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List of works by Juan S. Bonifacino

A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availability

scientific article

A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2

scientific article

A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.

scientific article

A myosin-7B-dependent endocytosis pathway mediates cellular entry of α-synuclein fibrils and polycation-bearing cargos

scientific article published on 04 May 2020

A new variant of Hermansky-Pudlak syndrome due to mutations in a gene responsible for vesicle formation

scientific article published on 01 April 2000

A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells

scientific article (publication date: 15 October 1999)

ADP-Ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes.

scientific article

AP-1A controls secretory granule biogenesis and trafficking of membrane secretory granule proteins

scientific article

ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network

scientific article published on 01 October 2019

Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.

scientific article

Adaptor proteins involved in polarized sorting

scientific article

Aggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targeting

scientific article published in December 1997

Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome

scientific article published on 26 April 2018

Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet ⬇️

scientific article published on August 1, 1997

Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor

scientific article

An ear-core interaction regulates the recruitment of the AP-3 complex to membranes

scientific article

Anchors aweigh: protein localization and transport mediated by transmembrane domains

scientific article published on 24 June 2013

Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex

scientific article

Assembly and Architecture of Biogenesis of Lysosome-related Organelles Complex-1 (BLOC-1) ⬇️

scientific article published on December 27, 2011

Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9

scientific journal article

Association between Rare Variants in AP4E1, a Component of Intracellular Trafficking, and Persistent Stuttering

scientific journal article

Association of the AP-3 adaptor complex with clathrin

scientific article

BLOC-3, a protein complex containing the Hermansky-Pudlak syndrome gene products HPS1 and HPS4

scientific article

BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks.

scientific article

BORC, a multisubunit complex that regulates lysosome positioning.

scientific article

Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXXPhi motif with the clathrin adaptors AP-1A and AP-1B

scientific article published on 16 February 2012

Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex.

scientific article

CD1a and MHC class I follow a similar endocytic recycling pathway

scientific article

CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms.

scientific article

Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting

scientific article

Cargo recognition in clathrin-mediated endocytosis

scientific article

Clathrin adaptor AP-2 is essential for early embryonal development.

scientific article

Cloning, expression, and localization of a novel γ‐adaptin‐like molecule ⬇️

scientific article published on September 18, 1998

Co-assembly of viral envelope glycoproteins regulates their polarized sorting in neurons

scientific article

Coat proteins: shaping membrane transport ⬇️

scientific article published on May 1, 2003

Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants

scientific article

Definition of the consensus motif recognized by gamma-adaptin ear domains

scientific article published on 9 December 2003

Degradation from the endoplasmic reticulum: disposing of newly synthesized proteins

scientific article published on 01 July 1988

Direct binding to Rsp5p regulates ubiquitination-independent vacuolar transport of Sna3p.

scientific article

Disorders of intracellular protein trafficking in human disease.

scientific article

Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex

scientific article

Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.

scientific article published on 31 January 2007

EARP is a multisubunit tethering complex involved in endocytic recycling

scientific article

Effect of the incomplete separation of bound and free ligand on binding measurements

scientific article published on 01 December 1981

Endosome-specific localization and function of the ARF activator GNOM.

scientific article published on January 2003

Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells.

scientific article

Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex

scientific article published on 01 January 1988

Formation of Tubulovesicular Carriers from Endosomes and Their Fusion to the trans-Golgi Network

scientific article published on 08 July 2015

Functional Domain Mapping of the Clathrin-associated Adaptor Medium Chains ॖ1 and ॖ2 ⬇️

scientific article published on October 24, 1997

Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs).

scientific article

Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster

scientific article

Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes

scientific article

Genetic analyses of adaptin function from yeast to mammals.

scientific article

Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae

scientific article

Germline mutations in PRKCSH are associated with autosomal dominant polycystic liver disease

scientific article (publication date: March 2003)

Gga2 mediates sequential ubiquitin-independent and ubiquitin-dependent steps in the trafficking of ARN1 from the trans-Golgi network to the vacuole.

scientific article

Going forward with retromer.

scientific article

HIV-1 Vpu accessory protein induces caspase-mediated cleavage of IRF3 transcription factor

scientific article

Human Vam6p promotes lysosome clustering and fusion in vivo

scientific article

Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway.

scientific article published on 29 April 2009

Imaging intracellular fluorescent proteins at nanometer resolution

scientific article (publication date: 15 September 2006)

Imaging the Polarized Sorting of Proteins from the Golgi Complex in Live Neurons

scientific article published in January 2016

In vitro assays of Arf1 interaction with GGA proteins.

scientific article published on January 2005

Insights into the biogenesis of lysosome-related organelles from the study of the Hermansky-Pudlak syndrome

scientific article published on 01 December 2004

Interaction of Endocytic Signals from the HIV-1 Envelope Glycoprotein Complex with Members of the Adaptor Medium Chain Family ⬇️

scientific article published on November 24, 1997

Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor.

scientific article

Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors

scientific article

Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments

scientific article

Lactogen receptors in rat Leydig cells: analysis of their structure with bifunctional cross-linking reagents.

scientific article published in April 1985

Linking cargo to vesicle formation: receptor tail interactions with coat proteins.

