List of works by Aldons Jake Lusis

"Good enough solutions" and the genetics of complex diseases

scientific article

A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity

scientific article published on 23 December 2019

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism.

scientific article published in May 2018

A Suite of Tools for Biologists That Improve Accessibility and Visualization of Large Systems Genetics Datasets: Applications to the Hybrid Mouse Diversity Panel.

scientific article

A cluster of stearoyl CoA desaturase genes, Scd1 and Scd2, on mouse chromosome 19.

scientific article published in April 1998

A common mutation in paraoxonase-2 results in impaired lactonase activity.

scientific article published on December 2009

A comparison between whole transcript and 3' RNA sequencing methods using Kapa and Lexogen library preparation methods

A comprehensive catalogue of the coding and non-coding transcripts of the human inner ear.

scientific article published on September 2015

A gene homologous to plasminogen located on human chromosome 2q11-p11.

scientific article

A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11.

scientific article

A genome-wide panel of congenic mice reveals widespread epistasis of behavior quantitative trait loci

scientific article

A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background

scientific article

A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background

scientific article published in September 2005

A high-resolution association mapping panel for the dissection of complex traits in mice

scientific article

A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice

scientific article published on May 1996

A locus on the X chromosome is linked to body length in mice

scientific article published in March 1996

A multi-tissue full lifespan epigenetic clock for mice

A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland

scientific journal article

A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure

scientific article published on 24 February 2018

A polymorphism affecting apolipoprotein A-II translational efficiency determines high density lipoprotein size and composition

scientific article published in September 1990

A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids

scientific article published on 3 November 2005

A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models

scientific article published on 23 July 2011

A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response

scientific article published on 24 February 2017

A systems-based framework for understanding complex metabolic and cardiovascular disorders

scientific article

A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species

scientific article published on 27 February 2002

A thematic review series: systems biology approaches to metabolic and cardiovascular disorders

scientific article published on 01 September 2006

A treasure trove for lipoprotein biology

scientific article published in February 2008

ABCC6 deficiency is associated with activation of BMP signaling in liver and kidney

scientific article

ABCC6 localizes to the mitochondria-associated membrane

scientific article

ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response

scientific article published on May 2008

Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model

scientific article

Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits

scientific article published on 26 September 2019

Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells

scientific article published on January 2007

Allele-specific expression and eQTL analysis in mouse adipose tissue

scientific article

Allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to Bacillus anthracis

scientific article

Alteration of lipid profiles in plasma of transgenic mice expressing human lipoprotein lipase.

scientific article

Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity

scientific article published in 2022

Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress

scientific article published on 17 January 2008

An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits

scientific article

An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association

scientific article

An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease

scientific article published on 22 January 2021

An integrative systems genetic analysis of mammalian lipid metabolism

scientific article published on 27 February 2019

Analysis of allele-specific expression in mouse liver by RNA-Seq: a comparison with Cis-eQTL identified using genetic linkage

scientific article published on 11 September 2013

Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice

scientific article published on 3 January 2013

ApoA-II versus ApoA-I: two for one is not always a good deal.

scientific article

ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia.

scientific article published on 26 January 2007

Apolipoprotein A-I/C-III/A-IV gene cluster in familial combined hyperlipidemia: effects on LDL-cholesterol and apolipoproteins B and C-III.

scientific article published in January 1996

Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance

scientific article

Apolipoprotein B-100 Hopkins (arginine4019----tryptophan). A new apolipoprotein B-100 variant in a family with premature atherosclerosis and hyperapobetalipoproteinemia

scientific article published on 01 October 1989

Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis

scientific article published on 17 November 2016

Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis

scientific article (publication date: 2004)

Arterial colony stimulating factor-1 influences atherosclerotic lesions by regulating monocyte migration and apoptosis

scientific article

Assignment of Gpam to distal mouse chromosome 19 by linkage analysis

scientific article

Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13----q23 region of chromosome 5

scientific article published on 01 January 1986

Assignment of the gene for cyclic AMP-response element binding protein 2 (CREB2) to human chromosome 2q24.1–q32 ⬇️

scientific article published on December 1, 1991

Assignment of the human gene for CREB1 to chromosome 2q32.3-q34

scientific article

Assignment of the human gene for cholesteryl ester transfer protein to chromosome 16q12-16q21.

scientific article

Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter

scientific article

Assignment of the mouse ataxia-telangiectasia gene (Atm) to mouse chromosome 9.

scientific article published in July 1996

Assignment of the mouse sterol carrier protein gene (Scp2) to chromosome 4.

scientific article published in August 1996

Assignment of the mouse vesicular monoamine transporter genes, Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis

scientific article published in May 1996

Association between serum amyloid A proteins and coronary artery disease: evidence from two distinct arteriosclerotic processes

scientific article published on 01 November 1997

Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease

scientific article published on 12 December 2013

Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men.

scientific article published on 04 April 2013

Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia

scientific article

Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia

scientific article published on 4 March 2004

Atherosclerosis in C3H/HeJ mice reconstituted with apolipoprotein E-null bone marrow

scientific article

Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II.

