependent Cl- current in human atrial fibroblasts

scientific article published on 09 January 2014

Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells.

scientific article

Acute effects of adenosine triphosphates, cyclic 3',5'-adenosine monophosphates, and follicle-stimulating hormone on cytosolic calcium level in cultured immature rat Ssertoli cells

scientific article published on 01 August 1999

Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

scientific article published in March 2010

An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

scientific article published on 23 February 2011

Anion channels in a human pancreatic cancer cell line (Capan-1) of ductal origin

scientific article published on January 1, 1992

Anti-inflammatory effect of miglustat in bronchial epithelial cells.

scientific article published on 23 September 2008

Benzo(c)quinolizinium drugs inhibit degradation of Delta F508-CFTR cytoplasmic domain.

scientific article

C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.

scientific article

CFTR and Ca Signaling in Cystic Fibrosis.

scientific article published on 25 October 2011

CFTR channels and adenosine triphosphate release: the impossible rendez-vous revisited in skeletal muscle.

scientific article published on December 2010

CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three

scientific article published on 21 May 2007

CFTR mutation combinations producing frequent complex alleles with different clinical and functional outcomes.

scientific article published on 2 July 2012

CFTR: effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel.

scientific article published on 9 March 2013

Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.

scientific article

Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention.

scientific article published on 4 February 2017

Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells.

scientific article

Characterization of cAMP dependent CFTR-chloride channels in human tracheal gland cells

scientific article published on 01 April 1993

Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004.

scientific article published in July 2003

Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07.

scientific article

Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation.

scientific article

Cystic fibrosis transmembrane conductance regulator (CFTR) confers glibenclamide sensitivity to outwardly rectifying chloride channel (ORCC) in Hi-5 insect cells.

scientific article published on April 1999

Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: progress to date.

scientific article published on February 2010

Deficit of osteoprotegerin release by osteoblasts from a patient with cystic fibrosis

scientific article published on 01 March 2012

Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods.

scientific article published in August 2004

Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function.

scientific article published on 07 April 2017

Development of substituted Benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel.

scientific article published on September 1999

Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.

scientific article

Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

scientific article

Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells.

scientific article published on 4 August 2005

Effect of VX-770 (ivacaftor) and OAG on Ca2+ influx and CFTR activity in G551D and F508del-CFTR expressing cells.

scientific article published on 10 June 2013

Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells.

scientific article

Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation.

scientific article published on 28 August 2006

Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries

scientific journal article

From the vasodilator and hypotensive effects of an extract fraction from Agelanthus dodoneifolius (DC) Danser (Loranthaceae) to the active compound dodoneine.

scientific article published on 16 October 2010

Function, pharmacological correction and maturation of new Indian CFTR gene mutations.

scientific article

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels

scientific article

Genistein modifies the activation kinetics and magnitude of phosphorylated wild-type and G551D-CFTR chloride currents.

scientific article published on August 2002

Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells

scientific article

Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a

scientific article

Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells

scientific article

In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity.

scientific article

Inhibition of ATP-sensitive K+ channels by substituted benzo[c]quinolizinium CFTR activators.

scientific article published in August 2003

Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells

scientific article

MPB-07 Reduces the Inflammatory Response toPseudomonas aeruginosain Cystic Fibrosis Bronchial Cells

scientific article published on 29 December 2006

Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells.

scientific article published on May 2006

Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia

scientific article published on 11 April 2013

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

scientific article published on 18 March 2016

Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases

scientific article published on 28 June 2018

Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR.

scientific article published on 4 August 2016

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.

scientific article

NHE-RF1 protein rescues DeltaF508-CFTR function.

scientific article published on 19 January 2007

Orphan missense mutations in the cystic fibrosis transmembrane conductance regulator: A three-step biological approach to establishing a correlation between genotype and phenotype ⬇️

scientific article published on June 25, 2011

Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.

scientific article

Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells

scientific article published on 30 May 2006

Phosphatase inhibitors activate normal and defective CFTR chloride channels ⬇️

scientific article published on September 13, 1994

Possible regulation of CFTR-chloride channels by membrane-bound phosphatases in pancreatic duct cells

scientific article published on 01 August 1993

Predicting CFTR activity with front-runner cystic fibrosis drugs.

scientific article published on 27 January 2015

Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622.

scientific article published on 29 January 2008

Pushing the limits of catalytic C-H amination in polyoxygenated cyclobutanes

scientific article published on 01 March 2016

Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells

scientific article published on 29 May 2020

Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network

scientific article

Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors

scientific article

Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat

scientific article

Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

scientific article

SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells.

scientific article

Saturated fatty acids alter the late secretory pathway by modulating membrane properties

scientific article published on 02 October 2013

Searching for combinations of small-molecule correctors to restore f508del-cystic fibrosis transmembrane conductance regulator function and processing.

scientific article published on 26 June 2014

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain ⬇️

scientific article published on April 21, 2011

Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis.

scientific article published on January 2005

Stimulation of salivary secretion in vivo by CFTR potentiators in Cftr+/+ and Cftr−/− mice

scientific article published on 04 September 2007

Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel.

