Search filters

List of works by Giovanni Appendino

10-Deacetylbaccatin III Analogues from Taxus baccata

11,13-Methylenation of sesquiterpene exomethylene-γ-lactones: Synthesis of sesquiterpene cyclopropyl-γ-lactones

scientific article published on 28 August 2009

14β-Hydroxy-10-deacetylbaccatin III, a new taxane from Himalayan yew (Taxus wallichiana Zucc.)

article published in 1992

2′-Methyl taxanes: synthesis and NMR configurational assignment

8-Prenylnaringenin inhibits epidermal growth factor-induced MCF-7 breast cancer cell proliferation by targeting phosphatidylinositol-3-OH kinase activity

scientific article

8-Prenylnaringenin, inhibits estrogen receptor-alpha mediated cell growth and induces apoptosis in MCF-7 breast cancer cells

scientific article published on 22 June 2007

A 3,11-cyclotaxane from Taxus baccata

A Controlled Study of a Lecithinized Delivery System of Curcumin (Meriva®) to Alleviate the Adverse Effects of Cancer Treatment

scientific article published on 15 June 2013

A Meroterpenoid NF-κB Inhibitor and Drimane Sesquiterpenoids from Asafetida

scientific article published on 01 July 2006

A Multicomponent Carba-Betti Strategy to Alkylidene Heterodimers - Total Synthesis and Structure-Activity Relationships of Arzanol

A New Oxidative Rearrangement of a Phorbol Derivative

A Nrf-2 Stimulatory Hydroxylated Cannabidiol Derivative from Hemp (Cannabis sativa)

scientific article published in 2022

A Regiodivergent Synthesis of Ring A C-Prenylflavones

scientific article published on 03 May 2008

A Regioselective Synthesis of 3-Isoprenyl-4-Hydroxycoumarins

A Straightforward Entry into Polyketide Monoprenylated Furanocoumarins and Pyranocoumarins1

A cannabigerol quinone alleviates neuroinflammation in a chronic model of multiple sclerosis.

scientific article

A multicomponent synthesis of gem-(β-dicarbonyl)arylmethanes

A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

scientific article published in January 2003

A new rearrangement of oxetane-type taxoids

A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor

scientific article published on 01 March 1996

A prenylbisabolane with NF-kappaB inhibiting properties from Cascarilla (Croton eluteria).

scientific article published in July 2005

A rearranged taxane from the Himalayan yew

A seco-bis-norguaianolide from Achillea pseudoaleppica

article published in 1993

A serendipitous clue to the biogenesis of taxchins

article published in 1995

A sesquiterpene alcohol from Pallenis spinosa

scientific article published on 25 July 2002

A sesquiterpene alcohol from the fruits of Laurus nobilis

A sesquiterpene ketal from Bunium paucifolium

A single oxidosqualene cyclase produces the seco-triterpenoid α-onocerin

scientific article

A single-dose, randomized, cross-over, two-way, open-label study for comparing the absorption of boswellic acids and its lecithin formulation

scientific article published on 27 July 2016

A structure-activity relationship study on N-arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase

scientific article

A taxane epoxide from Taxus wallichiana

Ab InitioConformational Study of the Phenylisoserine Side Chain of Paclitaxel

scientific article published on 01 January 1999

Acid and base catalysed rearrangements of 9,10-dioxotaxanes

Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes

scientific article published on 08 January 2021

Activation of TRPA1 on dural afferents: a potential mechanism of headache pain

scientific article

Activation of latent HIV-1 expression by protein kinase C agonists. A novel therapeutic approach to eradicate HIV-1 reservoirs.

scientific article published on March 2011

Advances in the Universal NMR Database Approach. 2‘-Substituted Taxanes as Probes for an Improved Protocol of Diastereomeric Differentiation

scientific article published on 01 March 2005

Ammodoremin, an Epimeric Mixture of Prenylated Chromandiones from Ammoniacum

article published in 1991

Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum

scientific article

An Expeditious Procedure for the Isolation of Ingenol from the Seeds ofEuphorbialathyris

scientific article published on 01 January 1999

An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery?

scientific article published on January 2011

An expeditious hydroxyamidation of carboxylic acids

An improved preparation of phorbol from croton oil.

scientific article published on 11 July 2017

Analysis of pharmaceutically relevant taxoids in wild yew trees from Sardinia.

scientific article published in February 2003

Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway.

scientific article published on February 2003

Anionic and Photochemical Behaviour of the Medium-Sized Terpenoid Ketone 8-Dehydro-12-O-methyl-deacylhallerin

Anti-inflammatory and vascularprotective properties of 8-prenylapigenin

scientific article

Antibacterial cannabinoids from Cannabis sativa: a structure-activity study

scientific article

Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis).

scientific article published in February 2006

Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum

scientific article

Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis).

scientific article published in December 2004

Antioxidant activity of capsinoids

scientific article published on December 2002

Antioxidant activity of oligomeric acylphloroglucinols from Myrtus communis L.

scientific article published in September 2003

Antioxidant properties of extracts and compounds fromPsoralea morisiana

Antiproliferative effects on tumour cells and promotion of keratinocyte wound healing by different lichen compounds

scientific article

Artarborol, a nor-Caryophyllane Sesquiterpene Alcohol from Artemisia arborescens. Stereostructure Assignment Through Concurrence of NMR Data and Computational Analysis. ⬇️

scientific article published on 4 October 2007

Artarborol, a nor-caryophyllane sesquiterpene alcohol from Artemisia arborescens. stereostructure assignment through concurrence of NMR data and computational analysis

scientific article

Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo

scientific article published on 8 October 2010

Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum

scientific article

Basiliolides, a class of tetracyclic C19 dilactones from Thapsia garganica, release Ca(2+) from the endoplasmic reticulum and regulate the activity of the transcription factors nuclear factor of activated T cells, nuclear factor-kappaB, and activato

scientific article published on 13 July 2006

Benzamide-type vanilloid (TRPV1) antagonists

Best practice in research - Overcoming common challenges in phytopharmacological research

scientific article published on 14 September 2019

Betulinic acid hydroxamate prevents colonic inflammation and fibrosis in murine models of inflammatory bowel disease

scientific article published on 18 August 2020

Bioactive Prenylogous Cannabinoid from Fiber Hemp (Cannabis sativa)

scientific article published on 08 September 2011

Bioactive triterpenoids from the caffeine-rich plants guayusa and maté

scientific article published on 04 October 2018

Biological properties of jatrophane polyesters, new microtubule-interacting agents

scientific article published on 20 November 2002

Bisnorsesquiterpenoids from Euphorbia resinifera Berg. and an Expeditious Procedure to Obtain Resiniferatoxin from Its Fresh Latex ⬇️

Block and allosteric modulation of GABAergic currents by oenanthotoxin in rat cultured hippocampal neurons

scientific article published on July 2010

Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium.

scientific article

Broccoli, PTEN deletion and prostate cancer: where is the link?

scientific article published on December 2010

Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line

scientific article published on September 2004

Cannabidiol (CBD) From Non-Cannabis Plants: Myth or Reality?

scientific article published in 2022

Cannabimovone, a Cannabinoid with a Rearranged Terpenoid Skeleton from Hemp

Cannabinoid derivatives acting as dual PPARγ/CB2 agonists as therapeutic agents for systemic sclerosis

scientific article published on 27 February 2019

Cannabinoquinones: Synthesis and Biological Profile

scientific article published in 2021

Cannabioxepane, a novel tetracyclic cannabinoid from hemp, Cannabis sativa L

Cannabitwinol, a Dimeric Phytocannabinoid from Hemp, Cannabis sativa L., Is a Selective Thermo-TRP Modulator

scientific article published on 03 September 2020

Cannflavins from hemp sprouts, a novel cannabinoid-free hemp food product, target microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

scientific article published in July 2014

Carbonyl Activation in Electrophilic Polyene Cyclizations: A Toolbox for the Design of Isoprenoid Libraries.

scientific article

Cerium(III) chloride-promoted chemoselective esterification of phenolic alcohols

Chapter Two Taxine

Characterization of anti-coagulant properties of prenylated coumarin ferulenol

scientific article published on 12 July 2007

ChemInform Abstract: Secondary Metabolites from Edible Plants and Spices. Part 3. Structural Revision of the Parsley Sesquiterpenes Crispanone and Crispane.

scientific article published in 2010

Chemical and biomolecular characterization of Artemisia umbelliformis Lam., an important ingredient of the alpine liqueur "Genepi".

scientific article

Chemistry and occurrence of taxane derivatives. Part 16. Rearranged taxoids from Taxus×media Rehd. cv Hicksii. X-Ray molecular structure of 9-O-benzoyl-9,10-dide-O-acetyl-11(15 → 1)abeo-baccatin VI

Chemoselective Esterification of Phenolic Acids and Alcohols

scientific article published on 01 October 2002

Clinically useful vanilloid receptor TRPV1 antagonists: just around the corner (or too early to tell)?

scientific article

Combined use of isotopic fingerprint and metabolomics analysis for the authentication of saw palmetto (Serenoa repens) extracts

scientific article published on 21 April 2018

Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation

scientific article

Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva(®)), nimesulide, and acetaminophen

scientific article published on 8 March 2013

Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins

scientific article published on 05 May 2010

Conformational studies on resiniferatoxin (RTX), an ultrapotent vanilloid agonist

scientific article published on 01 February 1998

Conformational study of shiromodiol and related epoxygermacranes: X-ray, molecular mechanics and NMR analyses

Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes

scientific article published on May 2009

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

scientific article published on 23 November 2018

Corrigendum to Halogenation of a capsaicin analogue leads to novel vanilloid TRPVI receptor antagonists.

scientific article

Corrigendum to “Book Review: Phytochemical Reference Standards of Selected Indian Medicinal Plants” [FTT 83 (2012) 253]

article

Coumarins from Heptaptera anisoptera

Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin.

scientific article published in April 2004

Crispolide, an unusual hydroperoxysesquiterpene lactone from Tanacetum vulgare

scientific article published on 25 July 2002

Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis

scientific article published on June 2005

Daphnane-type diterpene orthoesters and their biological activities

scientific article published in April 2002

Daucane esters from Ferula arrigonii

Daucane phytoestrogens: a structure-activity study

scientific article

Denbinobin inhibits nuclear factor-kappaB and induces apoptosis via reactive oxygen species generation in human leukemic cells.

scientific article published on 21 January 2009

Denbinobin, a naturally occurring 1,4-phenanthrenequinone, inhibits HIV-1 replication through an NF-kappaB-dependent pathway

scientific article published on 18 September 2008

Development of the first potent and specific inhibitors of endocannabinoid biosynthesis

scientific article published on 23 January 2006

Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential

scientific article

Dietary acetylenic oxylipin falcarinol differentially modulates GABAA receptors

scientific article published on 4 December 2014

Dietary zerumbone from shampoo ginger: new insights into its antioxidant and anticancer activity

scientific article published on 01 March 2019

Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation.

scientific article published on 23 December 2007

Discovery of a Remarkable Methyl Shift Effect in the Vanilloid Activity of Triterpene Amides

scientific article published on 02 November 2020

Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands

scientific article published on 28 January 2015

Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?

scientific article published on 6 June 2013

Diterpenoid (poly)esters and a ring A-seco-phorboid from the aerial parts of Euphorbia macroclada Boiss

scientific article published on 01 June 2010

Diterpenoids from Cascarilla (Croton eluteria Bennet).

scientific article published in August 2002

Diterpenoids fromEuphorbiapithyusasubsp.cupanii

scientific article published on 01 October 1999

EHP-101, an oral formulation of the cannabidiol aminoquinone VCE-004.8, alleviates bleomycin-induced skin and lung fibrosis

scientific article published on 02 August 2018

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels

scientific article published on May 2014

Effects of yew alkaloids and related compounds on guinea-pig isolated perfused heart and papillary muscle.

scientific article published in January 1996

Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients.

scientific article

Electron impact fragmentation of pyranocoumarin derivatives. Tandem mass spectrometric study of abundant singly and doubly charged fragment ions at high and low collision energy

scholarly article by F. M. Rubino et al published May 1992 in Journal of Mass Spectrometry

Electrophilic Triterpenoid Enones: A Comparative Thiol-Trapping and Bioactivity Study.

scientific article published on 28 July 2017

Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract

scientific article published on 23 October 2012

Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine.

