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List of works by Todd L. Edwards

A Trans-Ethnic Genome-Wide Association Study of Uterine Fibroids.

scientific article published on 12 June 2019

A catalog of genetic loci associated with kidney function from analyses of a million individuals

scientific article published on 31 May 2019

A cross-validation procedure for general pedigrees and matched odds ratio fitness metric implemented for the multifactor dimensionality reduction pedigree disequilibrium test

scientific article published on February 2010

A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT.

scientific article

A genome-wide association study meta-analysis of clinical fracture in 10,012 African American women

scientific article

A genome-wide association study to identify genomic modulators of rate control therapy in patients with atrial fibrillation

scientific article

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

scientific article

A multi-stage genome-wide association study of uterine fibroids in African Americans

scientific article

A rare novel deletion of the tyrosine hydroxylase gene in Parkinson disease

scientific article

A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma

scientific article published on 02 May 2012

A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers

scientific article published in Nature Communications

Addressing population-specific multiple testing burdens in genetic association studies

scientific article

Admixture mapping identifies a locus at 15q21.2-22.3 associated with keloid formation in African Americans.

scientific article

Admixture mapping of pelvic organ prolapse in African Americans from the Women's Health Initiative Hormone Therapy trial

scientific article

Admixture mapping of uterine fibroid size and number in African American women

scientific article published in December 2017

African genetic ancestry interacts with body mass index to modify risk for uterine fibroids.

scientific article

Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction

scientific article

An Extension to and Application of the Multifactor Dimensionality Reduction Pedigree Disequilibrium Test ⬇️

doctoral dissertation

An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.

scientific article

Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry

scientific article published on 12 September 2017

Apoptotic engulfment pathway and schizophrenia

scientific article

Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program

scientific article published on 24 July 2019

Association of Thyroid Function Genetic Predictors With Atrial Fibrillation: A Phenome-Wide Association Study and Inverse-Variance Weighted Average Meta-analysis

scientific article published on 01 February 2019

Association of gene coding variation and resting metabolic rate in a multi-ethnic sample of children and adults

scientific article

Association of genetic variants for colorectal cancer differs by subtypes of polyps in the colorectum

scientific article

BET1L and TNRC6B associate with uterine fibroid risk among European Americans

scientific article published on 19 April 2013

Blunted PTH response to vitamin D insufficiency/deficiency and colorectal neoplasia risk

scientific article published on 06 November 2020

CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa

scientific article published on January 2011

Calcium intake and ion transporter genetic polymorphisms interact in human colorectal neoplasia risk in a 2-phase study

scientific article

Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study

scientific article published on 31 August 2015

Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial

scientific article published on 23 September 2019

Combined linkage and association analysis identifies rare and low frequency variants for blood pressure at 1q31

scientific article published on 27 September 2018

Common genetic variants and response to atrial fibrillation ablation

scientific article published on 14 February 2015

Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals

scientific article

Correction: Interleukin 12B (IL12B) Genetic Variation and Pulmonary Tuberculosis: A Study of Cohorts from The Gambia, Guinea-Bissau, United States and Argentina

scientific article published in PLoS ONE

Correction: Interleukin 12B (IL12B) Genetic Variation and Pulmonary Tuberculosis: A Study of Cohorts from The Gambia, Guinea-Bissau, United States and Argentina

Correction: Interleukin 12B (IL12B) Genetic Variation and Pulmonary Tuberculosis: A Study of Cohorts from The Gambia, Guinea-Bissau, United States and Argentina

Correction: Interleukin 12B (IL12B) Genetic Variation and Pulmonary Tuberculosis: A Study of Cohorts from The Gambia, Guinea-Bissau, United States and Argentina.

scientific article

Correction: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

scientific article

Corrigendum re “Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma” [Eur Urol 2017;72:747–54]

scholarly article published in European Urology

Cross-cancer genome-wide association study of endometrial cancer and epithelial ovarian cancer identifies genetic risk regions associated with risk of both cancers

scientific article published on 03 November 2020

Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data

scientific article

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

scientific article published on 15 June 2020

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

scientific article published on 23 November 2020

Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky

scientific article published in January 2007

Enhancing uterine fibroid research through utilization of biorepositories linked to electronic medical record data

scientific article

Equity in Health: Consideration of Race and Ethnicity in Precision Medicine

scientific article published on 22 July 2020

Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans

scientific article published on 4 October 2017

Estimating Uterine Fibroid SNP-Based Heritability in European American Women with Imaging-Confirmed Fibroids

scientific article published on 03 September 2019

Evaluating electronic health record data sources and algorithmic approaches to identify hypertensive individuals.

scientific article

Evaluating risk factors for differences in fibroid size and number using a large electronic health record population

scientific article published on 11 May 2018

Evaluating the role of race and medication in protection of uterine fibroids by type 2 diabetes exposure

scientific article

Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans

scientific article published on 9 November 2012

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women

article

Evidence of selection as a cause for racial disparities in fibroproliferative disease.

scientific article published on 8 August 2017

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

scientific article

Exploring epistasis in candidate genes for rheumatoid arthritis

scientific article

Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models

scientific article published on 15 December 2008

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.

scientific article published on 8 May 2018

FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals

scientific article

Factors associated with the prevalence of hypertension in the southeastern United States: insights from 69,211 blacks and whites in the Southern Community Cohort Study

scientific article published on 23 December 2013

Gene-based evaluation of low-frequency variation and genetically-predicted gene expression impacting risk of keloid formation.

