List of works - Frédéric Becq

9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.

scientific article published on 25 February 2008

Phosphatase inhibitors activate normal and defective CFTR chloride channels

scientific article published on September 13, 1994

Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat

scientific article

Development of substituted Benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel.

scientific article published on September 1999

Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis.

scientific article published on January 2005

Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling

scientific article

Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells.

scientific article published on May 2006

Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07.

scientific article

Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells.

scientific article published on 4 August 2005

Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network

scientific article

Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation.

scientific article published on 28 August 2006

Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.

scientific article

Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel.

scientific article published on February 1998

The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation

scientific article

A Novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells

scientific journal article

Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator channel dysfunction in cystic fibrosis.

scientific article

Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: progress to date.

scientific article published on February 2010

Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.

scientific article

Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia

scientific article published on 11 April 2013

Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries

scientific journal article

Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity.

scientific article

MPB-07 Reduces the Inflammatory Response toPseudomonas aeruginosain Cystic Fibrosis Bronchial Cells

scientific article published on 29 December 2006

Anion channels in a human pancreatic cancer cell line (Capan-1) of ductal origin

scientific article published on January 1, 1992

Anti-inflammatory effect of miglustat in bronchial epithelial cells.

scientific article published on 23 September 2008

CFTR and Ca Signaling in Cystic Fibrosis.

scientific article published on 25 October 2011

Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

scientific article

Acute effects of adenosine triphosphates, cyclic 3',5'-adenosine monophosphates, and follicle-stimulating hormone on cytosolic calcium level in cultured immature rat Ssertoli cells

scientific article published on 01 August 1999

Possible regulation of CFTR-chloride channels by membrane-bound phosphatases in pancreatic duct cells

scientific article published on 01 August 1993

Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors

scientific article

Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods.

scientific article published in August 2004

Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells.

scientific article

The cystic fibrosis mutation G1349D within the signature motif LSHGH of NBD2 abolishes the activation of CFTR chloride channels by genistein.

scientific article

Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

scientific article published in March 2010

Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

scientific article

Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels.

scientific article published in February 2004

The cystic fibrosis mutation G551D alters the non-Michaelis-Menten behavior of the cystic fibrosis transmembrane conductance regulator (CFTR) channel and abolishes the inhibitory Genistein binding site.

scientific article

Benzo(c)quinolizinium drugs inhibit degradation of Delta F508-CFTR cytoplasmic domain.

scientific article

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

scientific article published on 18 March 2016

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain

scientific article published on April 21, 2011

Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel

scientific journal article

Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells.

scientific article

NHE-RF1 protein rescues DeltaF508-CFTR function.

scientific article published on 19 January 2007

Characterization of cAMP dependent CFTR-chloride channels in human tracheal gland cells

scientific article published on 01 April 1993

Saturated fatty acids alter the late secretory pathway by modulating membrane properties

scientific article published on 02 October 2013

Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622.

scientific article published on 29 January 2008

CFTR: effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel.

scientific article published on 9 March 2013

Searching for combinations of small-molecule correctors to restore f508del-cystic fibrosis transmembrane conductance regulator function and processing.

scientific article published on 26 June 2014

Cystic fibrosis transmembrane conductance regulator (CFTR) confers glibenclamide sensitivity to outwardly rectifying chloride channel (ORCC) in Hi-5 insect cells.

scientific article published on April 1999

CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three

scientific article published on 21 May 2007

Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells

scientific article

List of works by Frédéric Becq

9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.

Phosphatase inhibitors activate normal and defective CFTR chloride channels

Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat

Development of substituted Benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel.

Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis.

Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling

Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells.

Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07.

Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells.

Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network

Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation.

Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.

Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel.

The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation

A Novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells

Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator channel dysfunction in cystic fibrosis.

Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: progress to date.

Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.

Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia

Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries

Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity.

MPB-07 Reduces the Inflammatory Response toPseudomonas aeruginosain Cystic Fibrosis Bronchial Cells

Anion channels in a human pancreatic cancer cell line (Capan-1) of ductal origin

Anti-inflammatory effect of miglustat in bronchial epithelial cells.

CFTR and Ca Signaling in Cystic Fibrosis.

Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

Acute effects of adenosine triphosphates, cyclic 3',5'-adenosine monophosphates, and follicle-stimulating hormone on cytosolic calcium level in cultured immature rat Ssertoli cells

Possible regulation of CFTR-chloride channels by membrane-bound phosphatases in pancreatic duct cells

Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors

Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods.

Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells.

The cystic fibrosis mutation G1349D within the signature motif LSHGH of NBD2 abolishes the activation of CFTR chloride channels by genistein.

Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels.

The cystic fibrosis mutation G551D alters the non-Michaelis-Menten behavior of the cystic fibrosis transmembrane conductance regulator (CFTR) channel and abolishes the inhibitory Genistein binding site.

Benzo(c)quinolizinium drugs inhibit degradation of Delta F508-CFTR cytoplasmic domain.

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain

Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel

Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells.

NHE-RF1 protein rescues DeltaF508-CFTR function.

Characterization of cAMP dependent CFTR-chloride channels in human tracheal gland cells

Saturated fatty acids alter the late secretory pathway by modulating membrane properties

Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622.

CFTR: effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel.

Searching for combinations of small-molecule correctors to restore f508del-cystic fibrosis transmembrane conductance regulator function and processing.

Cystic fibrosis transmembrane conductance regulator (CFTR) confers glibenclamide sensitivity to outwardly rectifying chloride channel (ORCC) in Hi-5 insect cells.

CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three

Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells