List of works - Nuria Casals

A new LC-ESI-MS/MS method to measure long-chain acylcarnitine levels in cultured cells

scientific article published on 03 August 2007

A single-residue mutation, G203E, causes 3-hydroxy-3-methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG-CoA lyase.

scientific article

A two-base deletion in exon 6 of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene producing the skipping of exons 5 and 6 determines 3-hydroxy-3-methylglutaric aciduria

scientific article published on 01 November 1997

Aberrantly spliced mRNAs of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene with a donor splice-site point mutation produce hereditary HL deficiency

scientific article published on 01 November 1996

Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids

scientific article published on 7 September 2017

Blattella germanica has two HMG-CoA synthase genes. Both are regulated in the ovary during the gonadotrophic cycle.

scientific article published on April 1994

Buccal fat pad, an oral access source of human adipose stem cells with potential for osteochondral tissue engineering: an in vitro study.

scientific article published in October 2010

C-terminal end and aminoacid Lys48 in HMG-CoA lyase are involved in substrate binding and enzyme activity

scientific article

CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons.

scientific article published in February 2003

CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity.

scientific article

CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy.

scientific article

CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity

scientific journal article

Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity.

scientific article published on 21 August 2013

Carnitine palmitoyltransferase 1C: From cognition to cancer.

scientific article published on 17 December 2015

Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance

scientific article published on 02 October 2014

Ceramides and mitochondrial fatty acid oxidation in obesity.

scientific article

Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol

scientific article

Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway

scientific article

Coordinated expression and activity of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase in the fat body of Blattella germanica (L.) during vitellogenesis.

scientific article

Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei.

scientific article published on 13 May 2013

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation.

scientific article published on 24 February 2015

Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors

scientific article published in 2022

Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex.

scientific article

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

scientific article

Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin.

scientific article published on 14 March 2013

Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C (CPT1C) in male mice.

scientific article published on 3 May 2017

Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae.

scientific article

Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice

scientific article published on 22 November 2017

Isolation of pluripotent stem cells from human third molar dental pulp.

scientific article

Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a

scientific article published on 20 April 2011

Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement

scientific article published on 08 August 2018

Mediterranean tomato-based sofrito protects against vascular alterations in obese Zucker rats by preserving NO bioavailability.

scientific article

Molecular basis of 3-hydroxy-3-methylglutaric aciduria.

scientific article

Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome

scientific article

N-cadherin expression is regulated by UTP in schwannoma cells.

scientific article published on 28 December 2012

Novel Regulation of the Synthesis of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus.

scientific article published on 3 September 2015

Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity

scientific article

Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase protein by starvation, fat feeding, and diabetes

scientific journal article

Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin

scientific article

Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene. Its role in the control of ketogenesis ⬇️

scientific article published on April 1, 1992

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

scientific article published on 23 December 2019

Skipping of exon 2 and exons 2 plus 3 of HMG-CoA lyase (HL) gene produces the loss of beta sheets 1 and 2 in the recently proposed (beta-alpha)8 TIM barrel model of HL.

scientific article

Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria

scientific article

The diagnosis of mitochondrial HMG-CoA synthase deficiency.

scientific article published in June 2002

Two missense point mutations in different alleles in the 3-hydroxy-3-methylglutaryl coenzyme A lyase gene produce 3-hydroxy-3-methylglutaric aciduria in a French patient.

scientific article

Uridine-5'-Triphosphate Partially Blocks Differentiation Signals and Favors a more Repair State in Cultured rat Schwann Cells

scientific article published on 11 January 2018

List of works by Nuria Casals

A new LC-ESI-MS/MS method to measure long-chain acylcarnitine levels in cultured cells

A single-residue mutation, G203E, causes 3-hydroxy-3-methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG-CoA lyase.

A two-base deletion in exon 6 of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene producing the skipping of exons 5 and 6 determines 3-hydroxy-3-methylglutaric aciduria

Aberrantly spliced mRNAs of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene with a donor splice-site point mutation produce hereditary HL deficiency

Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids

Blattella germanica has two HMG-CoA synthase genes. Both are regulated in the ovary during the gonadotrophic cycle.

Buccal fat pad, an oral access source of human adipose stem cells with potential for osteochondral tissue engineering: an in vitro study.

C-terminal end and aminoacid Lys48 in HMG-CoA lyase are involved in substrate binding and enzyme activity

CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons.

CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity.

CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy.

CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity

Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity.

Carnitine palmitoyltransferase 1C: From cognition to cancer.

Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance

Ceramides and mitochondrial fatty acid oxidation in obesity.

Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol

Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway

Coordinated expression and activity of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase in the fat body of Blattella germanica (L.) during vitellogenesis.

Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei.

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation.

Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors

Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex.

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin.

Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C (CPT1C) in male mice.

Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae.

Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice

Isolation of pluripotent stem cells from human third molar dental pulp.

Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a

Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement

Mediterranean tomato-based sofrito protects against vascular alterations in obese Zucker rats by preserving NO bioavailability.

Molecular basis of 3-hydroxy-3-methylglutaric aciduria.

Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome

N-cadherin expression is regulated by UTP in schwannoma cells.

Novel Regulation of the Synthesis of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus.

Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity

Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase protein by starvation, fat feeding, and diabetes

Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin

Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene. Its role in the control of ketogenesis ⬇️

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

Skipping of exon 2 and exons 2 plus 3 of HMG-CoA lyase (HL) gene produces the loss of beta sheets 1 and 2 in the recently proposed (beta-alpha)8 TIM barrel model of HL.

Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria

The diagnosis of mitochondrial HMG-CoA synthase deficiency.

Two missense point mutations in different alleles in the 3-hydroxy-3-methylglutaryl coenzyme A lyase gene produce 3-hydroxy-3-methylglutaric aciduria in a French patient.

Uridine-5'-Triphosphate Partially Blocks Differentiation Signals and Favors a more Repair State in Cultured rat Schwann Cells