List of works by David I Broadhurst

(1)H-NMR urinary metabolomic profiling for diagnosis of gastric cancer

scientific article

1H NMR Derived Metabolomic Profile of Neonatal Asphyxia in Umbilical Cord Serum: Implications for Hypoxic Ischemic Encephalopathy

scientific article published on 21 August 2013

A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols

scientific article published in April 2008

A comparative evaluation of the generalised predictive ability of eight machine learning algorithms across ten clinical metabolomics data sets for binary classification

scientific article published on 15 November 2019

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

scientific article (publication date: 2001)

Angiogenic imbalance and plasma lipid alterations in women with preeclampsia from a developing country.

scientific article published on 10 April 2012

Biomarkers of dietary energy restriction in women at increased risk of breast cancer.

scientific article

Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia.

scientific article published on 22 September 2009

Characterizing the plasma metabolome during and following a maximal exercise cycling test

scientific article published on 02 August 2018

Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics.

scientific article published in January 2007

Detection and identification of novel metabolomic biomarkers in preeclampsia

scientific article published on 20 May 2008

Development and Performance of a Gas Chromatography−Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum

article

Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum

scientific article

Direct infusion mass spectrometry metabolomics dataset: a benchmark for data processing and quality control

scientific article

Discrimination of modes of action of antifungal substances by use of metabolic footprinting.

scientific article

Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC-MS based untargeted metabolomics practitioners

scientific article published on 12 October 2020

Does exercise impact gut microbiota composition in men receiving androgen deprivation therapy for prostate cancer? A single-blinded, two-armed, randomised controlled trial

article

Early Cord Metabolite Index and Outcome in Perinatal Asphyxia and Hypoxic-Ischaemic Encephalopathy

scientific article published on 3 August 2016

Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.

scientific article

Explanatory Optimization of Protein Mass Spectrometry via Genetic Search

scientific article published on 01 December 2003

Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells

scientific article published on July 2015

Functional genomics via metabolic footprinting: monitoring metabolite secretion by Escherichia coli tryptophan metabolism mutants using FT-IR and direct injection electrospray mass spectrometry

scientific article

Genetic algorithms as a method for variable selection in multiple linear regression and partial least squares regression, with applications to pyrolysis mass spectrometry

scholarly article by David I Broadhurst et al published August 1997 in Analytica Chimica Acta

Gestation-specific D-dimer reference ranges: a cross-sectional study

scientific article published on 15 May 2014

Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites.

scientific article

Growth control of the eukaryote cell: a systems biology study in yeast ⬇️

scientific article (publication date: 2007)

Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies.

scientific article

High-throughput classification of yeast mutants for functional genomics using metabolic footprinting.

scientific article

High-throughput metabolic fingerprinting of legume silage fermentations via Fourier transform infrared spectroscopy and chemometrics

scientific article published on March 2004

Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles

scientific article published on 7 February 2006

Improvement in the Prediction of Neonatal Hypoxicischemic Encephalopathy with the Integration of Umbilical Cord Metabolites and Current Clinical Makers

scientific article published on 08 October 2020

Macronutrient Regulation of Ghrelin and Peptide YY in Pediatric Obesity and Prader-Willi Syndrome

scientific article

Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics

scientific article

MetaboAnalyst 2.0--a comprehensive server for metabolomic data analysis

scientific article

Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system

scientific article

Metabolic profiling uncovers a phenotypic signature of small for gestational age in early pregnancy.

scientific article

Metabolomic profiling in multiple sclerosis: insights into biomarkers and pathogenesis

scientific article

Metabolomics enables precision medicine: "A White Paper, Community Perspective"

scientific article

Metabolomics reveals the physiological response of Pseudomonas putida KT2440 (UWC1) after pharmaceutical exposure

scientific article published on 2 March 2016

Migrating from PLS to Artificial Neural Networks - Adapting Interpretation Strategies

poster

Migrating from partial least squares discriminant analysis to artificial neural networks: a comparison of functionally equivalent visualisation and feature contribution tools using jupyter notebooks

scientific article published on 21 January 2020

Molecular phenotyping of a UK population: defining the human serum metabolome

scientific article

Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: application to gibberellic acid production

scientific article

On the statistics of identifying candidate pathogen effectors

scientific article

OnPLS-Based Multi-Block Data Integration: A Multivariate Approach to Interrogating Biological Interactions in Asthma

scientific article published on 02 November 2018

PYCHEM: a multivariate analysis package for python

scientific article

Perinatal determinants of D-dimer levels in a cross-sectional study of low risk pregnant women

scientific article published on 24 February 2016

Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for “Precision Medicine and Pharmacometabolomics Task Group”—The Metabolomics Society Initiative)

scientific article published on 19 June 2018

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

article

Proposed minimum reporting standards for data analysis in metabolomics

article

Rapid and quantitative detection of the microbial spoilage of meat by fourier transform infrared spectroscopy and machine learning

scientific article

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS

scientific article

Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers

scientific article published in October 2010

Sildenafil Therapy Normalizes the Aberrant Metabolomic Profile in the Comt(-/-) Mouse Model of Preeclampsia/Fetal Growth Restriction

scientific article

Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

scientific article published on 17 August 2010

The application of artificial neural networks in metabolomics: a historical perspective

scientific article published on 18 October 2019

The effect of haemolysis on the metabolomic profile of umbilical cord blood

scientific article published on 16 February 2015

The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans

scientific article published on September 2012

The metabolomic profile of umbilical cord blood in neonatal hypoxic ischaemic encephalopathy

scientific article

Toward collaborative open data science in metabolomics using Jupyter Notebooks and cloud computing

scientific article published on 14 September 2019

Towards quality assurance and quality control in untargeted metabolomics studies

scientific article published on 03 January 2019

Translational biomarker discovery in clinical metabolomics: an introductory tutorial

scientific article

Untargeted metabolomic analysis and pathway discovery in perinatal asphyxia and hypoxic-ischaemic encephalopathy.

scientific article

Using metabolic fingerprinting of plants for evaluating nitrogen deposition impacts on the landscape level

article

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