List of works - Kenneth Kin Wah To

A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells.

scientific article published on 5 June 2015

A platinum-based hybrid drug design approach to circumvent acquired resistance to molecular targeted tyrosine kinase inhibitors

scientific article published on 6 May 2016

ABCG2: a perspective.

scientific article

Aberrant promoter methylation of the ABCG2 gene in renal carcinoma

scientific article

Afatinib enhances the efficacy of conventional chemotherapeutic agents by eradicating cancer stem-like cells

scientific article

An efficient way of studying protein-protein interactions involving HIF-α, c-Myc, and Sp1

scientific article published on 01 January 2013

Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters

scientific article

CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function

scientific article

Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats

scientific article published on 01 January 1999

Constitutive AhR activation leads to concomitant ABCG2-mediated multidrug resistance in cisplatin-resistant esophageal carcinoma cells.

scientific article published on 15 June 2011

Differential nephrotoxicity of cisplatin and a novel series of traditional Chinese medicine-platinum anticancer agents correlates with their chemical reactivity towards sulfur-containing nucleophiles.

scientific article published on July 2006

Drug repurposing to overcome resistance to various therapies for colorectal cancer

scientific article published on 13 May 2019

Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresistance in colorectal cancer.

scientific article published on 16 September 2015

Expression and activity of ABCG2, but not ABCB1 or OATP1B1, are associated with cholesterol levels: evidence from in vitro and in vivo experiments

scientific article published on 01 June 2014

Fabrication of doxorubicin nanoparticles by controlled antisolvent precipitation for enhanced intracellular delivery

scientific article published on 18 December 2015

Genetic instability: the dark side of the hypoxic response.

scientific article published on 11 July 2005

Genomic organization and functional characterization of the human concentrative nucleoside transporter-3 isoform (hCNT3) expressed in mammalian cells.

scientific article published on 18 September 2003

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

scientific article published in March 2005

In vitro and in vivo suppression of growth of hepatocellular carcinoma cells by novel traditional Chinese medicine-platinum anti-cancer agents.

scientific article published in September 2005

Increased expression of activated endothelial nitric oxide synthase contributes to antiandrogen resistance in prostate cancer cells by suppressing androgen receptor transactivation.

scientific article

Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma

scientific article

Micellar delivery of dasatinib for the inhibition of pathologic cellular processes of the retinal pigment epithelium.

scientific article published on 2 January 2016

MicroRNA: a prognostic biomarker and a possible druggable target for circumventing multidrug resistance in cancer chemotherapy

scientific article published on 20 December 2013

Monofunctional Platinum (PtII) Compounds - Shifting the Paradigm in Designing New Pt-based Anticancer Agents

scientific article published on 10 March 2016

Pelitinib (EKB-569) targets the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer

scientific article

Platinum-based anticancer agents: innovative design strategies and biological perspectives.

scientific article

Polyoxypregnane steroids from the stems of Marsdenia tenacissima

scientific article published on 12 September 2014

Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity

scientific article published on 14 March 2016

Protein phosphatase 2A inhibition and circumvention of cisplatin cross-resistance by novel TCM-platinum anticancer agents containing demethylcantharidin.

scientific article published in September 2004

Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan.

scientific article

Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line.

scientific article published on 23 June 2008

Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza

scientific article published on 25 July 2014

Reversal of P-glycoprotein-mediated multidrug resistance by a synthetic α-aminoxy peptidomimetic.

scientific article published on 2 January 2012

Reversal of P-gp and BCRP-mediated MDR by tariquidar derivatives

scientific article published on 10 July 2015

Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes.

scientific article published on April 2008

Synergistic cytotoxicity from combination of imatinib and platinum-based anticancer drugs specifically in Bcr-Abl positive leukemia cells.

scientific article published on 6 November 2015

Synergistic interaction between platinum-based antitumor agents and demethylcantharidin.

scientific article published on 8 December 2004

Targeting the ABCG2-overexpressing multidrug resistant (MDR) cancer cells by PPARγ agonists.