scientific article

Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated α-pyrone–phloroglucinol etherodimer from Helichrysum italicum subsp.microphyllum

scientific article published in 2007

Falcarindiol allosterically modulates GABAergic currents in cultured rat hippocampal neurons.

scientific article

Ferprenin, a prenylated coumarin from Ferula communis

scientific article published on 25 July 2002

First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands

scientific article published on 29 December 2005

Flavonoid-induced autophagy in hormone sensitive breast cancer cells

scientific article published on 14 April 2009

Functional characterization of transient receptor potential channels in mouse urothelial cells

scientific article

Functionalization of β-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System

scientific article

Furohyperforin, a Prenylated Phloroglucinol from St. John's Wort (Hypericumperforatum)

scientific article published on 01 May 1999

Genepolide, a sesterpene gamma-lactone with a novel carbon skeleton from mountain wormwood (Artemisia umbelliformis). ⬇️

scientific article published in March 2009

Genetic differentiation of two distinct chemotypes of Ferula communis (Apiaceae) in Sardinia (Italy)

article

Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists

scientific article published on August 2003

Herbal Products in Italy: The Thin Line between Phytotherapy, Nutrition and Parapharmaceuticals; A Normative Overview of the Fastest Growing Market in Europe

scientific article

Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors

scientific article published in January 2003

Hyperforin Analogues from St. John's Wort (Hypericum perforatum)

scientific article published on 01 March 2000

Hyperforin inhibits cancer invasion and metastasis

scientific article published in September 2004

Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy

scientific article published in March 2018

Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa, as a Novel PPARγ Agonist via a Combined Computational and Functional Study

scientific article published on 03 March 2020

Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity

scientific article published on 08 January 2019

Identification of molecular targets of the oligomeric nonprenylated acylphloroglucinols from Myrtus communis and their implication as anti-inflammatory compounds

scientific article published on 13 July 2005

Immediate urticaria to Euphorbiaceae

scientific article published on 01 January 1999

Immunosuppressive activity of capsaicinoids: capsiate derived from sweet peppers inhibits NF-kappaB activation and is a potent antiinflammatory compound in vivo

scientific article

Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappa B, NFAT, and activator protein 1 signaling pathways

scientific article (publication date: 15 February 2004)

Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway

scientific article published on 24 June 2004

Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT.

scientific article published in November 2004

In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure-activity study

scientific article

In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin

scientific article

Ingenane Diterpenoids

scientific article

Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-κB independent pathway

scholarly article by M Blanco-Molina et al published August 2001 in Chemistry and Biology

Inhibition of NF-κB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus

scientific article published on 01 June 2005

Inhibitory effects of oenanthotoxin analogues on GABAergic currents in cultured rat hippocampal neurons depend on the polyacetylenes' polarity

scientific article published on 15 March 2012

Intramolecular diels-alder reaction with furan-diene. Comparison of reactivity and stereoselectivity within a set of structurally related substrates of ⬇️

scholarly article

Involvement of reactive oxygen species in capsaicinoid-induced apoptosis in transformed cells

scientific article published in June 2003

Iodinated N-acylvanillamines: potential "multiple-target" anti-inflammatory agents acting via the inhibition of t-cell activation and antagonism at vanilloid TRPV1 channels.

scientific article published on 4 January 2006

Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids.

scientific article published on 14 December 2017

Iodine-mediated cyclization of cannabigerol (CBG) expands the cannabinoid biological and chemical space

scientific article published on 27 July 2018

Ischemic neuroprotection by TRPV1 receptor-induced hypothermia

scientific article published on 21 March 2012

Isomeric hydroperoxyeudesmanolides from Artemisia umbelliformis

scientific article published on 25 July 2002

Jatrophane diterpenes as P-glycoprotein inhibitors. First insights of structure-activity relationships and discovery of a new, powerful lead

scientific article

Jatrophanes from Euphorbia squamosa as Potent Inhibitors of Candida albicans Multidrug Transporters

scientific article published on 01 December 2014

Lifting properties of the alkamide fraction from the fruit husks of Zanthoxylum bungeanum

scientific article published on 01 February 2011

Ligustilide: a novel TRPA1 modulator

scientific article published on 6 September 2011

Localization of the cytotoxic hydroperoxyeudesmanolides in Artemisia umbelliformis

