List of works - Frédéric Becq

Stimulation of salivary secretion in vivo by CFTR potentiators in Cftr+/+ and Cftr−/− mice

scientific article published on 04 September 2007

The glycine residues G551 and G1349 within the ATP-binding cassette signature motifs play critical roles in the activation and inhibition of cystic fibrosis transmembrane conductance regulator channels by phloxine B.

scientific article published in December 2005

From the vasodilator and hypotensive effects of an extract fraction from Agelanthus dodoneifolius (DC) Danser (Loranthaceae) to the active compound dodoneine.

scientific article published on 16 October 2010

Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004.

scientific article published in July 2003

Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.

scientific article

ANO1 contributes to angiotensin-II-activated Ca2+-dependent Cl- current in human atrial fibroblasts

scientific article published on 09 January 2014

The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy

scientific article published on 11 December 2013

Genistein modifies the activation kinetics and magnitude of phosphorylated wild-type and G551D-CFTR chloride currents.

scientific article published on August 2002

Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells

scientific article

Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells

scientific article published on 30 May 2006

The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity.

scientific article published on 18 November 2014

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells.

scientific article published on 8 August 2015

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.

scientific article

The hypotensive agent dodoneine inhibits L-type Ca2+ current with negative inotropic effect on rat heart.

scientific article published on 5 February 2014

Stimulation of wild-type, F508del- and G551D-CFTR chloride channels by non-toxic modified pyrrolo[2,3-b]pyrazine derivatives

scientific article published on August 23, 2011

Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells

scientific article

CFTR mutation combinations producing frequent complex alleles with different clinical and functional outcomes.

scientific article published on 2 July 2012

C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.

scientific article

Deficit of osteoprotegerin release by osteoblasts from a patient with cystic fibrosis

scientific article published on 01 March 2012

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

scientific article

Structure elucidation of a dihydropyranone from Tapinanthus dodoneifolius.

scientific article published on 6 December 2007

Vasorelaxation induced by dodoneine is mediated by calcium channels blockade and carbonic anhydrase inhibition on vascular smooth muscle cells.

scientific article

Function, pharmacological correction and maturation of new Indian CFTR gene mutations.

scientific article

CFTR channels and adenosine triphosphate release: the impossible rendez-vous revisited in skeletal muscle.

scientific article published on December 2010

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels

scientific article

Inhibition of ATP-sensitive K+ channels by substituted benzo[c]quinolizinium CFTR activators.

scientific article published in August 2003

Effect of VX-770 (ivacaftor) and OAG on Ca2+ influx and CFTR activity in G551D and F508del-CFTR expressing cells.

scientific article published on 10 June 2013

Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells.

scientific article

Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a

scientific article

Targeting surface voids to counter membrane disorders in lipointoxication-related diseases.

scientific article published on 3 May 2016

Predicting CFTR activity with front-runner cystic fibrosis drugs.

scientific article published on 27 January 2015

Pushing the limits of catalytic C-H amination in polyoxygenated cyclobutanes

scientific article published on 01 March 2016

Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR.

scientific article published on 4 August 2016

Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases

scientific article published on 28 June 2018

An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

scientific article published on 23 February 2011

SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells.

scientific article

The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection

scientific article

Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function.

scientific article published on 07 April 2017

Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

scientific article published on 04 December 2018

Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention.

scientific article published on 4 February 2017

Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation.

scientific article

Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells

scientific article published on 29 May 2020

Understanding nucleotide binding and CFTR ion channel gating: how many cycles?

scientific article published on 01 August 2010

Orphan missense mutations in the cystic fibrosis transmembrane conductance regulator: A three-step biological approach to establishing a correlation between genotype and phenotype

scientific article published on June 25, 2011

A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.

scientific article published on 14 June 2014

In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity.

scientific article

List of works by Frédéric Becq

Stimulation of salivary secretion in vivo by CFTR potentiators in Cftr+/+ and Cftr−/− mice

The glycine residues G551 and G1349 within the ATP-binding cassette signature motifs play critical roles in the activation and inhibition of cystic fibrosis transmembrane conductance regulator channels by phloxine B.

From the vasodilator and hypotensive effects of an extract fraction from Agelanthus dodoneifolius (DC) Danser (Loranthaceae) to the active compound dodoneine.

Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004.

Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.

ANO1 contributes to angiotensin-II-activated Ca2+-dependent Cl- current in human atrial fibroblasts

The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy

Genistein modifies the activation kinetics and magnitude of phosphorylated wild-type and G551D-CFTR chloride currents.

Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells

Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells

The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity.

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells.

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.

The hypotensive agent dodoneine inhibits L-type Ca2+ current with negative inotropic effect on rat heart.

Stimulation of wild-type, F508del- and G551D-CFTR chloride channels by non-toxic modified pyrrolo[2,3-b]pyrazine derivatives

Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells

CFTR mutation combinations producing frequent complex alleles with different clinical and functional outcomes.

C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.

Deficit of osteoprotegerin release by osteoblasts from a patient with cystic fibrosis

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

Structure elucidation of a dihydropyranone from Tapinanthus dodoneifolius.

Vasorelaxation induced by dodoneine is mediated by calcium channels blockade and carbonic anhydrase inhibition on vascular smooth muscle cells.

Function, pharmacological correction and maturation of new Indian CFTR gene mutations.

CFTR channels and adenosine triphosphate release: the impossible rendez-vous revisited in skeletal muscle.

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels

Inhibition of ATP-sensitive K+ channels by substituted benzo[c]quinolizinium CFTR activators.

Effect of VX-770 (ivacaftor) and OAG on Ca2+ influx and CFTR activity in G551D and F508del-CFTR expressing cells.

Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells.

Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a

Targeting surface voids to counter membrane disorders in lipointoxication-related diseases.

Predicting CFTR activity with front-runner cystic fibrosis drugs.

Pushing the limits of catalytic C-H amination in polyoxygenated cyclobutanes

Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR.

Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases

An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells.

The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection

Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function.

Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention.

Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation.

Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells

Understanding nucleotide binding and CFTR ion channel gating: how many cycles?

Orphan missense mutations in the cystic fibrosis transmembrane conductance regulator: A three-step biological approach to establishing a correlation between genotype and phenotype

A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.

In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity.