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List of works by G Kees Hovingh

2017 Update of ESC/EAS Task Force on practical clinical guidance for proprotein convertase subtilisin/kexin type 9 inhibition in patients with atherosclerotic cardiovascular disease or in familial hypercholesterolaemia

scientific article published on 16 October 2017

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

scientific article

A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations

scientific article published on 13 May 2015

Adrenal Function in females with low plasma HDL-C due to mutations in ABCA1 and LCAT.

scientific article

Analysis of vitamin D levels in patients with and without statin-associated myalgia - a systematic review and meta-analysis of 7 studies with 2420 patients

scientific article

Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study

scientific article published on 4 May 2017

Assessment of the 1% of Patients with Consistent < 15% Reduction in Low-Density Lipoprotein Cholesterol: Pooled Analysis of 10 Phase 3 ODYSSEY Alirocumab Trials

scientific article published on 7 April 2018

Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study

scientific article published in January 2002

Association between statin use and plasma D-dimer levels. A systematic review and meta-analysis of randomised controlled trials.

scientific article

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events

scientific article published on 21 March 2019

Association of Factor V Leiden with Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data

scientific article published on 13 July 2020

Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study

scientific article

Association of exome sequences with plasma C-reactive protein levels in >9000 participants

scientific article

Biological, clinical and population relevance of 95 loci for blood lipids

scientific article

Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial

scientific article (publication date: August 2015)

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

scientific article published on 2 March 2016

Common genetic variants do not associate with CAD in familial hypercholesterolemia

scientific article

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Diabetes: Anti-PCSK9 antibodies - beneficial or inducers of diabetes?

scientific article published in November 2017

Diagnosis and Management of Individuals With Heterozygous Familial Hypercholesterolemia: Too Late and Too Little

scientific article published in September 2016

Discovery and refinement of loci associated with lipid levels

scientific article

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA

scientific article

European Society of Cardiology/European Atherosclerosis Society Task Force consensus statement on proprotein convertase subtilisin/kexin type 9 inhibitors: practical guidance for use in patients at very high cardiovascular risk

scientific article published on 27 October 2016

Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia

scientific article published on 26 September 2013

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

scientific article

Exome sequencing in suspected monogenic dyslipidemias

scientific article

Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment.

scientific article

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

scientific article

Familial hypercholesterolemia treatments: Guidelines and new therapies

article published in 2018

Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection

scientific article

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

scientific article published on 20 February 2014

Genetic evidence of assortative mating in humans

article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetically determined height and coronary artery disease

scientific article

Genetics of familial hypercholesterolemia: a tool for development of novel lipid lowering pharmaceuticals?

scientific article published on 19 January 2018

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

HDL and cardiovascular disease

scientific article

HDL re-examined

scientific article

Heterogeneous impact of classic atherosclerotic risk factors on different arterial territories: the EPIC-Norfolk prospective population study

scientific article published on 17 December 2015

Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man.

scientific article

High prevalence of mutations in LCAT in patients with low HDL cholesterol levels in The Netherlands: identification and characterization of eight novel mutations

scientific article

High-density lipoprotein (HDL) particle subpopulations in heterozygous cholesteryl ester transfer protein (CETP) deficiency: maintenance of antioxidative activity

scientific article

Homozygous familial hypercholesterolaemia: light at the end of the tunnel

scientific article published on 29 August 2017

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

scientific article

Identification and Management of Statin-Associated Symptoms in Clinical Practice: Extension of a Clinician Survey to 12 Further Countries

scientific article

Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans

scientific article

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

scientific article published on 12 September 2017

Impact of statin therapy on coronary plaque composition: a systematic review and meta-analysis of virtual histology intravascular ultrasound studies

scientific article

In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1.

scientific article published on 6 May 2013

Inactivating mutations in NPC1L1 and protection from coronary heart disease

scientific article

Is Cholesteryl Ester Transfer Protein Inhibition an Effective Strategy to Reduce Cardiovascular Risk? CETP as a Target to Lower CVD Risk: Suspension of Disbelief?

scientific article published on August 2015

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci

scientific article

Levels and changes of HDL cholesterol and apolipoprotein A-I in relation to risk of cardiovascular events among statin-treated patients: a meta-analysis

scientific article published on 21 August 2013

Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations

scientific article published on 27 September 2012

Lipoprotein(a) and risk of coronary, cerebrovascular, and peripheral artery disease: the EPIC-Norfolk prospective population study

scientific article

Loci influencing blood pressure identified using a cardiovascular gene-centric array

scientific article published on 8 January 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

scientific article

Long-term safety and efficacy of alirocumab in patients with heterozygous familial hypercholesterolemia: An open-label extension of the ODYSSEY program

scientific article published on 01 September 2018

Lysosomal acid lipase deficiency--an under-recognized cause of dyslipidaemia and liver dysfunction.

scientific article

Managing the challenging homozygous familial hypercholesterolemia patient: Academic insights and practical approaches for a severe dyslipidemia, a National Lipid Association Masters Summit

scientific article published on 5 April 2017

Measurement of subclinical atherosclerosis: beyond risk factor assessment

scientific article

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

scientific article

Monocyte gene expression signature of patients with early onset coronary artery disease

scientific article

Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis

scientific article

New Approaches in Detection and Treatment of Familial Hypercholesterolemia

scientific article

New prospects for PCSK9 inhibition?

scientific article published on 22 March 2018

Non-high-density lipoprotein cholesterol: current status as cardiovascular marker

scientific article published in December 2015

Nonpharmacological lipoprotein apheresis reduces arterial inflammation in familial hypercholesterolemia.

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Novel therapies focused on the high-density lipoprotein particle

scientific article

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) ⬇️

scientific article published in October 2018

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

scientific article published on 28 November 2016

PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial

scientific article published in October 2014

PCSK9 inhibitors: Novel therapeutic agents for the treatment of hypercholesterolemia

scientific article published on 16 May 2015

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

scientific article

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

scientific article published on 29 October 2019

Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study

scientific article published on 31 January 2016

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Recent failures in antiatherosclerotic drug development: examples from the thyroxin receptor agonist, the secretory phospholipase A2 antagonist, and the acyl coenzyme A: cholesterol acyltransferase inhibitor programs

scientific article published on December 2013

Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia.

scientific article published on 18 June 2009

Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study

scientific article published on 31 July 2013

Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol

scientific article

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Statin intolerance - an attempt at a unified definition. Position paper from an International Lipid Expert Panel

scientific article

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

article

Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

scientific article

Subsequent Event Risk in Individuals With Established Coronary Heart Disease

scientific article published on 21 March 2019

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ⬇️

scientific article published on February 2017

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The PCSK9 decade ⬇️

scientific article published on July 17, 2012

The effect of statins on cardiovascular outcomes by smoking status: A systematic review and meta-analysis of randomized controlled trials

scientific article

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The impact of statin therapy on plasma levels of von Willebrand factor antigen. Systematic review and meta-analysis of randomised placebo-controlled trials.

scientific article published on 3 December 2015

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management

scientific article

The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia

scientific article published on 16 April 2003

Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol

scientific article published in November 2002

Very low LDL-cholesterol concentrations achieved: which target is next?

scientific article published on 25 August 2017

Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials

scientific article published on August 2014

eNOS activation by HDL is impaired in genetic CETP deficiency.

scientific article

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