scientific article published on 10 February 2003

Macrocyclic Diterpenoids fromEuphorbiasemiperfoliata

scientific article published on 01 June 1998

Macrocyclic diterpenoids from Euphorbia hyberna L. subsp. insularis and their reaction with oxyphilic reagents

scientific article published on 01 December 2002

Macrocyclic diterpenoids from the Iranian plant Euphorbia bungei Boiss

article

Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine

scientific article

Minor Taxoids from Taxus wallichiana

scientific article published on 01 June 1995

Minor diterpenoids from cascarilla (Croton eluteria Bennet) and evaluation of the cascarilla extract and cascarillin effects on gastric acid secretion

scientific article published in November 2003

Modified jatrophane diterpenes as modulators of multidrug resistance from Euphorbia dendroides L.

scientific article published on November 2003

Modulation of GABAergic synaptic currents and current responses by α-thujone and dihydroumbellulone

scientific article published on 24 February 2012

Modulation of chemoselectivity by protein additives. Remarkable effects in the oxidation of hyperforin

scientific article published in November 2004

Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study

scientific article published on May 2009

Molecular diversity and natural products ⬇️

scientific article published on 01 May 2011

N-Acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor

scientific article

N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia

scientific article published on 4 February 2003

Neuroactive and Anti-inflammatory Frankincense Cembranes: A Structure-Activity Study.

scientific article published on 28 June 2016

Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii

scientific article published in October 2002

New insights into the antioxidant activity and cytotoxicity of arzanol and effect of methylation on its biological properties

scientific article

New oxetane-type taxanes from Taxus wallichiana Zucc

New taxoids fromTaxus baccata L.

scientific article published on 20 July 2007

Nitration versus nitrosation chemistry of menthofuran: remarkable fragmentation and dimerization pathways and expeditious entry into dehydromenthofurolactone

scientific article published on 29 November 2007

Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues

scientific article (publication date: 27 February 2002)

Non volatile constituents of the vermouth ingredient Artemisia vallesiaca

scientific article published on 13 August 2019

Non-pungent capsaicinoids from sweet pepper synthesis and evaluation of the chemopreventive and anticancer potential

scientific article published on January 2003

Novel Base-Catalyzed Rearrangement of the Taxane Skeleton1

O-Methyl Phytocannabinoids: Semi-synthesis, Analysis in Cannabis Flowerheads, and Biological Activity

scientific article published on 01 April 2019

Olfaction, taste and chemoreception: scientific evidence replaces "Essays in biopoetry"

scientific article published on 01 May 2017

Oligomeric acylphloroglucinols from myrtle (Myrtus communis).

scientific article published in March 2002

Omnia praeclara rara. The Quest for Ingenol Heats Up

scientific article published on 01 January 2014

One-Pot Total Synthesis of Cannabinol via Iodine-Mediated Deconstructive Annulation

scientific article published on 24 July 2019

Oxidative Addition of 4-Hydroxycoumarin to Alkenes. An Expeditious Entry to 2,3-Dihydro-4H-furo-[3,2-c][1]benzopyran-4-ones1

article

Oxidative Fragmentation of the Bridgedβ-Triketone Core of Hyperforin

Oxygenated Sesquiterpenoids from a Nonpoisonous Sardinian Chemotype of Giant Fennel (Ferulacommunis)

scientific article published on 01 March 2001

Oxygenated nerolidol derivatives from Artemisia alba

scientific article published on 25 July 2002

Oxyhomologation of the amide bond potentiates neuroprotective effects of the endolipid N-palmitoylethanolamine

scientific article published on 26 October 2006

Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity

scientific article published on April 2006

Paclitaxel Analogues fromTaxus×mediacv. Hicksii

scientific article published on 01 February 1999

Paclitaxel analogues from Taxus baccata

Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.

scientific article published on 8 August 2013

Pharmacology of vanilloid transient receptor potential cation channels

scientific article

Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism

scientific article published on July 2000

Phytocannabinoids: a unified critical inventory

scientific article

Pietro Biginelli: The Man Behind the Reaction

Plant triterpenoids with bond-missing skeletons: biogenesis, distribution and bioactivity

scientific article published on 05 May 2020

Plant volatiles: production, function and pharmacology

scientific article published on 13 June 2011

Pleasant natural scent with unpleasant effects: cluster headache-like attacks triggered by Umbellularia californica.

