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List of works by Ramiro Jover

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Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells.

scientific article published on September 2006
Human hepatocytes as a tool for studying toxicity and drug metabolism.

scientific article
Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.

scientific article published on 11 June 2013
Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

scientific article published on March 2001
Transcriptional regulation and expression of CYP3A4 in hepatocytes.

scientific article published on February 2007
Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix

scientific article published on 01 December 1998
Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent

scientific article published on 01 July 2000
Re-expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells

article
Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation.

scientific article published on 24 November 2016
Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS.

scientific article published in December 2003
Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma

scientific article
Human mesenchymal stem cells from adipose tissue: Differentiation into hepatic lineage

scientific article published on 05 September 2006
Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.

scientific article published on 4 August 2006
Transcriptional regulation of cytochrome p450 genes by the nuclear receptor hepatocyte nuclear factor 4-alpha.

scientific article published on June 2009
Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile.

scientific article published on 15 January 2010
Quantitative RT-PCR Measurement of Human Cytochrome P-450s: Application to Drug Induction Studies

scientific article published on 01 April 2000
ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses.

scientific article published on 10 March 2008
Transcriptional regulation of the human hepatic CYP3A4: identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein).

scientific article
Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.

scientific article
Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver

scientific article
Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease

scientific article published on 2 April 2015
Sequential hepatogenic transdifferentiation of adipose tissue-derived stem cells: relevance of different extracellular signaling molecules, transcription factors involved, and expression of new key marker genes.

scientific article published on 5 August 2009
Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes.

scientific article published on June 2004
Evaluation of the cytotoxicity of ten chemicals on human cultured hepatocytes: Predictability of human toxicity and comparison with rodent cell culture systems

scientific article published on January 1, 1992
Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis

scientific article published on 28 May 2016
Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8.

scientific article
Cocaine hepatotoxicity: two different toxicity mechanisms for phenobarbital-induced and non-induced rat hepatocytes.

scientific article published in December 1993
A simple transcriptomic signature able to predict drug-induced hepatic steatosis.

scientific article published on 28 January 2014
Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin.

scientific article
Intracellular glutathione in human hepatocytes incubated with S-adenosyl-L-methionine and GSH-depleting drugs

scientific article published on 01 January 1991
Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes

scientific article published on 01 October 2003
Increased toxicity of cocaine on human hepatocytes induced by ethanol: role of GSH.

scientific article published in November 1999
Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesis

scientific article published on 01 September 1996
Role of glutathione in the induction of apoptosis and c-fos and c-jun mRNAs by oxidative stress in tumor cells.

scientific article published on May 2004
Molecular mechanism of diclofenac hepatotoxicity: Association of cell injury with oxidative metabolism and decrease in ATP levels

scientific article published on 01 August 1995
Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis.

scientific article published on 15 April 2016
Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.

scientific article published on January 2013
Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.

scientific article published on 4 May 2016
In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression.

scientific article published on 16 September 2014
Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium.

scientific article published on 19 November 2016
Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells.

scientific article
New microRNA Biomarkers for Drug-Induced Steatosis and Their Potential to Predict the Contribution of Drugs to Non-alcoholic Fatty Liver Disease

scientific article published on 25 January 2017
Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease

scientific article published on 9 January 2015
The effects of buprenorphine on the metabolism of human hepatocytes.

scientific article published in January 1991
Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Non-Alcoholic Fatty Liver Pathogenesis

article
Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers

scientific article published on 13 July 2018
Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High-Fat Diet Determine Non-Alcoholic Fatty Liver Disease Development in Germ-Free Mice

scientific article published on 04 February 2019
Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems

scientific article published on 07 July 2018
The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function.

scientific article
Preliminary results from the Scandinavian multicentre evaluation of in vitro cytotoxicity (MEIC)

scientific article published on 01 January 1990

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