Search filters

Authors whose works are in public domain in at least one jurisdiction

List of works by Tomas Smutny

1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria

scientific article published on 02 June 2014

2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.

scientific article published on 4 May 2016

Bioinformatic analysis of miRNAs targeting the key nuclear receptors regulating CYP3A4 gene expression: The challenge of the CYP3A4 "missing heritability" enigma

scientific article published in July 2015

Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR).

scientific article

Correction to 2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.

scientific article published on 8 December 2016

Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis

scientific article published on 05 March 2016

Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation

scientific article

Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.

scientific article published on January 2013

Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats.

scientific article published on 6 September 2017

Laminin-511 and laminin-521-based matrices for efficient hepatic specification of human pluripotent stem cells.

scientific article published on 23 June 2016

Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier ⬇️

scientific article published on September 10, 2013

Resveratrol as an inhibitor of pregnane X receptor (PXR): another lesson in PXR antagonism.

scientific article published on January 2014

Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation

scientific article published on 5 September 2017

The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator

scientific article published on 27 February 2016

Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism

scientific article published on 09 November 2020

U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.

scientific article published on 14 May 2014

Paulina is supported by:

About Paulina

Help