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List of works by Lap Ho

A comprehensive database and analysis framework to incorporate multiscale data types and enable integrated analysis of bioactive polyphenols

scientific article

A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis

scientific article

Alzheimer's disease biomarker discovery in symptomatic and asymptomatic patients: experimental approaches and future clinical applications

scientific article

Amyloid immunization in Alzheimer's disease: do we promote amyloid scavenging at the cost of inflammatory degeneration?

scientific article

Autonomic Nervous System Dysfunctions as a Basis for a Predictive Model of Risk of Neurological Disorders in Subjects with Prior History of Traumatic Brain Injury: Implications in Alzheimer's Disease.

scientific article published in December 2016

Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease

scientific article published on January 2009

Biomarkers of Resilience in Stress Reduction for Caregivers of Alzheimer's Patients

scientific article published on 17 March 2016

Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment

scientific article

Caloric Intake, Dietary Lifestyles, Macronutrient Composition, and Alzheimer′ Disease Dementia ⬇️

scientific article published on June 19, 2011

Caloric intake and Alzheimer's disease. Experimental approaches and therapeutic implications

scientific article published on January 2007

Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease

scientific article published on 13 January 2005

Carvedilol as a potential novel agent for the treatment of Alzheimer's disease

scientific article

Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease

scientific article

Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology

scientific article published on 26 September 2005

Cyclooxygenase (COX)-2 and COX-1 Potentiate β-Amyloid Peptide Generation through Mechanisms That Involve γ-Secretase Activity ⬇️

scientific article published on September 24, 2003

Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology

scientific article published in May 2002

Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology.

scientific article

Decreased Level of Olfactory Receptors in Blood Cells Following Traumatic Brain Injury and Potential Association with Tauopathy ⬇️

scientific article published on January 1, 2013

Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies

scientific article

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

scientific article published on 19 March 2004

Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology

scientific article published on 21 October 2009

Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice

scientific article

Diffuse Disconnectivity in tBi: a resting state fMri anD Dti stuDy ⬇️

scientific article published on March 2012

Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity

scientific article

Elevated Plasma MCP-1 Concentration Following Traumatic Brain Injury as a Potential “Predisposition” Factor Associated with an Increased Risk for Subsequent Development of Alzheimer's Disease ⬇️

scientific article published on January 1, 2012

Epigenetic mechanisms linking diabetes and synaptic impairments

scientific article

Expression profile of genes associated with antimetastatic gene: nm23-mediated metastasis inhibition in breast carcinoma cells

scientific article published on March 2004

GSPE interferes with tau aggregation in vivo: implication for treating tauopathy ⬇️

scientific article published on November 4, 2011

Grape Derived Polyphenols Attenuate Tau Neuropathology in a Mouse Model of Alzheimer's Disease ⬇️

scientific article published on January 1, 2010

Grape seed polyphenolic extract as a potential novel therapeutic agent in tauopathies

scientific article published on January 2009

Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease

scientific article

Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy

scientific article

Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration

scientific article

IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway

scientific article published in August 2013

Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization

scientific article published in January 2009

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease

scientific article published on 24 October 2012

Immunomodulation with glatiramer acetate prevents long-term inflammatory pain

scientific article

Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects

scientific article

In Silico Modeling of Novel Drug Ligands for Treatment of Concussion Associated Tauopathy

scientific article

Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2.

scientific article published on 24 November 2001

Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat.

scientific article published in June 2017

Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols

scientific article published on 30 July 2015

Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease cases

scientific article

Investigation of nebivolol as a novel therapeutic agent for the treatment of Alzheimer's disease

scientific article published in January 2013

Is there a future for cyclo-oxygenase inhibitors in Alzheimer's disease?

scientific article

Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementia

scientific article published on January 2006

Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD mice

scientific article published on March 2011

Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease

scientific article

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

scientific article

Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders

scientific article

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

scientific article published on 9 January 2013

Novel application of brain-targeting polyphenol compounds in sleep deprivation-induced cognitive dysfunction

scientific article published on 30 July 2015

Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice

scientific article

PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia

scientific article

POTENTIAL APPLICATION OF GRAPE DERIVED POLYPHENOLS IN HUNTINGTON'S DISEASE

scientific article

Personalized medicine in traumatic brain injury

scientific article published on December 2010

Pharmacokinetics and Tissue Distribution of14C-Labeled Grape Polyphenols in the Periphery and the Central Nervous System Following Oral Administration ⬇️

scientific article published on August 1, 2010

Polyphenolic Compounds Alter Stress-Induced Patterns of Global DNA Methylation in Brain and Blood

scientific article published on 22 February 2018

Polyphenolic compounds for treating neurodegenerative disorders involving protein misfolding

scientific article published on August 2010

Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's disease

scientific article

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms

scientific article published on 2 November 2017

Recommendations for Development of New Standardized Forms of Cocoa Breeds and Cocoa Extract Processing for the Prevention of Alzheimer's Disease: Role of Cocoa in Promotion of Cognitive Resilience and Healthy Brain Aging

scientific article

Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration

scientific article published on December 2008

Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity

scientific article published in May 2002

Role of grape seed polyphenols in Alzheimer's disease neuropathology

scientific article published on August 2010

Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization.

scientific article

Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model

scientific article

Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment

scientific article

S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10

scientific article

Select non-coding RNA in blood components provide novel clinically accessible biological surrogates for improved identification of traumatic brain injury in OEF/OIF Veterans.

scientific article

Select small nucleolar RNAs in blood components as novel biomarkers for improved identification of comorbid traumatic brain injury and post-traumatic stress disorder in veterans of the conflicts in Afghanistan and Iraq

scientific article

Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease

scientific article published on 04 February 2016

Shared genetic etiology underlying Alzheimer's disease and type 2 diabetes

scientific article

Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications

scientific article

The Role of the Gut Microbiota in the Metabolism of Polyphenols as Characterized by Gnotobiotic Mice

scientific article published on 11 April 2018

The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans

scientific article published on 27 June 2017

The potential of selective COX-2 inhibitors in inflammatory and other diseases

scientific article published on March 2001

The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology

scientific article

Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols

scientific article published on 31 December 2010

Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer's disease

scientific article

Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease

scientific article

Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis

scientific article

nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing

scientific article

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