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List of works by Tzu-Ming Pan

A novel PPARgamma agonist monascin's potential application in diabetes prevention.

scientific article published on July 2014

A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia.

scientific article published on 15 August 2013

A simple and cost-saving approach to optimize the production of subtilisin NAT by submerged cultivation of Bacillus subtilis natto.

scientific article

A simple and rapid approach for removing citrinin while retaining monacolin K in red mold rice.

scientific article

Alleviation of metabolic syndrome by monascin and ankaflavin: the perspective of Monascus functional foods.

scientific article published on 13 June 2017

Ankaflavin and monascin regulate endothelial adhesion molecules and endothelial NO synthase (eNOS) expression induced by tumor necrosis factor-α (TNF-α) in human umbilical vein endothelial cells (HUVECs).

scientific article published on 8 February 2012

Ankaflavin, a novel Nrf-2 activator for attenuating allergic airway inflammation.

scientific article

Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo

scientific article published on 26 September 2012

Anti-allergic activity of R-phycocyanin from Porphyra haitanensis in antigen-sensitized mice and mast cells.

scientific article

Anti-inflammatory properties of yellow and orange pigments from Monascus purpureus NTU 568

scientific article published on 08 March 2013

Anti-obesity effects of gut microbiota are associated with lactic acid bacteria

scientific article

Anti-tumor and anti-inflammatory properties of ankaflavin and monaphilone A from monascus purpureus NTU 568. ⬇️

scientific article published on 24 January 2011

Anticancer and Antimigration Effects of a Combinatorial Treatment of 5-Fluorouracil and Lactobacillus paracasei subsp. paracasei NTU 101 Fermented Skim Milk Extracts on Colorectal Cancer Cells

scientific article published on 22 May 2018

Antidepressant Effect of GABA-Rich Monascus-Fermented Product on Forced Swimming Rat Model ⬇️

scientific article published on March 4, 2011

Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats

scientific article published on 04 April 2011

Antihypertriglyceridemia and anti-inflammatory activities of monascus-fermented dioscorea in streptozotocin-induced diabetic rats.

scientific article

Antiosteoporotic effects of Lactobacillus -fermented soy skim milk on bone mineral density and the microstructure of femoral bone in ovariectomized mice

scientific article published on 21 June 2011

Beneficial effects of Lactobacillus paracasei subsp. paracasei NTU 101 and its fermented products.

scientific article published on 09 December 2011

Beneficial preventive effects of gastric mucosal lesion for soy-skim milk fermented by lactic acid bacteria.

scientific article

Benefit of Monascus-fermented products for hypertension prevention: a review.

scientific article published on 25 April 2012

Centella asiatica extract protects against amyloid β1-40-induced neurotoxicity in neuronal cells by activating the antioxidative defence system.

scientific article published on August 2015

Cloning, Expression, and the Effects of Processing on Sarcoplasmic-Calcium-Binding Protein: An Important Allergen in Mud Crab.

scientific article

Detection of genetically modified maize MON810 and NK603 by multiplex and real-time polymerase chain reaction methods.

scientific article published in June 2004

Development of Monascus fermentation technology for high hypolipidemic effect.

scientific article published on 06 May 2012

Down-regulation of Slit-Robo pathway mediating neuronal cytoskeletal remodeling processes facilitates the antidepressive-like activity of Gastrodia elata Blume

scientific article published on 16 October 2014

Effect of bioactive compounds in lactobacilli-fermented soy skim milk on femoral bone microstructure of aging mice.

scientific article published on 4 August 2011

Effect of probiotic-fermented, genetically modified soy milk on hypercholesterolemia in hamsters

scientific article published on 29 June 2012

Effect of red mold rice on antifatigue and exercise-related changes in lipid peroxidation in endurance exercise

scientific article published on 28 June 2005

Effect of red mold rice supplements on serum and egg yolk cholesterol levels of laying hens

scientific article

Effect of red mold rice supplements on serum and meat cholesterol levels of broilers chicken.

scientific article published on 17 November 2005

Effects of Monascus-fermented rice extract on malignant cell-associated neovascularization and intravasation determined using the chicken embryo chorioallantoic membrane model.