scientific article

Atherosclerosis: Association between the gut microbiome and atherosclerosis

scientific article published on 3 November 2017

Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics

scientific article

Author Correction: Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

scientific article published in Nature Communications

Author Correction: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

article

BSB: a new mouse model of multigenic obesity

scientific article

Biochemical and Genetic Association of Plasma Apolipoprotein A-II Levels With Familial Combined Hyperlipidemia ⬇️

scientific article published on May 8, 2003

Biosynthetic relationships between three rat apolipoprotein B peptides

scientific article published on 01 October 1988

Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet

scientific article published on 01 February 1999

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

scientific article published on 20 July 2016

CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade

scientific article

Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification.

scientific article published on 15 November 2016

Cardiovascular disease genes come together

scientific article published on 23 June 2015

Cardiovascular networks: systems-based approaches to cardiovascular disease

scientific article

Characterization of the murine homing receptor gene reveals correspondence between protein domains and coding exons

scientific article

Chromatin variation associated with liver metabolism is mediated by transposable elements

scientific article published on 08 July 2016

Chromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipase.

scientific article

Chromosomal organization of mammalian POU domain factors.

scientific article published in October 1993

Chromosomal organization of the inducible and constitutive prostaglandin synthase/cyclooxygenase genes in mouse

scientific article published on 01 February 1993

Chylomicronemia elicits atherosclerosis in mice--brief report

scientific article published on 08 October 2009

Cis-acting expression quantitative trait loci in mice

scientific article

Cloning and expression of apolipoprotein B, the major protein of low and very low density lipoproteins

scientific article

Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5

scientific article published on 01 October 2002

Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA.

scientific article

Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model

scientific article

Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice

scientific article published on 20 February 2020

Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution

scientific article published on 01 December 2019

Combined QTL and selective sweep mappings with coding SNP annotation and cis-eQTL analysis revealed PARK2 and JAG2 as new candidate genes for adiposity regulation

scientific article

Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q

scientific article

Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis

scientific article published on June 2000

Comparative analysis of proteome and transcriptome variation in mouse

scientific article

Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine

scientific article

Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes

scientific article published on March 1997

Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism

scientific article published on March 1997

Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice

scientific article

Conducting the metabolic syndrome orchestra

scientific article published on June 2011

Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease

scientific article published on 01 June 2019

Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia

scientific article published on February 2000

Copy number variation influences gene expression and metabolic traits in mice

scientific article published on 31 July 2009

Correction: Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains

scientific article published on 2 March 2016

Correction: Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss

scientific article published on 11 June 2015

Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease

scientific article published on 3 March 2016

DNA Methylation Changes More Slowly Than Physiological States in Response to Weight Loss in Genetically Diverse Mouse Strains

scientific article published on 20 December 2019

DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States

scientific article published on 11 January 2016

DNA polymorphism haplotypes of the human lipoprotein lipase gene: possible association with high density lipoprotein levels

scientific article published on 01 April 1991

Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice

scientific article

Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice

scientific article published on 22 March 2007

Defective elongation of fatty acids in a recessive 25-hydroxycholesterol-resistant mutant cell line.

scientific article published on August 1990

Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice

scientific article published on 28 January 2014

Deficiency of inducible NO synthase reduces advanced but not early atherosclerosis in apolipoprotein E-deficient mice

scientific article

Description of two different patients with abetalipoproteinemia: synthesis of a normal-sized apolipoprotein B-48 in intestinal organ culture

scientific article published on 01 January 1990

Determinants of atherosclerosis susceptibility in the C3H and C57BL/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism

scientific article published on May 2000

Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential

Diesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia, and Liver Steatosis

scientific article published on 25 July 2019

Diesel exhaust particles dysregulate multiple immunological pathways in murine macrophages: Lessons from microarray and scRNA-seq technologies

scientific article published on 27 September 2019

Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression

scientific article

Differential accumulation of intimal monocyte-macrophages relative to lipoproteins and lipofuscin corresponds to hemodynamic forces on cardiac valves in mice.

scientific article published in July 1991

Dilated cardiomyopathy: learning to live with yourself.

scientific article published in December 2003

Discovering Single Nucleotide Polymorphisms Regulating Human Gene Expression Using Allele Specific Expression from RNA-seq Data

scientific article

Dispersed family of human genes with sequence similarity to farnesyl pyrophosphate synthetase

scientific article published in October 1989

Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice

scientific article

Dissection of multigenic obesity traits in congenic mouse strains

scientific article

Dosage compensation is less effective in birds than in mammals

scientific article

ENU Large-scaleMutagenesis andQuantitativeTraitLinkage(QTL) Analysis inMice:NovelTechnologies forSearchingPolygeneticDeterminants ofCraniofacialAbnormalities ⬇️

scientific article published on January 1, 2003

Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice ⬇️

scientific article

Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice

scientific journal article

Effect of dietary cholesterol and taurocholate on cholesterol 7 alpha-hydroxylase and hepatic LDL receptors in inbred mice

scientific article published on 01 June 1993

Effect of macrophage-derived apolipoprotein E on established atherosclerosis in apolipoprotein E-deficient mice.

