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List of works by Juan Carlos Zuniga-Pflucker

A 2020 View of Thymus Stromal Cells in T Cell Development

scientific article published on 01 January 2021

A Notch ligand, Delta-like 1 functions as an adhesion molecule for mast cells.

scientific article published on September 2010

A human thymic epithelial cell culture system for the promotion of lymphopoiesis from hematopoietic stem cells.

scientific article

A key role for IL-7R in the generation of microenvironments required for thymic dendritic cells.

scientific article published on 11 September 2017

A monoclonal antibody against the extracellular domain of mouse and human epithelial V-like antigen 1 reveals a restricted expression pattern among CD4- CD8- thymocytes.

scientific article published on October 2014

A survival guide to early T cell development

scientific article

Adapting in vitro embryonic stem cell differentiation to the study of locus control regions

scientific article

An in vitro model of innate lymphoid cell function and differentiation.

scientific article published on 20 August 2014

An overview of the intrathymic intricacies of T cell development

scientific article

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

scholarly article

Branching out to gain control: how the pre-TCR is linked to multiple functions

scientific article

CD8+ T cells are kept in tune by modulating IL-7 responsiveness

scientific article published on 01 October 2007

Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch

scientific article published on 12 July 2013

Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells.

scientific article published on 2 June 2009

Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection

scientific article published on 24 February 2020

Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.

scientific article published on 27 August 2012

Complete TCR-α gene locus control region activity in T cells derived in vitro from embryonic stem cells

scientific article published on 29 May 2013

Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.

scientific article published in November 2007

Dedicated mTEC progenitors stay true, even into adulthood

scientific article published on 20 November 2014

Derivation of T cells in vitro from mouse embryonic stem cells

scientific article

Determining γδ versus αß T cell development.

scientific article published on 20 August 2010

Development of lymphoid lineages from embryonic stem cells in vitro

scientific article published on January 2003

Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.

scientific article

Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes.

scientific article published on 14 June 2010

Directed differentiation of embryonic stem cells to the T-lymphocyte lineage.

scientific article published on January 2013

Dynamics of human prothymocytes and xenogeneic thymopoiesis in hematopoietic stem cell-engrafted nonobese diabetic-SCID/IL-2rγnull mice.

scientific article

EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay

scientific article

Early hematopoietic lineage restrictions directed by Ikaros.

scientific article published on 05 March 2006

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

scientific article (publication date: 29 March 2001)

Expression and function of CD105 during the onset of hematopoiesis from Flk1(+) precursors.

scientific article published in December 2001

Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.

scientific article published on December 1999

FOXN1 (GFP/w) reporter hESCs enable identification of integrin-β4, HLA-DR, and EpCAM as markers of human PSC-derived FOXN1(+) thymic epithelial progenitors.

scientific article

Functional characterization of B lymphocytes generated in vitro from embryonic stem cells.

scientific article

GATA-3 regulates the self-renewal of long-term hematopoietic stem cells

scientific article published on 25 August 2013

Gamma delta T-cell differentiation and effector function programming, TCR signal strength, when and how much?

scientific article published on 25 March 2015

Generation and function of progenitor T cells from StemRegenin-1-expanded CD34+ human hematopoietic progenitor cells

scientific article published on 01 October 2019

Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells

scientific article published on 01 December 2018

Generation of pro-T cells in vitro: potential for immune reconstitution.

scientific article published on October 2007

Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins

scientific article published on 31 March 2018

HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.

scientific article

Hematopoiesis: from start to immune reconstitution potential

scientific article

Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages

scientific article published on 01 June 2004

Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature.

scientific article

Human proT-cells generated in vitro facilitate hematopoietic stem cell-derived T-lymphopoiesis in vivo and restore thymic architecture

scientific article published on 8 November 2013

Identification of a Novel Developmental Stage Marking Lineage Commitment of Progenitor Thymocytes ⬇️

scientific article published on July 21, 1997

Identification of upstream cis-acting regulatory elements controlling lineage-specific expression of the mouse NK cell activation receptor, NKR-P1C.

scientific article published on 17 June 2003

In vitro generation of T lymphocytes from embryonic stem cell–derived prehematopoietic progenitors ⬇️

scientific article published on May 8, 2003

In vitro-generated MART-1-specific CD8 T cells display a broader T-cell receptor repertoire than ex vivo naïve and tumor-infiltrating lymphocytes

scientific article published on 15 February 2019

Induction of T Cell Development In Vitro by Delta-Like (Dll)-Expressing Stromal Cells.

scientific article published on January 2016

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

scientific article published on December 2002

Induction of T-cell development by Delta-like 4-expressing fibroblasts.

scientific article published on 29 August 2013

Integration of T-cell receptor, Notch and cytokine signals programs mouse γδ T-cell effector differentiation

scientific article published on 28 June 2018

Leukocyte infiltration and activation of the NLRP3 inflammasome in white adipose tissue following thermal injury

scientific article

Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions

scientific article

Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency.

scientific article

Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates

scientific article published on 28 November 2014

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

scientific article published in January 2012

Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12

scientific article published on 26 August 2019

Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors

scientific article published on 20 December 2013

On becoming a T cell, a convergence of factors kick it up a Notch along the way.

scientific article published on 06 October 2011

Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes

scientific article published on 01 April 2001

Parameters controlling the programmed death of mature mouse T lymphocytes in high-dose suppression

scientific article published on 01 January 1995

Peroxisome Proliferator-Activated Receptor-δ Supports the Metabolic Requirements of Cell Growth in TCRβ-Selected Thymocytes and Peripheral CD4+ T Cells

scientific article published on 26 September 2018

Positive selection of T cells, an in vitro view.

scientific article published on October 2010

Primary Immune Deficiency Treatment Consortium (PIDTC) report

scientific article published on 15 October 2013

RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors

scientific article published on 21 October 2019

Regulation of thymocyte development from immature progenitors.

scientific article published on April 1996

Regulation of thymocyte differentiation: pre-TCR signals and beta-selection

scientific article

Removal of myeloid cytokines from the cellular environment enhances T-cell development in vitro ⬇️

scientific article published on August 29, 2013

Role of Recycling, Mindbomb1 Association, and Exclusion from Lipid Rafts of Delta-like 4 for Effective Notch Signaling To Drive T Cell Development ⬇️

scientific article published on November 16, 2012

Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation

scientific article published on 29 June 2006

Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death

scientific article

Synergy between T cell Receptor and Fas (CD95/APO-1) signaling in mouse thymocyte death

scientific article published on 01 April 1996

T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures.

scientific article

T-cell development, doing it in a dish.

scientific article

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

scientific journal article

The BTG/TOB family protein TIS21 regulates stage-specific proliferation of developing thymocytes.

scientific article published in October 2005

The OP9-DL1 system: generation of T-lymphocytes from embryonic or hematopoietic stem cells in vitro.

scientific article

The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification

scientific article

The ion channel TRPM7 is required for B cell lymphopoiesis.

scientific article

The original intrathymic progenitor from which T cells originate.

scientific article published in July 2009

The orphan nuclear receptor Ear-2 (Nr2f6) is a novel negative regulator of T cell development.

scientific article published on 2 October 2013

The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation.

scientific article published in April 2005

The role of nuclear factor-kappaB essential modulator (NEMO) in B cell development and survival.

scientific article

The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.

scientific article

Thymic selection of the T-cell repertoire.

scientific article published on January 1988

Transcriptional control of IL-2 and IL-4 in T cells of young and old mice

scientific article published on 01 September 1995

When three negatives made a positive influence in defining four early steps in T cell development.

scientific article published in November 2012

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

scientific article

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