scientific article published on 31 March 2010

Effects of chemical and low-temperature treatments and adaption on the responses of virulence factor genes and outer membrane proteins in Escherichia coli O157:H7.

scientific article

Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats.

scientific article published on 31 January 2013

Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model ⬇️

scientific article published on March 17, 2011

Effects of red mold dioscorea with pioglitazone, a potentially functional food, in the treatment of diabetes.

scientific article published on 21 July 2015

Enhanced Hypolipidemic Effect and Safety of Red Mold Dioscorea Cultured in Deep Ocean Water ⬇️

scientific article published on July 15, 2011

Enhanced anti-obesity activities of red mold dioscorea when fermented using deep ocean water as the culture water.

scientific article published on 15 October 2013

Establishment of a system based on universal multiplex-PCR for screening genetically modified crops.

scientific article published on 24 October 2009

Event-specific real-time detection and quantification of genetically modified Roundup Ready soybean

scientific article published on 01 May 2005

Exopolysaccharide activities from probiotic bifidobacterium: Immunomodulatory effects (on J774A.1 macrophages) and antimicrobial properties.

scientific article published on 15 September 2010

Fermentation of a milk-soymilk and Lycium chinense Miller mixture using a new isolate of Lactobacillus paracasei subsp. paracasei NTU101 and Bifidobacterium longum.

scientific article published on 18 November 2004

Glyceryl 1,3-Dipalmitate Produced from Lactobacillus paracasei subspecies. paracasei NTU 101 Inhibits Oxygen-Glucose Deprivation and Reperfusion-Induced Oxidative Stress via Upregulation of Peroxisome Proliferator-Activated Receptor γ in Neuronal SH

scientific article

Immune responses and gene expression in white shrimp, Litopenaeus vannamei, induced by Lactobacillus plantarum

scientific article published on 05 December 2006

Immunomodulating Activity of Lactobacillus paracasei subsp. paracasei NTU 101 in Enterohemorrhagic Escherichia coli O157H7-Infected Mice ⬇️

scientific article published on October 13, 2010

Immunomodulatory activities and antioxidant properties of polysaccharides from Monascus-fermented products in vitro.

scientific article published on 5 December 2011

Immunomodulatory and antioxidant potential of Lactobacillus exopolysaccharides.

scientific article published on 10 May 2011

Improvement of monacolin K, gamma-aminobutyric acid and citrinin production ratio as a function of environmental conditions of Monascus purpureus NTU 601.

scientific article published on 19 November 2003

Improving the ratio of monacolin K to citrinin production of Monascus purpureus NTU 568 under dioscorea medium through the mediation of pH value and ethanol addition.

scientific article

In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid β-protein-induced neurotoxicity and memory impairment ⬇️

scientific article published on February 21, 2012

Induction of apoptosis in human breast adenocarcinoma cells MCF-7 by monapurpyridine A, a new azaphilone derivative from Monascus purpureus NTU 568.

scientific article published on 11 January 2012

Inhibition of Th2 cytokine production in T cells by monascin via PPAR-γ activation.

scientific article published on 14 August 2013

Inhibition of leukemia proliferation by a novel polysaccharide identified from Monascus-fermented dioscorea via inducing differentiation ⬇️

scientific article published on May 14, 2012

Inhibitory Effects of Dioscorea Polysaccharide on TNF-α-Induced Insulin Resistance in Mouse FL83B Cells ⬇️

scientific article published on April 20, 2011

Legionella pneumophila infection in the Taiwan area.

scientific article published in October 2005

Metabolic protein patterns and monascorubrin production revealed through proteomic approach for Monascus pilosus treated with cycloheximide.

scientific article

Modified mutation method for screening low citrinin-producing strains of Monascus purpureus on rice culture

scientific article published in November 2004

Monacolin K and monascin attenuated pancreas impairment and hyperglycemia induced by advanced glycation endproducts in BALB/c mice.

scientific article

Monaphilones A-C, three new antiproliferative azaphilone derivatives from Monascus purpureus NTU 568. ⬇️

scientific article published on July 2010

Monascin and AITC attenuate methylglyoxal-induced PPARγ phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation.