scientific article

The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins ⬇️

scientific article published on November 23, 2010

The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression

scientific article

Up-regulation of ABCB1/P-glycoprotein by escaping promoter hypermethylation indicates poor prognosis in hematologic malignancy patients with and without bone marrow transplantation.

scientific article published on 21 May 2010

Upregulation of ABCG2 by romidepsin via the aryl hydrocarbon receptor pathway.

scientific article published on 25 February 2011

Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport function

scientific article

Whole soy, but not purified daidzein, had a favorable effect on improvement of cardiovascular risks: a 6-month randomized, double-blind, and placebo-controlled trial in equol-producing postmenopausal women.

scientific article published on 24 November 2013

List of works by Kenneth Kin Wah To

A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells.

A platinum-based hybrid drug design approach to circumvent acquired resistance to molecular targeted tyrosine kinase inhibitors

ABCG2: a perspective.

Aberrant promoter methylation of the ABCG2 gene in renal carcinoma

Afatinib enhances the efficacy of conventional chemotherapeutic agents by eradicating cancer stem-like cells

An efficient way of studying protein-protein interactions involving HIF-α, c-Myc, and Sp1

Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters

CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function

Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats

Constitutive AhR activation leads to concomitant ABCG2-mediated multidrug resistance in cisplatin-resistant esophageal carcinoma cells.

Differential nephrotoxicity of cisplatin and a novel series of traditional Chinese medicine-platinum anticancer agents correlates with their chemical reactivity towards sulfur-containing nucleophiles.

Drug repurposing to overcome resistance to various therapies for colorectal cancer

Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresistance in colorectal cancer.

Expression and activity of ABCG2, but not ABCB1 or OATP1B1, are associated with cholesterol levels: evidence from in vitro and in vivo experiments

Fabrication of doxorubicin nanoparticles by controlled antisolvent precipitation for enhanced intracellular delivery

Genetic instability: the dark side of the hypoxic response.

Genomic organization and functional characterization of the human concentrative nucleoside transporter-3 isoform (hCNT3) expressed in mammalian cells.

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

In vitro and in vivo suppression of growth of hepatocellular carcinoma cells by novel traditional Chinese medicine-platinum anti-cancer agents.

Increased expression of activated endothelial nitric oxide synthase contributes to antiandrogen resistance in prostate cancer cells by suppressing androgen receptor transactivation.

Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma

Micellar delivery of dasatinib for the inhibition of pathologic cellular processes of the retinal pigment epithelium.

MicroRNA: a prognostic biomarker and a possible druggable target for circumventing multidrug resistance in cancer chemotherapy

Monofunctional Platinum (PtII) Compounds - Shifting the Paradigm in Designing New Pt-based Anticancer Agents

Pelitinib (EKB-569) targets the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer

Platinum-based anticancer agents: innovative design strategies and biological perspectives.

Polyoxypregnane steroids from the stems of Marsdenia tenacissima

Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity

Protein phosphatase 2A inhibition and circumvention of cisplatin cross-resistance by novel TCM-platinum anticancer agents containing demethylcantharidin.

Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan.

Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line.

Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza

Reversal of P-glycoprotein-mediated multidrug resistance by a synthetic α-aminoxy peptidomimetic.

Reversal of P-gp and BCRP-mediated MDR by tariquidar derivatives

Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes.

Synergistic cytotoxicity from combination of imatinib and platinum-based anticancer drugs specifically in Bcr-Abl positive leukemia cells.

Synergistic interaction between platinum-based antitumor agents and demethylcantharidin.

Targeting the ABCG2-overexpressing multidrug resistant (MDR) cancer cells by PPARγ agonists.

The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins ⬇️

The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression

Up-regulation of ABCB1/P-glycoprotein by escaping promoter hypermethylation indicates poor prognosis in hematologic malignancy patients with and without bone marrow transplantation.

Upregulation of ABCG2 by romidepsin via the aryl hydrocarbon receptor pathway.

Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport function

Whole soy, but not purified daidzein, had a favorable effect on improvement of cardiovascular risks: a 6-month randomized, double-blind, and placebo-controlled trial in equol-producing postmenopausal women.