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List of works by Hongbo Chi

AMPK helps T cells survive nutrient starvation

scientific article published on January 2015

Acetylation of MKP-1 and the control of inflammation.

scientific article published on 14 October 2008

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

scientific article published on 25 January 2016

Autophagy modulates CD4+ T-cell lineage recommitment upon pathogen infection

scientific article published on 11 February 2020

Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-mediated enhancement of the MKP-IRF3 axis.

scientific article

COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.

scientific article

CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

scientific article published on 18 November 2021

Control of IL-17 receptor signaling and tissue inflammation by the p38α-MKP-1 signaling axis in a mouse model of multiple sclerosis

scientific article

Control of T Cell Fates and Immune Tolerance by p38α Signaling in Mucosal CD103+ Dendritic Cells ⬇️

scientific article published on June 10, 2013

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.

scientific article published on 16 March 2014

Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis

scientific article

Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.

scientific article published on 7 August 2017

Cutting edge: Discrete functions of mTOR signaling in invariant NKT cell development and NKT17 fate decision.

scientific article published on 26 September 2014

Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis

scientific article

Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1.

scientific article

Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload

scientific article

Dietary Fat Inflames CD4+ T Cell Memory in Obesity.

scientific article

Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis.

scientific article

Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells

scientific article published on 01 March 2007

GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.

scientific article published on 25 March 2004

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever.

scientific article

Genetic dissection of dendritic cell homeostasis and function: lessons from cell type-specific gene ablation

scientific article published on 24 December 2013

Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes

scientific article published on 19 December 2016

Gfi1: a unique controller of T(reg) cells.

scientific article published on 21 October 2013

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

scientific article

Hallmarks of T-cell Exit from Quiescence

scientific article published in May 2018

Helper T cell differentiation

scientific article published on 12 March 2019

Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells

scientific article published in Nature

Homeostasis and transitional activation of regulatory T cells require c-Myc

scientific article published on 01 January 2020

Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling.

scientific article published on 23 August 2017

I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection

scientific article published on 19 February 2013

Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cells

scientific article published on 17 February 2012

Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells.

scientific article published on 05 August 2013

Innate recognition of non-self nucleic acids.

scientific article published on 10 March 2008

Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation.

scientific article published on 3 March 2017

Investigating Cellular Quiescence of T Lymphocytes and Antigen-Induced Exit from Quiescence.

scientific article published in January 2018

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.

scientific article

JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance.

scientific article published on November 2005

LCK senses asparagine for T cell activation

scientific article published in 2021

LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity

scientific article published on 25 March 2019

Lipid signalling enforces functional specialization of T<sub>reg</sub> cells in tumours

scientific article published on 24 February 2021

Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination

scientific article

Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.

scientific article

Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation.

scientific article

Metabolic adaptation of lymphocytes in immunity and disease

scientific article published in 2022

Metabolic control of T<sub>FH</sub> cells and humoral immunity by phosphatidylethanolamine

scientific article published on 07 July 2021

Metabolic control of regulatory T cell development and function

scientific article

Metabolic coordination of T cell quiescence and activation

scientific article published on 12 August 2019

Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity.

scientific article published on 19 December 2018

Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation

scientific article published on 7 March 2016

Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells

scientific article published on 01 July 2018

Metabolic sleuthing solves a rare immunodeficiency disease

scientific article published on 01 October 2019

Metabolism and lymphocyte biology

scientific article published on 06 November 2015

Metabolism in Immune Cell Differentiation and Function.

scientific article published on January 2017

Naturally activated V gamma 4 gamma delta T cells play a protective role in tumor immunity through expression of eomesodermin.

scientific article published on 04 June 2010

Novel specialized cell state and spatial compartments within the germinal center

scientific article published on 27 April 2020

Nutrient and Metabolic Sensing in T Cell Responses

scientific article published on 09 March 2017

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.

scientific article published on 13 November 2017

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

scientific article published on 24 March 2013

Regulation and function of mTOR signalling in T cell fate decisions ⬇️

scientific article published on April 20, 2012

Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination.

scientific article published on 08 September 2009

Regulation of TH17 cell differentiation by innate immune signals ⬇️

scientific article published on April 16, 2012

Sensing the enemy within

scientific article published in Nature

Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates

scientific article

Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity

scientific article

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

scientific article published on 8 January 2012

Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas.

scientific article

Sphingosine-1-phosphate and immune regulation: trafficking and beyond

scientific article

Sprouty branches out to control T cell memory.

scientific article published on 4 September 2018

Studies on MAP Kinase signaling in the immune system.

scientific article

T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming

scientific article published on 05 December 2013

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation.

scientific article

Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo

scientific article

The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells

scientific article

The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.

scientific article

The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function.

scientific article

The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.

scientific article

The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

scientific article published on 31 May 2009

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

scientific article

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

scientific article

Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function.

scientific article published on 23 January 2012

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.

scientific article

Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner.

scientific article published on 16 July 2015

Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs

scientific journal article

Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells.

scientific article

Tuning mTOR activity for immune balance.

scientific article

c-Myc and AP4: a relay team for metabolic reprogramming of CD8+ T cells

scientific article published on 01 September 2014

iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions

scientific article published on 10 March 2014

mTOR Links Environmental Signals to T Cell Fate Decisions.

scientific article

mTOR and lymphocyte metabolism ⬇️

scientific article published on May 28, 2013

mTOR and metabolic pathways in T cell quiescence and functional activation ⬇️

scientific article published on February 1, 2013

mTOR and metabolic regulation of conventional and regulatory T cells.

scientific article

mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis.

scientific article

mTOR signaling and transcriptional regulation in T lymphocytes

scientific article published on 21 February 2014

mTOR signaling at the crossroads of environmental signals and T-cell fate decisions

scientific article published on 25 March 2020

mTOR signaling in the differentiation and function of regulatory and effector T cells.

scientific article published on 20 May 2017

mTOR signaling, Tregs and immune modulation

scientific article

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.

scientific article published on 7 September 2016

mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function

scientific article published on 30 June 2013

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