scientific article published in February 2010

Poly-Electrophilic Sesquiterpene Lactones from Vernonia amygdalina: New Members and Differences in Their Mechanism of Thiol Trapping and in Bioactivity

scientific article

Polyacetylenes from sardinian Oenanthe fistulosa: a molecular clue to risus sardonicus

scientific article

Polycyclic diterpenoids from Euphorbia characias

scientific article published on 01 April 2000

Polyoxygenated eudesmanes and trans-chrysanthemanes from the aerial parts of Santolina insularis

scientific article published in January 2004

Prenylated coumarins and sesquiterpenoids from Ferula communis

scientific article published on 25 July 2002

Prenylated isocoumarins from Bunium paucifolium

Prenylation preserves antioxidant properties and effect on cell viability of the natural dietary phenol curcumin

Protective effect and relation structure-activity of nonivamide and iododerivatives in several models of lipid oxidation

scientific article

Protective effect of capsinoid on lipid peroxidation in rat tissues induced by Fe-NTA.

scientific article

Protective effect of the oligomeric acylphloroglucinols from Myrtus communis on cholesterol and human low density lipoprotein oxidation

scientific article published in May 2008

Protective effect of vanilloids against tert-butyl hydroperoxide-induced oxidative stress in vero cells culture

scientific article published on 26 April 2008

Protective role of arzanol against lipid peroxidation in biological systems

Pseudoalkaloid taxanes from Taxus baccata

Pterocarpans from Bituminaria morisiana and Bituminaria bituminosa

scientific article published in September 2003

Pterocarpans from Bituminaria morisiana and Bituminaria bituminosa.

scientific article published on 28 July 2005

Rearranged taxanes from Taxus baccata

Receptor Agonism and Antagonism of Dietary Bitter Compounds

scientific article published on 01 October 2011

Recreational drug discovery: natural products as lead structures for the synthesis of smart drugs

scientific article

Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial

scientific article published on 18 June 2014

Remarkable differences in the reactivity of echinadiol and shiromodiol, biologically active epimeric germacrane derivatives

Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses

scientific article

Reprint of: Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum.

scientific article published on 11 April 2018

Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1.

scientific article

Revised structure of brevifoliol and some baccatin VI derivatives

Roasting impact on the contents of clovamide (N-caffeoyl-L-DOPA) and the antioxidant activity of cocoa beans (Theobroma cacao L.)

SAR Studies on Curcumin’s Pro-inflammatory Targets: Discovery of Prenylated Pyrazolocurcuminoids as Potent and Selective Novel Inhibitors of 5-Lipoxygenase

scientific article published on 24 June 2014

SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

scientific article published in August 2005

SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitro

scientific article

STAT-3 Inhibitory Bisabolanes from Carthamus glaucus

scientific article published on 06 February 2012

Selective analysis of phenolic compounds in propolis by HPLC-MS/MS

scientific article published on 01 January 2008

Sesquiterpene coumarin ethers from asafetida

Sesquiterpene coumarin ethers from the genus Heptaptera

article published in 1992

Sesquiterpene lactols from Laserpitium halleri

scientific article published on 25 July 2002

Sesquiterpene lactones and furanocoumarins from Cicerbita alpina

Sesquiterpene lactones from Artemisia genipi Weber: isolation and determination in plant material and in liqueurs

scientific article published on 10 March 2005

Sesquiterpene lactones from Centaurea uniflora subsp. Nervosa

scientific article published on 25 July 2002

Sesquiterpene lactones from Laserpitium gallicum

Sesquiterpenoid esters from the fruits of Ferula communis

Sesquiterpenoids from Common Ragweed (Ambrosia artemisiifolia L.), an Invasive Biological Polluter

Sesquiterpenoids from Pallenis spinosa

Shedding light on curcumin stability

scientific article published in 2022

Some like it pungent and vile. TRPA1 as a molecular target for the malodorous vinyl disulfides from asafoetida

scientific article

Spices: the savory and beneficial science of pungency

scientific article published on January 2013

Stereostructure assignment of medium-sized rings through an NMR-computational combined approach. Application to the new germacranes ketopelenolides C and D.

