List of works - John Spencer

The potential of palladacycles: more than just precatalysts.

scientific article

Small molecule induced reactivation of mutant p53 in cancer cells

scientific article

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia

scientific article

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03115j.

scientific article published on 22 December 2015

Cytotoxic effects of Jay Amin hydroxamic acid (JAHA), a ferrocene-based class I histone deacetylase inhibitor, on triple-negative MDA-MB231 breast cancer cells

scientific article published in November 2012

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.

scientific article published on December 2015

Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors

scientific article

Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones

scientific article

Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency.

scientific article published on 17 October 2014

On the noninnocent nature of 1,3-dialkylimidazolium ionic liquids

scientific article published on 01 October 2004

Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

scientific article

Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion

scientific article published on 31 May 2007

Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity.

scientific article

Carbon dots (C-dots) from cow manure with impressive subcellular selectivity tuned by simple chemical modification

scientific article published on 18 February 2015

Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles

scientific article

A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin.

scientific article

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

scientific article

Synthesis of an [(NHC)2 Pd(SiMe3 )2 ] Complex and Catalytic cis-Bis(silyl)ations of Alkynes with Unactivated Disilanes.

scientific article published on 9 April 2015

Novel, achiral 1,3,4-benzotriazepine analogues of 1,4-benzodiazepine-based CCK(2) antagonists that display high selectivity over CCK(1) receptors.

scientific article published on April 2006

New cyclodextrin-bearing 8-hydroxyquinoline ligands as multifunctional molecules

scientific article published on 22 August 2013

Recent advances in the development of selective CB(2) agonists as promising anti-inflammatory agents.

scientific article published on January 2012

1,4-Benzodiazepin-2-Ones in Medicinal Chemistry

scientific article (publication date: September 2010)

Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib

scientific article published on 15 January 2010

Biological Effect of a Hybrid Anticancer Agent Based on Kinase and Histone Deacetylase Inhibitors on Triple-Negative (MDA-MB231) Breast Cancer Cells.

scientific article published on 30 July 2016

Prodrug and covalent linker strategies for the solubilization of dual-action antioxidants/iron chelators.

scientific article published in November 2002

Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

scientific article

Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

scientific article

Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template.

scientific article published on 25 December 2007

Synthesis, physicochemical properties and antioxidant activity of deferiprone-cyclodextrin conjugates and their iron(III) complexes

scientific article published on 30 November 2011

The Histone Deacetylase Inhibitor JAHA Down-Regulates pERK and Global DNA Methylation in MDA-MB231 Breast Cancer Cells.

scientific article published on 16 October 2015

Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks

scientific article

Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells.

scientific article published on 28 May 2015

Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation

scientific article published on 26 May 2014

Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines.

scientific article

Regioselective routes to orthogonally-substituted aromatic MIDA boronates

scientific article published on 01 July 2016

Bismuth coordination networks containing deferiprone: synthesis, characterisation, stability and antibacterial activity

scientific article published on 01 August 2015

Late Stage CH Activation of a Privileged Scaffold; Synthesis of a Library of Benzodiazepines

G-Protein Coupled Receptor and Kinase Targets: Advances in Drug Discovery from Molecular to Clinical

scientific article published on July 1, 2011

Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases

scientific article published on 09 October 2018

Synthesis and solid-state characterisation of 4-substituted methylidene oxindoles

scientific article published on 20 December 2013

The nature of the bonding in symmetrical pincer palladacycles

scientific article published on 01 April 2015

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C

scientific article published on 01 October 2019

Cytotoxic Activity of the Histone Deacetylase 3-Selective Inhibitor Pojamide on MDA-MB-231 Triple-Negative Breast Cancer Cells

scientific article published on 13 February 2019

Boron medicinal chemistry and synthetic aspects

scientific article published in April 2013

Microwave-mediated synthesis of an arylboronate library

scientific article

A cyclodextrin-capped histone deacetylase inhibitor.

scientific article published on 2 April 2013

Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki–Miyaura cross-couplings

Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

scientific article published on 6 October 2017

Isoskeletal Schiff base polynuclear coordination clusters: synthetic and theoretical aspects

scientific article published in 2016

List of works by John Spencer

The potential of palladacycles: more than just precatalysts.

Small molecule induced reactivation of mutant p53 in cancer cells

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03115j.

Cytotoxic effects of Jay Amin hydroxamic acid (JAHA), a ferrocene-based class I histone deacetylase inhibitor, on triple-negative MDA-MB231 breast cancer cells

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.

Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors

Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones

Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency.

On the noninnocent nature of 1,3-dialkylimidazolium ionic liquids

Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion

Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity.

Carbon dots (C-dots) from cow manure with impressive subcellular selectivity tuned by simple chemical modification

Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles

A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin.

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

Synthesis of an [(NHC)2 Pd(SiMe3 )2 ] Complex and Catalytic cis-Bis(silyl)ations of Alkynes with Unactivated Disilanes.

Novel, achiral 1,3,4-benzotriazepine analogues of 1,4-benzodiazepine-based CCK(2) antagonists that display high selectivity over CCK(1) receptors.

New cyclodextrin-bearing 8-hydroxyquinoline ligands as multifunctional molecules

Recent advances in the development of selective CB(2) agonists as promising anti-inflammatory agents.

1,4-Benzodiazepin-2-Ones in Medicinal Chemistry

Seven 3-methylidene-1H-indol-2(3H)-ones related to the multiple-receptor tyrosine kinase inhibitor sunitinib

Biological Effect of a Hybrid Anticancer Agent Based on Kinase and Histone Deacetylase Inhibitors on Triple-Negative (MDA-MB231) Breast Cancer Cells.

Prodrug and covalent linker strategies for the solubilization of dual-action antioxidants/iron chelators.

Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template.

Synthesis, physicochemical properties and antioxidant activity of deferiprone-cyclodextrin conjugates and their iron(III) complexes

The Histone Deacetylase Inhibitor JAHA Down-Regulates pERK and Global DNA Methylation in MDA-MB231 Breast Cancer Cells.

Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks

Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells.

Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation

Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines.

Regioselective routes to orthogonally-substituted aromatic MIDA boronates

Bismuth coordination networks containing deferiprone: synthesis, characterisation, stability and antibacterial activity

Late Stage CH Activation of a Privileged Scaffold; Synthesis of a Library of Benzodiazepines

G-Protein Coupled Receptor and Kinase Targets: Advances in Drug Discovery from Molecular to Clinical

Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases

Synthesis and solid-state characterisation of 4-substituted methylidene oxindoles

The nature of the bonding in symmetrical pincer palladacycles

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C

Cytotoxic Activity of the Histone Deacetylase 3-Selective Inhibitor Pojamide on MDA-MB-231 Triple-Negative Breast Cancer Cells

Boron medicinal chemistry and synthetic aspects

Microwave-mediated synthesis of an arylboronate library

A cyclodextrin-capped histone deacetylase inhibitor.

Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki–Miyaura cross-couplings

Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

Isoskeletal Schiff base polynuclear coordination clusters: synthetic and theoretical aspects

The Trans Influence in Unsymmetrical Pincer Palladacycles: An Experimental and Computational Study