scientific article published on August 1997

Mechanism of acidification of the trans-Golgi network (TGN). In situ measurements of pH using retrieval of TGN38 and furin from the cell surface

scientific article published on 01 January 1998

Mechanisms and functions of lysosome positioning

scientific article published on 31 October 2016

Mechanisms of Polarized Organelle Distribution in Neurons

scientific article

Molecular characterization of hepatocystin, the protein that is defective in autosomal dominant polycystic liver disease.

scientific article published in June 2004

Morphology and dynamics of clathrin/GGA1-coated carriers budding from the trans-Golgi network

scientific article

Moving and positioning the endolysosomal system.

scientific article published on 20 February 2017

Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells

scientific article

Mutational analysis of the fusion peptide of the human immunodeficiency virus type 1: identification of critical glycine residues.

scientific article published in April 1996

Nef-arious goings-on at the Golgi

scientific article published on 05 July 2012

Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3

scientific article published on 06 November 2019

Novel Aspects of Degradation of T Cell Receptor Subunits from the Endoplasmic Reticulum (ER) in T Cells: Importance of Oligosaccharide Processing, Ubiquitination, and Proteasome-dependent Removal from ER Membranes ⬇️

scientific article published on March 16, 1998

Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism

scientific article

Polarized sorting of the copper transporter ATP7B in neurons mediated by recognition of a dileucine signal by AP-1.

scientific article

Polarized trafficking of the sorting receptor SorLA in neurons and MDCK cells.

scientific article

Polycystic liver disease is a disorder of cotranslational protein processing.

scientific article

Preface

Presence of an autoantibody against a Golgi cisternal membrane protein in the serum and cerebrospinal fluid from a patient with idiopathic late onset cerebellar ataxia.

scientific article

Properties of human growth hormone binding sites solubilized from female rabbit kidney

scientific article published on 01 April 1982

Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components

scientific article

Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon

scientific article published on 24 August 2016

Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3

scientific article

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7.

scientific article

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

scientific article published on 9 June 2016

Retrograde transport from endosomes to the trans-Golgi network

scientific article (publication date: August 2006)

Reversal of fortune for nascent proteins

scientific article published in Nature

Reversible association with motor proteins (RAMP): A streptavidin-based method to manipulate organelle positioning

scientific article published on 17 May 2019

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

scientific article

Segregation in the Golgi complex precedes export of endolysosomal proteins in distinct transport carriers.

scientific article published on 4 October 2017

Signal-mediated, AP-1/clathrin-dependent sorting of transmembrane receptors to the somatodendritic domain of hippocampal neurons

scientific article

Solubilization of the lactogenic receptors from rat liver microsomes ⬇️

scientific article published on November 14, 1978

Sorting of Dendritic and Axonal Vesicles at the Pre-axonal Exclusion Zone.

scientific article

Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery

scientific article published in May 2001

Structural Basis for the Recognition of Tyrosine-based Sorting Signals by the  3A Subunit of the AP-3 Adaptor Complex

scientific article

Structural Mechanism for Cargo Recognition by the Retromer Complex.

scientific article

Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1

scientific article

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex

scientific article

Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.

scientific article

Structural characteristics of the Leydig cell lactogen receptors

scientific article published on 01 January 1984

Structural determinants of interaction of tyrosine-based sorting signals with the adaptor medium chains

scientific article published on 01 November 1996

Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins

scientific article

Structural requirements for function of yeast GGAs in vacuolar protein sorting, alpha-factor maturation, and interactions with clathrin.

scientific article

TSSC1 is novel component of the endosomal retrieval machinery

scientific article

The Medium Subunits of Adaptor Complexes Recognize Distinct but Overlapping Sets of Tyrosine-based Sorting Signals ⬇️

scientific article published on October 2, 1998

The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain

scientific article published on 05 January 2006

The Vps27/Hse1 Complex Is a GAT Domain-Based Scaffold for Ubiquitin-Dependent Sorting

scientific article

The adaptor protein-1 μ1B subunit expands the repertoire of basolateral sorting signal recognition in epithelial cells

scientific article

The autophagy protein ATG9A promotes HIV-1 infectivity

scientific article published on 03 July 2019

The clathrin adaptor AP-1A mediates basolateral polarity ⬇️

scientific article published on April 2012

The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.

scientific article

The mechanisms of vesicle budding and fusion

scientific article (publication date: 23 January 2004)

The retromer complex and clathrin define an early endosomal retrograde exit site.

scientific article

The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain

scientific article

The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting.

scientific article

The transmembrane domain of a carboxyl-terminal anchored protein determines localization to the endoplasmic reticulum

scientific article published on 01 January 1997

The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites

scientific article

Transient aggregation of major histocompatibility complex class II chains during assembly in normal spleen cells.

scientific article published in May 1995

Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.

scientific article published on 16 November 2011

Transport according to GARP: receiving retrograde cargo at the trans-Golgi network.

scientific article

Ubiquitin and the control of protein fate in the secretory and endocytic pathways

scientific article published on 01 January 1998

Ultrastructure of long-range transport carriers moving from the trans Golgi network to peripheral endosomes

scientific article published on 19 June 2006

Vesicular transport earns a Nobel

scientific article published on January 2014

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