scientific article

Structural and conformational studies on sesquiterpenoids Part II: X-ray, molecular mechanics and NMR analysis of slovanolides

Structural revision of the parsley sesquiterpenes crispanone and crispane1Part 3 in the series “Secondary Metabolites from Edible Plants and Spices”. For part 2, see: Appendino, G., Tagliapietra, S. and Nano, G.M. and Jakupovic, J. (1994) Phytoch

article

Structure--activity relationships of the estrogenic sesquiterpene ester ferutinin. Modification of the terpenoid core

scientific article published in September 2004

Structure-activity relationships of new taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.

scientific article

Structure-activity relationships of ring C-secotaxoids. 1. Acylative modifications

scientific article published in February 2004

Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene

scientific article

Structure–activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The homovanillyl moiety

scientific article published on 29 September 2006

Syntheses and Structure−Activity Relationships of Novel Nor-seco Taxoids

Synthesis and Biological Evaluation of Phorbol-Resiniferatoxin (RTX) Hybrids

Synthesis and Evaluation of Phorboid 20-Homovanillates: Discovery of a Class of Ligands Binding to the Vanilloid (Capsaicin) Receptor with Different Degrees of Cooperativity

scientific article published on 01 August 1996

Synthesis and Structure-Activity Relationships of Novel Nor-Seco Analogs of Taxol and Taxotere

article published in 1994

Synthesis and biological evaluation of 12-aminoacylphorboids.

scientific article published in March 2010

Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety

scientific article published in April 2002

Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390.

scientific article published on 23 September 2005

Synthesis and biological evaluation of paclitaxel-thiocolchicine hybrids

scientific article published on February 2004

Synthesis and evaluation of C-seco paclitaxel analogues

Synthesis of 7,9-nitrogen-substituted paclitaxel derivatives

Synthesis of a conformationally restricted analogue of paclitaxel

Synthesis of azetidine-type taxanes

Synthesis of fercoprolone, a degraded prenylated coumarin

Synthesis of modified baccatins via an oxidation-reduction protocol

Synthesis of paclitaxel (docetaxel) / 2-deacetoxytaxinine J dimers

TRPV1 (vanilloid receptor, capsaicin receptor) agonists and antagonists

Tanacetols A and B, non-volatile sesquiterpene alcohols, from Tanacetum vulgare

scientific article published on 25 July 2002

Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia

scientific article published on 27 December 2011

Tasty and healthy TR(i)Ps. The human quest for culinary pungency

scientific article

Taxanes from Taxus baccata

Taxanes from the Seeds of Taxus baccata

article published in 1993

Taxanes from the needles of Taxus wallichiana

Taxoids from the Roots of Taxus × media cv. Hicksii

article published in 1994

Taxol analogues from the roots of Taxus x media

Tetrahydrocannabinolic acid A (THCA-A) reduces adiposity and prevents metabolic disease caused by diet-induced obesity

scientific article published on 09 November 2019

Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.

scientific article

Tetrahydrofuran-type terpenoids from Tanacetum vulgare

article by Giovanni Appendino et al published 25 July 2002 in Phytochemistry

The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system

scientific article

The 1,2,3-triazole ring as a peptido- and olefinomimetic element: discovery of click vanilloids and cannabinoids

scientific article published in January 2007

The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains

scientific article published on 6 February 2017

The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway

scientific article published on 6 October 2003

The Chemistry of Coumarin Derivatives. Part 5. Unusual course of the reaction of 4-hydroxycoumarin and aliphatic aldehydes

The Chemistry of Coumarin Derivatives. Part VI. Diels-Alder Trapping of 3-Methylene-2,4-chromandione. A New Entry to Substituted Pyrano[3,2-c]coumarins

The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors

scientific article

The Oxidation of Phytocannabinoids to Cannabinoquinoids

scientific article published on 21 April 2020

The Reaction of Hyperforin with Hydride Reducing Agents

The Reductive Fragmentation of 7-Hydroxy-9,10-dioxotaxoids

The Thia-Michael Reactivity of Zerumbone and Related Cross-Conjugated Dienones: Disentangling Stoichiometry, Regiochemistry, and Addition Mode with an NMR-Spectroscopy-Based Cysteamine Assay