scientific article

Monascin and Ankaflavin Act as Novel Hypolipidemic and High-Density Lipoprotein Cholesterol-Raising Agents in Red Mold Dioscorea ⬇️

scientific article published on July 28, 2010

Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice.

scientific article published on 22 November 2013

Monascin and ankaflavin have more anti-atherosclerosis effect and less side effect involving increasing creatinine phosphokinase activity than monacolin K under the same dosages.

scientific article published on 24 December 2012

Monascin attenuates oxidative stress-mediated lung inflammation via peroxisome proliferator-activated receptor-gamma (PPAR-γ) and nuclear factor-erythroid 2 related factor 2 (Nrf-2) modulation

scientific article

Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans

scientific article published on 12 October 2011

Monascin improves diabetes and dyslipidemia by regulating PPARγ and inhibiting lipogenesis in fructose-rich diet-induced C57BL/6 mice.

scientific article published on 14 May 2013

Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent--monacolin K and antiinflammation agent--monascin

scientific article published on 28 March 2006

Monascus purpureus-fermented products and oral cancer: a review.

scientific article published on March 2012

Monascus secondary metabolites monascin and ankaflavin inhibit activation of RBL-2H3 cells.

scientific article published on January 2015

Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans

scientific article

Monascus-fermented metabolite monascin suppresses inflammation via PPAR-γ regulation and JNK inactivation in THP-1 monocytes.

scientific article

Monascus-fermented red mold dioscorea protects mice against alcohol-induced liver injury, whereas its metabolites ankaflavin and monascin regulate ethanol-induced peroxisome proliferator-activated receptor-γ and sterol regulatory element-binding tra

scientific article published on 13 September 2017

New anti-inflammatory and anti-proliferative constituents from fermented red mold rice Monascus purpureus NTU 568. ⬇️

scientific article published on 3 November 2010

New bioactive orange pigments with yellow fluorescence from Monascus-fermented dioscorea. ⬇️

scientific article published on 20 April 2011

Optimization of antimicrobial substances produced from Lactobacillus paracasei subsp. paracasei NTU 101 (DSM 28047) and Lactobacillus plantarum NTU 102 by response surface methodology

scientific article

Optimization of culture condition for ACEI and GABA production by lactic acid bacteria

scientific article published on 04 October 2011

Osteoprotective effect of Monascus-fermented dioscorea in ovariectomized rat model of postmenopausal osteoporosis.

scientific article published on 9 August 2011

PCR-denaturing gradient gel electrophoresis analysis to assess the effects of a genetically modified cucumber mosaic virus-resistant tomato plant on soil microbial communities

scientific article

Peroxisome proliferator-activated receptor-γ activators monascin and rosiglitazone attenuate carboxymethyllysine-induced fibrosis in hepatic stellate cells through regulating the oxidative stress pathway but independent of the receptor for advanced

scientific article published on 05 July 2013

Production of red mold rice using a modified Nagata type koji maker

scientific article published on 7 October 2006

Profiling the Monascus pilosus proteome during nitrogen limitation.

scientific article published on 21 December 2007

Protection of Monascus-fermented dioscorea against DMBA-induced oral injury in hamster by anti-inflammatory and antioxidative potentials.

scientific article published on June 2010

Protective effect of Monascus-fermented red mold rice against alcoholic liver disease by attenuating oxidative stress and inflammatory response.

scientific article published on 31 August 2011

Proteome changes in Caco-2 cells treated with Monascus-fermented red mold rice extract

scientific article

Proteome response of Monascus pilosus during rice starch limitation with suppression of monascorubramine production.

scientific article

Proteomic analysis of Caco-2 cells treated with monacolin K.

scientific article

Proteomic insight into the effect of ethanol on citrinin biosynthesis pathway in Monascus purpureus NTU 568

scientific article published on 21 August 2014

Quantification bias caused by plasmid DNA conformation in quantitative real-time PCR assay

scientific article

Recombinant expression of bioactive peptide lunasin in Escherichia coli.