scientific article published in October 2000

Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice

scientific article

Efficient and Accurate Multiple-Phenotype Regression Method for High Dimensional Data Considering Population Structure

scientific article

Elevated Adiponectin Levels Suppress Perivascular and Aortic Inflammation and Prevent AngII-induced Advanced Abdominal Aortic Aneurysms

scientific article published on 23 September 2016

Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes

scientific article

Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks

scientific article published on 30 October 2008

Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis

scientific article

Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice

scientific article published on July 2000

Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration

scientific article

Epigenome-wide association in adipose tissue from the METSIM cohort.

scientific article published on 16 March 2018

Epigenome-wide association in adipose tissue from the METSIM cohort.

scientific article published in July 2018

Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice

scientific article

Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression

scientific article

Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling

scientific article published on 01 August 2020

Evidence for independent genetic regulation of heart and adipose lipoprotein lipase activity

scientific article published on 01 November 1983

Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit

scientific article published on December 1985

Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia

scientific article published on December 2011

Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene

scientific article (publication date: 11 July 2001)

Expression of human paraoxonase (PON1) during development.

scientific article published in June 2003

Expression quantitative trait loci: replication, tissue- and sex-specificity in mice

scientific article

FAM13A affects body fat distribution and adipocyte function

scientific article published on 19 March 2020

FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice

journal article published in 2007

FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice

scientific article published on 6 July 2006

Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1.

scientific article published on 23 June 2005

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).

scientific article published on 29 February 2004

Familial combined hyperlipidemia: upstream transcription factor 1 and beyond

scientific article

Families with familial combined hyperlipidemia and families enriched for coronary artery disease share genetic determinants for the atherogenic lipoprotein phenotype

scientific article

Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity

scientific article published on 17 September 2020

Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHL.

scientific article published in March 2001

Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids

scientific article published on 23 March 2008

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

scientific article

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk

scientific article published on 09 August 2018

Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration

scientific article published on 7 August 2017

From hairballs to an understanding of transendothelial migration of monocytes in atherosclerosis

scientific article published on September 2014

Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus

scientific article

Future of osteoporosis genetics: enhancing genome-wide association studies

scientific article

Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association

scientific article

Gene expression analyses of mouse aortic endothelium in response to atherogenic stimuli

scientific article

Gene networks associated with conditional fear in mice identified using a systems genetics approach

scientific article

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits

article

Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid

scientific article published on 11 October 2007

Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains

scientific article (publication date: December 2015)

Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report

scientific article published on 01 June 2019

Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model

scientific article

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits

scientific article

Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis

scientific article published on 01 September 2018

Genetic and environmental control of host-gut microbiota interactions

scientific article published on 10 August 2015

Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity

scientific article

Genetic and hormonal control of hepatic steatosis in female and male mice

scientific article published on 3 November 2016

Genetic architecture of insulin resistance in the mouse

scientific article

Genetic backgrounds but not sizes of atherosclerotic lesions determine medial destruction in the aortic root of apolipoprotein E-deficient mice

scientific article

Genetic basis of atherosclerosis: part I: new genes and pathways

scientific article published in September 2004

Genetic basis of atherosclerosis: part II: clinical implications

scientific article published in October 2004

Genetic characterization of the Dyscalc locus

scientific article published in June 2002

Genetic contributions to quantitative lipoprotein traits associated with coronary artery disease: analysis of a large pedigree from the Bogalusa Heart Study

scientific article published on 01 November 1993

Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J).

scientific article published in December 2000

Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice

scientific article published on June 1993

Genetic control of lipid transport in mice. I. Structural properties and polymorphisms of plasma lipoproteins

scientific article published on 01 April 1983

Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice

scientific article

Genetic control of the inflammatory response induced by oxidized lipids

scientific article published on February 1995

Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneity

scientific article published on 08 January 2019

Genetic determination of cartilaginous metaplasia in mouse aorta.

scientific article published in December 1995

Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling

scientific article published on 31 March 2009

Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice

scientific article

Genetic factors controlling structure and expression of apolipoproteins B and E in mice

scientific article published on 01 June 1987

Genetic factors in cardiovascular disease. 10 questions

scientific article published on November 2003

Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach

scientific article published on October 1995

Genetic linkage of hyperglycemia, body weight and serum amyloid-P in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice

scientific article

Genetic loci contributing to age-related hippocampal lesions in mice

scientific article

Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model

scientific article published on June 1998

Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice

scientific article

Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia

scientific article published in July 2001

Genetic locus on mouse chromosome 7 controls elevated heart rate

scientific article

Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation

scientific article

Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery

scientific article

Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice

scientific article published on 02 January 2009

Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes.

scientific article published in July 1996

Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits

scientific article published on 04 April 2013

Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis

scientific article published on 01 January 2021

Genetic regulation of mouse liver metabolite levels

scientific article

Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus.

scientific article published on January 1995

Genetic variation in mouse apolipoprotein A-IV expression is determined pre- and post-transcriptionally

scientific article published on 01 June 1993

Genetic, dietary, and sex-specific regulation of hepatic ceramides and relationship between hepatic ceramides and insulin resistance.

