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List of works by Genhong Cheng

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MicroRNA-155 is induced during the macrophage inflammatory response

scientific article
IRF3 mediates a TLR3/TLR4-specific antiviral gene program

scientific article published on September 2002
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

scientific article
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice

scientific article
Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice

scientific article published on July 2009
Type I interferon production enhances susceptibility to Listeria monocytogenes infection

scientific article
Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway

scientific article published in December 2004
LXR-dependent gene expression is important for macrophage survival and the innate immune response

scientific article
Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism

scientific article published on October 1, 2003
Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

scientific article published on October 2011
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses

scientific article
The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

scientific article published on May 2008
Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol

scientific article
The signaling adaptors and pathways activated by TNF superfamily

scientific article
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

scientific article
Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

scientific article (publication date: 14 March 2002)
Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection

scientific article
DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells

scientific article published on June 24, 2011
MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus

scientific article published in January 2006
Systematic identification of type I and type II interferon-induced antiviral factors

scientific article published on February 27, 2012
Toll-like receptors induce a phagocytic gene program through p38.

scientific article published on 29 December 2003
The host type I interferon response to viral and bacterial infections

scientific article
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

scientific journal article
NF-kappaB inhibits gammaherpesvirus lytic replication

scientific article
Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

scientific article published on October 2017
Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo

scientific article published in November 2007
Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

scientific article published on May 10, 2012
Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses

scientific article
Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production

scientific article published in June 2007
Control of canonical NF-kappaB activation through the NIK-IKK complex pathway

scholarly article
From Mosquitos to Humans: Genetic Evolution of Zika Virus

scientific article
Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice

scientific article
Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK

scientific article
Non‐canonical NF‐κB signaling activation and regulation: principles and perspectives

scientific article published on November 1, 2011
Asian Zika virus strains target CD14(+) blood monocytes and induce M2-skewed immunosuppression during pregnancy

scientific article published on 21 August 2017
Rescue of TRAF3-null mice by p100 NF-kappa B deficiency

scientific journal article
25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model

scientific article (publication date: March 2017)
Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury

scientific article published in August 2005
Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm

scholarly article
Divergence of macrophage phagocytic and antimicrobial programs in leprosy

scientific article published on October 2009
Lipopolysaccharide-Mediated IL-10 Transcriptional Regulation Requires Sequential Induction of Type I IFNs and IL-27 in Macrophages

scientific article published on December 1, 2010
New developments in the induction and antiviral effectors of type I interferon

scientific article published on November 29, 2010
Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response

scientific article published on February 2009
PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production

scientific article published on November 2008
Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4

scientific article (publication date: April 2003)
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation

scientific article
NF-κB and Innate Immunity

scientific article published on January 1, 2011
NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy

scientific article
Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway

scientific article
Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes

scientific article

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