List of works - Ramiro Jover

A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non-Alcoholic Fatty Liver Disease

scientific article published on 30 July 2019

A simple transcriptomic signature able to predict drug-induced hepatic steatosis.

scientific article published on 28 January 2014

ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses.

scientific article published on 10 March 2008

Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8.

scientific article

Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems

scientific article published on 07 July 2018

Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis.

scientific article published on 15 April 2016

Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Non-Alcoholic Fatty Liver Pathogenesis

article

Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development.

scientific article published on 17 October 2016

Cocaine hepatotoxicity: two different toxicity mechanisms for phenobarbital-induced and non-induced rat hepatocytes.

scientific article published in December 1993

Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

scientific article published on March 2001

Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS.

scientific article published in December 2003

Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile.

scientific article published on 15 January 2010

Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes

scientific article published on 01 January 2020

Evaluation of the cytotoxicity of ten chemicals on human cultured hepatocytes: Predictability of human toxicity and comparison with rodent cell culture systems ⬇️

scientific article published on January 1, 1992

Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver

scientific article

Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High-Fat Diet Determine Non-Alcoholic Fatty Liver Disease Development in Germ-Free Mice

scientific article published on 04 February 2019

Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.

scientific article published on January 2013

Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.

scientific article

Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent

scientific article published on 01 July 2000

Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis

scientific article published on 28 May 2016

Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells.

scientific article published on September 2006

Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium.

scientific article published on 19 November 2016

Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.

scientific article published on 4 May 2016

Human hepatocytes as a tool for studying toxicity and drug metabolism.

scientific article

Human mesenchymal stem cells from adipose tissue: Differentiation into hepatic lineage

scientific article published on 05 September 2006

In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression.

scientific article published on 16 September 2014

Increased toxicity of cocaine on human hepatocytes induced by ethanol: role of GSH.

scientific article published in November 1999

Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesis

scientific article published on 01 September 1996

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.

scientific article published on 11 June 2013

Intracellular glutathione in human hepatocytes incubated with S-adenosyl-L-methionine and GSH-depleting drugs

scientific article published on 01 January 1991

Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix

scientific article published on 01 December 1998

Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin.

scientific article

Molecular mechanism of diclofenac hepatotoxicity: Association of cell injury with oxidative metabolism and decrease in ATP levels

scientific article published on 01 August 1995

New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease

scientific article published on 25 January 2017

Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers

scientific article published on 13 July 2018

Potentiation of cocaine hepatotoxicity in human hepatocytes by ethanol

scientific article published on 01 March 1992

Predicting drug-induced cholestasis: preclinical models

scientific article published on 20 June 2018

Preliminary results from the Scandinavian multicentre evaluation of in vitro cytotoxicity (MEIC)

scientific article published on 01 January 1990

Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation.

scientific article published on 24 November 2016

Quantitative RT-PCR Measurement of Human Cytochrome P-450s: Application to Drug Induction Studies

scientific article published on 01 April 2000

Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease

scientific article published on 2 April 2015

Re-expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells

article

Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease

scientific article published on 9 January 2015

Role of K+ and Ca2+ fluxes in the cerebroarterial vasoactive effects of sildenafil.

scientific article published on 28 November 2007

Role of glutathione in the induction of apoptosis and c-fos and c-jun mRNAs by oxidative stress in tumor cells.

scientific article published on May 2004

Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes.

scientific article published on June 2004

Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes

scientific article published on 01 October 2003

Sequential hepatogenic transdifferentiation of adipose tissue-derived stem cells: relevance of different extracellular signaling molecules, transcription factors involved, and expression of new key marker genes.

scientific article published on 5 August 2009

Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.

scientific article published in February 2005

The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes

scientific article published on 24 March 2020

The effects of buprenorphine on the metabolism of human hepatocytes.

scientific article published in January 1991

The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function.

scientific article

Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells.

scientific article

Transcriptional regulation and expression of CYP3A4 in hepatocytes.

scientific article published on February 2007

Transcriptional regulation of cytochrome p450 genes by the nuclear receptor hepatocyte nuclear factor 4-alpha.

scientific article published on June 2009

Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma

scientific article

Transcriptional regulation of the human hepatic CYP3A4: identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein).

scientific article

Transfection of Primary Hepatocytes with Liver-Enriched Transcription Factors Using Adenoviral Vectors

scientific article

Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.

scientific article published on 4 August 2006

List of works by Ramiro Jover

A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non-Alcoholic Fatty Liver Disease

A simple transcriptomic signature able to predict drug-induced hepatic steatosis.

ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses.

Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8.

Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems

Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis.

Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Non-Alcoholic Fatty Liver Pathogenesis

Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development.

Cocaine hepatotoxicity: two different toxicity mechanisms for phenobarbital-induced and non-induced rat hepatocytes.

Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS.

Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile.

Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes

Evaluation of the cytotoxicity of ten chemicals on human cultured hepatocytes: Predictability of human toxicity and comparison with rodent cell culture systems ⬇️

Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver

Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High-Fat Diet Determine Non-Alcoholic Fatty Liver Disease Development in Germ-Free Mice

Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.

Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.

Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent

Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis

Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells.

Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium.

Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.

Human hepatocytes as a tool for studying toxicity and drug metabolism.

Human mesenchymal stem cells from adipose tissue: Differentiation into hepatic lineage

In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression.

Increased toxicity of cocaine on human hepatocytes induced by ethanol: role of GSH.

Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesis

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.

Intracellular glutathione in human hepatocytes incubated with S-adenosyl-L-methionine and GSH-depleting drugs

Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix

Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin.

Molecular mechanism of diclofenac hepatotoxicity: Association of cell injury with oxidative metabolism and decrease in ATP levels

New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease

Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers

Potentiation of cocaine hepatotoxicity in human hepatocytes by ethanol

Predicting drug-induced cholestasis: preclinical models

Preliminary results from the Scandinavian multicentre evaluation of in vitro cytotoxicity (MEIC)

Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation.

Quantitative RT-PCR Measurement of Human Cytochrome P-450s: Application to Drug Induction Studies

Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease

Re-expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells

Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease

Role of K+ and Ca2+ fluxes in the cerebroarterial vasoactive effects of sildenafil.

Role of glutathione in the induction of apoptosis and c-fos and c-jun mRNAs by oxidative stress in tumor cells.

Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes.

Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes

Sequential hepatogenic transdifferentiation of adipose tissue-derived stem cells: relevance of different extracellular signaling molecules, transcription factors involved, and expression of new key marker genes.

Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.

The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes

The effects of buprenorphine on the metabolism of human hepatocytes.

The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function.

Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells.

Transcriptional regulation and expression of CYP3A4 in hepatocytes.

Transcriptional regulation of cytochrome p450 genes by the nuclear receptor hepatocyte nuclear factor 4-alpha.

Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma

Transcriptional regulation of the human hepatic CYP3A4: identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein).

Transfection of Primary Hepatocytes with Liver-Enriched Transcription Factors Using Adenoviral Vectors

Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.