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List of works by Aki S Havulinna

A blood pressure genetic risk score is a significant predictor of incident cardiovascular events in 32,669 individuals

scientific article published on 18 March 2013

A common variant near the KCNJ2 gene is associated with T-peak to T-end interval

scientific article published on 15 February 2012

A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern

scientific article

A metabolic view on menopause and ageing

scientific article published on 21 August 2014

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

scientific article published on 13 April 2020

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

scientific article

A multiple biomarker risk score for guiding clinical decisions using a decision curve approach

scientific article published on 20 July 2011

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

scientific article published on 23 November 2016

Adiposity as a cause of cardiovascular disease: a Mendelian randomization study

scientific article

Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

scientific article published on 23 February 2015

Aging of the population may not lead to an increase in the numbers of acute coronary events: a community surveillance study and modelled forecast of the future

scientific article

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation

scientific article

Answer to Dr. Sabours letter about our article 'the validity of hospital discharge register data on non-ST-elevation and ST-elevation myocardial infarction in Finland'

scientific article published on 29 June 2020

Apolipoproteins and HDL cholesterol do not associate with the risk of future dementia and Alzheimer's disease: the National Finnish population study (FINRISK).

scientific article published on 23 September 2016

Are coronary event rates declining slower in women than in men - evidence from two population-based myocardial infarction registers in Finland?

scientific article

Assessment of causality of natriuretic peptides and atrial fibrillation and heart failure: a Mendelian randomization study in the FINRISK cohort

scientific article published on 23 August 2020

Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals

scientific article published on 21 July 2020

Association of LIN28B with adult adiposity-related traits in females

scientific article

Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

scientific article published on 28 February 2018

Associations between circulating metabolites and arterial stiffness

scientific article published on 22 October 2020

Bayesian age-period-cohort models with versatile interactions and long-term predictions: mortality and population in Finland 1878-2050.

scientific article

Biological, clinical and population relevance of 95 loci for blood lipids

scientific article

Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons

scientific article

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

scientific article published on 29 September 2017

Calcium:magnesium ratio in local groundwater and incidence of acute myocardial infarction among males in rural Finland

scientific article

Cardiovascular Risk Factors and Ischemic Heart Disease: Is the Confluence of Risk Factors Greater Than the Parts? A Genetic Approach

scientific article published on 21 April 2016

Case fatality of acute coronary events is improving even among elderly patients; the FINAMI study 1995-2012.

scientific article published on 20 September 2017

Ceramide stearic to palmitic acid ratio predicts incident diabetes

scientific article published on 15 March 2018

Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort

scientific article published on 20 October 2016

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

Clinical and molecular genetic risk determinants in adult long QT syndrome type 1 and 2 patients : Koponen et al. Follow-up of adult LQTS patients.

scientific article

Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort

scientific article published on 13 September 2020

Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort

scientific article published in February 2022

Common genetic variants associated with sudden cardiac death: the FinSCDgen study

scientific article

Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study

scientific article

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

scientific article

Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals

scientific article

Comparison of three troponins as predictors of future cardiovascular events--prospective results from the FINRISK and BiomaCaRE studies

scientific article

Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: the MONICA, risk, genetics, archiving, and monograph (MORGAM) biomarker project

scientific article published on 24 May 2010

Coronary events in persons aged 75 years or older in Finland from 1995 to 2002: the FINAMI study.

scientific article published in March 2008

Correction to: Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes

scientific article published on 29 November 2017

Correction: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution.

scientific article published on 27 July 2009

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 23 August 2017

Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

scientific article published on 21 October 2019

Decreased mortality risk due to first acute coronary syndrome in women with postmenopausal hormone therapy use.

scientific article published on 28 September 2016

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

scientific article

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

scientific article published on 23 November 2020

Distribution and medical impact of loss-of-function variants in the Finnish founder population

scientific article

Does the clinical spectrum of incident cardiovascular disease differ between men and women? ⬇️

scientific article published on March 12, 2013

Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence

scientific article published on 18 August 2016

Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project

scientific article

Endotoxemia Is Associated With an Increased Risk of Incident Diabetes ⬇️

scientific article published on February 1, 2011

Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events

scientific article published on 15 March 2007

Erratum: Corrigendum: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

scholarly article published in Nature Genetics

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article published in November 2011

Evidence of inbreeding depression on human height

scientific article

Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

scientific article published on 14 June 2017

FINEMAP: efficient variable selection using summary data from genome-wide association studies

scientific article

Fine-Scale Genetic Structure in Finland

scientific article published on 5 October 2017

Follow-up of 316 molecularly defined pediatric long-QT syndrome patients: clinical course, treatments, and side effects

scientific article published on 10 June 2015

Gender differences in the prevalence, causes and treatment of high cardiovascular risk: findings from the FINRISK Survey

scientific article published on 2 September 2011

Genetic Variants Contributing to Circulating Matrix Metalloproteinase 8 Levels and Their Association With Cardiovascular Diseases: A Genome-Wide Analysis

scientific article published in December 2017

Genetic Variants on Chromosome 1p13.3 Are Associated with Non-ST Elevation Myocardial Infarction and the Expression of DRAM2 in the Finnish Population

scientific article published on 28 October 2015

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic evidence of assortative mating in humans

article

Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease

scientific article

Genetic support for the causal role of insulin in coronary heart disease

scientific article published on 26 August 2016

Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study

scientific article published on 24 October 2011

Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General Population

scientific article published in December 2017

Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors

scientific article published on 13 December 2016

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

scientific article

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

scientific article published in June 2009

Genome-wide association studies with high-dimensional phenotypes

scientific article published in August 2013

Genome-wide association study of white-coat effect in hypertensive patients

scientific article published on 02 May 2019

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 27 April 2017

Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits

scientific journal article

Genomic prediction of coronary heart disease

scientific article published on 21 September 2016

Geographic patterns of incidence of ischemic stroke and acute myocardial infarction in Finland during 1991-2003.