scientific article published on 8 May 2018

Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model

scientific article published on April 1996

Genetics of atherosclerosis

scientific article published in January 2004

Genetics of atherosclerosis

article

Genetics of common forms of heart disease: a long and winding road

scientific article published on October 2013

Genetics of common forms of heart failure: challenges and potential solutions

scientific article published on May 2015

Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A

scientific article published on 01 November 2000

Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p.

scientific article

Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice

scientific article published on 18 August 2016

Genome-wide association mapping of blood cell traits in mice

scientific article published on 17 February 2013

Genome-wide association study for age-related hearing loss (AHL) in the mouse: a meta-analysis

scientific article

Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss

scientific article

Genome-wide screening for genetic loci associated with noise-induced hearing loss

scientific article

Genomewide Association Study Identifies Cxcl Family Members as Partial Mediators of LPS-Induced Periodontitis.

scientific article

Genomic analysis of metabolic pathway gene expression in mice

scientific article

Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding

scientific article

Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci

scientific article published on 15 March 2013

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

scientific article

Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes

scientific article published on 27 October 2021

Granulocyte macrophage colony-stimulating factor regulates dendritic cell content of atherosclerotic lesions

scientific article

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

scientific article

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

scientific article

HDL inhibits the effects of oxidized phospholipids on endothelial cell gene expression via multiple mechanisms

scientific article

Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but don't predict tissue iron levels in inbred mice

scientific article published on 10 August 2017

Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis.

scientific article published on 10 May 2007

Heme oxygenase-1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice

scientific article published in March 2001

Hepatocellular carcinoma in Txnip-deficient mice.

scientific article

Heritability and genetic loci of fatty liver in familial combined hyperlipidemia.

scientific article published on 13 September 2006

Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice

scientific article

High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping

scientific article

High-density lipoprotein modulates oxidized phospholipid signaling in human endothelial cells from proinflammatory to anti-inflammatory

scientific article published on 22 March 2007

High-resolution association mapping of atherosclerosis loci in mice

scientific article

High-resolution mapping of gene expression using association in an outbred mouse stock

scientific article

Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to Fructose Consumption in Mice

scientific article published on 28 August 2020

Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to Fructose Consumption in Mice

scientific article published on 11 October 2018

Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing

scientific article published on 5 October 2005

Human apolipoprotein B: chromosomal mapping and DNA polymorphisms of hepatic and intestinal species

scientific article published on 01 May 1986

Human apolipoprotein B: partial amino acid sequence ⬇️

scientific article published on 01 May 1984

Human genes involved in lipolysis of plasma lipoproteins: mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to 15q21

scientific article

Human lipoprotein lipase complementary DNA sequence

scholarly article

Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids

scientific article (publication date: April 2001)

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits

scientific article

Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice

scientific article published on 10 June 2013

Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men

scientific article

Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosis

scientific article

Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes

scientific article (publication date: 13 September 2016)

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

scientific article published on 8 December 2017

Identification and validation of genes affecting aortic lesions in mice

scientific article

Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice

scientific article

Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics

scholarly article

Identification of CAD candidate genes in GWAS loci and their expression in vascular cells

scientific article

Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.

scientific article published on September 1997

Identification of four chromosomal loci determining obesity in a multifactorial mouse model

scientific article

Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids

scholarly article

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

scientific article

Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data

scientific article

Identifying loci for behavioral traits using genome‐tagged mice ⬇️

scientific article published on November 15, 2003

Immune-complex-mediated vasculitis increases coronary artery lipid accumulation in autoimmune-prone MRL mice

scientific article published on 01 June 1993

Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet

scientific article published in December 1994

Impact of Individual Traits, Saturated Fat, and Protein Source on the Gut Microbiome

scientific article published in 2018

Impact of chromosome 2 obesity loci on cardiovascular complications of insulin resistance in LDL receptor-deficient C57BL/6 mice.

scientific article published in August 2006

Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis

scientific article

Imputing Phenotypes for Genome-wide Association Studies

scientific article published on 08 June 2016

In vivo interactions of apoA-II, apoA-I, and hepatic lipase contributing to HDL structure and antiatherogenic functions.

scientific article published in April 2001

Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense

scholarly article

Inaugural Charles River World Congress on Animal Models in Drug Discovery and Development.

scientific article published on 5 September 2017

Increased atherosclerosis in myeloperoxidase-deficient mice

scientific article

Increased lipogenesis and fatty acid reesterification contribute to hepatic triacylglycerol stores in hyperlipidemic Txnip-/- mice

scientific article published in June 2004

Increasing association mapping power and resolution in mouse genetic studies through the use of meta-analysis for structured populations

scientific article

Individual diet has sex-dependent effects on vertebrate gut microbiota

scientific article

Induction of chemotactic cytokines by minimally oxidized LDL.

scientific article published in January 1993

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins ⬇️

scientific article published on March 15, 1990

Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL ⬇️

scientific article published on September 1, 1997

Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice

scientific article

Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification

scientific article

Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels

scientific article published on 29 August 2005

Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice

scientific article

Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice

scientific article

Integrating genetic and network analysis to characterize genes related to mouse weight

scientific article

Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits

scientific article

Integrating global gene expression analysis and genetics

scientific article

Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-Alcoholic Fatty Liver Disease

Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease

scientific article published on 17 January 2018

Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS.

