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List of works by Genhong Cheng

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model

scientific article (publication date: March 2017)

A MyD88-dependent IFNγR-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge

scientific article

A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon

scientific article published on 12 December 2007

A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections

scientific article

A triclade DNA vaccine designed on the basis of a comprehensive serologic study elicits neutralizing antibody responses against all clades and subclades of highly pathogenic avian influenza H5N1 viruses

scientific article

Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants

scientific article published on 17 May 2022

Asian Zika virus strains target CD14(+) blood monocytes and induce M2-skewed immunosuppression during pregnancy

scientific article published on 21 August 2017

Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies

scholarly article by Suan-Sin Foo et al published 2 November 2018 in JCI insight

Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity ⬇️

scientific article published on May 10, 2012

Cathelicidin signaling via the Toll-like receptor protects against colitis in mice

scientific article published on 14 July 2011

Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice

scientific article

Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm

scholarly article

Complex Regulation Pattern of IRF3 Activation Revealed by a Novel Dimerization Reporter System

scientific article published on 04 April 2016

Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response

scientific article published on February 2009

Control of canonical NF-kappaB activation through the NIK-IKK complex pathway

scholarly article

Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses

scientific article

Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes

scientific article

Coronavirus MHV-A59 infects the lung and causes severe pneumonia in C57BL/6 mice

scientific article published on 22 December 2014

Cross-protection of newly emerging HPAI H5 viruses by neutralizing human monoclonal antibodies: A viable alternative to oseltamivir

scientific article published on 11 May 2016

Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism ⬇️

scientific article published on October 1, 2003

Crystal structure of the ubiquitin-like domain of human TBK1 ⬇️

scientific article published on May 20, 2012

Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway

scientific article published in December 2004

Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production

scientific article published in June 2007

DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells ⬇️

scientific article published on June 24, 2011

Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection

scientific article

Disruption of Type I Interferon Induction by HIV Infection of T Cells

scientific article published on 16 September 2015

Divergence of macrophage phagocytic and antimicrobial programs in leprosy

scientific article published on October 2009

E90 subunit vaccine protects mice from Zika virus infection and microcephaly

scholarly article by Xing-Liang Zhu et al published 10 August 2018 in Acta neuropathologica communications

Erratum to: Structural and functional analyses of human DDX41 DEAD domain

scientific article published on 13 January 2017

From Mosquitos to Humans: Genetic Evolution of Zika Virus

scientific article

From plankton to pathogen recognition

article

Functional Genomics Reveals Linkers Critical for Influenza Virus Polymerase

scientific article published on 30 December 2015

Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets

scientific article

Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection

scientific article published on 03 June 2022

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice

scientific article

IL-27 Suppresses Antimicrobial Activity in Human Leprosy

scientific article

IRF3 mediates a TLR3/TLR4-specific antiviral gene program

scientific article published on September 2002

IRF3-dependent type I interferon response in B cells regulates CpG-mediated antibody production

scientific article published on 9 October 2007

Identification of as a Type I IFN-Stimulated Gene Controlling Hepatitis B Virus Replication by Targeting HBx

article

Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1

scientific journal article

Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo

scientific article published in November 2007

Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons

scientific article (publication date: May 2016)

Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein

scientific article

Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol

scientific article

Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms

scientific article

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

scientific article (publication date: 14 March 2002)

Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation

scientific journal article

LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells

scientific article published on December 2007

LXR-dependent gene expression is important for macrophage survival and the innate immune response

scientific article

Lipopolysaccharide-Mediated IL-10 Transcriptional Regulation Requires Sequential Induction of Type I IFNs and IL-27 in Macrophages ⬇️

scientific article published on December 1, 2010

Macrophage differentiation from embryoid bodies derived from human embryonic stem cells

scientific article

MicroRNA-155 is induced during the macrophage inflammatory response

scientific article

Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK

scientific article

MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus

scientific article published in January 2006

NF-kappaB inhibits gammaherpesvirus lytic replication

scientific article

NF-κB and Innate Immunity ⬇️

scientific article published on January 1, 2011

NF-κB: Much Learned, Much to Learn ⬇️

scientific article published on September 7, 2010

NOD so fast: NLRX1 puts the brake on inflammation

scientific article

NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy

scientific article

Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation

scientific article

Network of co-mutations in Ebola virus genome predicts the disease lethality

scientific article published on 15 May 2015

Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice

scientific article

New developments in the induction and antiviral effectors of type I interferon ⬇️

scientific article published on November 29, 2010

New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16

scientific article

New targets for controlling Ebola virus disease

scientific article

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

scientific article

Non‐canonical NF‐κB signaling activation and regulation: principles and perspectives ⬇️

scientific article published on November 1, 2011

PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins

scientific article published on 19 June 2018

PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway ⬇️

scientific article published on February 18, 2011

PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production

scientific article published on November 2008

Polyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3

scientific article

Polymeric structure and host Toll-like receptor 4 dictate immunogenicity of NY-ESO-1 antigen in vivo

scientific article

Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS

scientific article

Positive feedback regulation of type I interferon by the interferon-stimulated gene STING.

scientific article

Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications

scientific article published on 17 September 2021

Potential for treatment and a Zika virus vaccine

scientific article published on 30 November 2016

Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol

Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

scientific article

Rescue of TRAF3-null mice by p100 NF-kappa B deficiency

scientific journal article

Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon

scientific article

Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System

scientific article published on 28 December 2016

Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

scientific article

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

scientific article published on October 2017

Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5

scientific article

Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway

scientific article

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding ⬇️

scientific article published on May 10, 2012

Structural and functional analyses of human DDX41 DEAD domain

scientific article published on 7 December 2016

Structural basis for DNA recognition by STAT6.

scientific article

Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation

scientific article

Systematic identification of type I and type II interferon-induced antiviral factors ⬇️

scientific article published on February 27, 2012

T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1).

scientific article

TANK-Binding Kinase 1 Attenuates PTAP-Dependent Retroviral Budding through Targeting Endosomal Sorting Complex Required for Transport-I ⬇️

scientific article published on January 26, 2011

TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response

scientific article published on July 2006

TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk

scientific article

TRAF3 and its biological function

scientific article published on January 2007

TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein

scientific article

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

scientific journal article

The hepatitis C virus protein NS3 suppresses TNF-α-stimulated activation of NF-κB by targeting LUBAC.

scientific article

The host type I interferon response to viral and bacterial infections

scientific article

The interferon response to bacterial and viral infections

scientific article published in January 2006

The signaling adaptors and pathways activated by TNF superfamily

scientific article

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

scientific article published on May 2008

Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4

scientific article (publication date: April 2003)

Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance

scientific article published on 16 March 2010

Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury

scientific article published in August 2005

Toll-like receptors and innate antiviral responses

scientific article

Toll-like receptors induce a phagocytic gene program through p38.

scientific article published on 29 December 2003

Type I IFN Promotes IL-10 Production from T Cells to Suppress Th17 Cells and Th17-Associated Autoimmune Inflammation ⬇️

scientific article published on December 6, 2011

Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication

scientific article published on 13 February 2017

Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice

scientific article published on July 2009

Type I interferon production enhances susceptibility to Listeria monocytogenes infection

scientific article

Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses

scientific article

Type III interferon-induced CBFβ inhibits HBV replication by hijacking HBx.

scientific article published on 9 March 2018

Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways

scientific article

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

scientific article published on October 2011

When Hepatitis B Virus Meets Interferons

scientific article published in 2018

Zika virus shedding in the stool and infection through the anorectal mucosa in mice

scholarly article published by Yong-Qiang Deng in 2018

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