scientific article

Geographical variation of medicated parkinsonism in Finland during 1995 to 2000.

scientific article

Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants

scientific article

Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland

scholarly article by Alicia R Martin et al published 3 May 2018 in American Journal of Human Genetics

High-sensitivity cardiac troponin I and NT-proBNP as predictors of incident dementia and Alzheimer's disease: the FINRISK Study

scientific article published on 30 December 2016

Hundreds of variants clustered in genomic loci and biological pathways affect human height

scientific article

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Improving genomics-based predictions for precision medicine through active elicitation of expert knowledge.

scientific article

Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes

scientific article published on 13 September 2017

Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies

scientific article

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies

scientific article published on 19 May 2008

Long-term exposure to ambient air pollution and incidence of cerebrovascular events: results from 11 European cohorts within the ESCAPE project

scientific article

Low-expression variant of fatty acid-binding protein 4 favors reduced manifestations of atherosclerotic disease and increased plaque stability

scientific article published on 13 August 2014

Machine learning of human plasma lipidomes for obesity estimation in a large population cohort

scientific article published on 18 October 2019

Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort

scientific article published in January 2017

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change

scientific article (publication date: December 2014)

Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts

scientific article

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

scientific article published on 21 May 2020

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

scientific article published on 12 March 2018

NT-proBNP and the risk of dementia: a prospective cohort study with 14 years of follow-up

scientific article published in January 2015

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

scientific article published in October 2017

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

scientific article published on February 2016

Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome

scientific article published on 17 December 2015

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Nuclear magnetic resonance-based metabolomics identifies phenylalanine as a novel predictor of incident heart failure hospitalisation: results from PROSPER and FINRISK 1997.

scientific article published on 11 December 2017

Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes: a longitudinal population-based study in Finland

scientific article published on 15 October 2018

Phylogeny-Aware Analysis of Metagenome Community Ecology Based on Matched Reference Genomes while Bypassing Taxonomy

scientific article published on 04 April 2022

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

scientific article (publication date: 11 August 2012)

Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers

scientific article published on 07 April 2020

Prediction of Blood Pressure and Blood Pressure Change With a Genetic Risk Score.

scientific article published on 5 October 2015

Predictive value of electrocardiographic T-wave morphology parameters and T-wave peak to T-wave end interval for sudden cardiac death in the general population

scientific article published on 23 July 2013

Predictive value of galectin-3 for incident cardiovascular disease and heart failure in the population-based FINRISK 1997 cohort

scientific article published on 9 May 2015

Predictive value of midregional pro-adrenomedullin compared to natriuretic peptides for incident cardiovascular disease and heart failure in the population-based FINRISK 1997 cohort

Prevalence and clinical correlates of familial hypercholesterolemia founder mutations in the general population

scientific article published on 18 November 2014

Prevalence of arrhythmia-associated gene mutations and risk of sudden cardiac death in the Finnish population

scientific article published on 08 May 2013

Prospects of Fine-Mapping Trait-Associated Genomic Regions by Using Summary Statistics from Genome-wide Association Studies

scientific article published on 16 September 2017

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

scientific article published on 01 July 2019

Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma

scientific article published on 05 May 2020

Risk Factors for Early-Onset Ischemic Stroke: A Case-Control Study

scientific article published on 01 November 2018

ST2 may not be a useful predictor for incident cardiovascular events, heart failure and mortality

scientific article published on 30 July 2014

Serum tissue-degrading proteinases and incident cardiovascular disease events

scientific article published on 18 October 2012

Significant interactions between traditional risk factors affect cardiovascular risk prediction in healthy general population

scientific article published on 18 November 2014

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

scientific article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

Soluble HLA-DR serum levels are associated with smoking but not with acute coronary syndrome

scientific article published on 21 September 2017

Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

scientific article published on 28 April 2015

Taxonomic signatures of cause-specific mortality risk in human gut microbiome

scientific article published on 11 May 2021

The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection

scientific article published on 22 October 2015

The effect of LRRK2 loss-of-function variants in humans

scientific article published on 27 May 2020

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The impact of low-frequency and rare variants on lipid levels

scientific article published on 11 May 2015

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

scientific article (publication date: 2013)

The validity of heart failure diagnoses in the Finnish Hospital Discharge Register

scientific article published on 09 May 2019

The validity of hospital discharge register data on non-ST-elevation and ST-elevation myocardial infarction in Finland

scientific article published on 08 November 2019

Thirty-one novel biomarkers as predictors for clinically incident diabetes

scientific article (publication date: 9 April 2010)

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

Trends in long-term prognosis after acute coronary syndrome

scientific article

Twenty-five-year trends in myocardial infarction attack and mortality rates, and case-fatality, in six European populations

scientific article published on 8 April 2015

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health

scientific article

Utilizing twins as controls for non-twin case-materials in genome wide association studies

scientific article

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

article

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