scientific article

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

scientific article published on 23 February 2021

Integrative approaches for large-scale transcriptome-wide association studies

scientific article published on 8 February 2016

Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.

scientific article

Interaction of monocytes with cocultures of human aortic wall cells involves interleukins 1 and 6 with marked increases in connexin43 message ⬇️

scientific article published on May 1, 1991

Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model

scientific article published on 05 November 2018

Intergenerational genomic DNA methylation patterns in mouse hybrid strains

scientific article

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

scientific article

Involvement of the tyrosinase gene in the deposition of cardiac lipofuscin in mice. Association with aortic fatty streak development

scientific article

Isoproterenol-Induced Cardiac Diastolic Dysfunction in Mice: A Systems Genetics Analysis

scientific article published on 31 July 2019

KpnI RFLP for the human CSF-1 gene

scientific article published on August 1989

LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice

scientific article

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

scientific article published on 01 August 2019

Life after GWAS: functional genomics in vascular biology

scientific article published on February 2012

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

scientific journal article

Limited RNA editing in exons of mouse liver and adipose

scientific article published on 14 February 2013

Linkage between the APOB gene and serum ApoB levels in a large pedigree from the Bogalusa Heart Study

scientific article published on 01 January 1994

Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse

scientific article published on November 1993

Linkage of a candidate gene locus to familial combined hyperlipidemia: lecithin:cholesterol acyltransferase on 16q.

scientific article published on November 1999

Linkage of the mouse LDL receptor gene on chromosome 9.

scientific article published in October 1989

Lipid retention in the arterial wall of two mouse strains with different atherosclerosis susceptibility

scientific article

Lipid-induced changes in intracellular iron homeostasis in vitro and in vivo

scientific article

Lipin-1 and lipin-3 together determine adiposity in vivo

scientific article

Lipoprotein (a) displays increased accumulation compared with low-density lipoprotein in the murine arterial wall

scientific article published on 01 January 1994

Liver Pyruvate Kinase Promotes NAFLD/NASH in both Mice and Humans in a Sex-Specific Manner

scientific article published on 14 September 2020

Local M-CSF (Macrophage Colony-Stimulating Factor) Expression Regulates Macrophage Proliferation and Apoptosis in Atherosclerosis

scientific article published on 22 October 2020

Localization and evolution of two human phospholipase A2 genes and two related genetic elements.

scientific article published in January 1990

Localization of monocyte chemotactic protein-1 gene (SCYA2) to human chromosome 17q11.2-q21.1

scientific article

Localization of mouse peroxisome proliferator-activated receptor delta (Ppard) on chromosome 17 near colipase (Clps).

scientific article published in July 1996

Localization of mouse peroxisome proliferator-activated receptor gamma on chromosome 6.

scientific article published in May 1996

Localization of murine macrophage inducible nitric oxide synthase to mouse chromosome 11

scientific article published on 01 August 1994

Localization of profilin-1 (Pfn1) and a related sequence (Pfn1-rs) to mouse chromosomes 11 and 15 respectively

scientific article published in July 1997

Localization of the delta-opioid receptor gene to mouse chromosome 4 by linkage analysis

scientific article

Localization of the gene for apolipoprotein D on mouse chromosome 16

scientific article published on April 1, 1992

Localization of the gene for high-density lipoprotein binding protein (HDLBP) to human chromosome 2q37

scientific article

Localization of the gene for the DNA-binding protein AP-2 to human chromosome 6p22.3-pter

scientific article

Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23

scientific article

Localization of the mouse glucocorticoid receptor-interacting protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysis.

scientific article

Localization of the transcription factor SP1 gene to human chromosome 12q12-->q13.2.

scientific article published in January 1993

Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24.

scientific article

Localization of ubiquitin gene family members to mouse chromosomes 5, 11, and 18.

scientific article

Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia

scientific article published in May 2002

Longitudinal differences in familial combined hyperlipidemia quantitative trait loci

scientific article published on 01 June 2006

Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low density lipoprotein receptor-deficient mice.

scientific article

Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice.

scientific article published on 21 September 2006

Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human

scientific article

Macrophage accumulation in atherosclerosis

scientific article published on December 2013

Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response

scientific article

Mapping a gene for combined hyperlipidaemia in a mutant mouse strain.

scientific article published in April 1998

Mapping behavioral traits by use of genome-tagged mice

scientific article published in March 2004

Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice

scientific article

Mapping of multiple mouse loci related to the farnesyl pyrophosphate synthetase gene

scientific article published in January 1993

Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24.

scientific article

Mapping of the gene for calreticulin (Calr) to mouse chromosome 8.

scientific article published in January 1997

Mapping of the gene for high-density lipoprotein binding protein (Hdlbp) to proximal mouse chromosome 1

scientific article published on 01 September 1994

Mapping of the gene for the cardiac sarcolemmal Na(+)-Ca2+ exchanger to human chromosome 2p21-p23.

scientific article published in March 1992

Mapping of the glycoprotein 330 (Gp330) gene to mouse chromosome 2.