scientific article

Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women’s Health Initiative SHARe Study ⬇️

scientific article published on November 29, 2012

Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program

scientific article published on 28 September 2020

Genetic Determinants of Metabolism and Benign Prostate Enlargement: Associations with Prostate Volume

scientific article published on 9 July 2015

Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative.

scientific article published on 6 November 2015

Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma ⬇️

scientific article published on 7 August 2017

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus

scientific article published on 15 July 2021

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic epidemiology of pelvic organ prolapse: a systematic review

scientific article

Genetic heterogeneity is not as threatening as you might think

scientific article published on 01 November 2007

Genetic variation in SLC7A2 interacts with calcium and magnesium intakes in modulating the risk of colorectal polyps

scientific article published on 5 May 2017

Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group

scientific article published on 01 November 2019

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

scientific article published in September 2016

Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis

Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations

scientific article

Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis

scientific article published on 24 October 2019

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

scientific article published on 11 September 2019

Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease

scientific article

Genome-wide association study identifies multiple risk loci for renal cell carcinoma ⬇️

scientific article

Genome-wide association study identifies possible genetic risk factors for colorectal adenomas

scientific article published on 15 May 2013

Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci

scientific article published on 03 September 2013

HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes

scientific article published on 20 November 2011

Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network

scientific article published on 15 April 2019

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

scientific article

Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis

scientific article published on 22 December 2012

Incidence and predictors of end stage renal disease among low-income blacks and whites

scientific article

Information Loss in Harmonizing Granular Race and Ethnicity Data: Descriptive Study of Standards

scientific article published on 20 July 2020

Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia

scientific article

Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two-phase study

scientific article published on 23 May 2017

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

scientific article published in Nature Communications

Interleukin 12B (IL12B) genetic variation and pulmonary tuberculosis: a study of cohorts from The Gambia, Guinea-Bissau, United States and Argentina

scientific article

Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes

scientific article published on April 2017

LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins

Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases

scientific article

Large-scale genome-wide association meta-analysis of endometriosis reveals 13 novel loci and genetically-associated comorbidity with other pain conditions

MCP1 SNPs and pulmonary tuberculosis in cohorts from West Africa, the USA and Argentina: lack of association or epistasis with IL12B polymorphisms

scientific article

Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity

scientific article

Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program

scientific article published on 26 August 2019

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

scientific article published in 2021

Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk

scientific article published on 12 February 2020

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

scientific article published on 12 September 2016

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

scientific article

Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension

scientific article

Methods for detecting and correcting for population stratification

scientific article published on April 2012

Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia ⬇️

scientific article published on July 5, 2012

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

scientific article published in October 2017

Nonsteroidal Anti-inflammatory Drug Interaction with Prostacyclin Synthase Protects from Miscarriage

scientific article

Obesity and pelvic organ prolapse: a systematic review and meta-analysis of observational studies

scientific article

Patterns of cytokine profiles differ with pregnancy outcome and ethnicity.

scientific article published on 16 May 2008

Peroxisome Proliferator-Activated Receptor Delta (PPARD) Genetic Variation and Type 2 Diabetes in Middle-Aged Chinese Women ⬇️

scientific article published on September 1, 2011

PheMap: a multi-resource knowledge base for high-throughput phenotyping within electronic health records

scientific article published on 24 September 2020

Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index

scientific article

Phenotype risk scores identify patients with unrecognized Mendelian disease patterns

scientific article published in Science

Phenotyping clinical disorders: lessons learned from pelvic organ prolapse.

scientific article published on 27 November 2012

Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm

scientific article

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

scientific article

Pleiotropy between genetic markers of obesity and risk of prostate cancer

scientific article published on 27 June 2013

Population Stratification in Genetic Association Studies

scientific article published on 18 October 2017

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Race-Specific Impact of Atrial Fibrillation Risk Factors in Blacks and Whites in the Southern Community Cohort Study ⬇️

scientific article published on August 23, 2012

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure.

scientific article

Renal cell cancer histological subtype distribution differs by race and sex.

scientific article published on 13 October 2014

Sex specific associations in genome wide association analysis of renal cell carcinoma

scientific article published on 23 June 2019

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

scientific article

Smoking, sex, risk factors and abdominal aortic aneurysms: a prospective study of 18 782 persons aged above 65 years in the Southern Community Cohort Study

scientific article published on 6 January 2015

Subclinical hypothyroidism and risk for incident ischemic stroke among postmenopausal women

scientific article

Subclinical hypothyroidism and risk for incident myocardial infarction among postmenopausal women

scientific article published on 28 March 2013

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

scientific article published on 02 October 2019

Testing the role of predicted gene knockouts in human anthropometric trait variation

scientific article

The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study ⬇️

scientific article published on 03 January 2019

The polygenic architecture of left ventricular mass mirrors the clinical epidemiology

scientific article published on 05 May 2020

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

scientific article

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin

scientific article

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

scientific article published on 21 December 2018

Transethnic and race-stratified genome-wide association study of fibroid characteristics in African American and European American women

Variants in BET1L and TNRC6B associate with increasing fibroid volume and fibroid type among European Americans

scientific article published on 28 July 2013

Vitamin D receptor gene as a candidate gene for Parkinson disease

scientific article

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