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List of works by Gordon L. Amidon

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A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals

scientific article
Lessons learned from marketed and investigational prodrugs

scientific article published on May 2004
Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

scientific article published on August 2006
Prediction of solubility and permeability class membership: provisional BCS classification of the world's top oral drugs

scientific article published on 30 October 2009
Physiological parameters for oral delivery and in vitro testing

scientific article
Quantification of gastrointestinal liquid volumes and distribution following a 240 mL dose of water in the fasted state

scientific article
The solubility-permeability interplay in using cyclodextrins as pharmaceutical solubilizers: mechanistic modeling and application to progesterone

scientific article published in June 2010
The Biopharmaceutics Classification System: subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC

scientific article published on 28 January 2014
The Solubility–Permeability Interplay: Mechanistic Modeling and Predictive Application of the Impact of Micellar Solubilization on Intestinal Permeation

scientific article published on August 11, 2011
The use of BDDCS in classifying the permeability of marketed drugs

scientific article published on 31 January 2008
Molecular Basis of Prodrug Activation by Human Valacyclovirase, an  -Amino Acid Ester Hydrolase

scientific article
Blockade of interleukin-6 receptor suppresses the proliferation of H460 lung cancer stem cells

scientific article published on 26 April 2012
Comparative gene expression profiles of intestinal transporters in mice, rats and humans

scientific article published on 23 June 2007
Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis.

scientific article published on September 2003
Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability

scientific article
Applying the biopharmaceutics classification system to veterinary pharmaceutical products. Part II. Physiological considerations

scientific article
In vitro testing of drug absorption for drug 'developability' assessment: forming an interface between in vitro preclinical data and clinical outcome

scientific article
Toward an in vivo dissolution methodology: a comparison of phosphate and bicarbonate buffers

scientific article
Summary of the National Institute of Child Health and Human Development–Best Pharmaceuticals for Children Act Pediatric Formulation Initiatives Workshop–Pediatric Biopharmaceutics Classification System Working Group

scientific article published on November 1, 2012
Comparison of the permeability of metoprolol and labetalol in rat, mouse, and Caco-2 cells: use as a reference standard for BCS classification

scientific article published on 4 February 2013
Mechanistic analysis of solute transport in an in vitro physiological two-phase dissolution apparatus

scientific article published on 4 September 2012
Summary workshop report: bioequivalence, biopharmaceutics classification system, and beyond

scientific article published on June 2008
G.L. Amidon, H. Lennernas, V.P. Shah, and J.R. Crison. A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of In Vitro Drug Product Dissolution and In Vivo Bioavailability, Pharm Res 12, 413–420, 1995—Backstory of BCS

scientific article published on June 25, 2014
Enhancing the intestinal absorption of molecules containing the polar guanidino functionality: a double-targeted prodrug approach

scientific article published in January 2010
Permeability dominates in vivo intestinal absorption of P-gp substrate with high solubility and high permeability

scientific article published in July 2005
Evaluation of a Three Compartment In Vitro Gastrointestinal Simulator Dissolution Apparatus to Predict In Vivo Dissolution

scientific article published on September 22, 2014
In vitro dissolution methodology, mini-Gastrointestinal Simulator (mGIS), predicts better in vivo dissolution of a weak base drug, dasatinib

scientific article
Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs

scientific article (publication date: 2005)
The development of orally administrable gemcitabine prodrugs with D-enantiomer amino acids: enhanced membrane permeability and enzymatic stability

scientific article
Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

scientific article published on 30 November 2016
The Evaluation of In Vitro Drug Dissolution of Commercially Available Oral Dosage Forms for Itraconazole in Gastrointestinal Simulator With Biorelevant Media.

scientific article
Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization

scientific article published on 15 February 2016
In Vitro Dissolution of Fluconazole and Dipyridamole in Gastrointestinal Simulator (GIS), Predicting in Vivo Dissolution and Drug–Drug Interaction Caused by Acid-Reducing Agents

scientific article published on May 27, 2015
In Vivo Predictive Dissolution: Transport Analysis of the CO2, Bicarbonate In Vivo Buffer System

scientific article (publication date: November 2014)
The Feasibility of Enzyme Targeted Activation for Amino Acid/Dipeptide Monoester Prodrugs of Floxuridine; Cathepsin D as a Potential Targeted Enzyme

scientific article published on March 26, 2012
Utilization of Gastrointestinal Simulator, an in Vivo Predictive Dissolution Methodology, Coupled with Computational Approach To Forecast Oral Absorption of Dipyridamole.

scientific article
Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect

scientific article
Potential of Amino Acid/Dipeptide Monoester Prodrugs of Floxuridine in Facilitating Enhanced Delivery of Active Drug to Interior Sites of Tumors: A Two-Tier Monolayer In Vitro Study

scientific article published on June 14, 2011
Mechanistic enhancement of the intestinal absorption of drugs containing the polar guanidino functionality

scientific article published on January 14, 2011
The Combination of GIS and Biphasic to Better Predict In Vivo Dissolution of BCS Class IIb Drugs, Ketoconazole and Raloxifene

scientific article
Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum.

scientific article published in August 2003
Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma

scientific article published on 22 March 2007
Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue

scientific article (publication date: February 2016)
The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC–MS

scientific article published on March 5, 2011
The dipeptide monoester prodrugs of floxuridine and gemcitabine-feasibility of orally administrable nucleoside analogs.

scientific article published on 27 January 2014
In Vivo Predictive Dissolution: Comparing the Effect of Bicarbonate and Phosphate Buffer on the Dissolution of Weak Acids and Weak Bases.

scientific article published on 15 May 2015
Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes

scientific article
The impact of supersaturation level for oral absorption of BCS class IIb drugs, dipyridamole and ketoconazole, using in vivo predictive dissolution system: Gastrointestinal Simulator (GIS)

scientific article published on 03 March 2017
Mechanistic Understanding of Food Effects: Water Diffusivity in Gastrointestinal Tract Is an Important Parameter for the Prediction of Disintegration of Solid Oral Dosage Forms

scientific article published on May 8, 2013
Cytomegalovirus Protease Targeted Prodrug Development

scientific article published on March 20, 2013

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