scientific article published in September 1993

Mapping of three members of the mouse protein disulfide isomerase family

scientific article published in February 1998

Mapping the genetic architecture of gene expression in human liver ⬇️

scientific article

Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice

scientific article published on 4 October 2007

Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring

scientific article published on 11 December 2018

Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction

scientific article published on 10 December 2008

Maximal information component analysis: a novel non-linear network analysis method

scientific article published on 12 March 2013

Mechanisms controlling competence gene expression in murine fibroblasts stimulated with minimally modified LDL.

scientific article published in July 1992

Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-II.

scientific article published in October 2004

Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease

scientific article published on 23 June 2011

Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces

scientific article

Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems

scientific article

Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice

scientific article published on 09 January 2014

Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2 induced systemic toxicity

scientific article published on 07 December 2020

Metabolic syndrome as a modifier of atherosclerosis in murine models

scientific article

Metabolic syndrome: from epidemiology to systems biology

scientific article

Metalloproteinase processing of HBEGF is a proximal event in the response of human aortic endothelial cells to oxidized phospholipids

scientific article

Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals

scientific article published on 26 March 2004

Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential

scientific article published on 01 October 2018

Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio

scientific article published on April 1997

Minimally modified low density lipoprotein is biologically active in vivo in mice

scientific article

Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: Evidence for "polygenic epistasis"

scientific article published on 26 October 2020

Molecular Cloning and Functional Expression of Murine JE (Monocyte Chemoattractant Protein 1) and Murine Macrophage Inflammatory Protein 1 Receptors

scientific article published in Journal of Biological Chemistry

Mouse chromosomal localization of the cortexin (Ctxn) gene

scientific article published in July 1994

Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis

scientific article

Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1

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Multi-omics approaches to disease

scientific article

Multilocus genetic determinants of LDL particle size in coronary artery disease families

scientific article published in March 1996

Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol

scientific article

Myeloperoxidase, a leukocyte-derived vascular NO oxidase

scientific article published in June 2002

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

scientific article published on August 2013

NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection ⬇️

scientific article published on October 14, 2010

NIH3T3 transforming gene not a general feature of atherosclerotic plaque DNA (atherosclerosis/oncogene/NIH3T3 transfection assay).

scientific article published on December 1989

Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling

scientific article published on 12 May 2020

Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival

scientific article

Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1.

scientific article

Network-centered view of coronary artery disease

scientific article

Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis

scientific article published in April 2002

Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis

scientific article

New insights into atherosclerosis from studies with mouse models

scientific article published on November 1995

Noggin depletion in adipocytes promotes obesity in mice

scientific article published on 10 April 2019

Novel QTLs for HDL levels identified in mice by controlling for Apoa2 allelic effects: confirmation of a chromosome 6 locus in a congenic strain

scientific article

Novel gene exon homologous to pancreatic phospholipase A2: sequence and chromosomal mapping of both human genes

scientific article

Novel genes for familial combined hyperlipidemia

scientific article

Nucleotide sequence of rat adipose hormone sensitive lipase cDNA.

scientific article published on October 1988

Null mutation of myeloperoxidase in mice prevents mechanical activation of neutrophil lysis of muscle cell membranes in vitro and in vivo

scientific article published on 24 March 2005

Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction

scientific article

Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition

scientific article published on 06 August 2019

Obesity-linked suppression of membrane-bound -acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

scientific article published on 17 October 2019

Open chromatin profiling in mice livers reveals unique chromatin variations induced by high fat diet

scientific article

Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles ⬇️

scientific article published on July 15, 1997

Oxidized lipoproteins influence gene expression by causing oxidative stress and activating the transcription factor NF-kappa B.

scientific article

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.

scientific article

PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

scientific article

PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response

scientific article published on 3 August 2013

Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages

scientific article published on March 1999

Paradoxical reduction of fatty streak formation in mice lacking endothelial nitric oxide synthase

scientific article

Paraoxonase 1 (PON1) status and risk of insecticide exposure

journal article published in 2005

Paraoxonase and coronary heart disease

scientific article published on 01 August 1998

Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2.

scientific article published on 4 August 2006

Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia.

scientific article published on 22 November 2006

Paraoxonase-2 modulates stress response of endothelial cells to oxidized phospholipids and a bacterial quorum-sensing molecule

scientific article published on November 2011

Pathogenesis of atherosclerosis

scientific article published in September 1995

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure.

scientific article published on 24 June 2019

Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification

scientific article published in September 1994

Phenotypic characterization of the Ath-1 gene controlling high density lipoprotein levels and susceptibility to atherosclerosis.

scientific article published in January 1990

Placental genomics mediates genetic associations with complex health traits and disease

scientific article published on 04 February 2022

Positional cloning of the combined hyperlipidemia gene Hyplip1

scientific article

Prediction of Causal Candidate Genes in Coronary Artery Disease Loci

scientific article

Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans

scientific article

Proceedings of the 11th Congress of the International Society of Nutrigenetics and Nutrigenomics (ISNN 2017).

scientific article published on 17 January 2018

Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway

scientific article published on 15 December 2015

Publisher Correction: RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice

scientific article published on 08 October 2020

Quantitative analysis of 3-dimensional facial soft tissue photographic images: technical methods and clinical application

scientific article published on 2 July 2015

Quantitative trait loci for apolipoprotein B, cholesterol, and triglycerides in familial combined hyperlipidemia pedigrees

scientific article

Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E gene

scientific article

Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice

scientific article published in December 1994

Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism.