scientific article published on 13 July 2010

Red Mold Rice Mitigates Oral Carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-Induced Oral Carcinogenesis in Hamster

scientific article

Red mold dioscorea has a greater antihypertensive effect than traditional red mold rice in spontaneously hypertensive rats.

scientific article published in June 2009

Red mold dioscorea has greater hypolipidemic and antiatherosclerotic effect than traditional red mold rice and unfermented dioscorea in hamsters

scientific article

Red mold dioscorea-induced G2/M arrest and apoptosis in human oral cancer cells.

scientific article published on December 2010

Red mold dioscorea: a potentially safe traditional function food for the treatment of hyperlipidemia.

scientific article published on 16 March 2012

Red mold fermented products and Alzheimer's disease: a review.

scientific article published on 18 June 2011

Red mold rice ameliorates impairment of memory and learning ability in intracerebroventricular amyloid beta-infused rat by repressing amyloid beta accumulation

scientific article published in November 2007

Red mold rice extract represses amyloid beta peptide-induced neurotoxicity via potent synergism of anti-inflammatory and antioxidative effect

scientific article

Red mold rice promoted antioxidase activity against oxidative injury and improved the memory ability of zinc-deficient rats.

scientific article published in November 2009

Red mold rice promotes neuroprotective sAPPalpha secretion instead of Alzheimer's risk factors and amyloid beta expression in hyperlipidemic Abeta40-infused rats

scientific article published in February 2010

Red mold, diabetes, and oxidative stress: a review.

scientific article published on 02 March 2012

Safety and mutagenicity evaluation of Vigiis 101 powder made from Lactobacillus paracasei subsp. paracasei NTU 101.

scientific article published on 3 December 2014

Safety and mutagenicity evaluation of nanoparticulate red mold rice

scientific article

Safety and mutagenicity evaluation of red mold dioscorea fermented from Monascus purpureus NTU 568.

scientific article published on 28 February 2014

Safety and risk assessment of the genetically modified Lactococci on rats intestinal bacterial flora.

scientific article published on 25 June 2010

Safety assessment and detection method of genetically modified Chinese Kale (Brassica oleracea cv. alboglabra ).

scientific article published in March 2009

Statistical optimization of medium components for the production of Antrodia cinnamomea AC0623 in submerged cultures.

scientific article published on 23 February 2006

Stress responses of thermophilic Geobacillus sp. NTU 03 caused by heat and heat-induced stress ⬇️

scientific article published on September 23, 2010

Substitution of Asp189 residue alters the activity and thermostability of Geobacillus sp. NTU 03 lipase.

scientific article published on 5 May 2011

Suppression of Th2 immune responses by the sulfated polysaccharide from Porphyra haitanensis in tropomyosin-sensitized mice.

scientific article

Suppression of dimerumic acid on hepatic fibrosis caused from carboxymethyl-lysine (CML) by attenuating oxidative stress depends on Nrf2 activation in hepatic stellate cells (HSCs).

scientific article published on 12 September 2013

The Monascus metabolite monascin against TNF-α-induced insulin resistance via suppressing PPAR-γ phosphorylation in C2C12 myotubes

scientific article

The effect of Monascus secondary polyketide metabolites, monascin and ankaflavin, on adipogenesis and lipolysis activity in 3T3-L1.

scientific article published on 16 November 2010

The effect of probiotic-fermented soy milk on enhancing the NO-mediated vascular relaxation factors.

scientific article

The effects of Lactobacillus-fermented milk on lipid metabolism in hamsters fed on high-cholesterol diet.

scientific article published on 20 September 2005

The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits.

scientific article published on 23 September 2012

Time-dependent persistence of enhanced immune response by a potential probiotic strain Lactobacillus paracasei subsp. paracasei NTU 101

scientific article published on 26 August 2008

Treatment of metabolic syndrome with ankaflavin, a secondary metabolite isolated from the edible fungus Monascus spp.

scientific article published on 13 April 2014

Use of murine models to detect the allergenicity of genetically modified Lactococcus lactis NZ9000/pNZPNK

scientific article published on 29 March 2011

Use of the duplex TaqMan PCR system for detection of Shiga-like toxin-producing Escherichia coli O157.

scientific article published in June 2005

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