The Vinylogous Aldol Reaction: A Valuable, Yet Understated Carbon−Carbon Bond-Forming Maneuver

scientific article published on 01 June 2000

The acetaminophen-derived bioactive N-acylphenolamine AM404 inhibits NFAT by targeting nuclear regulatory events

scientific article published on 15 December 2006

The allylic oxidation of tigliane esters

scientific article published on 09 December 2020

The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel.

scientific article published on 16 June 2017

The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways

scientific article published on 18 February 2016

The chemistry of coumarin derivatives, part 2. Reaction of 4-hydroxycoumarin with ?,?-unsaturated aldehydes

The chemistry of coumarin derivatives. Part 3. Synthesis of 3-alkyl-4-hydroxycoumarins by reductive fragmentation of 3,3?-alkyiidene-4,4?-dihydroxybis[coumarins]

The dietary flavonoid eupatilin attenuates in vitro lipid peroxidation and targets lipid profile in cancer HeLa cells

scientific article published on 21 May 2020

The dimerization of Δ 9-tetrahydrocannabinolic acid A (THCA-A)

scientific article published on 24 June 2019

The endocannabinoid system of the skin. A potential approach for the treatment of skin disorders

scientific article published on 20 August 2018

The génépi Artemisia species. Ethnopharmacology, cultivation, phytochemistry, and bioactivity

scientific article published on 07 September 2015

The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin

scientific article

The phytochemistry of the yew tree ⬇️

scientific article published on August 1, 1995

The reaction of 6,8-disubstituted E,E-germacra-1(10),4-diene 4-epoxides with oxyphilic reagents

The reaction of cinnamaldehyde and cinnam(o)yl derivatives with thiols

scientific article

The role of natural products in the ligand deorphanization of TRP channels.

scientific article published on January 2008

The stereochemistry of matricin and 4-epimatricin, proazulene sesquiterpene lactones from Artemisia arborescens

scientific article published on 25 July 2002

The structure and chemistry of hallerin, a mixture of anomeric sesquiterpenoids from Laserpitium halleri Crantz subsp. halleri

scientific article published on 26 April 2004

The structure and conformation of umbellifolide, a 4,5-secoeudesmane derivative

scientific article published on 26 April 2004

The synthesis of A-nor-B-homobaccatin III derivatives

The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination

scientific article published on July 2005

The transient receptor potential channel TRPA1: from gene to pathophysiology

scientific article published on 22 September 2012

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

article by James B. McAlpine et al published 13 July 2018 in Natural Product Reports

Topical anti-inflammatory activity of Eupatilin, a lipophilic flavonoid from mountain wormwood ( Artemisia umbelliformis Lam.).

scientific article published in September 2009

Triterpenes from the frond exudate of the fern Notholaena greggii

Triterpenoid Hydroxamates as HIF Prolyl Hydrolase Inhibitors

scientific article published on 10 October 2018

Triterpenoid p-aminobenzoates from the seeds of zucchini

scientific article published on 01 June 2000

Turmeric Sesquiterpenoids: Expeditious Resolution, Comparative Bioactivity, and a New Bicyclic Turmeronoid

scientific article published on 20 January 2016

Umbellulone modulates TRP channels

scientific article published on 29 October 2011

Unnatural Natural Products from the Transannular Cyclization of Lathyrane Diterpenes

scientific article published on 01 May 2001

VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington's disease.

scientific article published on 19 July 2016

VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB2 receptor-dependent pathways

scientific article published on 23 August 2018

VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity

scientific article published in Scientific Reports

Vanilloid receptor TRPV1 antagonists as the next generation of painkillers. Are we putting the cart before the horse?

scientific article

Vittae fluorescence as a tool to differentiate between poisonous and non-poisonous populations of giant fennel (Ferula communis) of the island Sardinia (Italy)

article

Δ9-TETRAHYDROCANNABINOLIC ACID ALLEVIATES COLLAGEN-INDUCED ARTHRITIS: ROLE OF PPARγ AND CB1 RECEPTORS

scientific article published on 08 June 2020

Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in mice

scientific article published on 30 November 2020

ω-Oxygenated prenylated coumarins from Ferula communis

scientific article published on 25 July 2002

Paulina is supported by:

About Paulina

Help