scientific article

Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22.

scientific article published on May 1996

RFLP for the human lipoprotein lipase (LPL) gene: HindIII.

scientific article

RIPK1 Expression Associates with Inflammation in Early Atherosclerosis in Humans and Can be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice

scientific article published on 23 November 2020

RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice

scientific article published on 28 September 2020

Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION.

scientific article published on 16 May 2016

Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association

scientific article published on 20 July 2017

Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association

scientific article

Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV.

scientific article published on April 1997

Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling

scientific article

Regional mapping of human chromosome 19: organization of genes for plasma lipid transport (APOC1, -C2, and -E and LDLR) and the genes C3, PEPD, and GPI.

scientific article published on June 1986

Regulation of NF-κB signaling by oxidized glycerophospholipid and IL-1β induced miRs-21-3p and -27a-5p in human aortic endothelial cells

scientific article

Regulation of chicken apolipoprotein B: cloning, tissue distribution, and estrogen induction of mRNA.

scientific article

Regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A synthase and the chromosomal localization of the human gene

scientific article

Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis

scientific article published on 02 November 2018

Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.

scientific article

Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia

scientific article (publication date: November 2002)

Relationship of disease-associated gene expression to cardiac phenotype is buffered by genetic diversity and chromatin regulation

scientific article published on 10 June 2016

Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk

scientific article

Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort

scientific article

Response to Pomozi et al's research commentary

scientific article published on 26 April 2013

Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2.

scientific article published on May 1999

Role of group II secretory phospholipase A2 in atherosclerosis: 2. Potential involvement of biologically active oxidized phospholipids

scientific article published on May 1999

Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function

scientific article published on 30 September 2016

Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice.

scientific article published on May 1997

Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants

scientific article

Role of phospholipid oxidation products in atherosclerosis

scientific article published on August 2012

Role of the GRO family of chemokines in monocyte adhesion to MM-LDL-stimulated endothelium

scientific article

Rosuvastatin Prevents the Exacerbation of Atherosclerosis in Ligature-Induced Periodontal Disease Mouse Model

scientific article published on 14 April 2020

Scavenger receptor class A member 5 (SCARA5) and suprabasin (SBSN) are hub genes of coexpression network modules associated with peripheral vein graft patency

scientific article

Secretory non-pancreatic phospholipase A2: influence on lipoprotein metabolism

scientific article published on 01 November 1997

Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes

scientific journal article

Sequence, structure, and chromosomal mapping of the mouse Lgals6 gene, encoding galectin-6.

scientific article published in January 1998

Serum amyloid A protein family. Differential induction by oxidized lipids in mouse strains

scientific article

Sex differences and hormonal effects on gut microbiota composition in mice

scientific article published on 29 June 2016

Sex differences in metabolism and cardiometabolic disorders

scientific article published on 01 October 2018

Sex-Specific Role of Adipose-Derived Lipocalin-2 in Diet-Induced Obesity and Insulin Resistance

scholarly article by Karthickeyan Chella Krishnan et al published May 2018 in Diabetes

Sex-specific metabolic functions of adipose Lipocalin-2

scientific article published on 27 September 2019

Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States

scientific article published on 28 September 2017

Shared molecular pathways and gene networks for cardiovascular disease and type 2 diabetes mellitus in women across diverse ethnicities.

scientific article published on 4 November 2014

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

scientific article published on April 2016

Srb1 maps to mouse chromosome 5 in a region harboring putative QTLs for plasma lipoprotein levels

scientific article

Structure and chromosomal localization of the murine gene encoding GLYCAM 1. A mucin-like endothelial ligand for L selectin ⬇️

scientific article published on February 25, 1993

Structure of the murine tissue factor gene. Chromosome location and conservation of regulatory elements in the promoter

scientific article published on April 1992

Structure, evolution, and regulation of chicken apolipoprotein A-I.

scientific article

Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein

scientific article

Suppression of inflammatory arthritis in human serum paraoxonase 1 transgenic mice

scientific article published on 08 October 2020

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

scientific article

Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse.

scientific article published in August 2003

Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice

scientific article

Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans

article

Systems Genetics for Mechanistic Discovery in Heart Diseases

scientific article published on 04 June 2020

Systems biology asks new questions about sex differences

scientific article published on 23 September 2009

Systems genetic analysis of osteoblast-lineage cells

scientific article

Systems genetics analysis of gene-by-environment interactions in human cells

scientific article

Systems genetics analysis of mouse chondrocyte differentiation

scientific article

Systems genetics applications in metabolism research

scientific article published on 21 October 2019

Systems genetics approaches to understand complex traits

scientific article published on 03 December 2013

Systems genetics of susceptibility to obesity-induced diabetes in mice

scientific article published on 18 October 2011

Systems toxicogenomics of prenatal low-dose BPA exposure on liver metabolic pathways, gut microbiota, and metabolic health in mice

scientific article published on 19 November 2020

Systems-based approaches for investigation of inter-tissue communication

article by Marcus M Seldin & Aldons J Lusis published March 2019 in Journal of Lipid Research

Systems-based approaches to cardiovascular disease

scientific article published on 10 January 2012

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism

scientific article published on 14 March 2019

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

scientific article published on 05 June 2019

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.

scientific article

Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development

scientific article

Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysis

scientific article published on January 2010

Testing the iron hypothesis in a mouse model of atherosclerosis

scientific article published on 05 December 2013

Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase

scientific article

Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD.

scientific article published on 9 March 2016

The Ca transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations

scientific article published on 25 September 2018

The Collaborative Cross, a community resource for the genetic analysis of complex traits

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The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes

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The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice

scientific article published on 28 August 2020

The Genetic Architecture of Diet-Induced Hepatic Fibrosis in Mice

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The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants

scientific article

The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction

scientific article

The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice

scientific article published on 4 June 2015

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits

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The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides

scientific article published on 03 July 2007

The L-isoaspartyl/D-aspartyl protein methyltransferase gene (PCMT1) maps to human chromosome 6q22.3-6q24 and the syntenic region of mouse chromosome 10

scientific article (publication date: December 1992)

The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases

scientific article published on 24 January 2017

The State of Systems Genetics in 2017.

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The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

scientific article published in June 2017

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.

scientific article

The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture

scientific article published on July 1996

The allelic structure of common disease

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The apolipoprotein(a) gene resides on human chromosome 6q26?27, in close proximity to the homologous gene for plasminogen ⬇️

scientific article published on August 1, 1988

The gene for human liver arginase (ARG1) is assigned to chromosome band 6q23.

scientific article

The genetic architecture of NAFLD among inbred strains of mice

scientific article published on 12 June 2015

The glutathione peroxidase gene, Gpx1, maps to mouse chromosome 9.

scientific article

The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle

scientific article published on 04 December 2018

The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL.

scientific article published on April 2004

The problem of passenger genes in transgenic mice

scientific article published on 9 August 2007

The roles of PON1 and PON2 in cardiovascular disease and innate immunity

scientific article published on August 2009

The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family

scientific article

The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002).

scientific article published on 21 November 2008

The systems genetics resource: a web application to mine global data for complex disease traits

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The unfolded protein response is an important regulator of inflammatory genes in endothelial cells

scientific article

Thematic review series: The pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis

scientific article published in August 2004

Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition

scientific article published in November 2004

Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes

scientific article published on 13 June 2008

Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis

scientific article published on 2 January 2008

Tissue-specific expression and developmental regulation of the rat apolipoprotein B gene

scientific article published in November 1986

Tissue-specific expression and regulation of sexually dimorphic genes in mice

scientific article

Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

scientific article published on 22 October 2018

Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity

scientific article published on 24 April 2018

Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism ⬇️

journal article published in 2005

Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus

scientific article

Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.

scientific article published on 12 February 2018

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes

scientific article published on 17 February 2022

Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid

scientific article published on October 2013

Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice

scientific article published in January 2002

Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice

scientific article

Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males

scientific article

Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum

scientific article published on 7 June 2017

Transmission of atherosclerosis susceptibility with gut microbial transplantation

scientific article

Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis

scientific article

Tribute to Dr. Steve Schwartz

scientific article published on 11 April 2020

Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB.

scientific article published on 22 February 2016

Trimethylamine N-Oxide levels are associated with NASH in obese subjects with type 2 diabetes

scientific article published on 10 August 2020

Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation

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Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice

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Two members of the S-lac lectin gene family, LGALS1 and LGALS2, reside in close proximity on human chromosome 22q12-q13.

scientific article

Two polymorphisms for the human hepatic lipase (HL) gene

scientific article published on May 1988

Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury

scientific article published on 02 July 2020

USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease

scientific article published on 02 August 2007

Ubiquinone biosynthesis in eukaryotic cells: tissue distribution of mRNA encoding 3,4-dihydroxy-5-polyprenylbenzoate methyltransferase in the rat and mapping of the COQ3 gene to mouse chromosome 4.

scientific article

Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility

scientific article published in April 2005

Understanding atherosclerosis through mouse genetics

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Understanding the sexome: measuring and reporting sex differences in gene systems

scientific article

Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages

scientific article

Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota

scientific article published on 3 June 2015

Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice

scientific article

Using genetic markers to orient the edges in quantitative trait networks: the NEO software

scientific article

Using mice to dissect genetic factors in atherosclerosis

scientific article

Using the natural variation of mouse populations to understand host-gut microbiome interactions

scientific article published on 01 January 2018

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

scientific article

Variations in DNA elucidate molecular networks that cause disease

scientific article

Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice

scientific article published on 20 February 2012

Vestigial-like 3 is an inhibitor of adipocyte differentiation

scientific article

Weighted gene coexpression network analysis strategies applied to mouse weight

scientific article

XX sex chromosome complement promotes atherosclerosis in mice

scientific article published on 14 June 2019

Y-Chromosome Genetic Variation Associated With Atherosclerosis and Inflammation

scientific article published on 23 October 2019

cis-acting determinants of basal and lipid-regulated apolipoprotein A-IV expression in mice

scientific article published on 01 November 1989

γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO

scientific article

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