scientific article published on February 1998

Structure elucidation of a dihydropyranone from Tapinanthus dodoneifolius.

scientific article published on 6 December 2007

Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity.

scientific article

Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels.

scientific article published in February 2004

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

scientific article

Targeting surface voids to counter membrane disorders in lipointoxication-related diseases.

scientific article published on 3 May 2016

Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling

scientific article

The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection

scientific article

The cystic fibrosis mutation G1349D within the signature motif LSHGH of NBD2 abolishes the activation of CFTR chloride channels by genistein.

scientific article

The cystic fibrosis mutation G551D alters the non-Michaelis-Menten behavior of the cystic fibrosis transmembrane conductance regulator (CFTR) channel and abolishes the inhibitory Genistein binding site.

scientific article

The glycine residues G551 and G1349 within the ATP-binding cassette signature motifs play critical roles in the activation and inhibition of cystic fibrosis transmembrane conductance regulator channels by phloxine B.

scientific article published in December 2005

The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy

scientific article published on 11 December 2013

The hypotensive agent dodoneine inhibits L-type Ca2+ current with negative inotropic effect on rat heart.

scientific article published on 5 February 2014

The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity.

scientific article published on 18 November 2014

The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation

scientific article

Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator channel dysfunction in cystic fibrosis.

scientific article

Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel

scientific journal article

Understanding nucleotide binding and CFTR ion channel gating: how many cycles?

scientific article published on 01 August 2010

Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

scientific article published on 04 December 2018

Vasorelaxation induced by dodoneine is mediated by calcium channels blockade and carbonic anhydrase inhibition on vascular smooth muscle cells.

scientific article

List of works by Frédéric Becq

9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.

A Novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells.

A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.

ANO1 contributes to angiotensin-II-activated Ca2+-dependent Cl- current in human atrial fibroblasts

Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells.

Acute effects of adenosine triphosphates, cyclic 3',5'-adenosine monophosphates, and follicle-stimulating hormone on cytosolic calcium level in cultured immature rat Ssertoli cells

Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

Anion channels in a human pancreatic cancer cell line (Capan-1) of ductal origin

Anti-inflammatory effect of miglustat in bronchial epithelial cells.

Benzo(c)quinolizinium drugs inhibit degradation of Delta F508-CFTR cytoplasmic domain.

C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.

CFTR and Ca Signaling in Cystic Fibrosis.

CFTR channels and adenosine triphosphate release: the impossible rendez-vous revisited in skeletal muscle.

CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three

CFTR mutation combinations producing frequent complex alleles with different clinical and functional outcomes.

CFTR: effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel.

Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.

Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention.

Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells.

Characterization of cAMP dependent CFTR-chloride channels in human tracheal gland cells

Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004.

Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07.

Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation.

Cystic fibrosis transmembrane conductance regulator (CFTR) confers glibenclamide sensitivity to outwardly rectifying chloride channel (ORCC) in Hi-5 insect cells.

Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: progress to date.

Deficit of osteoprotegerin release by osteoblasts from a patient with cystic fibrosis

Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods.

Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function.

Development of substituted Benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel.

Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.

Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells.

Effect of VX-770 (ivacaftor) and OAG on Ca2+ influx and CFTR activity in G551D and F508del-CFTR expressing cells.

Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells.

Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation.

Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries

From the vasodilator and hypotensive effects of an extract fraction from Agelanthus dodoneifolius (DC) Danser (Loranthaceae) to the active compound dodoneine.

Function, pharmacological correction and maturation of new Indian CFTR gene mutations.

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels

Genistein modifies the activation kinetics and magnitude of phosphorylated wild-type and G551D-CFTR chloride currents.

Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells

Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a

Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells

In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity.

Inhibition of ATP-sensitive K+ channels by substituted benzo[c]quinolizinium CFTR activators.

Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells

MPB-07 Reduces the Inflammatory Response toPseudomonas aeruginosain Cystic Fibrosis Bronchial Cells

Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells.

Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases

Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR.

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.

NHE-RF1 protein rescues DeltaF508-CFTR function.

Orphan missense mutations in the cystic fibrosis transmembrane conductance regulator: A three-step biological approach to establishing a correlation between genotype and phenotype ⬇️

Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.

Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells

Phosphatase inhibitors activate normal and defective CFTR chloride channels ⬇️

Possible regulation of CFTR-chloride channels by membrane-bound phosphatases in pancreatic duct cells

Predicting CFTR activity with front-runner cystic fibrosis drugs.

Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622.

Pushing the limits of catalytic C-H amination in polyoxygenated cyclobutanes

Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells

Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network

Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors

Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat

Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells.

Saturated fatty acids alter the late secretory pathway by modulating membrane properties

Searching for combinations of small-molecule correctors to restore f508del-cystic fibrosis transmembrane conductance regulator function and processing.

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain ⬇️

Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis.

Stimulation of salivary secretion in vivo by CFTR potentiators in Cftr+/+ and Cftr−/− mice

Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel.

Structure elucidation of a dihydropyranone from Tapinanthus dodoneifolius.

Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity.

Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels.